COVID-19
Regístrese
metricas
covid
Archivos de la Sociedad Española de Oftalmología
Suscríbase a esta revista
Buscar en
Archivos de la Sociedad Española de Oftalmología
Toda la web
Inicio Archivos de la Sociedad Española de Oftalmología Impacto presupuestario de XEN®63 en el tratamiento del glaucoma primario de án...
Información de la revista
Volver al artículo

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Artículo original
Impacto presupuestario de XEN®63 en el tratamiento del glaucoma primario de ángulo abierto en España
Budget impact analysis of the XEN®63 for the treatment of primary open angle glaucoma in Spain
J. Vila Arteagaa,
Autor para correspondencia
jorgevilaarteaga@gmail.com

Autor para correspondencia.
, E. Gutierrez Díazb, J.M. Martínez de la Casac, E. Millá Griñód, A. Asorey Garcíae, J. Salvador Alepuzf, C. de Miguel Gonzálezg, R. Palomino Menesesg, E. Uría Mundog
a Hospital Universitario y Politécnico La Fe, Valencia, España
b Hospital Universitario 12 de Octubre, Madrid, España
c Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, España
d Hospital Clínic, Barcelona, España
e AbbVie Spain, S.L.U
f Former AbbVie employee
g Market Access Area, Pharmalex Spain, Barcelona, España
Leído
184
Veces
se ha leído el artículo
52
Total PDF
132
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0365669122002313"
  "issn" => "03656691"
  "doi" => "10.1016/j.oftal.2022.09.004"
  "estado" => "S300"
  "fechaPublicacion" => "2023-01-01"
  "aid" => "2057"
  "copyright" => "Sociedad Española de Oftalmología"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Arch Soc Esp Oftalmol. 2023;98:2-10"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S2173579422001748"
      "issn" => "21735794"
      "doi" => "10.1016/j.oftale.2022.11.002"
      "estado" => "S300"
      "fechaPublicacion" => "2023-01-01"
      "aid" => "2057"
      "copyright" => "Sociedad Española de Oftalmología"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Arch Soc Esp Oftalmol. 2023;98:2-10"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Budget impact analysis of the XEN&#174;63 for the treatment of primary openangle glaucoma in Spain"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "2"
            "paginaFinal" => "10"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Impacto presupuestario de XEN&#174;63 en el tratamiento del glaucoma primario de &#225;ngulo abierto en Espa&#241;a"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2338
                "Ancho" => 3250
                "Tamanyo" => 390330
              ]
            ]
            "detalles" => array:1 [
              0 => array:3 [
                "identificador" => "at0055"
                "detalle" => "Figure "
                "rol" => "short"
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Candidate target population for XEN&#174;63&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">POAG&#58; primary open-angle glaucoma</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Source&#58; 1&#46; INE<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#59; 2&#46; Ant&#243;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#59; 3&#46; EGS<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#59; 4&#46; Stein et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&#59; 5&#46; Lorenz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&#59; 6&#46; Allergan&#46; Internal data&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Vila Arteaga, E&#46; Gutierrez D&#237;az, J&#46;M&#46; Mart&#237;nez de la Casa, E&#46; Mill&#225; Gri&#241;&#243;, A&#46; Asorey Garc&#237;a, J&#46; Salvador Alepuz, C&#46; de Miguel Gonz&#225;lez, R&#46; Palomino Meneses, E&#46; Ur&#237;a Mundo"
            "autores" => array:9 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Vila Arteaga"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Gutierrez D&#237;az"
              ]
              2 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Mart&#237;nez de la Casa"
              ]
              3 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Mill&#225; Gri&#241;&#243;"
              ]
              4 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Asorey Garc&#237;a"
              ]
              5 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Salvador Alepuz"
              ]
              6 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "de Miguel Gonz&#225;lez"
              ]
              7 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Palomino Meneses"
              ]
              8 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Ur&#237;a Mundo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S0365669122002313"
          "doi" => "10.1016/j.oftal.2022.09.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669122002313?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579422001748?idApp=UINPBA00004N"
      "url" => "/21735794/0000009800000001/v1_202301060758/S2173579422001748/v1_202301060758/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S036566912200212X"
    "issn" => "03656691"
    "doi" => "10.1016/j.oftal.2022.04.008"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "2054"
    "copyright" => "Sociedad Espa&#241;ola de Oftalmolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Arch Soc Esp Oftalmol. 2023;98:11-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo original</span>"
      "titulo" => "Resultados del mundo real de la ciclofotocoagulaci&#243;n con l&#225;ser micropulsado en una poblaci&#243;n latinoamericana y an&#225;lisis de los factores asociados con la tasa de &#233;xito"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "11"
          "paginaFinal" => "17"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Real-world outcomes of micropulse cyclophotocoagulation in a Latin American population and analysis of the factors associated with the success rate"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 994
              "Ancho" => 1258
              "Tamanyo" => 40698
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Diagrama de caja de la presi&#243;n intraocular &#40;PIO&#41; al inicio y en el seguimiento&#46;&#40;En figura 1&#44; cambiar&#58; en horizontal &#8216;Baseline&#8217; por &#8216;Referencia&#8217;&#59; &#8216;week&#8217; por &#8216;semana&#8217;&#59; &#8216;month&#8217; por &#8216;me&#39;s&#59; &#8216;Time&#8217; por &#8216;Tiempo&#8217; y en vertical&#58; &#8216;IOP&#8217; por &#8216;PIO&#8217;&#46;&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Prado-Larrea, D&#46; Alvarez-Ascencio, M&#46; Garc&#237;a-Huerta, J&#46; Jim&#233;nez-Rom&#225;n, C&#46; Gonz&#225;lez-Castor, F&#46; Dom&#237;nguez-Due&#241;as"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Prado-Larrea"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Alvarez-Ascencio"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Garc&#237;a-Huerta"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Jim&#233;nez-Rom&#225;n"
            ]
            4 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Gonz&#225;lez-Castor"
            ]
            5 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Dom&#237;nguez-Due&#241;as"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2173579422001529"
        "doi" => "10.1016/j.oftale.2022.10.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579422001529?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036566912200212X?idApp=UINPBA00004N"
    "url" => "/03656691/0000009800000001/v1_202301030725/S036566912200212X/v1_202301030725/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0365669122002143"
    "issn" => "03656691"
    "doi" => "10.1016/j.oftal.2022.09.003"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "2056"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "edi"
    "cita" => "Arch Soc Esp Oftalmol. 2023;98:1"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Gu&#237;as de pr&#225;ctica cl&#237;nica en progresi&#243;n y glaucoma avanzado"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "1"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Clinical practice guidelines on progression and advanced glaucoma"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46;E&#46; Pablo"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "L&#46;E&#46;"
              "apellidos" => "Pablo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2173579422001761"
        "doi" => "10.1016/j.oftale.2022.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579422001761?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669122002143?idApp=UINPBA00004N"
    "url" => "/03656691/0000009800000001/v1_202301030725/S0365669122002143/v1_202301030725/es/main.assets"
  ]
  "es" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo original</span>"
    "titulo" => "Impacto presupuestario de XEN&#174;63 en el tratamiento del glaucoma primario de &#225;ngulo abierto en Espa&#241;a"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "2"
        "paginaFinal" => "10"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Vila Arteaga, E&#46; Gutierrez D&#237;az, J&#46;M&#46; Mart&#237;nez de la Casa, E&#46; Mill&#225; Gri&#241;&#243;, A&#46; Asorey Garc&#237;a, J&#46; Salvador Alepuz, C&#46; de Miguel Gonz&#225;lez, R&#46; Palomino Meneses, E&#46; Ur&#237;a Mundo"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Vila Arteaga"
            "email" => array:1 [
              0 => "jorgevilaarteaga@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Gutierrez D&#237;az"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Mart&#237;nez de la Casa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Mill&#225; Gri&#241;&#243;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Asorey Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Salvador Alepuz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "de Miguel Gonz&#225;lez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Palomino Meneses"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Ur&#237;a Mundo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:7 [
          0 => array:3 [
            "entidad" => "Hospital Universitario y Polit&#233;cnico La Fe&#44; Valencia&#44; Espa&#241;a"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Hospital Universitario 12 de Octubre&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Hospital Cl&#237;nico San Carlos&#44; Facultad de Medicina&#44; Universidad Complutense&#44; Madrid&#44; Espa&#241;a"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Hospital Cl&#237;nic&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "AbbVie Spain&#44; S&#46;L&#46;U"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Former AbbVie employee"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Market Access Area&#44; Pharmalex Spain&#44; Barcelona&#44; Espa&#241;a"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Autor para correspondencia</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Budget impact analysis of the XEN&#174;63 for the treatment of primary open angle glaucoma in Spain"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 3902
