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Inicio Annals of Hepatology Short-term efficacy and safety of l-ornithine l-aspartate therapy in patients wi...
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Vol. 27. Núm. S3.
Abstracts from XVII Mexican Congress of Hepatology
(diciembre 2022)
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Vol. 27. Núm. S3.
Abstracts from XVII Mexican Congress of Hepatology
(diciembre 2022)
Open Access
Short-term efficacy and safety of l-ornithine l-aspartate therapy in patients with cirrhosis and minimal hepatic encephalopathy: a real-life cohort study
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AB Moreno-Cobos, F Higuera-de la Tijera, CI Hinojosa-Segura, D Montemira-Orozco, J Reyes-Méndez, IG Cruz-Reyes, J Zavala-Ramírez, D Santana-Vargas, A Servín-Caamaño, JM Abdo-Francis, JL Pérez- Hernandez
Department of Gastroenterology and Hepatology. General Hospital of Mexico “Dr. Eduardo Liceaga.” Mexico City, Mexico
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Vol. 27. Núm S3

Abstracts from XVII Mexican Congress of Hepatology

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Introduction and Objectives

MHE is related to a higher risk of accidents and deterioration in the quality of life; it can be detected with PHES and CFP. There is currently insufficient evidence that treatment with oral LOLA improves performance in PHES and CFP in patients with MHE. This study aimed to verify the response and safety of LOLA treatment in a real-life cohort of patients with MHE.

Materials and Methods

Cirrhotic patients in the Hepatology clinic diagnosed with MHE received LOLA 6 grams three times a day for three days and were reassessed with PHES and CFP. The results were analyzed by descriptive statistics, the comparison between parameters by paired t-Student or Wilcoxon test as appropriate, a value of p<0.01 was considered significant. The trial was approved by the research ethics committee, and informed consent was obtained.

Results

ninety-eight patients with cirrhosis were evaluated; 38.8% had baseline MHE, 68.4% were women, the mean age of 53.3 years, and the median education was nine years. According to Child-Pugh: 68.4% A, 23.7% B, and 7.9% C. 34 patients were analyzed, the PHES score improved significantly post-treatment (baseline -6.44±1.7 vs -2.79±1.9; p<0.0001), CFP improved (baseline 37±1.8 vs 39.8±2.2; p<0.0001). According to PHES 88.2% and CFP 85.3%, patients showed remission. The incidence rate ratio for persisting with MHE was 4 and 5 per 34 person-times, and the prevented fraction of 0.88 and 0.85 according to PHES and CFP, respectively. No adverse effect was reported.

Conclusions

LOLA is effective in improving cognitive performance and reversing very early alterations in PHES and CFP in patients with cirrhosis and MHE.

Funding

Donation from LOLA by the volunteer ladies of the Hospital General de México “Dr. Eduardo Liceaga.”

Declaration of interest

The authors declare no potential conflicts of interest.

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