Resistencias primarias de VIH en una población penitenciaria. Estudio REPRICOVA-2

Introducción

Existen escasos estudios sobre resistencias primarias en pacientes presos.

Métodos

Estudio descriptivo, de prevalencia en un día, de mutaciones de resistencia en presos infectados crónicos nunca tratados; muestreo aleatorio sistemático. Genotipado por secuenciación automática.

Resultados

Se estudiaron 90 pacientes. Dos muestras tienen mutaciones de inhibidores de la transcriptasa inversa análogos de nucleósidos (ITIAN), cuatro de no nucleósidos (ITINN) y una de inhibidores de la proteasa (IP).

Conclusión

Hallamos baja proporción de resistencias primarias en nuestra serie. No es necesario test de resistencias antes de la primera terapia antirretroviral.

Introduction

Currently, there are few reports on primary human immunodeficiency virus (HIV) drug resistance in the prison population.

Methods

This is a descriptive, one-day prevalence study to identify HIV drug-resistant mutations in chronically infected treatment-naïve prisoners. Systematic randomized sampling was performed and genotyping was done by automatic sequencing.

Results

A total of 90 patients were studied. Two samples were found to have nucleoside reverse transcriptase inhibitor (NRTI)-resistant mutations, four had non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutations and one had protease inhibitor (PI)-resistant mutations.

Conclusions

There was a low rate of primary resistance in our series. Therefore, resistance testing is not required before prescribing initial antiretroviral therapy in these patients.