            "Ancho" => 3083
            "Tamanyo" => 353795
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Resultados del impacto presupuestario&#46; a&#41;<span class="elsevierStyleHsp" style=""></span>Coste e impacto presupuestario total&#46; b&#41;<span class="elsevierStyleHsp" style=""></span>Coste e impacto presupuestario desglosado por categor&#237;as&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El glaucoma primario de &#225;ngulo abierto &#40;GPAA&#41; es el subtipo m&#225;s frecuente de glaucoma&#44; con una prevalencia en Espa&#241;a del 2&#44;1&#37; en la poblaci&#243;n mayor de 40<span class="elsevierStyleHsp" style=""></span>a&#241;os<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">1</span></a>&#46; Es una neuropat&#237;a cr&#243;nica progresiva caracterizada por una alteraci&#243;n o aumento sostenido de la presi&#243;n intraocular &#40;PIO&#41; debido a una obstrucci&#243;n de los canales de drenaje del humor acuoso que deriva en un da&#241;o irreversible en el nervio &#243;ptico&#44; ocasionando una p&#233;rdida progresiva de visi&#243;n hasta ocasionar ceguera irreversible prevenible<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El objetivo del tratamiento es alargar los a&#241;os de vida &#250;til de visi&#243;n&#59; sin embargo&#44; el manejo actual solo permite prevenir el avance de la enfermedad y retrasar el deterioro del campo visual reduciendo la PIO&#46; El primer abordaje terap&#233;utico son las f&#243;rmulas t&#243;picas<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a>&#44; pero para muchos pacientes no son suficientes para controlar la enfermedad<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">3</span></a>&#44; produci&#233;ndose una p&#233;rdida progresiva del campo visual a medida que se incrementa el n&#250;mero de principios activos en su tratamiento&#44; aumentando el riesgo de efectos adversos&#44; problemas de tolerancia y adherencia<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">4&#44;5</span></a>&#46; Otros pacientes&#44; debido a comorbilidades f&#237;sicas o ps&#237;quicas o a su estilo de vida&#44; no son capaces de instilarse correctamente el tratamiento o no desean depender de un tratamiento cr&#243;nico<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">6</span></a>&#46; El abordaje quir&#250;rgico suele ser la opci&#243;n de tratamiento tras el fallo farmacol&#243;gico y&#47;o del l&#225;ser&#44; cuando hay un mal control&#44; causan alergias o intolerancia&#46; El <span class="elsevierStyleItalic">gold standard</span> quir&#250;rgico es la trabeculectom&#237;a&#44; una cirug&#237;a filtrante penetrante que reduce eficazmente la PIO&#44; aunque sus complicaciones y sus efectos adversos asociados han derivado en la b&#250;squeda de nuevas cirug&#237;as que pudieran mejorar el perfil de seguridad&#44; como la esclerectom&#237;a profunda no perforante &#40;EPNP&#41;&#44; los dispositivos convencionales de drenaje del glaucoma &#40;DDG&#41;&#44; como la v&#225;lvula de Ahmed&#44; o m&#225;s recientemente las t&#233;cnicas quir&#250;rgicas microincisionales<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Seg&#250;n las &#250;ltimas Gu&#237;as Europeas&#44; solo se considerar&#237;an <span class="elsevierStyleItalic">minimally invasive glaucoma surgery</span> &#40;MIGS&#41; aquellas t&#233;cnicas <span class="elsevierStyleItalic">ab interno</span> que no formen ampolla de filtraci&#243;n conjuntival&#44; como iStent inject&#174;&#44; generalmente con bajadas modestas de la PIO&#46; Las t&#233;cnicas cuyo funcionamiento requiere manipular la conjuntiva&#44; gener&#225;ndose la ampolla&#44; no pueden considerarse m&#237;nimamente invasivas y se denominan cirug&#237;as de glaucoma m&#237;nimamente penetrante &#40;<span class="elsevierStyleItalic">minimally penetrating glaucoma surgery</span> &#91;MPGS&#93;&#41;&#44; como XEN&#174; y PRESERFLO&#174;&#44; con una bajada de la PIO superior y para un perfil de paciente m&#225;s amplio<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Las MIGS&#47;MPGS presentan un mejor perfil de seguridad comparadas con la trabeculectom&#237;a y otras cirug&#237;as filtrantes<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">7-9</span></a>&#46; Cuando los tratamientos t&#243;picos no son una opci&#243;n&#44; estas alternativas permitir&#237;an retrasar el paso a una cirug&#237;a m&#225;s invasiva&#44; sin perjudicar su potencial &#233;xito al ser respetuosas con la conjuntiva<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">10</span></a>&#46; De hecho&#44; al contribuir reduciendo la carga de tratamiento t&#243;pico que es delet&#233;reo para la superficie ocular&#44; estas alternativas podr&#237;an disminuir las tasas de sangrado y de fibrosis<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Glaucoma y cataratas suelen coexistir frecuentemente&#44; ya que la prevalencia de ambas enfermedades aumenta con la edad<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">12</span></a>&#46; La facoemulsificaci&#243;n por s&#237; sola no se recomienda como intervenci&#243;n para el control del GPAA por ofrecer un beneficio limitado en la reducci&#243;n de la PIO<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a>&#46; La combinaci&#243;n de dispositivos MPGS&#47;MIGS y facoemulsificaci&#243;n ha demostrado ser similar o m&#225;s eficaz en la disminuci&#243;n de la PIO en comparaci&#243;n con la facoemulsificaci&#243;n sola&#44; minimizando potencialmente el riesgo adicional de una segunda cirug&#237;a y acortando los tiempos de recuperaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">12-15</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">El implante XEN&#174;63 est&#225; indicado para la reducci&#243;n de la PIO en pacientes con GPAA cuyos tratamientos previos fueron ineficaces<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">16</span></a>&#44; pudiendo emplearse solo o combinado con facoemulsificaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">17&#44;18</span></a>&#46; Se trata de una MPGS que emplea como mecanismo de drenaje el espacio subconjuntival mediante un abordaje <span class="elsevierStyleItalic">ab interno</span>&#44; siendo muy poco invasivo al mantener la integridad de la conjuntiva<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">19&#44;20</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La introducci&#243;n de una nueva alternativa terap&#233;utica para el manejo de una determinada patolog&#237;a y poblaci&#243;n requiere herramientas que permitan a los agentes decisores evaluar su impacto econ&#243;mico en el presupuesto sanitario&#46; Por ello&#44; en los procesos de toma de decisi&#243;n del Sistema Nacional de Salud &#40;SNS&#41; se utilizan habitualmente los modelos de impacto presupuestario &#40;IP&#41;<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">21&#44;22</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">El objetivo del presente estudio fue evaluar el impacto econ&#243;mico para el SNS espa&#241;ol tras la introducci&#243;n de XEN&#174;63 en sustituci&#243;n de XEN&#174;45 &#40;un implante similar pero con un menor di&#225;metro interno &#91;45<span class="elsevierStyleHsp" style=""></span>&#956;m&#93;&#41;&#44; en el tratamiento quir&#250;rgico del GPAA con o sin cataratas en pacientes que no responden al tratamiento farmacol&#243;gico o l&#225;ser&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materiales y m&#233;todos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Se elabor&#243; un modelo de IP en Microsoft Excel 2016 para valorar las consecuencias econ&#243;micas asociadas a la utilizaci&#243;n de XEN&#174;63 sustituyendo completamente al modelo anterior XEN&#174;45 en el tratamiento quir&#250;rgico de GPAA en Espa&#241;a&#46; Se defini&#243; un horizonte temporal de un a&#241;o para simplificar el c&#225;lculo y atendiendo a una estabilidad temporal del uso de XEN&#174;63 y de las otras alternativas en a&#241;os posteriores&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">La perspectiva del an&#225;lisis fue la del SNS&#46; Todos los par&#225;metros utilizados en el modelo &#40;poblaci&#243;n diana&#44; tratamientos comparadores&#44; cuotas de mercado&#44; uso de recursos y complicaciones&#41; fueron validados y consensuados por un panel de expertos compuesto por cuatro oftalm&#243;logos especializados en el tratamiento quir&#250;rgico del glaucoma&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">La poblaci&#243;n diana se estim&#243; en base a los principales candidatos a recibir el tratamiento con XEN&#174;63<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">16</span></a>&#44; pacientes con GPAA que no responden y progresan a cirug&#237;a tras dos o tres tratamientos t&#243;picos&#46; Para ello&#44; se identific&#243; la poblaci&#243;n espa&#241;ola de entre 40 y 90<span class="elsevierStyleHsp" style=""></span>a&#241;os<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">23</span></a> diagnosticada con GPAA empleando los datos espa&#241;oles de prevalencia<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; De esta&#44; se consider&#243; el porcentaje de pacientes con dos o m&#225;s preparados t&#243;picos que progresaban a cirug&#237;a<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">24-26</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Para estimar el IP asociado a XEN&#174;63 se compararon dos escenarios&#58; escenario actual &#40;antes de comercializar XEN&#174;63&#41; y escenario potencial &#40;sustituci&#243;n de XEN&#174;45 por XEN&#174;63&#44; tras su comercializaci&#243;n&#41;&#46; Las alternativas terap&#233;uticas evaluadas se corresponden a las utilizadas en la pr&#225;ctica cl&#237;nica espa&#241;ola en base a los resultados de un reciente estudio de mercado realizado con 80 glaucomat&#243;logos<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">27</span></a>&#46; Se consideraron los siguientes comparadores&#58; trabeculectom&#237;a&#44; EPNP&#44; v&#225;lvula de Ahmed &#40;AJL Ophtalmic&#41;&#44; iStent