Grado de concordancia y diferencias entre valores maculares en niños mediante dos tipos de tomografía de coherencia óptica espectral | Archivos de la Sociedad Española de Oftalmología

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Particularmente las OCT de dominio espectral son ampliamente reconocidas por su r&#225;pida adquisici&#243;n de m&#250;ltiples im&#225;genes<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">8-10</span></a>&#46; Hoy en d&#237;a se cuenta con varios modelos de OCT espectral<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">11&#44;12</span></a>&#44; incluyendo las OCT Spectralis y Cirrus&#44; las cuales son ampliamente usadas en la pr&#225;ctica cl&#237;nica diaria tanto en adultos como en ni&#241;os<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">13</span></a>&#46; Estos sistemas poseen cada uno una base de datos procedentes de estudios independientes<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">14&#44;15</span></a>&#44; aunque en ninguno de ellos se incluyeron pacientes menores de 18<span class="elsevierStyleHsp" style=""></span>a&#241;os de edad<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">16&#44;17</span></a>&#46; Adem&#225;s&#44; en comparaci&#243;n con la poblaci&#243;n adulta&#44; pocos estudios han sido llevados a cabo en ni&#241;os haciendo uso de Cirrus o Spectralis<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">18-25</span></a>&#46; Estos estudios no hallaron correlaci&#243;n entre el grosor macular y la edad&#44; el sexo<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">24</span></a> y la refracci&#243;n<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">23</span></a>&#44; aunque otros s&#237; hallaron diferencias seg&#250;n el sexo<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">17&#44;20&#44;21</span></a>&#46; Se cuenta con cuatro estudios que realizaron la segmentaci&#243;n intrarretiniana con OCT Spectralis en ni&#241;os&#44; pero o bien usaron un software de propia configuraci&#243;n<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">26</span></a>&#44; mencionan solo algunas de las capas o bien incluyeron ni&#241;os con amplios rangos de poder di&#243;ptrico<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">28&#44;49&#44;50</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Seg&#250;n nuestra b&#250;squeda bibliogr&#225;fica&#44; no hemos hallado un estudio previo publicado que compare los valores maculares en ni&#241;os con estos dos instrumentos&#44; y tampoco un estudio previo publicado que mencione la segmentaci&#243;n de la mayor&#237;a de las capas intrarretinianas usando el software propio de Spectralis en ni&#241;os&#46; Debido a que la OCT es una herramienta confiable no invasiva y nos permite obtener medidas en ni&#241;os&#44; nuestro prop&#243;sito fue determinar el grado de concordancia entre los valores maculares de OCT Cirrus y Spectralis en ni&#241;os y proponer valores de normalidad en la poblaci&#243;n pedi&#225;trica&#44; as&#237; como evaluar las diferencias seg&#250;n sexo&#44; raza&#44; edad&#44; lateralidad y etnia de origen&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materiales y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Participantes</span><p id="par0015" class="elsevierStylePara elsevierViewall">Realizamos un estudio descriptivo&#44; transversal&#44; comparativo y observacional que fue previamente aprobado por el Comit&#233; de &#201;tica del Hospital Universitario Fundaci&#243;n Jim&#233;nez D&#237;az&#46; Los datos obtenidos de los pacientes fueron manejados con la mayor confidencialidad y se siguieron estrictamente las normas de la Declaraci&#243;n de Helsinki&#46; Los ni&#241;os mayores de 12<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; as&#237; como sus padres o tutores legales&#44; otorgaron su autorizaci&#243;n de forma escrita&#44; habi&#233;ndoseles explicado y comprendido los procedimientos que se iban a realizar&#46; Igualmente los pacientes menores de 12<span class="elsevierStyleHsp" style=""></span>a&#241;os dieron su consentimiento verbal y sus tutores legales o los padres consintieron de forma escrita su participaci&#243;n&#46; Tuvimos como criterios de inclusi&#243;n&#58; edad entre 5 y 15<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; no patolog&#237;a ocular previa o patolog&#237;a sist&#233;mica que pudiera influir a nivel ocular&#44; adecuada edad gestacional &#40;entre las semanas 37 y 42&#41; y adecuado peso al nacer &#40;entre 2&#46;500 y 4&#46;000<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; agudeza visual mejor corregida adecuada para su edad &#40;agudeza visual decimal &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;8 en ni&#241;os de 5<span class="elsevierStyleHsp" style=""></span>a&#241;os y 1&#44;0 en &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41; mediante los optotipos de la tabla de Snellen o la &#171;E&#187; direccional de Snellen&#44; los valores de equivalente esf&#233;rico entre &#8722;3D y &#43;3D&#44; y valores de astigmatismo menores a 2<span class="elsevierStyleHsp" style=""></span>dioptr&#237;as&#46; Los criterios de exclusi&#243;n fueron los siguientes&#58; presi&#243;n intraocular &#40;PIO&#41; &#62;<span