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Polimorfismo de un solo nucleótido rs1800795 en el gen IL6 y glaucoma: correspondencia
rs1800795 single nucleotide polymorphism in the IL6 gene and glaucoma: Correspondence
a Private Academic Consultant, Bangkok, Thailand
b Adjunct Professor, Joseph Ayobaalola University, Ikeji-Arakeji, Nigeria
c Honorary Professor, Dr. DY Patil University, Pune, India
d Visiting Professor, Faculty of Medicine, University of Nis, Serbia
e Distinguished Professor, Parasitic Disease Research Center, Suranaree University of Technology, Nakhon Ratchasima, Thailand
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Aunque la <span class="elsevierStyleItalic">IL6</span> desempeña un papel en la fisiopatología del GPAA, Ponce-Gallegos et al. destacaron que sus hallazgos refutaron la hipótesis de que la <span class="elsevierStyleItalic">IL-6</span> y el SNP rs1800795 están asociados a una mayor incidencia de GPAA en la población mexicana. El presente estudio puede revelar algunas interrelaciones en diversos grados. Cabe destacar que podrían existir otros efectos engañosos. Numerosas variantes genéticas se han relacionado con el glaucoma, entre ellas el gen HLA-DPA1 y el polimorfismo MTHFR C677T<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2,3</span></a>. Estudios adicionales podrían aportar pruebas más convincentes si se estudian más los efectos de otras diferencias genéticas.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicto de intereses</span><p id="par0010" class="elsevierStylePara elsevierViewall">Ninguno.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicto de intereses" ] 1 => array:1 [ "titulo" => "Bibliografía" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The rs1800795 single nucleotide polymorphism in the <span class="elsevierStyleItalic">IL6</span> gene is not associated with primary open angle glaucoma in Mexican population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Ponce-Gallegos" 1 => "N. Partida-Zavala" 2 => "C.R. Castro-Castaneda" 3 => "D. Navarro-Arregui" 4 => "D.A. Garcia-Hernandez" 5 => "B.A. García-Loza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Arch Soc Esp Oftalmol (Engl Ed)" "fecha" => "2022" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA-DPA1 gene polymorphism in primary glaucoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.H. Li" 1 => "J.F. Shao" 2 => "Z.G. Sui" 3 => "Y.X. Qin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Rev Med Pharmacol Sci" "fecha" => "2019" "volumen" => "23" "numero" => "Suppl 3" "paginaInicial" => "S24" "paginaFinal" => "S30" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between MTHFR C677T polymorphism and primary open-angle glaucoma: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Huo" 1 => "H. Zou" 2 => "M. Lang" 3 => "S.X. Ji" 4 => "X.L. Yin" 5 => "Z. Zheng" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gene" "fecha" => "2013" "volumen" => "512" "paginaInicial" => "179" "paginaFinal" => "184" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03656691/0000009700000012/v1_202212011049/S0365669122001903/v1_202212011049/es/main.assets" "Apartado" => array:4 [ "identificador" => "7310" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Cartas al director" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03656691/0000009700000012/v1_202212011049/S0365669122001903/v1_202212011049/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669122001903?idApp=UINPBA00004N" ]
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