inject&#174; &#40;GLAUKOS&#41;&#44; Preserflo&#174; microshunt &#40;SANTEN&#41; y XEN&#174;45 &#40;ALLERGAN&#41;&#46; Para cada intervenci&#243;n quir&#250;rgica considerada se incluy&#243; la posibilidad de realizar la intervenci&#243;n solo para el GPAA o junto a facoemulsificaci&#243;n&#46; Tras la introducci&#243;n de XEN&#174;63 en el mercado espa&#241;ol&#44; se asume que durante el primer a&#241;o este sustituir&#225; progresivamente a XEN&#174;45 hasta su retirada del mercado&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran las distintas alternativas consideradas y su distribuci&#243;n para los diferentes escenarios del an&#225;lisis&#46; La distribuci&#243;n actual de los comparadores potenciales fue estimada en base a un estudio de mercado<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">27</span></a> y consulta a expertos&#46; En el escenario potencial&#44; la distribuci&#243;n de los tratamientos comparadores y la previsi&#243;n de ventas de XEN&#174;63 es resultado de las estimaciones internas de Allergan&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Se consideraron las siguientes categor&#237;as de costes directos&#58; costes de adquisici&#243;n de los dispositivos implantados&#44; costes de intervenci&#243;n quir&#250;rgica y costes asociados a la intervenci&#243;n quir&#250;rgica &#40;visitas de seguimiento oftalmol&#243;gicas&#44; procedimientos adicionales poscirug&#237;a y manejo de complicaciones&#41; durante el primer a&#241;o tras la intervenci&#243;n&#46; El n&#250;mero de visitas de seguimiento y la frecuencia de procedimientos y complicaciones poscirug&#237;a se obtuvo a partir de datos de la literatura<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">28</span></a> y la opini&#243;n de expertos cl&#237;nicos en base a la pr&#225;ctica cl&#237;nica actual de estos pacientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Los costes unitarios de uso de recursos se obtuvieron de la base de datos ESALUD<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">29</span></a>&#44; y los de los implantes se revisaron con el panel de expertos&#46; Todos los costes se expresan en euros del a&#241;o 2021&#44; y cuando fueron necesarios los costes de periodos anteriores se actualizaron seg&#250;n el &#237;ndice de precios al consumo acumulado desde la publicaci&#243;n del coste hasta el 31 de diciembre del 2020 &#40;<a class="elsevierStyleCrossRef" href="#sec0055">tabla 1S</a>&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Los costes correspondientes a las visitas se calcularon multiplicando el n&#250;mero de visitas por el coste unitario de cada visita&#46; Los costes correspondientes a los procedimientos adicionales poscirug&#237;a y manejo de complicaciones se calcularon multiplicando la frecuencia de uso por el coste unitario correspondiente&#46; Debido a la falta de costes espec&#237;ficos para las intervenciones combinadas con la facoemulsificaci&#243;n&#44; se asumi&#243; el coste de la intervenci&#243;n principal y el 50&#37; del coste de la facoemulsificaci&#243;n&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0085" class="elsevierStylePara elsevierViewall">La poblaci&#243;n diana para el an&#225;lisis &#40;pacientes potencialmente tributarios de recibir el tratamiento espec&#237;fico para el GPAA&#41; se estim&#243; en 25&#46;718 pacientes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se recogen los resultados disgregados para los tipos de costes considerados en el an&#225;lisis&#46; Para la poblaci&#243;n diana estimada&#44; los resultados del an&#225;lisis muestran que en pacientes con GPAA con o sin cataratas el coste total sin considerar XEN&#174;63 &#40;escenario actual&#41; se estim&#243; en 85&#46;881&#46;517<span class="elsevierStyleHsp" style=""></span>&#8364; para el primer a&#241;o del an&#225;lisis&#44; traducido a un coste anual de 3&#46;339<span class="elsevierStyleHsp" style=""></span>&#8364; por paciente&#46; Considerando el escenario en el que se introduce XEN&#174;63 &#40;en sustituci&#243;n de XEN&#174;45&#41; en el 24&#37; de los pacientes &#40;escenario potencial&#41;&#44; el coste total del escenario desciende a 83&#46;311&#46;780<span class="elsevierStyleHsp" style=""></span>&#8364;&#44; lo que se tradujo a 3&#46;239<span class="elsevierStyleHsp" style=""></span>&#8364; por paciente &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>a&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Los resultados del impacto muestran que la introducci&#243;n del implante XEN&#174;63 como alternativa quir&#250;rgica del GPAA se asocia a un potencial ahorro total de 2&#46;569&#46;737<span class="elsevierStyleHsp" style=""></span>&#8364; &#40;&#8722;3&#37;&#41; para el SNS&#44; derivado del ahorro en el coste del implante y del procedimiento &#40;&#8722;423&#46;120&#59; &#8722;0&#44;7&#37;&#41;&#44; visitas de seguimiento &#40;&#8722;777&#46;407<span class="elsevierStyleHsp" style=""></span>&#8364;&#59; &#8722;4&#44;5&#37;&#41;&#44; procedimientos adicionales &#40;&#8722;1&#46;048&#46;145<span class="elsevierStyleHsp" style=""></span>&#8364;&#44; &#8722;20&#44;6&#37;&#41; y complicaciones poscirug&#237;a &#40;&#8722;321&#46;065<span class="elsevierStyleHsp" style=""></span>&#8364;&#44; &#8722;14&#44;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>b&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discusi&#243;n</span><p id="par0100" class="elsevierStylePara elsevierViewall">Este estudio estim&#243; el potencial impacto financiero para el SNS espa&#241;ol derivado de la introducci&#243;n de XEN&#174;63 como alternativa quir&#250;rgica en el tratamiento del GPAA con y sin cataratas en pacientes cuyos tratamientos previos fueron ineficaces&#46; En base a los supuestos y asunciones descritas&#44; se estim&#243; que su introducci&#243;n generar&#237;a un potencial ahorro de 2&#46;569&#46;737<span class="elsevierStyleHsp" style=""></span>&#8364; tras un a&#241;o despu&#233;s de su incorporaci&#243;n&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El glaucoma y la progresiva discapacidad visual resultante se asocian a una elevada carga socioecon&#243;mica debido al manejo cr&#243;nico de la patolog&#237;a y a sus implicaciones&#44; repercutiendo en costes directos e indirectos<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">30</span></a>&#46; Adem&#225;s&#44; en los pacientes con ceguera secundaria al glaucoma se deben considerar los costes directos no sanitarios &#40;rehabilitaci&#243;n&#44; transporte&#44; perros gu&#237;a&#44; modificaciones&#47;atenci&#243;n en el hogar&#41;&#44; que pueden suponer hasta un 11&#37; debido a la rehabilitaci&#243;n y un 77&#37; al coste de la ayuda en el hogar<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">31</span></a>&#46; Por lo tanto&#44; a&#241;adir escalones terap&#233;uticos o reforzar los ya existentes con nuevas alternativas eficaces en el retraso de la progresi&#243;n del glaucoma&#44; que ocasionen menores complicaciones y permitan un f&#225;cil manejo postoperatorio&#44; podr&#237;a reducir el coste global o carga econ&#243;mica de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">32</span></a>&#44; mejorando el abordaje de estos pacientes&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Las cirug&#237;as filtrantes convencionales son muy eficaces en la reducci&#243;n de la PIO en el GPAA&#59; sin embargo&#44; se asocian a posibles complicaciones posquir&#250;rgicas y requieren un tratamiento postoperatorio importante<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">33</span></a>&#46; En comparaci&#243;n con estas&#44; las MIGS&#47;MPGS son menos invasivas&#44; reducen el uso de medicaci&#243;n t&#243;pica y mejoran el perfil de seguridad<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">34</span></a>&#44; pudiendo ser tambi&#233;n una alternativa antes de cirug&#237;as m&#225;s invasivas en pacientes no aptos para el tratamiento t&#243;pico&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Aunque la evidencia de XEN&#174;63 es todav&#237;a limitada&#44; ha demostrado una reducci&#243;n sostenida de la PIO y de la medicaci&#243;n t&#243;pica<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">18&#44;35&#44;36</span></a>&#44; conservando la conjuntiva y evitando la formaci&#243;n de cicatrices&#44; preservando la posibilidad de futuras intervenciones y permitiendo una recuperaci&#243;n m&#225;s r&#225;pida y un menor impacto en la calidad de vida del paciente<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">36-39</span></a>&#46; Su dise&#241;o permite un mayor control de la hipoton&#237;a posquir&#250;rgica&#44; que&#44; cuando se produce&#44; habitualmente se resuelve espont&#225;neamente<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">35</span></a>&#46; El tiempo de intervenci&#243;n es de aproximadamente 10<span class="elsevierStyleHsp" style=""></span>minutos&#44; reduciendo significativamente el tiempo quir&#250;rgico respecto a la mayor&#237;a de cirug&#237;as tradicionales o DDG<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">9&#44;19</span></a>&#46; Por otra parte&#44; los MPGS&#44; como XEN&#174;63&#44; presentan curvas de aprendizaje m&#225;s r&#225;pidas que las cirug&#237;as tradicionales<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">40</span></a>&#44; y dada la experiencia previa con XEN&#174;45&#44; no se espera que los cl&#237;nicos requieran un tiempo adicional de aprendizaje con XEN&#174;63&#46; Su implantaci&#243;n requiere una t&#233;cnica accesible para todos los oftalm&#243;logos especialistas en glaucoma<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">17&#44;40</span></a>&#44; cuyo aprendizaje y mejora de la destreza se ha descrito m&#225;s favorable respecto a otras t&#233;cnicas &#40;trabeculectom&#237;a&#44; v&#225;lvula de Ahmed o iStent&#174;&#41;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">37</span></a>&#44; lo que permitir&#237;a una inclusi&#243;n y una estandarizaci&#243;n r&#225;pidas en los servicios oftalmol&#243;gicos&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Por lo tanto&#44; respecto a cirug&#237;as convencionales&#44; la mayor rapidez y la m&#237;nima invasividad del procedimiento con XEN&#174;63 se asocian a una menor tasa de complicaciones y procedimientos postoperatorios<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">37&#44;41</span></a>&#44; requiriendo potencialmente menos visitas de seguimiento rutinarias y asoci&#225;ndose a un manejo posquir&#250;rgico menos intenso&#44; en frecuencia y complejidad&#44; simplificando el procedimiento y evitando riesgos