class="elsevierStyleHsp" style=""></span>21<span class="elsevierStyleHsp" style=""></span>mmHg &#40;obtenida mediante neumoton&#243;metro&#59; en caso de valores por encima de 20<span class="elsevierStyleHsp" style=""></span>mmHg se volvi&#243; a medir con el ton&#243;metro de Perkins&#41;&#44; im&#225;genes con se&#241;al menor de 5&#47;10 &#40;Cirrus&#41; o menor a 20<span class="elsevierStyleHsp" style=""></span>dB &#40;Spectralis&#41;&#44; y pacientes no colaboradores&#46; Inicialmente 112<span class="elsevierStyleHsp" style=""></span>ni&#241;os cumplieron los criterios de inclusi&#243;n&#44; pero 12<span class="elsevierStyleHsp" style=""></span>pacientes fueron excluidos por mala calidad de la se&#241;al o mala colaboraci&#243;n&#44; teniendo una muestra final de 100 pacientes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46; A todos los pacientes se les realiz&#243; una exploraci&#243;n oftalmol&#243;gica completa&#44; incluyendo mejor agudeza visual corregida&#44; motilidad ocular extr&#237;nseca&#44; test de estereopsis&#44; PIO y observaci&#243;n de polo anterior y posterior mediante l&#225;mpara de hendidura&#46; Se obtuvo la refracci&#243;n ocular previa cicloplejia&#44; posteriormente se administr&#243; ciclopentolato al 1&#37; en tres oportunidades con intervalos de 10<span class="elsevierStyleHsp" style=""></span>min&#44; y a los 15 a 20<span class="elsevierStyleHsp" style=""></span>min de la &#250;ltima aplicaci&#243;n se repiti&#243; la autorrefracci&#243;n&#46; La longitud axial ocular se midi&#243; mediante el IOLMaster &#40;Carl Zeiss Meditec&#41;&#46; Se obtuvieron las medidas de ambos ojos&#44; pero debido a la semejanza hallada en el an&#225;lisis estad&#237;stico&#44; en los resultados solo consideramos los ojos derechos&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Tomograf&#237;a de coherencia &#243;ptica</span><p id="par0020" class="elsevierStylePara elsevierViewall">El modelo de OCT Cirrus utilizado fue el 4000 &#40;software 7&#46;0&#46;3&#46;19&#41; y el protocolo para la obtenci&#243;n de los valores maculares fue el Macular Cube 512<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>128&#46; Hicimos uso del mismo protocolo con la OCT Spectralis &#40;software 6&#46;3&#46;2&#46;0&#41;&#46; Aqu&#237; debe mencionarse que aunque el borde interno de la segmentaci&#243;n intrarretiniano para ambas OCT es el mismo &#40;la interfase vitreorretiniana&#41;&#44; el borde externo difiere&#44; siendo el epitelio pigmentario de la retina &#40;EPR&#41; la l&#237;nea de referencia para la OCT Cirrus y la membrana de Bruch para la OCT Spectralis&#46; Esta diferencia es la responsable de la variaci&#243;n en las mediciones maculares de ambas OCT&#44; como ha sido documentado en la poblaci&#243;n adulta&#59; sin embargo&#44; esto no ha sido demostrado en ni&#241;os por no contar con un estudio previo en esta poblaci&#243;n&#46; Por otro lado&#44; ambas OCT han demostrado gran reproducibilidad<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">30-38</span></a>&#44; pero Spectralis mostr&#243; mejor repetibilidad en las medidas maculares entre varias OCT<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">29</span></a>&#44; y en comparaci&#243;n a Cirrus fue m&#225;s confiable en la detecci&#243;n de patolog&#237;a retiniana<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">39</span></a>&#46; Las im&#225;genes fueron obtenidas por un mismo investigador y se realiz&#243; la revisi&#243;n manual de cada imagen&#44; excluyendo los pacientes que tuvieran errores de segmentaci&#243;n&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0025" class="elsevierStylePara elsevierViewall">Con el prop&#243;sito de mantener en estricta confidencialidad los datos de los participantes del estudio&#44; se otorgaron c&#243;digos a cada uno y se incluyeron en una base de datos en la cual se introdujeron los datos de las variables&#46; El an&#225;lisis estad&#237;stico se llev&#243; a cabo mediante la versi&#243;n 23&#46;0 del paquete estad&#237;stico SPSS&#46; Primeramente se hizo uso del test de Kolmogorov-Smirnov para evaluar la normalidad de las variables&#44; y debido a que no todas las variables eran normales&#44; optamos por el uso de test no param&#233;tricos con la finalidad de obtener resultados m&#225;s uniformes en el contraste de hip&#243;tesis&#46; El nivel de significaci&#243;n estad&#237;stica que tomamos en cuenta fue de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; con un intervalo de confianza &#40;IC&#41; del 95&#37;&#46; Se obtuvo la media&#44; la desviaci&#243;n est&#225;ndar&#44; la mediana y los percentiles 1&#44; 5 y 95 &#40;para variables continuas&#41; y se llev&#243; a cabo el an&#225;lisis de frecuencias para variable categ&#243;ricas&#46; El coeficiente de correlaci&#243;n intraclase &#40;CCI&#41; de tipo absoluto se utiliz&#243; para calcular el grado de concordancia entre los valores de ambas OCT&#46; Los valores &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;2 fueron considerados de &#171;muy bajo grado de concordancia&#187;&#44; valores entre 0&#44;2 y 0&#44;5&#44; fueron interpretados como de &#171;bajo grado de concordancia&#187;&#44; valores entre 0&#44;5 y 0&#44;7 como de &#171;moderado grado de concordancia&#187;&#44; valores &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;7 y 0&#44;9 como de &#171;buen grado de concordancia&#187;&#44; y valores &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;9 como de &#171;concordancia excelente&#187;&#46; La gr&#225;fica de Bland-Altman fue utilizada para representar el grado de concordancia entre los valores maculares de ambas OCT&#46; El coeficiente de correlaci&#243;n de Spearman evalu&#243; la correlaci&#243;n entre la longitud axial y los valores del disco &#243;ptico&#46; El test de Mann-Whitney <span class="elsevierStyleItalic">U</span> nos permiti&#243; valorar las diferencias seg&#250;n sexo y etnia de origen y el test de Wilcoxon las diferencias interoculares y aquellas entre los valores de ambas OCT&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Participantes</span><p id="par0030" class="elsevierStylePara elsevierViewall">Doce pacientes fueron excluidos debido a mala calidad de imagen o falta de cooperaci&#243;n&#44; teniendo una muestra final de 200 ojos y 100 pacientes&#59; sin embargo&#44; debido a la alta correlaci&#243;n entre los ojos derechos &#40;OD&#41; y los ojos izquierdos &#40;OI&#41; al llevar a cabo el an&#225;lisis estad&#237;stico&#44; tuvimos en cuenta solo los resultados de los OD&#46; Las edades de los pacientes fueron entre 5 a 15<span class="elsevierStyleHsp" style=""></span>a&#241;os y una media de edad de 10&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Las ni&#241;as representaron un 60&#37; y los varones un 40&#37;&#46; La mayor&#237;a fue de etnia europea &#40;72&#37;&#41;&#44; seguido de pacientes de etnia latinoamericana &#40;20&#37;&#41;&#44; asi&#225;tica &#40;6&#37;&#41;&#44; y de &#193;frica del Norte &#40;2&#37;&#41;&#46; La media de la longitud axial fue de 23&#44;1<span class="elsevierStyleHsp" style=""></span>mm&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Par&#225;metros maculares</span><p id="par0035" class="elsevierStylePara elsevierViewall">La media del grosor macular central &#40;GMC&#41; fue de 244&#44;2<span class="elsevierStyleHsp" style=""></span>&#956;m con Cirrus y de 261&#44;7<span class="elsevierStyleHsp" style=""></span>&#956;m Spectralis &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; y el volumen medio del GMC fue de 0&#44;21<span class="elsevierStyleHsp" style=""></span>&#956;m<span class="elsevierStyleSup">3</span> &#40;Spectralis&#41;&#46; En el anillo externo el grosor mayor fue para el sector nasal con ambos instrumentos&#46; En el anillo interno tambi&#233;n fue para el sector nasal con Cirrus&#44; mientras con Spectralis fue el sector superior&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> muestra los valores de las capas intrarretinianas de los OD&#44; OI y la media aritm&#233;tica de ambos&#46; Los valores del epitelio pigmentario de la retina &#40;EPR&#41; fueron los m&#225;s altos &#40;sin tomar en cuenta la suma de las capas internas&#41; y los de la capa de fibras nerviosas de la retina macular &#40;CFNRm&#41; fueron los m&#225;s bajos&#46; La correlaci&#243;n entre los sectores inferior externo y temporal externo &#40;Cirrus&#41; y la longitud axial fue negativa y baja&#44; aunque esta fue estad&#237;sticamente significativa&#46; Los valores de los sectores externos &#40;Spectralis&#41; tuvieron correlaci&#243;n negativa significativamente estad&#237;stica con la longitud adxial &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; El grado de concordancia absoluto entre los valores maculares fue desde moderado &#40;CCI&#58; 0&#44;66&#59; IC<span class="elsevierStyleHsp" style=""></span>95&#37; &#8722;0&#44;06 a 0&#44;90&#41; a muy bajo para los vol&#250;menes maculares &#40;CCI&#58; 0&#44;11&#59; IC<span class="elsevierStyleHsp" style=""></span>95&#37;&#58; &#8722;0&#44;01 a 0&#44;39&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; Los gr&#225;ficos de Bland-Altman para los valores de GMC se muestran en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> y para el volumen macular central en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Diferencias seg&#250;n edad&#44; sexo&#44; etnia de origen&#44; lateralidad y tipo de OCT</span><p id="par0045" class="elsevierStylePara elsevierViewall">Al evaluar las diferencias entre los valores maculares se observ&#243; que el GMC fue mayor en ni&#241;os que en ni&#241;as&#44; y esta diferencia fue estad&#237;sticamente significativa &#40;ni&#241;os&#58; 253<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; ni&#241;as&#58; 242<span class="elsevierStyleHsp" style=""></span>&#956;m&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;037&#59; Cirrus&#41; &#40;ni&#241;os&#58; 266<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; ni&#241;as&#58; 258<span class="elsevierStyleHsp" style=""></span>&#956;m&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;025&#59; Spectralis&#41;&#46; En relaci&#243;n con las diferencias seg&#250;n edad&#44; dividimos la muestra en dos grupos etarios&#58; grupo<span class="elsevierStyleHsp" style=""></span>1 &#40;pacientes &#60;<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41; y grupo<span class="elsevierStyleHsp" style=""></span>2 &#40;pacientes &#8805;<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>52&#41; con la finalidad