Información del artículo
Después de una breve introducción sobre el sistema renina-angiotensinaaldosterona, se resaltan las circunstancias tanto fisiológicas como patológicas que modifican el sistema, así como también los fármacos que estimulan e inhiben la secreción de renina y aldosterona, que servirán al lector de guía para la interpretación de los resultados. La utilidad clínica de la determinación de la actividad renina plasmática (ARP) y la aldosterona se centra en el diagnóstico de algunas hipertensiones secundarias (hipertensión vasculorrenal, tumores secretantes de renina, hipermineralocorticismos y ciertas tubulopatías hereditarias infrecuentes), para el estudio de las alteraciones del metabolismo del potasio (hipo e hiperpotasemia), y para la evaluación pronóstica y/o terapéutica de ciertos estados edematosos (cirrosis hepática y syndrome nefrótico).
Palabras clave:
Sistema renina-angiotensina-aldosterona
Actividad renina plasmática
Hipertensión arterial secundaria
After a brief introduction on the renin-angiotensin-aldosterone system, the article analyses the physiological and pathological circumstances which modify it, and the drugs which stimulate or inhibit the release of rennin and aldosterone. This analysis is intended as a guide to interpret results.
In order to establish the medical effectiveness of determining the plasmatic renin activity (PRA) and the aldosterone, the article focuses on the diagnosis of some secondary hypertensions (vascularrenal hypertension, renin releasing tumours, hypermineralcorticisms and certain infrequent hereditary tubular pathologies), on the analysis of the alterations of potassium metabolism (hypo- and hyperpotassaemia), and on the prognostic and therapeutic evaluation of certain oedematous states (cirrhosis of the liver and nephritic syndrome).
Key words:
Renin-angiotensin-aldosterone system
Plasmatic renin activity
Secondary hypertension
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