mayores al paciente&#44; normalmente de edad avanzada&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">El glaucoma es la segunda causa m&#225;s frecuente de ceguera tras las cataratas&#44; y con la edad aumenta la coexistencia de ambas patolog&#237;as<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">2&#44;12</span></a>&#46; Dado que ambas est&#225;n muy extendidas en la poblaci&#243;n de edad avanzada&#44; es necesario planificar el tratamiento de la catarata al tiempo que se afronta el glaucoma como comorbilidad&#44; y viceversa<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">42</span></a>&#46; Adem&#225;s&#44; de acuerdo a un reciente estudio&#44; en comparaci&#243;n con la facoemulsificaci&#243;n sola&#44; la cirug&#237;a combinada parecer ser m&#225;s coste-efectiva&#44; mitig&#225;ndose la inversi&#243;n adicional del implante<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">43</span></a>&#46; La implantaci&#243;n de XEN&#174;63 junto a facoemulsificaci&#243;n prolongar&#237;a la intervenci&#243;n en unos pocos minutos&#44; pudiendo ofrecer una ventaja a nivel econ&#243;mico&#44; ya que los costes incrementales de realizar ambas intervenciones ser&#237;an m&#237;nimos desde la perspectiva hospitalaria y potencialmente podr&#237;an reducir las listas de espera de los servicios oftalmol&#243;gicos&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">El tratamiento del GPAA debe tener como objetivo reducir la PIO preservando la calidad de vida del paciente a un coste sostenible para el sistema sanitario<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">2&#44;43</span></a>&#46; Aunque muchos estudios han demostrado la eficacia de los MIGS&#47;MPGS&#44; a&#250;n hay escasa evidencia econ&#243;mica sobre su implantaci&#243;n en pacientes con GPAA con o sin cataratas<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">40&#44;44</span></a>&#46; No obstante&#44; un estudio previo realizado con XEN&#174;45 demostr&#243; que su introducci&#243;n generaba potenciales ahorros al SNS espa&#241;ol en comparaci&#243;n con otras intervenciones &#40;trabeculectom&#237;a&#44; EPNP&#44; EXPRESS&#174; e iStent&#174;&#41;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">28</span></a>&#46; Los resultados de este estudio indican que la incorporaci&#243;n de XEN&#174;63 en el manejo quir&#250;rgico del GPAA podr&#237;a asociarse a potenciales ahorros derivados de una menor necesidad de visitas de seguimiento&#44; menores tasas de complicaciones y procedimientos adicionales posquir&#250;rgicos que las cirug&#237;as filtrantes convencionales u otros MIGS&#47;MPGS&#46; Adem&#225;s&#44; el menor coste de la intervenci&#243;n en comparaci&#243;n con el resto de alternativas permite que XEN&#174;63 se presente como una alternativa viable para ser incorporada en los servicios sanitarios&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El estudio no estuvo exento de limitaciones&#46; Por una parte&#44; el n&#250;mero de expertos del panel &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41; podr&#237;a limitar la representatividad a nivel nacional en los consensos acordados&#59; no obstante&#44; se emple&#243; un reciente estudio realizado en 80 glaucomat&#243;logos del &#225;mbito p&#250;blico espa&#241;ol con el objetivo de cubrir el manejo de la patolog&#237;a en todo el entorno espa&#241;ol<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">27</span></a>&#46; Por otra parte&#44; dada la falta de literatura publicada sobre la pr&#225;ctica cl&#237;nica y el uso de recursos asociados al manejo quir&#250;rgico del GPAA en Espa&#241;a&#44; se formularon varias hip&#243;tesis a trav&#233;s de la opini&#243;n de expertos y un an&#225;lisis de mercado reciente representativo del entorno sanitario nacional<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">27</span></a>&#46; Este estudio pretende servir al menos de ejemplo ilustrativo del potencial uso de recursos y de las actuales t&#233;cnicas quir&#250;rgicas empleadas en el tratamiento del GPAA en Espa&#241;a&#44; siendo conscientes de la posible variabilidad en los costes totales de las intervenciones seg&#250;n el tipo de hospital&#44; derivado del coste parcial referido a la adquisici&#243;n de los dispositivos en estos centros&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Se requerir&#225;n m&#225;s estudios que permitan evaluar el impacto m&#225;s a largo plazo de la introducci&#243;n de XEN&#174;63 en el manejo quir&#250;rgico del GPAA en pacientes con o sin cataratas cuyos tratamientos previos hayan fallado&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusiones</span><p id="par0145" class="elsevierStylePara elsevierViewall">La inclusi&#243;n de XEN&#174;63 como tratamiento quir&#250;rgico del GPAA refractario podr&#237;a suponer un ahorro econ&#243;mico para el SNS al ser una alternativa que&#44; a pesar de las limitaciones descritas&#44; permite satisfacer la necesidad no cubierta de intervenciones con un perfil de seguridad asociado a menores complicaciones quir&#250;rgicas&#44; a un coste asequible&#44; reduciendo el tiempo quir&#250;rgico y la necesidad de procedimientos adicionales&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Financiaci&#243;n</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Declaraci&#243;n de AbbVie</span><p id="par0150" class="elsevierStylePara elsevierViewall">El dise&#241;o&#44; la realizaci&#243;n del proyecto y el apoyo financiero para el estudio ha sido proporcionado por AbbVie&#46; AbbVie intervino en la interpretaci&#243;n de los datos&#44; la revisi&#243;n y la aprobaci&#243;n de la publicaci&#243;n&#46; No se efectuaron honorarios ni pagos por la autor&#237;a&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Declaraci&#243;n sobre la adquisici&#243;n de Allergan</span><p id="par0155" class="elsevierStylePara elsevierViewall">El 8 de mayo de 2020 AbbVie complet&#243; su adquisici&#243;n de Allergan&#44; que ahora forma parte de AbbVie&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicto de intereses</span><p id="par0160" class="elsevierStylePara elsevierViewall">Jorge Vila&#44; Esperanza Guti&#233;rrez&#44; Jos&#233; Mar&#237;a Mart&#237;nez de la Casa y Elena Mill&#225; declaran no tener ning&#250;n conflicto de intereses relacionado con esta publicaci&#243;n&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Cristina de Miguel&#44; Rosa Palomino y Estefan&#237;a Ur&#237;a son empleados a tiempo completo de Pharmalex&#46; Pharmalex ha recibido soporte financiero de AbbVie para asesor&#237;a t&#233;cnica en el desarrollo de proyectos con XEN&#46; Los empleados de Pharmalex a t&#237;tulo personal o Pharmalex a nivel empresarial no han recibido ninguna compensaci&#243;n econ&#243;mica de AbbVie por su participaci&#243;n como autores del presente art&#237;culo&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Julia Salvador es antigua empleada de AbbVie y Almudena Asorey es empleada de AbbVie&#44; y ambas pueden ser propietarias de acciones de AbbVie&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres1827350"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Antecedentes y objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Materiales y m&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1593394"
          "titulo" => "Palabras clave"
        ]
        2 => array:3 [
          "identificador" => "xres1827351"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Background and objective"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Materials and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1593393"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introducci&#243;n"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materiales y m&#233;todos"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Resultados"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discusi&#243;n"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conclusiones"
        ]
        9 => array:3 [
          "identificador" => "sec0030"
          "titulo" => "Financiaci&#243;n"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Declaraci&#243;n de AbbVie"
            ]
            1 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Declaraci&#243;n sobre la adquisici&#243;n de Allergan"
            ]
          ]
        ]
        10 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conflicto de intereses"
        ]
        11 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-05-04"
    "fechaAceptado" => "2022-09-29"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1593394"
          "palabras" => array:5 [
            0 => "Glaucoma primario de &#225;ngulo abierto"
            1 => "MIGS"
            2 => "An&#225;lisis de impacto presupuestario"
            3 => "Cataratas"
            4 => "Cirug&#237;a"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1593393"
          "palabras" => array:5 [
            0 => "Primary open angle glaucoma"
            1 => "MIGS"
            2 => "Budget impact analysis"
            3 => "Cataracts"
