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Implementación de un protocolo de paratiroidectomía selectiva radioguiada. Resultados preliminares
Implementation of a radio-guided selective parathyroidectomy protocol: Preliminary results
Isabel Blanco Saiza,
Autor para correspondencia
isablanco15@gmail.com

Autor para correspondencia.
, Pilar Salvador Egeab, Enma Anda Apiñánizc, Albert Alomar Casanovasa, Elena Goñi Gironésa
a Medicina Nuclear, Hospital Universitario de Navarra, Pamplona, Navarra, España
b Unidad Cirugía Endocrina, Hospital Universitario de Navarra, Pamplona, Navarra, España
c Endocrinología, Hospital Universitario de Navarra, Pamplona, Navarra, España
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edad media 61&#44;1 a&#241;os &#40;&#177; 11&#44;2&#41;&#44; 61 mujeres &#40;76&#44;3&#37;&#41;&#46; Los datos cl&#237;nicos y anal&#237;ticos se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Realizamos PMIR-MIBI tras su administraci&#243;n IV &#40;5 mCi <span class="elsevierStyleSup">99m</span>Tc-MIBI&#41;&#44; con adquisici&#243;n gammagr&#225;fica inmediata y procedimiento quir&#250;rgico radioguiado a los 60min&#44; aproximadamente&#46; Para realizar PMIR-MAA se administra intralesional ecoguiado &#40;0&#44;5 mCi <span class="elsevierStyleSup">99m</span>Tc-macroagregados alb&#250;mina&#41; el mismo d&#237;a de la intervenci&#243;n&#44; con posterior adquisici&#243;n gammagr&#225;fica &#40;SPECT&#47;TC&#41;&#46; Intraoperatoriamente empleamos gammasonda Neo2000&#174; &#40;Neoprobe Corporation&#44; Dublin&#44; EE&#46; UU&#46;&#41; con cabezal de 9 mm y gammac&#225;mara port&#225;til Sentinella&#174; &#40;Oncovision&#44; Valencia&#44; Espa&#241;a&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Las pruebas diagn&#243;sticas preoperatorias&#44; MIBI-SPECT&#47;TC y ecograf&#237;a&#44; hab&#237;an identificado la gl&#225;ndula patol&#243;gica en 70 &#40;87&#44;5&#37;&#41; y 59 &#40;73&#44;7&#37;&#41; pacientes&#44; respectivamente&#44; siendo negativos o no concluyentes los restantes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; En los 30 casos &#40;37&#44;5&#37;&#41; en que una de las anteriores era negativa o no eran totalmente concordantes se realiz&#243; PET-colina o metionina&#44; siendo diagn&#243;stica en 28 &#40;93&#44;3&#37;&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">La cirug&#237;a radioguiada fue m&#237;nimamente invasiva en 77 pacientes &#40;96&#44;3&#37;&#41;&#44; incluyendo los 2<span class="elsevierStyleHsp" style=""></span>con antecedente quir&#250;rgico cervical &#40;una tiroidectom&#237;a total&#44; una paratiroidectom&#237;a selectiva previa fallida&#41;&#46; Tres &#40;3&#44;7&#37;&#41; requirieron ampliaci&#243;n de la incisi&#243;n inicial&#58; 2<span class="elsevierStyleHsp" style=""></span>por afectaci&#243;n de 2<span class="elsevierStyleHsp" style=""></span>gl&#225;ndulas contralaterales y una por la localizaci&#243;n ect&#243;pica&#44; posterior&#44; del adenoma&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Se consigui&#243; la resecci&#243;n quir&#250;rgica de la lesi&#243;n en 79 pacientes &#40;98&#44;7&#37;&#41;&#44; siendo 76 &#40;96&#44;2&#37;&#41; adenomas y 3<span class="elsevierStyleHsp" style=""></span>&#40;3&#44;8&#37;&#41; hiperplasias &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Dos presentaron doble lesi&#243;n&#58; un adenoma y una hiperplasia&#46; Se registraron complicaciones quir&#250;rgicas leves en 4 &#40;5&#37;&#41;&#58; un peque&#241;o hematoma subcut&#225;neo autorresuelto&#44; 2<span class="elsevierStyleHsp" style=""></span>hipocalcemias transitorias y una paresia de cuerda vocal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Seg&#250;n la valoraci&#243;n previa del estudio de localizaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a>&#44; indicamos PMIR-MAA en 18 pacientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; realiz&#225;ndose finalmente en 17&#44; ya que en uno la gammagraf&#237;a demostr&#243; extensa contaminaci&#243;n cut&#225;nea por fuga del radiotrazador durante su inoculaci&#243;n ecogr&#225;fica&#44; invalidando el procedimiento&#46; Dado que era una lesi&#243;n paratiroidea MIBI-positiva&#44; se inyect&#243; a continuaci&#243;n MIBI&#44; extirp&#225;ndose