de contar con dos grupos de cifras similares&#46; No hubo diferencias significativas en el GMC seg&#250;n la edad con ninguna de las OCT&#44; pero s&#237; se observaron diferencias en los sectores&#58; nasal &#40;grupo<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>318&#44; grupo<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>322&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;017&#41;&#44; temporal &#40;grupo<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>303&#44; grupo<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>309&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;020&#41; y superior &#40;grupo<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>313&#44; grupo<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>319&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;014&#41; del anillo interno &#40;Cirrus&#41;&#46; Estas diferencias no se hallaron con la OCT Spectralis&#46; El an&#225;lisis seg&#250;n etnia de origen revel&#243; diferencias en el GMC &#40;europea<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>249&#44; latinoamericana<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>238&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;042&#59; Cirrus&#41; &#40;europea<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>264&#44; latinoamericana<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>249&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;033&#59; Spectralis&#41;&#46; En el an&#225;lisis de la discrepancia interocular no se hallaron diferencias en el GMC &#40;OD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>246&#44; OI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>245&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;862&#59; Cirrus&#41; &#40;OD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>262&#44; OI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>263&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;119&#59; Spectralis&#41;&#46; Los &#250;nicos sectores que fueron significativamente diferentes fueron el nasal interno &#40;OD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>320&#44; OI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>322&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;024&#59; Cirrus&#41; &#40;OD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>340&#44; OI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>342&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; Spectralis&#41; y el superior externo &#40;OD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>306&#44; OI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>309&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;024&#59; Spectralis&#41;&#46; Por &#250;ltimo&#44; todos los valores maculares de la OCT Spectralis fueron diferentes a los de la OCT Cirrus &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En relaci&#243;n con las capas intrarretinianas &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#44; los ni&#241;os tuvieron valores m&#225;s altos de CFNRm &#40;ni&#241;os&#58; 12&#44; ni&#241;as&#58; 11&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;034&#41;&#44; de capa de c&#233;lulas ganglionares &#40;CCG&#41; &#40;ni&#241;os&#58; 15&#44;5&#59; ni&#241;as&#58; 14&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41;&#44; de capa plexiforme interna &#40;CPI&#41; &#40;ni&#241;os&#58; 21&#44; ni&#241;as&#58; 19&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#41;&#44; de capa nuclear interna &#40;CNI&#41; &#40;ni&#241;os&#58; 17&#44;5&#59; ni&#241;as&#58; 16&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;029&#41; y de capas internas &#40;ni&#241;os&#58; 180&#44; ni&#241;as&#58; 170&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#41;&#46; No se obtuvieron diferencias seg&#250;n edad o lateralidad ocular&#46; Seg&#250;n la etnia de origen solo se observaron diferencias en las capas internas &#40;europea<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>176&#44; latinoamericana<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>163&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;043&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discusi&#243;n</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Valores normativos</span><p id="par0055" class="elsevierStylePara elsevierViewall">Nuestro estudio incluy&#243; 100 ojos de ni&#241;os normales entre las edades de 5 a 15<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Los estudios de valores maculares en ni&#241;os normales que consideran mayores muestras incluyeron 318 ojos<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">25</span></a> y 283 ojos<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">27</span></a> &#40;Cirrus&#41; y 162 ojos <a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">40</span></a> &#40;Spectralis&#41;&#46; Los valores m&#225;s altos reportados fueron en ni&#241;os europeos<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">23&#44;27</span></a> &#40;Cirrus&#41; y en ni&#241;os norteamericanos<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">20</span></a> &#40;Spectralis&#41; y los m&#225;s delgados en ni&#241;os indios<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">24</span></a> &#40;Cirrus&#41; y en ni&#241;os turcos<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">18</span></a> &#40;Spectralis&#41;&#46; En comparaci&#243;n con estos estudios&#44; nuestros valores pueden ser considerados medios&#44; probablemente por la heterogeneidad de la muestra&#46; Por otro lado&#44; en nuestra muestra los valores del anillo interno con cirrus fueron los m&#225;s altos&#44; hallazgos similares a lo mencionado por otros autores<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">25&#44;27</span></a>&#46; En relaci&#243;n con las medidas de Spectralis&#44; el sector superior interno fue el m&#225;s grueso&#44; resultado tambi&#233;n obtenido por P&#233;rez<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">40</span></a> y Yanni et al&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">20</span></a>&#46; En nuestro caso el sector nasal externo fue el m&#225;s grueso&#44; y esto coincidi&#243; con los hallazgos de otros autores<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">18&#44;20&#44;22</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Respecto a los valores de las capas intrarretinianas&#44; como se mencion&#243; previamente&#44; no pudimos realizar comparaciones con estudios previos realizados con Spectralis&#44; ya que o bien usaron un software de propia configuraci&#243;n<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">20</span></a> o bien incluyeron en sus hallazgos ni&#241;os con altos valores refractivos<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">28&#44;49</span></a>&#46; Debido a ello realizaremos la discusi&#243;n con dos estudios en adultos normales<a class="elsevierStyleCrossRefs" href="#bib0460"><span class="elsevierStyleSup">41&#44;42</span></a> que utilizaron el software propio de Spectralis&#44; como en nuestro caso&#46; En comparaci&#243;n con adultos de procedencia asi&#225;tica&#44; los grosores fueron variables&#59; las CFNRm&#44; CCG&#44; CPI&#44; capa plexiforme externa &#40;CPE&#41; y capas internas fueron mayores en nuestros pacientes que en estos adultos<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">42</span></a>&#46; La CNI&#44; la capa nuclear externa &#40;CNE&#41;&#44; la capa del EPR y las externas fueron m&#225;s delgadas en nuestros ni&#241;os&#46; Cabe mencionar que las capas plexiformes tendieron a ser mayores en ni&#241;os que en adultos&#44; y lo inverso sucedi&#243; en las capas nucleares&#46; Este hallazgo podr&#237;a estar en relaci&#243;n con el desarrollo de las sinapsis y conexiones neuronales en ni&#241;os mientras alcanzan la madurez de la edad adulta&#44; y adem&#225;s podr&#237;a estar relacionado con mayor prevalencia de patolog&#237;a retiniana en adultos que en ni&#241;os&#46; Al realizar la comparaci&#243;n con el segundo estudio se puede ver que sus valores de CFNRm y CPI fueron mayores en comparaci&#243;n a los de nuestros pacientes<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">41</span></a>&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Grado de concordancia</span><p id="par0065" class="elsevierStylePara elsevierViewall">Nuestra b&#250;squeda bibliogr&#225;fica no encontr&#243; art&#237;culos previos publicados comparando los valores maculares entre estas dos OCT en poblaci&#243;n pedi&#225;trica&#46; Cirrus y Spectralis han sido comparadas en adultos por Folgar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">45</span></a>&#44; que evaluaron los valores foveales y parafoveales&#44; y Polo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">48</span></a> utilizaron los gr&#225;ficos de Bland-Altman para evaluar la concordancia&#46; Sin embargo&#44; al ser este un m&#233;todo subjetivo&#44; no podr&#237;amos compararlos con nuestros gr&#225;ficos&#46; En relaci&#243;n con el grado de concordancia&#44; el valor m&#225;s alto de CCI correspondi&#243; al GMC &#40;0&#44;66&#41;&#44; aunque este se interpret&#243; como moderado&#46; El resto de valores se interpretaron como grado bajo a muy bajo de concordancia&#46; Esto estar&#237;a relacionado al nivel de segmentaci&#243;n interna considerado para cada instrumento&#44; habiendo sido esto previamente mencionado en poblaci&#243;n adulta&#46; Seg&#250;n nuestra b&#250;squeda bibliogr&#225;fica&#44; este ser&#237;a el primer estudio en ni&#241;os que evidencie esta falta de concordancia entre las medidas maculares de Cirrus y Spectralis&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Diferencias seg&#250;n sexo&#44; edad&#44; etnia de origen&#44; lateralidad y tipo de OCT</span><p id="par0070" class="elsevierStylePara elsevierViewall">Las diferencias obtenidas seg&#250;n sexo en el GMC&#44; donde los valores fueron mayores en varones que en mujeres&#44; se asemeja a lo mencionado por otros autores<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">18&#44;21&#44;25&#44;27</span></a>&#44; aunque estas diferencias no fueron halladas en otros estudios<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">20&#44;24&#44;40&#44;43</span></a>&#44; a pesar de que en algunos de estos estudios se consideraron m&#225;s ni&#241;os que ni&#241;as en sus muestras&#46; Es particularmente interesante enfatizar las diferencias estad&#237;sticamente significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; en