Cancer is a quite serious scientific and health problem, for which conventional or alternative therapies are used to solve these subjects. Among several methods, electrotherapy has been recently used by applying low and continuous electric current. In 1983, Nordenström reported in a systematic way for the first time, the main experiences and results using electrotherapy technologies with clinic effectiveness. In 1988, Pekar referred his experience about superficial tumours treatment using electrotherapy methods. Notwithstanding the great historic value of these experiences, this mode of treatment has not been so developed in occidental countries. Low cost combined with the high effectiveness of these processes lead China to a great development when compared to chemotherapy and radiotherapy. In this oriental country this technique is applied in more than 1200 hospitals, and reaches more than 9000 patients with serious cases. This therapy has been discussed by conventional doctors in several countries and recently has been observed a huge concern in this subject due to electrolysis phenomena. Based on published results it is intended to start improvements about electrotherapy. The aim of this first article is to evaluate the development status and its electrotherapeutical potentialities for cancer purpose.
Información de la revista
Vol. 26. Núm. 2.
Páginas 126-130 (julio - diciembre 2014)
Vol. 26. Núm. 2.
Páginas 126-130 (julio - diciembre 2014)
Acceso a texto completo
Electrotherapy, a recent mode for anticancer treatment
Visitas
2702
C.A.C. Sequeira
, D.S.P. Cardoso
Autor para correspondencia
Materials Electrochemistry Group, CeFEMA, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal
Este artículo ha recibido
Información del artículo
Abstract
Keywords:
electrotherapy
cancer treatment
electrolysis anticancer mechanisms
mathematical modelling.
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References
[1]
R.S. Cotran, S.L. Robbins. Patologia Estructural y Funcional – Séptima Edición. Ed. Elsevier, Saunders, Madrid (2005).
[2]
S.M. Cohen, L.L. Arnold.
J. Toxicol. Pathol, 21 (2008), pp. 1
[3]
Y. Kanai.
Pathol. Int., 58 (2008), pp. 544
[4]
A. Koliopanos, C. Avgerinos, C. Paraskeva, Z. Touloumis, D. Kelgiorgi, C. Dervenis.
Hepatobiliary Pancreat. Dis. Int, 7 (2008), pp. 345
[5]
S. Toyokuni.
IUBMB Life, 60 (2008), pp. 441
[6]
World Health Organization (WHO). Available in: http://www.int/mediacentre/factorsheets/fs2977es/index.html. Last update: July 2008.
[7]
Union for International Cancer Control (UICC). Available in: http://www.uicc.org/index.php?option=com_content&task= view&id=13&Itemid=113. Last update: September 2008.
[8]
I. Hoshino, H. Matsubara, A. Komatsu, Y. Akutsu, T. Nishimori, Y. Yoneyama, K. Murakami, H. Sakata, K. Matsushita, Y. Miyazawa, R. Brooks, M. Yoshida, T. Ochiai.
Oncology, 75 (2008), pp. 113
[10]
S.D. Xiang, K. Scalzo-Inguanti, G. Minigo, A. Park, C.L. Hardy, M. Plebanski.
Expert Rev. Vaccines, 7 (2008), pp. 1103
[11]
J.I. Toohey.
Cancer Lett, 263 (2008), pp. 164
[12]
H. Tanaka, K. Kageyama, R. Asada, N. Yoshimura.
N. Exp. Oncol, 30 (2008), pp. 143
[13]
M. Sadadcharam, D.M. Soden, G.C. O'Sullivan.
Int. J. Hyperthermia, 24 (2008), pp. 263
[14]
N. Schaefer, H. Schaefer, D. Maintz, M. Wagner, M. Overhaus, A.H. Hoelscher, A. Türler.
J. Surg. Res, 146 (2008), pp. 230
[15]
D.S. Yoon, Y.M. Ra, D.G. Ko, Y.M. Kim, K.W. Kim, H.Y. Lee, Y.L. Xin, W. Zhang, Z.H. Li, H.V. Kwon.