finalmente&#46; Se resec&#243; la lesi&#243;n marcada con MAA en los 17 restantes&#44; siendo el tiempo medio del procedimiento quir&#250;rgico 35&#44;8 min&#46; En 9 pacientes objetivamos significativa captaci&#243;n residual en el lecho quir&#250;rgico tras la resecci&#243;n de la gl&#225;ndula radiomarcada &#40;dispersi&#243;n del radiotrazador a tiroides o musculatura pretiroidea durante su administraci&#243;n&#41;&#46; En uno de ellos adem&#225;s se demostr&#243; gammagr&#225;ficamente fijaci&#243;n pulmonar del MAA &#40;administraci&#243;n parcial intravascular&#44; inocua&#41;&#59; en otro&#44; un discreto hematoma subcut&#225;neo postinyecci&#243;n&#44; autorresuelto&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se realiz&#243; PMIR-MIBI en 63 pacientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; confirm&#225;ndose la resecci&#243;n de la lesi&#243;n paratiroidea en 62 &#40;98&#44;4&#37;&#41;&#46; En la &#250;nica cirug&#237;a &#171;fallida&#187; se extirp&#243; una lesi&#243;n d&#233;bilmente MIBI-positiva&#44; macrosc&#243;picamente indicativa de paratiroides&#44; pero la histopatolog&#237;a demostr&#243; una adenopat&#237;a&#44; que excepcionalmente puede captar MIBI<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>&#46; El tiempo medio entre la administraci&#243;n del MIBI y el comienzo de la intervenci&#243;n fue 90 min&#46; La duraci&#243;n media de la PMIR-MIBI fue 33&#44;3 min&#44; inferior al MAA &#40;no significativamente p &#61; 0&#44;349&#41;&#46; Tampoco hubo diferencias significativas en el tama&#241;o de la lesi&#243;n extirpada &#40;p &#61; 0&#44;504&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se resecaron mediante PMIR-MIBI 22 adenomas ect&#243;picos &#40;27&#44;5&#37;&#41;&#58; 9 paraesof&#225;gicos&#44; 7 mediast&#237;nicos&#44; 3 pretraqueales&#44; 2 prevertebrales y 1 intrat&#237;mico&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En el seguimiento a 6 meses la &#250;nica PMIR en la que no se demostr&#243; histopatol&#243;gicamente una gl&#225;ndula paratiroidea patol&#243;gica&#44; presenta curaci&#243;n bioqu&#237;mica&#44; circunstancia cl&#237;nica excepcional<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>&#46; Dos presentaron hipercalcemia persistente&#44; a pesar de haberse resecado un adenoma&#59; uno ha sido recientemente reintervenido con &#233;xito &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41; tras objetivarse nueva lesi&#243;n paratiroidea &#40;MIBI y PET-positiva&#41;&#46; La tasa de curaci&#243;n provisional es 97&#44;5&#37;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">La PMIR-MIBI requiere estricta coordinaci&#243;n medicina nuclear-quir&#243;fano&#44; que en nuestro &#225;mbito ha sido satisfactoria&#44; aunque el tiempo entre inyecci&#243;n e inicio de cirug&#237;a super&#243; el objetivo inicialmente planteado&#44; debido a los traslados intrahospitalarios&#46; La fijaci&#243;n fisiol&#243;gica del MIBI en tejidos pr&#243;ximos &#40;tiroides&#44; musculatura&#41;&#44; puede dificultar la detecci&#243;n quir&#250;rgica&#44; especialmente en caso de gl&#225;ndulas paratiroideas con escasa intensidad de captaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> o &#171;lavado r&#225;pido&#187; &#40;estudio preoperatorio&#41;&#46; En este sentido&#44; la imagen intraoperatoria &#40;gammac&#225;mara port&#225;til&#41; es de gran ayuda&#44; minimizando dicho inconveniente y confirmando la extirpaci&#243;n de la lesi&#243;n&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">La PMIR-MIBI permite la resecci&#243;n m&#237;nimamente invasiva de las lesiones ect&#243;picas<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Aunque el procedimiento quir&#250;rgico con MAA es&#44; en principio&#44; t&#233;cnicamente m&#225;s sencillo&#44; no son raras las dificultades en la administraci&#243;n intralesional ecoguiada&#44; probablemente por la profundidad y el peque&#241;o tama&#241;o de las lesiones o la curva de aprendizaje&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; la PMIR&#44; tanto MIBI como MAA&#44; se ha implantado en nuestro centro y se desarrolla con fluidez&#44; gracias a la estrecha colaboraci&#243;n de los profesionales implicados&#46; El equipo quir&#250;rgico