Información del artículo
Resumen
El empleo de corticoides ante la posibilidad de un parto prematuro ha disminuido la incidencia de distress respiratorio, hemorragia intraventricular y muerte neonatal. En aquellas mujeres en que el parto se pospone más allá de una semana, el empleo de nuevas dosis semanales ha sido empleado en la práctica obstétrica pese a que hay poca evidencia de su eficacia. Nuevos estudios sugieren en estas pautas repetidas ocos beneficios y riesgos potenciales, por lo que sugieren las dosis únicas.
Abstract
A single course of corticosteroids given to women before an anticipated preterm birth reduces the incidence of respiratory distress syndrome, intraventricular hemorrhage, and neonatal death. For women who do not deliver within 1 week, administration of repeat courses of corticosteroids has become common obstetric practice, despite little evidence of efficacy. Emerging data suggest that this practice produces little benefit and may potentially be harmful. Therefore, the use of corticosteroids to improve perinatal outcomes should be restricted to a single course.
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Bibliografía
[1.]
National Institutes of Health Report of the consensus development conference on the effect of corticosteroids for fetal maduration on perinatal outcome NIH publication n.o 95–3784 National Institute of Child Health and Human Development Bethesda (1994).
[2.]
G.S. Berkowitz, E. Papiernik.
Epidemiology of preterm birth.
Epidemiol Rev, 15 (1993), pp. 414-443
[3.]
National Institutes of Health.
Antenatal corticosteorids revisited: repeat courses-National Institutes of Health Consensus Development Conference Statement.
Obstet Gynecol, 98 (2001), pp. 144-150
[4.]
K.S. Joseph, M.S. Kramer, S. Marcoux, A. Ohlsson, S.W. Wen, A. Allen, et al.
Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994.
N Engl J Med, 339 (1998), pp. 1434-1439
[5.]
G.C. Liggins, R.N. Howie.
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distres sybdrome in premature infants.
Pediatrics, 50 (1972), pp. 515-525
[6.]
P. Crowley, I. Chalmers, M.J. Keirse.
The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials (see comments).
Br J Obstet Gynaecol, 97 (1990), pp. 11-25
[7.]
P. Crowley.
Prophylactic corticosteroids for preterm birth (Cochrane review).
The Cochrane Library, Issue 2, Update Software, (2000),
[8.]
A. Walfisch, H. Mordechai, M. Mazor.
Multiple courses of antenatal Steroids: Risks and Benefits.
Obstet Gynecol, 98 (2001), pp. 491-497
[9.]
A. Goodman Gilman, T.W. Rall, A.S. Nies, P. Taylor.
The pharmacological basis of therapeutics.
Pergamon, (1990),
[10.]
P.L. Ballard, R.A. Ballard.
Scientific basis and therapeutic regimens for use of antenatal glucocorticoids.
Am J Obstet Gynecol, 173 (1995), pp. 254-262
[11.]
J.D. Stewart, A.E. Sienko, C.L. Gonzalez, H.D. Christnesen, W.F. Rayburn.
Placebo-controlled comparison between a single dose and multidose of betamethasona in accelerating lung maduration of mice offspring.
Am J Obstet Gynecol, 179 (1998), pp. 1241-1247
[12.]
M. Ikegami, A.H. Jobe, J. Newnham, D.H. Polk, K.E. Willet, P. Sly.
Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs.
Am J Respir Crit Care Med, 156 (1997), pp. 178-184
[13.]
A.H. Jobe, N. Wada, L.M. Berry, M. Ikegami, M.G. Ervin.
Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep.
Am J Obstet Gynecol, 178 (1998), pp. 880-885
[14.]
N.S. Levitt, R.S. Lindsay, M.C. Holmes, J.R. Seckl.
Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat.
Neuroendocrinology, 64 (1996), pp. 412-418
[15.]
R. Benediktsson, R.S. Lindsay, J. Noble, J.R. Seckl, C.R. Edwards.
Glucocorticoid exposure in utero: New model for adult hypertension.
Lancet, 341 (1993), pp. 339-341
[16.]
L. Pratt, R.R. Magness, T. Phernetton, S.K. Hendricks, D.H. Abbott, I.M. Bird.
Repeated use of betamethasone in rabbits: Effects of treatment variation on adrenal suppression, pulmonary maduration, and pregnancy outcome.
Am J Obstet Gynecol, 180 (1999), pp. 995-1005
[17.]
B.L. Tabor, E.D. Rider, M. Ikegami, A.H. Jobe, J.F. Lewis.
Dose effects of antenatal corticosteroids for induction of lung maduration in preterm rabbits.
Am J Obstet Gynecol, 164 (1991), pp. 675-681
[18.]
H. Uno, L. Lohmiller, C. Thieme, J.W. Kemnitz, M.J. Engle, E.B. Roecker, et al.
Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques in hippocampus.