Journal of Breast Cancer, 10 (2007), pp. 162
[16]
L.C. Bergues La electroterapia una nueva alternativa para el tratamiento de tumores malignos. Estudios preclínicos. Tesis de doctorado (2003).
[17]
Y. Xin The development of electrochemical therapy in China. Proceedings of the 8th Congress on tumours of the International Association of Biological Closed Electric Circuits, Nanning, China, September 21-23, pp. 4-8 (2004).
[18]
H. Hiller.
Arch. Phys. Ther, 17 (1965), pp. 67
[20]
B.E.W. Nordenström.
I.R.C.S. Med. Sci, 6 (1978), pp. 537
[21]
P. Turjanski, N. Olaiz, P. Abou-Adal, C. Suarez, M. Risk, G. Marshall.
Electrochim. Acta, 54 (2009), pp. 6199
[22]
A.K. Vijh.
Modern Aspects of Electrochemistry, 39 (2006), pp. 231
[23]
M. Kurokawa, H. Sakagawi, F. Kokubu, H. Noda, M. Takeda, M. Adachi.
J. Cancer Res. Clin. Oncol, 123 (1997), pp. 370
[24]
V.F. Veiga, L. Nimerichter, C.A. Teixeira, M.M. Morales, C.S. Alviano, M.L. Rodrigues, C. Holandino.
Cell. Biochem. Biophys, 42 (2005), pp. 61
[25]
V.F. Veiga, C. Holandino, M.L. Rodrigues, M.A. Capella, S. Menezes, C.S. Alviano.
Bioelectromagnetics, 21 (2000), pp. 597
[26]
B. Tang, L. Li, Z. Jiang, Y. Luan, D. Li, W. Zhang, E. Reed, Q.Q. Li.
Int., J. Oncol, 26 (2005), pp. 703
[27]
M. Wartenberg, N. Wirtz, A. Grob, W. Niedermeier, J. Hescheler, S.C. Peters, H. Sauer.
Bioelectromagnetics, 29 (2008), pp. 47
[28]
K.H. Li, Y.L. Xin, Y.N. Gu, B.L. Xu, D.J. Fan, B.F. Ni.
Bioelectromagnetics, 18 (1997), pp. 2
[29]
S.A. Wemyss-Holden, A.R. Dennison, D.P. Berry, G.J. Maddern.
Journal of Hepato-Biliary-Pancreatic Surgery, 11 (2004), pp. 97
[30]
H. Von Euler, J.M. Olsson, K. Hultenby, A. Thörne, A.S. Lagerstedt.
Bioelectrochemistry, 59 (2003), pp. 89
[31]
C.K. Chou, J.A. McDougall, C. Ahn, N. Vora.
Bioelectromagnetics, 18 (1997), pp. 18
[32]
M. Wójcicki, R. Kostyrka, B. Kaczmarek, J. Kordowski, M. Romanowski, M. Kaminski, J. Klonek, S. Zielinski.
Hepatogastroenterology, 46 (1999), pp. 278
[33]
H. Von Euler. Electrochemical treatment of tumours. Doctoral thesis. Swedish University of Agricultural Sciences, Uppsala (2002).
[34]
C.K. Chou.
Bioelectromagnetics, 28 (2007), pp. 3
[35]
International Association for Biological Closed Circuits (IABC), available in http://www.iabc.readywebsites.com/. Last actualization: March 2008.
[36]
B.P. Patel, U.M. Rawal, R.M. Rawal, S.N. Shukla.
P.S. Am. J. Clin. Oncol, 31 (2008), pp. 454
[37]
R.L. Ren, N. Vora, F. Yang, J. Longmate, W. Wang, H. Sun, J.R. Li, L. Weiss, C. Stand, J.A. McDougall, C.K. Chou.
Bioelectromagnetics, 22 (2001), pp. 205
[38]
H. Ando, K. Ito, L. Wang, K. Hibi, K. Hidemura, T. Yamazaki, Y. Kasai, S. Akiyama, A. Nakao Anticancer drugs13, 321 (2002).