estima que la PMIR es m&#225;s sencilla&#46; Consideramos el m&#233;todo adoptado reproductible en cualquier Unidad de Cirug&#237;a Endocrina&#46; Aunque la casu&#237;stica es escasa y el seguimiento limitado &#40;la mayor&#237;a de intervenciones en los &#250;ltimos meses incluidos&#44; debido a la interrupci&#243;n de actividad quir&#250;rgica por la pandemia de marzo-septiembre del 2020&#41;&#44; los favorables resultados nos permiten prescindir del estudio histol&#243;gico intraoperatorio&#46; No obstante&#44; la inclusi&#243;n de m&#225;s pacientes determinar&#225; el impacto en el &#233;xito quir&#250;rgico y la tasa de curaci&#243;n&#44; as&#237; como la duraci&#243;n de la intervenci&#243;n y la tasa de complicaciones&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicto de intereses</span><p id="par0075" class="elsevierStylePara elsevierViewall">La presente investigaci&#243;n no&#160;ha recibido ayudas espec&#237;ficas provenientes de agencias del&#160;sector&#160;p&#250;blico&#44; sector comercial o entidades sin &#225;nimo de lucro</p></span></span>"
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paciente con HPP al que se resec&#243; adenoma paratiroideo &#40;flecha amarilla&#41; en localizaci&#243;n posterior al polo caudal del LTI &#40;A&#41; mediante PMIR tras la administraci&#243;n ecoguiada de <span class="elsevierStyleSup">99m</span>Tc-MAA&#46; El corte transaxial de fusi&#243;n SPECT&#47;TC muestra la correcta localizaci&#243;n intralesional de la actividad &#40;B&#41;&#46; Al a&#241;o persiste hipercalcemia&#44; objetiv&#225;ndose una nueva lesi&#243;n paratiroidea &#40;C&#41; en localizaci&#243;n ect&#243;pica&#44; m&#225;s caudal&#44; para-esof&#225;gica derecha &#40;flecha roja&#41; que presenta captaci&#243;n significativa de <span class="elsevierStyleSup">99m</span>Tc-MIBI como muestra la imagen de fusi&#243;n SPECT&#47;TC &#40;D&#41;&#44; por lo que se extirpa satisfactoriamente mediante una segunda cirug&#237;a&#44; en esta ocasi&#243;n radioguiada con MIBI&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Localizaci&#243;n prequir&#250;rgica&#44; N &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MIBI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#47;80 &#40;87&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ecograf&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#47;80 &#40;73&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#47;30 &#40;93&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Localizaci&#243;n quir&#250;rgica&#44; N &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79 &#40;98&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adenoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;96&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hiperplasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Procedimiento quir&#250;rgico&#44; N &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77 &#40;96&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ampliaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cirug&#237;a radioguiada MIBI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;78&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Localizaci&#243;n lesi&#243;n PT&#44; N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;98&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dificultad t&#233;cnica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tiempo medio intervenci&#243;n &#40;min&#46;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peso medio gl&#225;ndula &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1273&#44;0 &#40;220-17000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cirug&#237;a radioguiada MAA</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;21&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dificultad t&#233;cnica&#44; N &#40;&#37;&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;52&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tiempo medio intervenci&#243;n &#40;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peso medio gl&#225;ndula &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;324&#44;7 &#40;270-5&#46;860&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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