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Vol. 58. Núm. 1.
Páginas 3-8 (enero 2010)
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Vol. 58. Núm. 1.
Páginas 3-8 (enero 2010)
Original article
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Glucose tolerance and plasma testosterone concentrations in men. Results of the Asturias Study
Tolerancia a la glucosa y concentraciones plasmáticas de testosterona en varones. Resultados del Estudio Asturias
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1679
Edelmiro Menéndeza,
Autor para correspondencia
, Sergio Valdésb, Patricia Botasa, Elías Delgadoa, Noelia Abelloc
a Servicio de Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, Spain
b Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain
c Servicio de Bioquímica, Hospital Universitario Central de Asturias, Oviedo, Spain
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Abstract
Background and objective

Studies in men have demonstrated a correlation between serum concentrations of androgens and sex hormone binding globulin (SHBG) with the presence of impaired glucose tolerance, diabetes and metabolic syndrome. The aim of this study was to evaluate circulating levels of total testosterone, SHBG, and bioavailable testosterone in the cohort of the Asturias Study and their association with the degree of glucose tolerance and metabolic syndrome.

Patients and methods

The study population consisted of 282 men aged 36 to 85 years old with normal concentrations of total testosterone. The degree of glucose tolerance and the presence of metabolic syndrome were evaluated.

Results

Serum concentrations of testosterone and bioavailable testosterone were negatively correlated with age, body mass index, waist circumference, blood glucose, glycosylated hemoglobin levels and insulin. Serum concentrations of total testosterone, bioavailable testosterone and SHBG were lower in men with glucose intolerance or diabetes than in those with normal glucose tolerance. After multivariate analysis, age and total testosterone levels were independent predictors of the presence of diabetes or glucose intolerance. The risk of glucose intolerance or diabetes mellitus was over 2.5 times higher in men with total testosterone levels in the lowest quartile than in those with total testosterone in the top quartile.

Conclusions

In this general population sample from Asturias, men with lower plasma concentrations of total testosterone - even when within the normal range - have an increased risk of glucose intolerance or diabetes, regardless of age and body mass index.

Keywords:
Type 2 diabetes
Glucose intolerance
Testosterone
Hypogonadism
Metabolic syndrome
Resumen
Antecedentes y objetivo

Diversos estudios realizados en varones han demostrado la existencia de una correlación entre las concentraciones séricas de andrógenos así como de proteína transportadora de hormonas sexuales (sex hormone binding globulin o SHBG), y la presencia de alteraciones de la tolerancia a la glucosa, diabetes y síndrome metabólico. El objetivo de este estudio fue evaluar las concentraciones séricas de testosterona total, SHBG y testosterona biodisponible en la cohorte del Estudio Asturias, y su asociación con el grado de tolerancia a la glucosa y el síndrome metabólico.

Pacientes y métodos

Se estudiaron 282 varones adultos de 36 a 85 años de edad con concentraciones séricas normales de testosterona total, evaluándose tanto su grado de tolerancia a la glucosa como la presencia o no de síndrome metabólico.

Resultados

Las concentraciones en suero de testosterona y testosterona biodisponible se correlacionaron negativamente con la edad, el índice de masa corporal, el perímetro de cintura, la glucemia, las concentraciones de hemoglobina glucosilada y la insulinemia. Los hombres con intolerancia a la glucosa o diabetes mellitus tenían concentraciones en suero de testosterona total, SHBG y testosterona biodisponible inferiores a las de los que tenían tolerancia normal a la glucosa. Tras el análisis multivariable, la edad y las concentraciones de testosterona total fueron predictores independientes de la presencia de diabetes mellitus o intolerancia a la glucosa. Los hombres con concentraciones de testosterona total en el cuartil inferior tenían un riesgo de padecer intolerancia o diabetes más de 2,5 veces mayor que el de los que tenían la testosterona plasmática en el cuartil superior.

Conclusiones

En esta muestra de población general de Asturias los hombres con concentraciones en plasma más bajas de testosterona total, aun dentro del rango de normalidad, tienen mayor riesgo de presentar intolerancia a la glucosa o diabetes, independientemente de la edad y del índice de masa corporal.

Palabras clave:
Diabetes tipo 2
Intolerancia a la glucosa
Testosterona
Hipogonadismo
Síndrome metabólico
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