Brain Res Dev Brain Res, 53 (1990), pp. 157-167
[19.]
D.M. Sloboda, T.J. Moss, J.P. Newham, L.C. Gurrin, J.R.G. Challis.
Prenatal programming of postnatal glucose tolerance in sheep.
J Soc Gynecol Invest, 7 (2000), pp. 192A
[20.]
W.L. Huang, L.D. Beazley, J.A. Quinlivan, S.F. Evans, J.P. Newnham, S.A. Dunlop.
Effect of corticosteroids on brain growth in fetal sheep.
Obstet Gynecol, 94 (1999), pp. 213-218
[21.]
J.A. Quinlivan, S.A. Dunlop, S.F. Evans, L.D. Beazley, J.P. Newham.
The effects of repeated prenatal maternal and ultrasoundguide fetal injections of betamethasone upon nervous system maturation in sheep.
J Soc Gynecol Invest, 7 (2000), pp. 62A-63A
[22.]
H. Uno, S. Eisele, A. Sakai, S. Shelton, E. Baker, O. DeJesus, et al.
Neurotoxicity of glucocorticoids in the primate brain.
Horm Behav, 28 (1994), pp. 336-348
[23.]
F. Dean, S.G. Matthews.
Maternal dexamethasone treatment in late gestation alters glucocorticoid and mineralocorticoid receptor mRNA in the fetal guinea pig brain.
Horm Behav, 846 (1994), pp. 253-259
[24.]
J.A. Quinlivan, S.F. Evans, S.A. Dunlop, L.D. Beazley, J.P. Newnham.
Use of corticosteroids by Australian obstetricians-a survey of clinical practice.
Aust N Z J Obstet Gynaecol, 38 (1998), pp. 1-7
[25.]
P. Brocklehurst, S. Gates, K. McKenzie-McHarg, Z. Alfirevic, G. Chamberlain.
Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK.
Br J Obstet Gynaecol, 106 (1999), pp. 977-979
[26.]
O. Baud, L.H.L. Foix, M. Kaminski, F. Audibert, P.H. Jarreau, E. Papiernik, et al.
Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants.
N Engl J Med, 341 (1999), pp. 1190-1196
[27.]
S. Rotmensch, M. Liberati, T.H. Vishne, C. Celentano, Z. BenRafael, U. Bellati.
The effect of betamethasone and dexamethasone on fetal heart rate patterns and biophysical activities. A prospective randomised trial.
Acta Obstet Gynecol Scand, 78 (1999), pp. 493-500
[28.]
M.V. Senat, S. Minoui, O. Multon, H. Fernández, R. Frydman, Y. Ville.
Effect of dexamethasone and betamethasone on fetal heart rate variability in preterm labour: A randomised tudy.
Br Obstet Gynaecol, 105 (1998), pp. 749-755
[29.]
O. Multon, M.V. Senat, S. Minoui, M.V. Hue, R. Frydman, Y. Ville.
Effect of antenatal betamethasone and dexamethasone adminstration on fetal heart rate variability in growth retarded fetuses.
Fetal Diagn Ther, 12 (1997), pp. 170-177
[30.]
O. Deren, C. Karaer, L. Onderoglu, T. Durukan, R. BahadoSingh.
The effect of steroids on the biophysical profile of the healthy preterm fetus and its relationship with timr.
Am J Obstet Gynecol, 182 (2000), pp. S108
[31.]
A.A. Moise, M.E. Wearden, C.A. Kozinetz, A.L. Gest, S.E. Welty, T.N. Hansen.
Antenatal steroids are associated with less need for blood pressure support in extremely premature infants.
Pediatrics, 95 (1995), pp. 845-850
[32.]
S. Vermillion, D. Soper, R. Newman.
Is betamethasone effective more than 7 days after treatment?.
Am J Obstet Gynecol, 182 (2000), pp. S46
[33.]
K.A. Martinelli, G.S. Burke, V.C. Herson.
Effects of dexamethasone on blood pressure in premature infants with bronchopulmonary dysplasia.
J Pediatr, 130 (1997), pp. 594-602
[34.]
N. Evans.
Cardiovascular effects of dexamethasone in the preterm infant.
Arch Dis Child Fetal Neonatal Ed, 70 (1994), pp. F25-F30
[35.]
K.A. Yunis, F.F. Bitar, P. Hayek, S.M. Mroueh, M. Mikati.
Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids.
Am J Perinatol, 16 (1999), pp. 17-21
[36.]
B.S. Bradley, S.P. Kumar, P.N. Mehta, S.G. Ezhuthachan.
Neonatal cushingoid syndrome resulting from serial courses of antenatal betamethasone.
Obstet Gynecol, 83 (1994), pp. 869-872
[37.]