            4 => "Surgery"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar el impacto econ&#243;mico en Espa&#241;a derivado de la introducci&#243;n del implante XEN&#174;63 como alternativa quir&#250;rgica en el manejo del glaucoma primario de &#225;ngulo abierto &#40;GPAA&#41; con o sin cataratas en pacientes refractarios&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materiales y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se dise&#241;&#243; un an&#225;lisis de impacto presupuestario para estimar los costes del tratamiento quir&#250;rgico del GPAA desde la perspectiva del Sistema Nacional de Salud &#40;SNS&#41; espa&#241;ol&#44; en un horizonte temporal de<span class="elsevierStyleHsp" style=""></span>1 a&#241;o&#46; Los comparadores considerados &#40;trabeculectom&#237;a&#44; esclerectom&#237;a profunda no perforante&#44; v&#225;lvula de Ahmed&#44; iStent inject&#174;&#44; Preserflo&#174; microshunt y XEN&#174;45&#41; se corresponden a los empleados en la pr&#225;ctica cl&#237;nica p&#250;blica espa&#241;ola&#46; Para el c&#225;lculo de la poblaci&#243;n diana&#44; cuotas de mercado y uso de recursos en t&#233;rminos de visitas de seguimiento&#44; procedimientos adicionales y complicaciones poscirug&#237;a&#44; se emplearon datos de la literatura y se validaron con un panel de cuatro expertos&#46; Los costes unitarios &#40;&#8364;<span class="elsevierStyleHsp" style=""></span>de<span class="elsevierStyleHsp" style=""></span>2021&#41; se obtuvieron de la base de datos ESALUD&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La inclusi&#243;n de XEN&#174;63 podr&#237;a generar un ahorro de 2&#46;569&#46;737<span class="elsevierStyleHsp" style=""></span>&#8364; tras un a&#241;o desde su introducci&#243;n&#44; derivado del ahorro en el coste del implante y del procedimiento &#40;&#8722;423&#46;120&#59; &#8722;0&#44;7&#37;&#41;&#44; de las visitas de seguimiento &#40;&#8722;777&#46;407<span class="elsevierStyleHsp" style=""></span>&#8364;&#59; &#8722;4&#44;5&#37;&#41;&#44; de los procedimientos adicionales &#40;&#8722;1&#46;048&#46;145<span class="elsevierStyleHsp" style=""></span>&#8364;&#44; &#8722;20&#44;6&#37;&#41; y de las complicaciones poscirug&#237;a &#40;&#8722;321&#46;065<span class="elsevierStyleHsp" style=""></span>&#8364;&#44; &#8722;14&#44;2&#37;&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La incorporaci&#243;n de XEN&#174;63 en el arsenal quir&#250;rgico para el tratamiento del GPAA refractario con y sin cataratas podr&#237;a generar ahorros para el SNS&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Antecedentes y objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Materiales y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the economic impact in Spain derived from the introduction of the XEN&#174;63 implant as a surgical alternative in the management of primary open angle glaucoma &#40;POAG&#41; with or without cataract in refractory patients&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A budget impact analysis was designed to estimate the costs of surgical treatment of POAG from the perspective of the Spanish National Health System &#40;NHS&#41;&#44; over a time horizon of 1<span class="elsevierStyleHsp" style=""></span>year&#46; The comparators considered &#40;trabeculectomy&#44; deep non-perforating sclerectomy&#44; Ahmed valve&#44; iStent inject&#174;&#44; Preserflo&#174; microshunt and XEN&#174;45&#41; correspond to those used in Spanish public clinical practice&#46; For the calculation of the target population&#44; market shares and resource use in terms of follow-up visits&#44; additional procedures and post-surgery complications&#44; data from the literature were used and validated with a panel of 4 experts&#46; Unit costs &#40;&#8364;2021&#41; were obtained from the ESALUD database&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The inclusion of XEN&#174;63 could generate savings of &#8364;2&#44;569&#44;737 after one year since its introduction&#44; derived from savings in the cost of the implant and procedure &#40;&#8722;&#8364;423&#44;120&#59; &#8722;0&#46;7&#37;&#41;&#44; follow-up visits &#40;&#8722;&#8364;777&#44;407&#59; &#8722;4&#46;5&#37;&#41;&#44; additional procedures &#40;&#8722;1&#44;048&#44;145&#59; &#8722;20&#46;6&#37;&#41; and post-surgery complications &#40;&#8722;&#8364;321&#44;065&#59; &#8722;14&#46;2&#37;&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The incorporation of XEN&#174;63 in the surgical arsenal for the treatment of refractory POAG with and without cataracts could generate savings for the NHS&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Background and objective"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Materials and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0180" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Anexo A"
            "titulo" => "Material adicional"
            "identificador" => "sec0055"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1559
            "Ancho" => 2167
            "Tamanyo" => 223318
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Poblaci&#243;n diana candidata a recibir XEN&#174;63&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">GPAA&#58; glaucoma primario de &#225;ngulo abierto&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Fuentes&#58; 1&#46; INE<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">23</span></a>&#59; 2&#46; Ant&#243;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">1</span></a>&#46; 3&#46; European Glaucoma Society<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">2</span></a>&#59; 4&#46; Stein et al&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">24</span></a>&#59; 5&#46; Lorenz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">25</span></a>&#59; 6&#46; Allergan&#46; Datos internos<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">26</span></a>&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 3902
            "Ancho" => 3083
            "Tamanyo" => 353795
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Resultados del impacto presupuestario&#46; a&#41;<span class="elsevierStyleHsp" style=""></span>Coste e impacto presupuestario total&#46; b&#41;<span class="elsevierStyleHsp" style=""></span>Coste e impacto presupuestario desglosado por categor&#237;as&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">EPNP&#58; esclerectom&#237;a profunda no perforante&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Fuente&#58; consulta de expertos y Allergan<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">27</span></a>&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Tratamientos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Escenario actual&#40;sin XEN&#174;63&#41;</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Escenario potencial&#40;con XEN&#174;63&#41;</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trabeculectom&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;80&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;806&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;086&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trabeculectom&#237;a<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;709&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;144&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EPNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;80&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;292&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;829&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EPNP<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;938&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;681&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preserflo&#174; microshunt&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;00&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preserflo&#174; microshunt<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;00&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">iStent inject&#174; inject&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">iStent inject&#174; inject<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;00&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;90&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;517&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;45<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;90&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;060&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ahmed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;80&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;492&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;080&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ahmed<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>catarata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">154&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;572&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;63<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;00&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;601&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n de mercado en los escenarios sin y con XEN&#174;63</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">EPNP&#58; esclerectom&#237;a profunda no perforante&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Fuente&#58; consulta a expertos y Mart&#237;nez de la Casa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">28</span></a>&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Intervenci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N&#250;mero de visitas al especialista&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Frecuencia de procedimientos adicionales</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Frecuencia de complicaciones poscirug&#237;a</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Revisi&#243;n ampolla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Retirar suturas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resuturas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Goniopunci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hipema &#40;en quir&#243;fano&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Desprendimiento coroidal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Contacto endotelial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Atalamia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trabeculectom&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trabeculectom&#237;a<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EPNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EPNP<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preserflo&#174; microshunt&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preserflo&#174; microshunt<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">iStent inject &#174;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">iStent inject &#174;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;45<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ahmed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ahmed<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>catarata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">XEN&#174;63<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>cataratas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Uso de recursos y complicaciones asociado a la intervenci&#243;n durante el primer a&#241;o tras la cirug&#237;a</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Escenario actual&#40;sin XEN&#174;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Escenario potencial&#40;con XEN&#174;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Coste de implante y procedimientos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;264&#46;332 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;841&#46;212 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Coste de visitas de seguimiento</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;264&#46;632 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;487&#46;225 