Información del artículo
La diabetes mellitus es un factor de riesgo conocido de enfermedad vascular. Las primeras fases de esta afección vascular implican la disfunción del endotelio vascular. El estudio funcional del endotelio supone una intervención demasiado laboriosa y costosa para formar parte de la valoración regular del paciente de riesgo. En consecuencia, ha crecido el interés en los últimos años en la valoración de la lesión endotelial por medio de la determinación de diferentes marcadores solubles. Los más estudiados son aquellos marcadores de síntesis predominantemente endotelial implicados en los procesos de trombosis y fibrinolisis. En este artículo se revisan aquellos que se han relacionado con la lesión endotelial en la diabetes: trombomodulina, tissue factor pathway inhibitor, factor von Willebrand, activador tisular del plasminógeno e inhibidor del activador del plasminógeno-1.
Palabras clave:
Lesión endotelial
Diabetes
Trombomodulina
Tissue factor pathway inhibitor
Diabetes mellitus is a known risk factor for vascular disease. Endothelial damage is an early event in this process. Endothelial dysfunction studies are too expensive and laborious for routine use in at-risk patients. Therefore, in the last few years interest has increased in soluble markers of endothelial damage, particularly in those involved in thrombosis and fibrinolysis. We review the markers of endothelial damage that have been shown to be increased in diabetic patients: thrombomodulin, tissue-type factor pathway inhibitor, von Willebrand factor, tissue plasminogen activator, and plasminogen-activator inhibitor-1.
Key words:
Endothelial damage
Diabetes
Thrombomodulin
Tissue factor pathway inhibitor
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