Estadísticas

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  "cita" => "Cir Esp. 1999;65:456-61"
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      "titulo" => "Expresión de la oncoproteína neu, receptores del factor de crecimiento epidérmico y catepsina D en el adenocarcinoma gástrico, en función de la ploidía nuclear"
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          "titulo" => "EXPRESSION OF THE NEU ONCOPROTEIN, EPIDERMAL GROWTH FACTOR AND CATHEPSIN D IN RELATION TO THE PLOIDY STATUS IN GASTRIC ADENOCARCINOMA"
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          "autoresLista" => "MC Peláez Buján, A Ruibal Morell, J Aza González"
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      "titulo" => "Complicaciones biliares del trasplante hepático"
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          "titulo" => "Biliary complications of liver transplantation"
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          "autoresLista" => "R Robles Campos"
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    "titulo" => "Inestabilidad de microsatélites y sobreexpresión de la proteína p53: dos acontecimientos genéticos de significado pronóstico opuesto en el carcinoma colorrectal esporádico"
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        "autoresLista" => "A Sánchez-Pernaute, FJ Cerdán, E Pérez Aguirre, P Iniesta, C de Juan, JC García Pérez, R Quevedo, MJ Massa, M Benito, A Torres, JL Balibrea Cantero"
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            "apellidos" => "Balibrea Cantero"
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        "titulo" => "MICROSATELLITE INSTABILITY AND p53 PROTEIN OVEREXPRESSION: TWO GENETIC EVENTS OF OPPOSITE PROGNOSTIC SIGNIFICANCE IN SPORADIC COLORECTAL CANCER"
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            0 => "Carcinoma colorrectal"
            1 => "Oncogenes"
            2 => "p53"
            3 => "Inestabilidad de microsatélites"
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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;n&#46;</span> En el presente trabajo se analiza la importancia pron&#243;stica de la inestabilidad en secuencias de microsat&#233;lites y la sobreexpresi&#243;n de prote&#237;na p53 en el carcinoma colorrectal espor&#225;dico&#46; <br/> <span class="elsevierStyleBold">Pacientes y m&#233;todos&#46;</span> Se estudiaron 87 pacientes operados por carcinoma colorrectal espor&#225;dico&#46; Se analiz&#243; la sobreexpresi&#243;n de prote&#237;na p53 por inmunohistoqu&#237;mica utilizando el anticuerpo PAb 1801&#46; Se analiz&#243; la inestabilidad de microsat&#233;lites en los loci 2p16&#44; 3p23&#44; 5q15-q23&#44; 11p14-p13 y 18q22&#46;3-q23&#46; <br/> <span class="elsevierStyleBold">Resultados&#46;</span> Se encontr&#243; inestabilidad de microsat&#233;lites en el 37&#37; de los casos y sobreexpresi&#243;n de p53 en el 60&#37; de las muestras&#46; Hubo asociaci&#243;n estad&#237;sticamente significativa entre la inestabilidad de microsat&#233;lites y la localizaci&#243;n proximal del tumor&#46; La presencia de inestabilidad de microsat&#233;lites se relacion&#243; con una mejor evoluci&#243;n tras la cirug&#237;a&#46; La existencia de sobreexpresi&#243;n de la prote&#237;na p53 se asoci&#243; a un comportamiento m&#225;s agresivo del tumor&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#46;</span> Las alteraciones gen&#233;ticas expresadas por los tumores colorrectales est&#225;n relacionadas con el pron&#243;stico de la enfermedad&#59; si se confirman estos resultados en series m&#225;s numerosas&#44; tendr&#225;n que ser valoradas junto a los par&#225;metros cl&#225;sicos histol&#243;gicos y de extensi&#243;n a la hora de plantear tratamientos adyuvantes a la cirug&#237;a"
      ]
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> The present work analyzes the prognostic importance of microsatellite instability and p53 overexpression in sporadic colorectal carcinoma&#46; <br/> <span class="elsevierStyleBold">Patients and methods&#46;</span> Eighty-seven patients with resected sporadic colorectal carcinoma were included&#46; p53 overexpression was immunohistochemically determined by means of PAb 1801&#46; Microsatellite instability was assessed in loci 2p16&#44; 3p23&#44; 5q15-q23&#44; 11p14-p13 and 18q22&#46;3-q23&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> Thirty-seven percent of the samples showed microsatellite instability&#44; and 60&#37; of them harbored p53 overexpression&#46; There was a significant association between microsatellite instability and a proximal location of the tumor and a better long term prognosis&#46; On the other hand&#44; p53 overexpression was related to a more agressive tumoral behaviour&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span> Genetic alterations in sporadic colorectal carcinoma are related to the prognosis of the disease&#59; if the present results remain in larger series&#44; these features should be considered all together with classic histologic and staging parameters when planning adjuvant therapy for colorectal carcinoma"
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