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Coste de procedimientos adicionales</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;098&#46;717 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;050&#46;571 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de revisi&#243;n de ampolla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;255&#46;976 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;288&#46;935 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de retirar suturas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&#46;882 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">224&#46;582 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de resuturas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149&#46;962 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#46;730 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de goniopunci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">434&#46;896 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">399&#46;324 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Coste de complicaciones poscirug&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;253&#46;836 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;932&#46;771 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de hipema &#40;en quir&#243;fano&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">396&#46;530 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">331&#46;643 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de desprendimiento coroidal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">261&#46;463 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">213&#46;272 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de contacto endotelial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">163&#46;408 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173&#46;179 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coste de atalamia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;432&#46;435 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;214&#46;677 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Coste total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#46;881&#46;517 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;311&#46;780 &#8364;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Costes &#91;euros&#93; totales y desglosados por &#237;tems para el escenario actual y potencial</p>"
        ]
      ]
      5 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.doc"
          "ficheroTamanyo" => 130579
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:44 [
            0 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of primary open-angle glaucoma in a Spanish population&#58; The Segovia study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Ant&#243;n"
                            1 => "M&#46;T&#46; Andrada"
                            2 => "V&#46; Mujica"
                            3 => "M&#46;A&#46; Calle"
                            4 => "J&#46; Portela"
                            5 => "A&#46; Mayo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.ijg.0000133385.74502.29"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Glaucoma&#46;"
                        "fecha" => "2004"
                        "volumen" => "13"
                        "paginaInicial" => "371"
                        "paginaFinal" => "376"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15354074"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "European Glaucoma Society Terminology and Guidelines for Glaucoma&#44; 5th Edition"
                        "fecha" => "2020"
                        "paginaInicial" => "172"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of long-term progression in the early manifest glaucoma trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Leske"
                            1 => "A&#46; Heijl"
                            2 => "L&#46; Hyman"
                            3 => "B&#46; Bengtsson"
                            4 => "L&#46; Dong"
                            5 => "Z&#46; Yang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ophtha.2007.03.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology&#46;"
                        "fecha" => "2007"
                        "volumen" => "114"
                        "paginaInicial" => "1965"
                        "paginaFinal" => "1972"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17628686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of ocular adverse effects in patients treated with topical prostaglandin analogs&#58; Changes in prescription patterns and patient persistence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;J&#46; Zimmerman"
                            1 => "S&#46;R&#46; Hahn"
                            2 => "L&#46; Gelb"
                            3 => "H&#46; Tan"
                            4 => "E&#46;E&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/jop.2008.0072"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ocul Pharmacol Ther&#46;"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "paginaInicial" => "145"
                        "paginaFinal" => "152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19284321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension an evidence-based review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Olthoff"
                            1 => "J&#46; Schouten"
                            2 => "B&#46; Vandeborne"
                            3 => "C&#46; Webers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ophtha.2004.12.035"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology&#46;"
                        "fecha" => "2005"
                        "volumen" => "112"
                        "paginaInicial" => "953"
                        "paginaFinal" => "961"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15885795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Barriers to adherence with glaucoma medications&#58; A qualitative research study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Lacey"
                            1 => "H&#46; Cate"
                            2 => "D&#46;C&#46; Broadway"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/eye.2008.103"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eye&#46;"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "924"
                        "paginaFinal" => "932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18437182"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microinvasive glaucoma surgery&#58; A review and classification of implant-dependent procedures and techniques"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Jab&#322;o&#324;ska"
                            1 => "K&#46; Lewczuk"
                            2 => "J&#46; Konopi&#324;ska"
                            3 => "Z&#46; Mariak"
                            4 => "M&#46; R&#281;kas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/aos.14906"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Ophthalmol&#46;"
                        "fecha" => "2022"
                        "volumen" => "100"
                        "paginaInicial" => "e327"
                        "paginaFinal" => "e338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33988310"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety profile of minimally invasive glaucoma surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Vinod"
                            1 => "S&#46;J&#46; Gedde"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/ICU.0000000000000731"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Ophthalmol&#46;"
                        "fecha" => "2021"
                        "volumen" => "32"
                        "paginaInicial" => "160"
                        "paginaFinal" => "168"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33315726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minimally invasive glaucoma surgery&#58; Where is the evidence&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Gillmann"
                            1 => "K&#46; Mansouri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/APO.0000000000000294"
                      "Revista" => array:6 [
                        "tituloSerie" => "Asia Pac J Ophthalmol &#40;Phila&#41;&#46;"
                        "fecha" => "2020"
                        "volumen" => "9"
                        "paginaInicial" => "203"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32501895"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Micro-invasive glaucoma surgery &#40;MIGS&#41;&#58; A review of surgical procedures using stents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;E&#46; Pillunat"
                            1 => "C&#46; Erb"
                            2 => "A&#46;G&#46; J&#252;nemann"
                            3 => "F&#46; Kimmich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/OPTH.S135316"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Ophthalmol&#46;"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "1583"
                        "paginaFinal" => "1600"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28919702"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preservative exposure and surgical outcomes in glaucoma patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Boimer"
                            1 => "C&#46;M&#46; Birt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Glaucoma&#46;"
                        "fecha" => "2013"
                        "volumen" => "22"
                        "paginaInicial" => "730"
                        "paginaFinal" => "735"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of cataract surgery in the management of glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Ling"
                            1 => "N&#46; Bell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IIO.0000000000000234"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Ophthalmol Clin&#46;"
                        "fecha" => "2018"
                        "volumen" => "58"
                        "paginaInicial" => "87"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29870412"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of XEN 45 gel stent alone or in combination with phacoemulsification in advanced open angle glaucoma patients&#58; 1-year retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Laborda-Guirao"
                            1 => "J&#46;M&#46; Cubero-Parra"
