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Inicio Annals of Hepatology P- 80 DIFFERENTIAL EXPRESSION OF MATRIX METALLOPROTEINASE 7 IN CHRONIC LIVER DIS...
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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P- 80 DIFFERENTIAL EXPRESSION OF MATRIX METALLOPROTEINASE 7 IN CHRONIC LIVER DISEASES
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Daniel Montes de Oca-Angeles1, M. Lemus-Peña1, A. Hernandez-Barragan1, M. Hernández-Santillán1, Moisés Martinez-Castillo1, Z. Medina-Avila1, D. Santana-Vargas2, A. Torre-Delgadillo4, J.L. Pérez-Hernández2, F. Higuera-De la Tijera2, P. Cordero-Pérez3, L. Muñoz-Espinosa3, D. Kershenobich4, G. Gutiérrez-Reyes1
1 Liver, Pancreas and Motility Laboratory, Unit of Research in Experimental Medicine, School of Medicine, Autonomy National University of México (UNAM), Mexico City, Mexico
2 Department of Gastroenterology, Mexican General Hospital “Dr. Eduardo Liceaga”, Mexico City, Mexico
3 Universitary Hospital “Dr. José Eluterio González”, School of Medicine, Autonomy National University of Nuevo León (UANL), Nuevo Leon, Mexico City, Mexico
4 National Institute of Medical Sciences and Nutrition “Salvador Zubirán,” Mexico City, Mexico
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Vol. 28. Núm S1

Abstracts of the 2022 Annual Meeting of the ALEH

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Introduction and Objectives

We recently published that in the serum of patients with chronic Hepatitis C, there are high concentrations of inactive Matrix Metalloproteinases (MMP). However, the MMP has not been studied in other liver diseases. This study aimed to evaluate serum concentrations of MMP-7 in different hepatic etiologies and according to fibrosis stage.

Materials and Methods

A cross-sectional and multicenter study was carried out, including subjects with alcoholism (WHO criteria), without (OH) and with liver injury (cirrhosis, CiOH); diagnosed by clinical, biochemical data, non-alcoholic fatty liver (NAFLD) and chronic Hepatitis C (CHC). Transitional elastography (Fibroscan) was performed in NAFLD and CHC, considering mild fibrosis (MF: F0, F1, F2) and advanced fibrosis (AF: F3, F4). As controls, subjects without alcohol consumption (CT) were recruited. For the quantification of MMP-7, Multiplex-MERCK© was used. Statistical analysis was performed using SPSS V.22 using Mann Whitney U, p<0.05.

Results

It included 99 subjects (OH); 45 (CiOH); 48 (CHC, FL); 54 (CHC, FA); 27 (NAFLD, FL); 36 (NAFLD, AF) and 131 CT. MMP-7 was found to be elevated in CHC (FL and FA) vs. CT; and decreased in OH, CiOH, NAFLD (FL and FA) vs. CT, plus there are significant differences between all etiologies, p<0.001. MMP-7 is a matrilysin that degrades extracellular matrix products (proteoglycans); it increases significantly in subjects with CHC compared to CT, while in other pathologies with stages, even in advanced fibrosis, the levels are decreased compared to CT.

Conclusions

The increased MMP-7 in serum of chronic Hepatitis C and decrease in alcoholism and non-alcoholic fatty liver patients suggests that, according to the etiology, the levels can be useful to make a differential diagnosis. We considered that it is a potential non-invasive biomarker.

Funding

This work was partially financed by CONACyT SALUD-2016-272579 and PAPIIT- UNAM TA200515.

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