Estadísticas

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  "cita" => "Cir Esp. 1998;63:5-10"
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      "titulo" => "Variaciones de los mastocitos mucosos gástricos tras vagotomía troncular unilateral. Estudio experimental en la rata"
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          "titulo" => "Changes in gastric mucosal mast cells after unilateral truncal vagotomy. experimental study in rats"
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          "autoresLista" => "C Tinoco Carrasco, JL Marcos Rodríguez, A Rodríguez Toves, MA Citores Pascual, C Vaquero Puerta"
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      "titulo" => "Reconstrucción de mama"
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    "titulo" => "¿Influye la transfusión sanguínea en el pronóstico a largo plazo del cáncer gástrico?"
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        "autoresLista" => "F Sánchez-Bueno, JA García-Marcilla, JM Pérez-Abad, R Vicente, F Aranda, J Luján, P Parrilla"
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        "titulo" => "Does blood transfusion influence the long-term prognosis in gastric cancer?"
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            0 => "Stomach"
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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;n&#46;</span> La influencia que la transfusi&#243;n de sangre ejerce sobre la supervivencia de los pacientes con c&#225;ncer g&#225;strico resecado es&#44; actualmente&#44; motivo de controversia&#46; El objetivo de esta comunicaci&#243;n es analizar la influencia de la transfusi&#243;n de concentrado de hemat&#237;es sobre el pron&#243;stico de 163 pacientes con adenocarcinoma g&#225;strico sometidos a gastrectom&#237;a subtotal con intenci&#243;n curativa&#46; <br/> <span class="elsevierStyleBold">Pacientes y M&#233;todo&#46;</span> Durante un per&#237;odo de 15 a&#241;os fueron ingresados en nuestro servicio 505 pacientes con adenocarcinoma g&#225;strico&#44; realiz&#225;ndose en 167 casos una gastrectom&#237;a subtotal curativa&#46; La edad media fue de 62&#44;2 a&#241;os &#40;rango&#44; 30-87 a&#241;os&#41;&#44; con un predominio de varones &#40;104 casos&#44; 63&#44;8&#37;&#41;&#46; Excluyendo a los 4 pacientes que fallecieron en el postoperatorio inmediato &#40;primeros 30 d&#237;as&#41;&#44; los 163 restantes fueron revisados semestralmente en nuestra consulta externa hasta su fallecimiento o el final de este estudio&#46; El tiempo medio de seguimiento fue de 49&#44;5 meses&#44; con una mediana de 36 meses&#46; <br/> <span class="elsevierStyleBold">Resultados&#46;</span> En 69 de los 163 pacientes &#40;42&#44;3&#37;&#41; se realizaron transfusiones de concentrado de hemat&#237;es&#46; Al correlacionar las variables estudiadas con la transfusi&#243;n&#44; &#250;nicamente encontramos significaci&#243;n estad&#237;stica entre la tasa de transfusi&#243;n y los pacientes mayores de 63 a&#241;os &#40;p &#60; 0&#44;01&#41;&#44; con un tiempo de evoluci&#243;n inferior a 3 meses &#40;p &#60; 0&#44;05&#41; y en los tumores de m&#225;s de 4 cm &#40;p &#60; 0&#44;05&#41;&#46; De los 163 enfermos&#44; en 69 &#40;42&#44;3&#37;&#41; se demostr&#243; la existencia de recidiva locorregional&#46; En cuanto a la relaci&#243;n con las transfusiones&#44; aunque &#233;stas fueron m&#225;s frecuentes en el grupo de pacientes con recidiva &#40;49&#44;3 frente al 37&#44;2&#37;&#41; las diferencias no fueron estad&#237;sticamente significativas&#46; La supervivencia global al a&#241;o fue del 81&#44;7&#37; y del 49&#44;8&#37; a los 5 a&#241;os&#46; La supervivencia a los 5 a&#241;os de los pacientes a los que no se les realizaron transfusiones fue del 56&#44;9&#37; y la de los pacientes con transfusiones del 40&#37;&#44; diferencias estad&#237;sticamente significativas &#40;p &#61; 0&#44;0132&#41;&#46; Al separar a los pacientes por su estadio tumoral&#44; encontramos que s&#243;lo en los pacientes con tumor en estadio III la transfusi&#243;n de sangre influy&#243; de forma estad&#237;sticamente significativa en el pron&#243;stico &#40;p &#61; 0&#44;0051&#41;&#46; En el an&#225;lisis univariante&#44; del resto de variables recogidas&#44; s&#243;lo la existencia de tumor abdominal &#40;p &#61; 0&#44;0307&#41;&#44; el tama&#241;o del tumor &#40;p &#61; 0&#44;00001&#41;&#44; el grado de afectaci&#243;n de la pared g&#225;strica &#40;p &#61; 0&#44;00001&#41;&#44; la afectaci&#243;n ganglionar &#40;p &#61; 0&#44;00001&#41; y el estadio del tumor &#40;p &#61; 0&#44;00001&#41; han demostrado influencia estad&#237;sticamente significativa en el pron&#243;stico&#46; Si aplicamos el modelo de regresi&#243;n de Cox&#44; en las variables que en el an&#225;lisis univariante tuvieron influencia estad&#237;sticamente significativa sobre el pron&#243;stico&#44; se observa que s&#243;lo el tama&#241;o del tumor y el estadio han sido predictores independientes de la supervivencia&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#46;</span> En nuestra experiencia&#44; la transfusi&#243;n sangu&#237;nea no tiene influencia sobre la supervivencia a largo plazo en los pacientes con adenocarcinoma g&#225;strico resecado"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> The impact of blood transfusion &#40;BT&#41; on survival after gastric cancer resection is currently a subject of controversy&#46; The objective of this report is to analyze the influence of packed red blood cell transfusion on prognosis in 163 gastric adenocarcinoma patients subjected to curative subtotal gastrectomy&#46; <br/> <span class="elsevierStyleBold">Patients and method&#46;</span> Over a 15-year period&#44; 505 gastric adenocarcinoma patients were admitted to our service&#46; Curative subtotal gastrectomy was performed in 167 cases&#46; The mean patient age was 62&#46;2 years &#40;range&#58; 30-87 years&#41;&#44; and men &#40;n &#61; 104&#44; 63&#46;8&#37;&#41; predominated over women&#46; Four patients died during the immediate postoperative period &#40;first 30 days&#41;&#46; The remaining 163 were examined every six months in our outpatient service until their deaths or the end of the study&#46; The mean follow-up time was 49&#46;5 months&#44; with a mean of 36 months&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> Packed red blood cell transfusions were administered to 69 &#40;42&#46;3&#37;&#41; of the 163 patients&#46; When each variable was assessed in terms of the incidence of transfusion&#44; only age over 63 years &#40;p &#60; 0&#46;01&#41;&#44; a history of disease of less than 3 months &#40;p &#60; 0&#46;05&#41;&#44; and tumor measuring over 4 cm &#40;p &#60; 0&#46;05&#41; were found to show statistically significant correlations&#46; Locoregional recurrence was detected in 69 patients &#40;42&#46;3&#37;&#41;&#46; Although transfusion was more common among patients with recurrence &#40;49&#46;3&#37; vs 37&#46;2&#37;&#41; the difference was not statistically significant&#46; The overall rate of survival was 81&#46;7&#37; at one year and 49&#46;8&#37; at five years&#46; The five-year survival rate was 56&#46;9&#37; among nontransfused patients and 40&#37; among those who had received blood products&#44; a difference that was statistically significant &#40;p &#61; 0&#46;0132&#41;&#46; When tumor stage was considered&#44; transfusion had a statistically significant impact on prognosis only in patients with stage III lesions &#40;p &#61; 0&#46;0051&#41;&#46; In the univariate analysis of the remaining variables&#44; only the existence of abdominal tumor &#40;p &#61; 0&#46;0307&#41;&#44; tumor size &#40;p &#61; 0&#46;00001&#41;&#44; the degree of involvement of gastric wall &#40;p &#61; 0&#46;00001&#41;&#44; lymph node involvement &#40;p &#61; 0&#46;00001&#41; and tumor stage &#40;p &#61; 0&#46;00001&#41; were seen to have had a statistically significant influence on prognosis&#46; When Cox&#39;s regression model was applied to the preceding variables&#44; only tumor size and stage were independent predictors of survival&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#46; In our experience&#44; blood transfusion has no influence on long-term survival in patients who undergo resection for gastric adenocarcinoma"
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