                            2 => "A&#46; Hidalgo-Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Ophthalmol&#46;"
                        "fecha" => "2020"
                        "volumen" => "45"
                        "paginaInicial" => "1250"
                        "paginaFinal" => "1256"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of concomitant cataract and glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Marchini"
                            1 => "P&#46; Ceruti"
                            2 => "G&#46; Vizzari"
                            3 => "D&#46; Berzaghi"
                            4 => "A&#46; Zampieri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000458494"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dev Ophthalmol&#46;"
                        "fecha" => "2017"
                        "volumen" => "59"
                        "paginaInicial" => "155"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28442695"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of minimally invasive glaucoma surgery devices in the management of glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Fingeret"
                            1 => "J&#46;E&#46; Dickerson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/OPX.0000000000001173"
                      "Revista" => array:6 [
                        "tituloSerie" => "Optom Vis Sci&#46;"
                        "fecha" => "2018"
                        "volumen" => "95"
                        "paginaInicial" => "155"
                        "paginaFinal" => "162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29370021"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Allergan&#46; Ficha t&#233;cnica XEN63&#46; 2019&#46;"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subconjunctival microinvasive glaucoma surgeries&#58; An update on the XEN gel stent and the PreserFlo MicroShunt"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;T&#46; Do"
                            1 => "H&#46; Parikh"
                            2 => "J&#46;F&#46; Panarelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/ICU.0000000000000643"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Ophthalmol&#46;"
                        "fecha" => "2020"
                        "volumen" => "31"
                        "paginaInicial" => "132"
                        "paginaFinal" => "138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31922979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparing medium-term clinical outcomes following XEN&#174;45 and XEN&#174;63 device implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Fern&#225;ndez-Garc&#237;a"
                            1 => "Y&#46; Zhou"
                            2 => "M&#46; Garci&#225;-Alonso"
                            3 => "H&#46;D&#46; Andrango"
                            4 => "F&#46; Poyales"
                            5 => "N&#46; Garz&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Ophthalmol&#46;"
                        "fecha" => "2020"
                        "volumen" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cirug&#237;a filtrante de glaucoma v&#237;a ab interno con implante de col&#225;geno XEN"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Lavin-Dapena"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Revista Espa&#241;ola de Glaucoma e Hipertensi&#243;n Ocular&#46;"
                        "fecha" => "2015"
                        "volumen" => "5"
                        "paginaInicial" => "350"
                        "paginaFinal" => "357"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ab interno approach to the subconjunctival space using a collagen glaucoma stent"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;A&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcrs.2014.01.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cataract Refract Surg&#46;"
                        "fecha" => "2014"
                        "volumen" => "40"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24943904"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Budget impact analysis&#8212;principles of good practice&#58; Report of the ISPOR 2012 Budget Impact Analysis Good Practice II Task Force"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;D&#46; Sullivan"
                            1 => "J&#46;A&#46; Mauskopf"
                            2 => "F&#46; Augustovski"
                            3 => "J&#46; Jaime Caro"
                            4 => "K&#46;M&#46; Lee"
                            5 => "M&#46; Minchin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jval.2013.08.2291"
                      "Revista" => array:6 [
                        "tituloSerie" => "Value Health&#46;"
                        "fecha" => "2014"
                        "volumen" => "17"
                        "paginaInicial" => "5"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24438712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Principios&#44; m&#233;todos y aplicaciones del an&#225;lisis del impacto presupuestario en el sector sanitario"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Brosa"
                            1 => "R&#46; Gisbert"
                            2 => "J&#46;M&#46; Rodr&#237;guez"
                            3 => "J&#46; Soto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharmacoeconomics&#46;"
                        "fecha" => "2005"
                        "volumen" => "2"
                        "paginaInicial" => "65"
                        "paginaFinal" => "78"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "INE&#46; Demograf&#237;a y poblaci&#243;n&#46; Cifras de poblaci&#243;n&#46; 2021 &#91;consultado 5 May 2021&#93;&#46; Disponible en&#58; https&#58;&#47;&#47;www&#46;ine&#46;es&#47;"
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rates of glaucoma medication utilization among persons with primary open-angle glaucoma&#44; 1992 to 2002"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;D&#46; Stein"
                            1 => "P&#46; Ayyagari"
                            2 => "F&#46;A&#46; Sloan"
                            3 => "P&#46;P&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ophtha.2007.12.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology&#46;"
                        "fecha" => "2008"
                        "volumen" => "115"
                        "paginaInicial" => "1315"
                        "paginaFinal" => "1320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18321581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Direct cost and predictive factors for treatment in patients with ocular hypertension or early&#44; moderate and advanced primary open-angle glaucoma&#58; The CoGIS study in Germany"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Lorenz"
                            1 => "C&#46; Wolfram"
                            2 => "L&#46; Breitscheidel"
                            3 => "M&#46; Shlaen"
                            4 => "Y&#46; Verboven"
                            5 => "N&#46; Pfeiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00417-013-2354-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "Graefes Arch Clin Exp Ophthalmol&#46;"
                        "fecha" => "2013"
                        "volumen" => "251"
                        "paginaInicial" => "2019"
                        "paginaFinal" => "2028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23624617"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Allergan&#46; Datos internos&#46; 2021&#46;"
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Allergan&#46; Estudio de mercado&#46; An&#225;lisis cuantitativo cirug&#237;as glaucoma en Espa&#241;a&#46; Datos internos&#46; 2021&#46;"
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Budget impact analysis of the XEN&#174; gel stent implant for glaucoma treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Mart&#237;nez de la Casa"
                            1 => "A&#46; Amaro-Barra"
                            2 => "M&#46;A&#46; Teus"
                            3 => "J&#46; Vila-Arteaga"
                            4 => "I&#46; Oyag&#252;ez"
                            5 => "C&#46; Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Expert Rev Ophthalmol&#46;"
                        "fecha" => "2019"
                        "volumen" => "14"
                        "paginaInicial" => "5"
                        "paginaFinal" => "13"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Gisbert R&#46; Brosa M&#46; Base de datos de costes sanitarios y ratios coste-efectividad espa&#241;oles&#58; eSalud&#46; Barcelona&#58; Oblikue Consulting S&#46;L&#46; 2007 &#91;&#250;ltima actualizaci&#243;n&#58; 2021&#93; &#91;consultado 1 Jul 2021&#93;&#46; Disponible en&#58; http&#58;&#47;&#47;www&#46;oblikue&#46;com&#47;bddcostes&#47;"
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Different strategies and cost-effectiveness in the treatment of primary open angle glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46;S&#46; Ting"
                            1 => "J&#46;F&#46;T&#46; Li Yim"
                            2 => "J&#46;Y&#46; Ng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CEOR.S30697"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clinicoecon Outcomes Res&#46;"
                        "fecha" => "2014"
                        "volumen" => "6"
                        "paginaInicial" => "523"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25506233"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late-stage&#44; primary open-angle glaucoma in Europe&#58; Social and health care maintenance costs and quality of life of patients from 4 countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Thygesen"
                            1 => "M&#46; Aagren"
                            2 => "S&#46; Arnavielle"
                            3 => "A&#46; Bron"
                            4 => "S&#46;J&#46; Fr&#246;hlich"
                            5 => "K&#46; Baggesen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1185/03007990802111068"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin&#46;"
                        "fecha" => "2008"
                        "volumen" => "24"
                        "paginaInicial" => "1763"
                        "paginaFinal" => "1770"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18559164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Direct costs of glaucoma and severity of the disease&#58; A multinational long term study of resource utilisation in Europe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Traverso"