L. Pratt, L. Waschbusch, W. Ladd, R. Gangnon, S.K. Hendricks.
Multiple vs single bethamethasone therapy. Neonatal and maternal effects.
J Reprod Med, 44 (1999), pp. 257-264
[38.]
A. Elimian, U. Verma, P. Visintainer, N. Tejani.
Effectiveness of multidose antenatal steroids.
Obstet Gynecol, 95 (2000), pp. 34-36
[39.]
S. Abbasi, D. Hirsch, J. Davis, J. Tolosa, N. Stouffer, R. Debbs, et al.
Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome.
Am J Obstet Gynecol, 182 (2000), pp. 1243-1249
[40.]
B.A. Banks, A. Cnaan, M.A. Morgan, J.T. Parer, J.D. Merrill, P.L. Ballard, et al.
Multiple courses of antenatal corticosteroids and outcome of premature neonates. North American Thyrotropin-Releasing Hormone Study Group.
Am J Obstet Gynecol, 181 (1999), pp. 709-717
[41.]
R.A. Ballard, P.L. Ballard, A. Cnaan, J. Pinto-Martin, D.J. Davis, J.F. Padbury, et al.
Antenatal thyrotropin-releasing hormone to prevent lung disease in preterm infants. North American Thyrotropin-Releasing Hormone Study Group.
N Engl J Med, 338 (1998), pp. 493-498
[42.]
N.P. French, R. Hagan, S.F. Evans, M. Godfrey, J.P. Newnham.
Repeated antenatal corticosteroids: Size at birth and subsequent development.
Am J Obstet Gynecol, 180 (1999), pp. 114-121
[43.]
S.T. Vermillon, D.E. Soper, R.B. Newman.
Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy.
Am J Obstet Gynecol, 183 (2000), pp. 810-814
[44.]
D.A. Guinn, BMZ study group.
Multicenterrandomized trial of single versus weekly courses of antenatal corticosteroids: Interim analysis.
Am J Obstet Gynecol, 182 (2000), pp. S12
[45.]
A.N. Papageorgiou, M.F. Desgranges, M. Masson, E. Colle, R. Shatz, M.M. Gelfand.
The antenatal use of betamethasone in the prevention of respiratory distress syndrome: a controlled double-blind study.
Pediatrics, 63 (1979), pp. 73-79
[46.]
M.S. Esplin, M.B. Fausett, S. Smith, B.T. Oshiro, T.F. Porter, D.W. Branch, et al.
Multiple courses of antenatal steroids are associated with a delay in long-term psychomotor developmente in children with birth weights < 1500 grams.
Am J Obstet Gynecol, 182 (2000), pp. S24
[47.]
B. Jacobson, G. Hagberg, B. Hagberg, L. Ladfords, A. Niklasson.
cerebral Plsy in preterm infants: A population based analysis of antenatal risk factor.
Am J Obstet Gynecol, 182 (2000), pp. S29
[48.]
K. Sinervo, I. Lange.
Maternal and neonatal outcomes following single versus multiple courses of corticosteroids.
Am J Ostet Gynecol, 182 (2000), pp. S52
[49.]
D.M. Esters, J. Pass, J.F.X. Egan.
Serial betamethasone use in a clinic practice: Does it affect fetal growth?.
Am J Obstet Gynecol, 182 (2000), pp. S57
[50.]
S. Rotmensch, Th. Vishne, C. Celentano, M. Dan, Z. BenRafael.
maternal infectious morbidity following multiple courses of betamethasone.
J Infect, 39 (1999), pp. 49-54
[51.]
K.J. Halel, M.C. Gordon, C.R. Lightner, W.H. Barth Jr.
Adrenal suppression induced by metamethasone in women at risk for premature delivery.
Obstet Gynecol, 96 (2000), pp. 287-290
[52.]
D.S. McKenna, G.M. Wittber, H.N. Nagaraja, P. Samuels.
The effect of repeat doses of antenatal corticosteroids on maternal adrenal function.
Am J Obstet Gynecol, 183 (2000), pp. 669-673
[53.]
J.E. Fisher, R.S. Smith, R. Lagrandeur, R.P. Lorenz.
Gestational diabetes mellitus in women receiving beta-adrenergic and corticosteroids for threatened preterm delivery.
Obstet Gynecol, 90 (1997), pp. 880-883
[54.]
National Institutes of Health. Report of the consensus development conference on antenatal corticosteroids revisited: Repeat courses..
Bethesda?.
National Institute of Child Health and Human Development, 17 (2000), pp. 1-10
[55.]
L.C. Gilstrap, M.E. Dalton, R. Berkowitz.
Repeat antenatal corticosteroids: a time for caution.
Contemp Obstet Gynecol, 8 (2002), pp. 32-40
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