los valores de grosor de la CFNRm&#44; CCG&#44; CPI&#44; CPE y capas internas&#44; donde los valores fueron mayores en varones&#46; A nuestro conocimiento&#44; este ser&#237;a el primer art&#237;culo en mencionar esta tendencia en las capas intrarretinianas&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Respecto a la edad&#44; obtuvimos diferencias en todos los sectores del anillo interno &#40;Cirrus&#41;&#44; de la misma forma que lo expresado por Molnar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">23</span></a>&#44; G&#252;ra&#287;a&#231; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">25</span></a> y Barrio et al&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">27</span></a>&#46; Sin embargo&#44; estos autores fueron los &#250;nicos en obtener diferencias en el GMC con Cirrus seg&#250;n la edad&#46; En relaci&#243;n con los valores de Spectralis&#44; ning&#250;n autor mencion&#243; diferencias en el GMC seg&#250;n grupo etario&#46; Al evaluar las discrepancias seg&#250;n lateralidad&#44; tampoco evidenciamos diferencias interoculares&#44; a excepci&#243;n del sector nasal interno&#44; hallazgo que fue tambi&#233;n mencionado por Molnar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">23</span></a>&#46; Al comparar los valores seg&#250;n etnia de origen&#44; no hallamos estudios previos que reportaran la tendencia en los ni&#241;os de origen europeo de tener mayor GMC que los ni&#241;os de origen latinoamericano&#46; Finalmente&#44; los valores de GMC haciendo uso de la OCT Spectralis fueron mayores que los de Cirrus &#40;d<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>&#956;m&#41;&#44; siendo esto similar a las diferencias en adultos mencionadas por Sander et al&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">46</span></a> &#40;d<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14<span class="elsevierStyleHsp" style=""></span>&#956;m&#41;&#44; Heussen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">47</span></a> &#40;d<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#44;6<span class="elsevierStyleHsp" style=""></span>&#956;m&#41;&#44; Pierro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">37</span></a> &#40;d<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;2<span class="elsevierStyleHsp" style=""></span>&#956;m&#41; y Han y Jaffe<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">44</span></a> &#40;d<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;4<span class="elsevierStyleHsp" style=""></span>&#956;m&#41;&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conclusi&#243;n</span><p id="par0080" class="elsevierStylePara elsevierViewall">En base a nuestros hallazgos con OCT Cirrus y Spectralis&#44; los valores no deber&#237;an ser intercambiables en el diagn&#243;stico&#44; el manejo y el seguimiento en la poblaci&#243;n pedi&#225;trica&#44; ya que podr&#237;a llevar a interpretaciones err&#243;neas&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Financiaci&#243;n</span><p id="par0085" class="elsevierStylePara elsevierViewall">La presente investigaci&#243;n no ha recibido ayudas espec&#237;ficas provenientes de agencias del sector p&#250;blico&#44; sector comercial o entidades sin &#225;nimo de lucro&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflicto de intereses</span><p id="par0090" class="elsevierStylePara elsevierViewall">Los autores declaramos que no existe ning&#250;n conflicto de intereses&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Agradecimientos</span><p id="par0105" class="elsevierStylePara elsevierViewall">Estamos realmente agradecidos a Oliver Shaw&#44; PhD &#40;IIS-FJD&#41;&#44; por llevar a cabo la revisi&#243;n y la correcci&#243;n en formato idioma ingl&#233;s&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar el grado de concordancia y las diferencias entre los par&#225;metros maculares en funci&#243;n de sexo&#44; edad&#44; lateralidad&#44; etnia y tipo de tomograf&#237;a de coherencia &#243;ptica &#40;OCT&#41; en pacientes pedi&#225;tricos&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materiales y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo&#44; transversal y comparativo&#46; Se hizo uso de la OCT Spectralis y la OCT Cirrus para obtener los valores maculares de ambos ojos en 100 pacientes entre 5 y 15<span class="elsevierStyleHsp" style=""></span>a&#241;os sin patolog&#237;a ocular&#46; Debido a la semejanza entre los valores de ambos ojos&#44; en la muestra final solo consideramos los ojos derechos &#40;OD&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La media del grosor macular central &#40;GMC&#41; fue de 244&#44;2<span class="elsevierStyleHsp" style=""></span>&#956;m con Cirrus y 261&#44;7<span class="elsevierStyleHsp" style=""></span>&#956;m con Spectralis&#46; El grado de concordancia para el GMC fue moderado &#40;coeficiente de correlaci&#243;n intraclase&#58; 0&#44;66&#41; y de bajo a muy bajo en el resto de cuadrantes&#46; Los valores de GMC de ambos sistemas fueron significativamente mayores en varones que en mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La capa de fibras nerviosas de la retina macular &#40;CFNRm&#41;&#44; la capa de c&#233;lulas ganglionares &#40;CCG&#41;&#44; la capa plexiforme interna &#40;CPI&#41; y la capa nuclear interna &#40;CNI&#41; tuvieron valores significativamente mayores en varones que en mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; No hubo diferencias estad&#237;sticamente significativas en el GMC seg&#250;n edad y lateralidad&#59; sin embargo&#44; fue significativamente mayor en ni&#241;os de etnia europea que en ni&#241;os de etnia latinoamericana&#59; Cirrus &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;042&#41; y Spectralis &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;033&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los par&#225;metros maculares obtenidos mediante OCT Spectralis y OCT Cirrus no deber&#237;an ser intercambiables en pacientes pedi&#225;tricos&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the degree of agreement and differences between macular parameters according to sex&#44; age&#44; laterality&#44; ethnicity and type of optical coherence tomography &#40;OCT&#41; in paediatric patients&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Prospective&#44; transversal&#44; and comparative study&#46; OCT Spectralis and OCT Cirrus were used to obtain the macular values of both eyes in 100 patients between 5 and 15<span class="elsevierStyleHsp" style=""></span>years without ocular pathology&#46; Due to the similarity between the values of both eyes&#44; in the final sample we only considered the right eyes &#40;OD&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The average central macular thickness &#40;CMT&#41; was 244&#46;2<span class="elsevierStyleHsp" style=""></span>&#956;m with Cirrus and 261&#46;7<span class="elsevierStyleHsp" style=""></span>&#956;m with Spectralis&#46; The degree of agreement for the GMC was moderate &#40;intraclass correlation coefficient&#58; 0&#46;66&#41; and from low to very low in the other quadrants&#46; The GMC values of both systems were significantly higher in men than in women &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; The macular retinal nerve fibre layer &#40;mRNC&#41;&#44; ganglion cell layer &#40;GCC&#41;&#44; the inner plexiform layer &#40;IPLC&#41;&#44; and the inner nuclear layer &#40;INFL&#41; had significantly higher values in men than in women &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; There were no statistically significant differences in the GMC by age and laterality&#44; however it was significantly higher in ethnic European children than in ethnic Latin American children&#59; Cirrus &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;042&#41; and Spectralis &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;033&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Macular parameters obtained by OCT Spectralis and OCT Cirrus should not be interchangeable in pediatric patients&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Presentado parcialmente en la obtenci&#243;n del t&#237;tulo de Doctor en Medicina otorgado por la Universidad Aut&#243;noma de Madrid&#46;</p>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;fico de Bland-Altman para la concordancia entre valores de grosor macular OCT Spectralis frente a OCT Cirrus&#46; Valores en &#956;m&#46; Desviaci&#243;n t&#237;pica&#58; 7&#44;05<span class="elsevierStyleHsp" style=""></span>&#956;m&#46;</p>"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;fico de Bland-Altman para la concordancia entre valores de volumen macular OCT Spectralis frente a OCT Cirrus&#46; Valores en &#956;m<span class="elsevierStyleSup">3</span>&#46; Desviaci&#243;n t&#237;pica&#58; 0&#44;23<span class="elsevierStyleHsp" style=""></span>&#956;m&#46;</p>"
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        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Segmentaci&#243;n de capas de la retina OCT Spectralis &#40;Li et al&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">42</span></a>&#41;&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">GCL&#58; capa de c&#233;lulas ganglionares&#59; ILM&#58; membrana limitante interna&#59; INL&#58; capa nuclear interna&#59; IPL&#58; capa plexiforme interna&#59; OLM&#58; membrana limitante externa&#59; OPL&#58; capa plexiforme externa&#59; PR&#58; capas de fotorreceptores&#59; RNFL&#58; capa de fibras nerviosas de la retina&#59; RPE&#58; epitelio pigmentario de la retina&#46;</p>"
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        "etiqueta" => "Tabla 1"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">OCT&#58; tomograf&#237;a de coherencia &#243;ptica&#59; V&#58; volumen&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Valores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grosor OCT Cirrus</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grosor OCT Spectralis</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Volumen OCT Spectralis</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Percentil</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Percentil</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Percentil</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Macular central&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">244&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">197&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">213&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">273&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">261&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">217&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">228&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">292&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nasal interno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">319&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">288&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">298&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">344&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">319&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">360&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inferior interno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">313&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">272&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">291&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">337&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">312&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">317&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">364&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Temporal interno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">305&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">280&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">287&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">327&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">326&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Superior interno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">317&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">284&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">294&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">341&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">320&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">363&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nasal externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">301&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">281&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">324&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">344&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inferior externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Temporal externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">265&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">307&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;42&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Superior externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">262&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">306&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">280&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">283&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;51&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;74&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Volumen macular total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Capas intrarretinianas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t" scope="col">Media&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Percentil</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Media&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Percentil</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Media&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Percentil</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CFNRm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#233;lulas ganglionares&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Plexiforme interna&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Nuclear interna&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Plexiforme externa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Nuclear externa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">EPR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Temporal externo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Volumen macular total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;&#8722;0&#44;06&#59; 0&#44;90&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Nasal interno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Temporal interno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Superior interno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nasal externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;38&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;&#8722;0&#44;03&#59; 0&#44;75&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inferior externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8722;0&#44;05&#59; 0&#44;63&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Temporal externo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8722;0&#44;02&#59; 0&#44;64&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Superior externo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8722;0&#44;08&#59; 0&#44;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Volumen macular total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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