                            1 => "J&#46; Walt"
                            2 => "S&#46; Kelly"
                            3 => "A&#46; Hommer"
                            4 => "A&#46; Bron"
                            5 => "P&#46; Denis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Ophthalmol&#46;"
                        "fecha" => "2005"
                        "volumen" => "89"
                        "paginaInicial" => "1245"
                        "paginaFinal" => "1249"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conventional glaucoma implants and the new MIGS devices&#58; A comprehensive review of current options and future directions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46;C&#46;F&#46; Pereira"
                            1 => "R&#46; van de Wijdeven"
                            2 => "H&#46;M&#46; Wyss"
                            3 => "H&#46;J&#46;M&#46; Beckers"
                            4 => "J&#46;M&#46;J&#46; den Toonder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eye &#40;Basingstoke&#41;&#46;"
                        "fecha" => "2021"
                        "volumen" => "35"
                        "paginaInicial" => "3202"
                        "paginaFinal" => "3221"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minimally-invasive glaucoma surgeries &#40;MIGS&#41; for open angle glaucoma&#58; A systematic review and meta-analysis Virgili G"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Lavia"
                            1 => "L&#46; Dallorto"
                            2 => "M&#46; Maule"
                            3 => "M&#46; Ceccarelli"
                            4 => "A&#46;M&#46; Fea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0183142"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One&#46;"
                        "fecha" => "2017"
                        "volumen" => "12"
                        "paginaInicial" => "e0183142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28850575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "XEN 63 gel stent device in glaucoma surgery&#58; A 5-years follow-up prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Lavin-Dapena"
                            1 => "R&#46; Cordero-Ros"
                            2 => "O&#46; d&#8217;Anna"
                            3 => "I&#46; Mogoll&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1120672120952033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Ophthalmol&#46;"
                        "fecha" => "2021"
                        "volumen" => "31"
                        "paginaInicial" => "1829"
                        "paginaFinal" => "1835"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32811168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Four-year results of a minimally invasive transscleral glaucoma gel stent implantation in a prospective multi-centre study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Lenzhofer"
                            1 => "I&#46; Kersten-Gomez"
                            2 => "A&#46; Sheybani"
                            3 => "H&#46; Gulamhusein"
                            4 => "C&#46; Strohmaier"
                            5 => "M&#46; Hohensinn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ceo.13463"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Experiment Ophthalmol&#46;"
                        "fecha" => "2019"
                        "volumen" => "47"
                        "paginaInicial" => "581"
                        "paginaFinal" => "587"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30578661"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgeon perspectives on learning ab-interno gelatin microstent implantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;A&#46; Szigiato"
                            1 => "S&#46; Sandhu"
                            2 => "G&#46; Ratnarajan"
                            3 => "M&#46;W&#46; Dorey"
                            4 => "I&#46;I&#46;K&#46; Ahmed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Can J Ophthalmology&#46;"
                        "fecha" => "2018"
                        "volumen" => "53"
                        "paginaInicial" => "246"
                        "paginaFinal" => "251"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Referral for first glaucoma surgery in Europe&#44; the ReF-GS study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Holl&#243;"
                            1 => "D&#46; Schmidl"
                            2 => "A&#46; Hommer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1120672118791937"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Ophthalmol&#46;"
                        "fecha" => "2019"
                        "volumen" => "29"
                        "paginaInicial" => "406"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30101618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "XEN&#174; implant and trabeculectomy medium-term quality of life assessment and comparison of results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;L&#46; Bas&#237;lio"
                            1 => "N&#46; Moura-coelho"
                            2 => "I&#46; Passos"
                            3 => "M&#46;S&#46; Cardoso"
                            4 => "I&#46; Domingues"
                            5 => "M&#46; Reina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.18240/ijo.2018.12.11"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Ophthalmol&#46;"
                        "fecha" => "2018"
                        "volumen" => "11"
                        "paginaInicial" => "1941"
                        "paginaFinal" => "1944"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30588427"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minimally Invasive Glaucoma Surgery &#40;MIGS&#41; for individuals glaucoma&#46; A health technology assessment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Lund"
                            1 => "J&#46; Bidonde"
                            2 => "H&#46; Korn&#248;r"
                            3 => "L&#46; Reinar"
                            4 => "B&#46; Fagerlund"
                            5 => "L&#46; Nguyen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2021"
                        "editorial" => "Norwegian Institute of Public Health&#46;"
                        "editorialLocalizacion" => "Oslo"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glaucoma gel implant learning curve in a teaching tertiary hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;E&#46; Marques"
                            1 => "N&#46;P&#46; Ferreira"
                            2 => "D&#46;C&#46; Sousa"
                            3 => "J&#46; Pinto"
                            4 => "A&#46; Barata"
                            5 => "P&#46; Sens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IJG.0000000000001107"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Glaucoma&#46;"
                        "fecha" => "2019"
                        "volumen" => "28"
                        "paginaInicial" => "56"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30312282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical and perioperative considerations for the treatment of cataract in eyes with glaucoma&#58; A literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Tsakiris"
                            1 => "G&#46; Kontadakis"
                            2 => "P&#46; Georgoudis"
                            3 => "Z&#46; Gatzioufas"
                            4 => "A&#46; Vergados"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Ophthalmol&#46;"
                        "fecha" => "2021"
                        "volumen" => "26"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative efficacy and cost-utility of combined cataract and minimally invasive glaucoma surgery in primary open-angle glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Bartelt-Hofer"
                            1 => "S&#46; Flessa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10792-020-01314-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Ophthalmol&#46;"
                        "fecha" => "2020"
                        "volumen" => "40"
                        "paginaInicial" => "1469"
                        "paginaFinal" => "1479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32185590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic literature review of clinical and economic outcomes of Micro-Invasive Glaucoma Surgery &#40;MIGS&#41; in primary open-angle glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Agrawal"
                            1 => "S&#46;E&#46; Bradshaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s40123-018-0131-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmol Ther&#46;"
                        "fecha" => "2018"
                        "volumen" => "7"
                        "paginaInicial" => "49"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29725860"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03656691/0000009800000001/v1_202301030725/S0365669122002313/v1_202301030725/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "7297"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Art&#237;culos Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03656691/0000009800000001/v1_202301030725/S0365669122002313/v1_202301030725/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669122002313?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 03656691
Idioma original: Español
DOI:10.1016/j.oftal.2022.09.004
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Octubre 1 0 1
2024 Septiembre 2 2 4
2024 Junio 15 0 15
2024 Mayo 1 0 1
2024 Abril 1 0 1
2024 Febrero 1 1 2
2024 Enero 1 0 1
2023 Septiembre 2 2 4
2023 Julio 1 1 2
2023 Junio 2 2 4
2023 Mayo 5 4 9
2023 Abril 3 2 5
2023 Marzo 6 5 11
2023 Febrero 10 4 14
2023 Enero 81 27 108
2022 Diciembre 0 2 2
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Suscríbase a la newsletter

Publique en
Archivos de la Sociedad Española de Oftalmología
Archivos de la Sociedad Española de Oftalmología se adhiere a los principios y procedimientos dictados por el Committee on Publication Ethics (COPE)
www.publicationethics.org.
Artículos de acceso gratuito
Formación en cirugía de cataratas en...
Arch Soc Esp Oftalmol. 2024;99:373-82
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos