Estadísticas

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      "titulo" => "Brotes epidémicos de salmonelosis por consumo de huevos"
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          "titulo" => "Epidemic outbreaks of salmonellosis due to the consumption of eggs"
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      "titulo" => "Detección del ADN del virus del papiloma humano por PCR en mujeres de alto riesgo. Validación de un protocolo"
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    "titulo" => "Caracterización de las mutaciones del gen rpoB en aislamientos clínicos de Mycobacterium tuberculosis resistentes a rifampicina"
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        "resumen" => "Objetivos&#58; Caracterizar y conocer la distribuci&#243;n de las diferentes mutaciones en el gen rpoB de cepas de Mycobacterium tuberculosis resistentes a rifampicina aisladas en Sevilla&#46; M&#233;todos&#58; Se determinaron las mutaciones en el gen rpoB en 21 cepas de M&#46; tuberculosis aisladas a partir muestras cl&#237;nicas durante un per&#237;odo de 3 a&#241;os &#40;1994-1996&#41;&#44; mediante tres m&#233;todos moleculares&#58; an&#225;lisis de los patrones de SSCP&#44; secuenciaci&#243;n y el m&#233;todo comercial InnoLiPA&#46; <br/>Resultados&#58; Se identificaron cinco tipos de mutaciones diferentes en el gen rpoB&#46; La mutaci&#243;n Ser531&#42;Leu se detect&#243; en 14 cepas &#40;66&#44;7&#37;&#41;&#44; la mutaci&#243;n H526&#42;Asp en 3 cepas &#40;14&#44;3&#37;&#41;&#44; Asn518&#42;Ser en una cepa &#40;4&#44;8&#37;&#41;&#44; Glu513&#42;Leu en una cepa &#40;4&#44;8&#37;&#41;&#46; En una cepa &#40;4&#44;8&#37;&#41; se detect&#243; una deleci&#243;n de 9 nucle&#243;tidos del cod&#243;n 510 al 513&#44; mientras que en la cepa restante &#40;4&#44;8&#37;&#41; no se detect&#243; ninguna mutaci&#243;n&#46; <br/>Conclusiones&#58; La distribuci&#243;n y frecuencia de mutaciones en las cepas de M&#46; tuberculosis resistentes a rifampicina son similares a las publicadas&#46; Sin embargo&#44; hemos detectado dos mutaciones en el gen rpoB no descritas previamente&#58; la deleci&#243;n de 9 nucle&#243;tidos &#40;510-513&#41; y la mutaci&#243;n puntual Asn518&#42;Ser&#46; La identificaci&#243;n de todas estas mutaciones podr&#237;a utilizarse como marcador epidemiol&#243;gico de los aislamientos cl&#237;nicos"
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        "resumen" => "Objectives&#58; Characterization and frecuency of the rpoB gene mutations associated with rifampin resistance in Mycobacterium tuberculosis clinical isolates in Sevilla&#46; <br/>Methods&#58; Characterization of rpoB mutations in 21 rifampicin-resistant strains of M&#46; tuberculosis isolated during a three-year period &#40;1994-1996&#41; by three different molecular methods&#58; a nonradiactive Single-strand conformation polymorphism &#40;SSCP&#41; analysis&#44; DNA sequence analysis and a commercial method the line probe assay InnoLiPA&#46; <br/>Results&#58; Five distinct rpoB mutations were identified&#46; Ser531&#42;Leu mutation was detected in 14 strains &#40;66&#46;7&#37;&#41;&#44; H526&#42;Asp in 3 strains &#40;14&#46;3&#37;&#41;&#44; Ans518&#42;Ser in 1 strain &#40;4&#46;8&#37;&#41;&#44; Glu513&#42;Leu in 1 strain &#40;4&#46;8&#37;&#41;&#46; A nine nucleotide deletion &#40;codon 510-513&#41; was found in one strain &#40;4&#46;8&#37;&#41; while in the remaining resistant strain &#40;4&#46;8&#37;&#41; no mutation was detected&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#58; The frecuency of the different mutations found in the rpoB gene&#44; associated with rifampicin resistance in Mycobacterium tuberculosis clinical isolates in Sevilla&#44; are similar to those previously reported&#46; However&#44; two new mutations has been detected&#58; a nine nucleotide deletion &#40;codon 510-513&#41;&#44; and the Asn518&#42;Ser point mutation&#46; The characterization of the mutations in the rpoB gene could serve as epidemiological marker for the rifampicin resistant clinical isolates of M&#46; tuberculosis&#46;"
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