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Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) Interleukin-6 concentrations in the vitreous body of patients with retinal detac...
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Vol. 90. Issue 11.
Pages 527-530 (November 2015)
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Vol. 90. Issue 11.
Pages 527-530 (November 2015)
Original article
Interleukin-6 concentrations in the vitreous body of patients with retinal detachment
Concentración de interleuquina-6 en el vítreo de pacientes con desprendimiento de retina
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526
V.M. Asensio-Sáncheza,
Corresponding author
victor_asensio@orangemail.es

Corresponding author.
, J.M. Collazosb, M. Cantónc
a Servicio de Oftalmología, Hospital Clínico Universitario, Valladolid, Spain
b Servicio de Bioquímica, Hospital Medina del Campo, Valladolid, Spain
c Bioestadística, Hospital Medina del Campo, Valladolid, Spain
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Tables (2)
Table 1. Characteristics of Group A (n=20).
Table 2. Characteristics of Group B (n=20).
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Abstract
Objective

To measure interleukin-6 (IL-6) levels in the vitreous body of patients with retinal detachment (RD).

Patients and methods

Undiluted vitreous samples were obtained from 40 patients with no history of prior vitreous or intraocular surgery. Patients were divided into two groups: A (n=20) patients with RD and B (n=20) patients with pre-retinal macular membranes and macular holes. IL-6 was determined using radioimmunoassay.

Results

IL-6 vitreous concentration in group A was 122.4±16pg/mL (range 91.5–620) and in group B was 46±23pg/mL (range 3–150) (p<.001).

Conclusions

These results show that the concentration of IL-6 in the vitreous body was significantly higher in patients with RD than in the control group.

Keywords:
Interleukin-6
Retinal detachment
Vitreous
Premacular membrane
Macular hole
Resumen
Objetivo

Determinar los niveles de interleuquina-6 (IL-6) en el vítreo de pacientes con desprendimiento de retina (DdR).

Material y método

Mediante vitrectomía vía pars plana, se recogieron muestras no diluidas de vítreo de 40 pacientes sin antecedentes de cirugía vítrea o intraocular previa, que fueron divididos en 2 grupos: A (n=20) pacientes con DdR y B (n=20) pacientes con membrana premacular y agujero macular. La concentración de IL-6 se determinó mediante radioinmunoensayo.

Resultados

La concentración vítrea de IL-6 en el grupo A fue 122,4±16pg/mL (rango 91,5–620) y en el grupo B fue 46±23pg/mL (rango 3–150) (p<0,001).

Conclusiones

Estos resultados demuestran que la concentración vítrea de IL-6 está más elevada en los pacientes con DdR en comparación con el grupo control.

Palabras clave:
Interleuquina-6
Desprendimiento de retina
Vítreo
Membrana premacular
Agujero macular

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