[40]
L. Samuelsson, L. Joensson, I.L. Lamm, C.J. Linden.
S.B. Acta Radiol, 32 (1991), pp. 178
[41]
L. Xie, C.A. Sun.
Int. J. Hyperthermia, 22 (2006), pp. 607
[42]
D. Maintz, R. Fischbach, N. Schafer, A. Turler, H. Kugel, H. Schafer, K. Lackner.
Rofö Forstschr. Geb. Röntgenstr. Neuen Bildbeg Verfahr, 173 (2001), pp. 471
[43]
J. Larkin, D. Soden, C. Collins, K. Tangney, J.M. Preston, L.J. Russel, A.P. McHale, C. Dunne, G.C. O'Sullivan.
Eur. J. Cancer, 41 (2005), pp. 1339
[44]
X.Z. Lin, C.M. Jen, C.K. Chou, C.S. Chou, M.J. Sung, T.C. Chou.
Dig. Dis. Sci, 45 (2000), pp. 509
[45]
C. Dobbins, S.A. Wemyss-Holden, J. Cockburn, G.J. Maddern.
J. Surg. Res, 144 (2008), pp. 111
[46]
H. Von Euler, K. Strähle, A. Thörne, G. Yongping.
Bioelectrochemistry, 62 (2004), pp. 57
[48]
L. Colombo, G. González, G. Marshall, F.V. Molina, A. Soba, C. Suarez, P. Turjanski.
Bioelectrochemistry, 71 (2007), pp. 223
[49]
A. Vijh.
Int. J. Hydrogen Energy, 29 (2004), pp. 663
[50]
A.T. Esser, K.C. Smith, T.R. Gowrishankar, J.C. Weaver.
Technol. Cancer Res. Treat, 6 (2007), pp. 261
[51]
L. Vodovnik, D. Miklavčič, G. Serša.
Med. & Biol. Eng. & Comput., 30 (1992), pp. CE21
[52]
F. Zhu, S. Tan, J. Lin.
Effects of direct pulse on tissues of tumours in mice.
Proceedings of the 18th Annual International Conference. IEEE Engineering in Medicine and Biology, Amsterdam, 35–36 (1996),
[53]
H.B. Kim, S. Ahn, H.J. Yang, S.B. Sim, K.W. Kim.
Micron, 38 (2007), pp. 747
[54]
G. Serša, V. Kotnik, M. Cemazar, D. Miklavčič, A. Kotnik.
Anti-Cancer Drugs, 7 (1996), pp. 785
[55]
A. Behera, C. O’Rourke.
Braz. J. Phys, 38 (2008), pp. 272
[56]
D. Grecu, A.S. Carstea, A.T. Grecu, A. Visinescu.
Romanian Reports in Physics, 59 (2007), pp. 447
[57]
J. Bayani, J. Paderova, J. Murphy, B. Rosen, M. Zielenska, J.A. Squire.
Neoplasia, 10 (2008), pp. 1057
[58]
E. Mehrara, E. Forssell-Aronsson, H. Ahlman, P. Bernhardt.
Cancer Research, 67 (2007), pp. 3970
[59]
H.M. Byrne.
Nature Reviews/Cancer, 10 (2010), pp. 223
[60]
L. Preziosi.
Chapman & Hall.
CRC, (2003),
[61]
A. D’Onofrio.
Mathematical and Computer Modelling, 47 (2008), pp. 614
[62]
P. Turjanski, A. Soba, C. Suarez, L. Colombo, G. González, F. Molina, G. Marshall.
Mecânica Computacional, 261 (2007), pp. 3458
[64]
D. Miklavčič, T. Jarm, R. Karba, G. Serša.
Math. Comp. Simulation, 39 (1995), pp. 597
[65]
S. Čorović, M. Pavlin, D. Miklavčič.
Biomed. Eng. Online, 6 (2007), pp. 37