Estadísticas

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      "titulo" => "Aspectos microbiológicos, farmacocinéticos y clínicos de los nuevos macrólidos de 14 y 15 átomos"
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          "titulo" => "Microbiologic, phamarcokinetic and clinical aspects of the new 14 and 15 atom macrolides"
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          "autoresLista" => "JM Ramos Rincón, R Fernández Roblas"
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      "titulo" => "Antibioterapia intravenosa domiciliaria"
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          "autoresLista" => "Julia Hazas, Manuel Francisco Fernández-Miera, Isabel Sampedro, Mª Carmen Fariñas, Ana M García de la Paz, Pedro Sanroma"
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    "titulo" => "Erradicación mediante triple terapia de Helicobacter pylori en pacientes ulcerosos: papel de la endoscopia y sensibilidad antibiótica"
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        "titulo" => "Eradication of Helicobacter pylori by triple therapy in ulcerous patients&#58; the role of endoscopy and antibiotic sensitivity"
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        "resumen" => "<span class="elsevierStyleBold">Fundamento&#58;</span> Evaluar el cumplimiento y los resultados de un protocolo diagn&#243;stico y terap&#233;utico de la infecci&#243;n por Helicobacter pylori en pacientes ulcerosos&#46; Dar a conocer la actividad de metronidazol&#44; claritromicina y amoxicilina frente a los aislados de Helicobacter pylori de dichos enfermos&#46; Pacientes y m&#233;todos&#58; Se estudiaron 35 pacientes con patolog&#237;a ulcerosa &#40;27 duodenal y 8 g&#225;strica&#41;&#46; El diagn&#243;stico de la infecci&#243;n se realiz&#243; mediante el test de la ureasa y cultivo de biopsias g&#225;stricas&#44; obtenidas mediante endoscopia&#46; Los pacientes fueron tratados con omeprazol &#40;20 mg&#47;12 h&#41;&#44; claritromicina &#40;500 mg&#47;12 h&#41; y amoxicilina &#40;1 g&#47;12 h&#41; durante una semana &#40;OCA &#42; 7&#41;&#46; La determinaci&#243;n de la sensibilidad se realiz&#243; mediante el sistema E-test en agar Wilkins-Chalgren&#46; <br/>Resultados&#58; Un total de 24 pacientes completaron el protocolo&#44; de los cuales 22 erradicaron Helicobacter pylori &#40;91&#44;7&#37;&#59; 10 fumadores y 12 no fumadores&#44; no significativo&#41;&#46; Once pacientes &#40;31&#44;4&#37;&#41; rechazaron la segunda endoscopia para verificar la erradicaci&#243;n&#46; Finalizado el tratamiento&#44; 10 pacientes &#40;28&#37;&#41; refer&#237;an pirosis que no hab&#237;an presentado con anterioridad&#46; La resistencia a metronidazol fue del 50&#37;&#44; a claritromicina del 1&#44;5&#37; y amoxicilina del 0&#37;&#46; <br/>Conclusiones&#58; La pauta OCA &#42; 7 logra una tasa de erradicaci&#243;n superior al 90&#37; en pacientes ulcerosos&#44; con independencia del h&#225;bito tab&#225;quico&#44; pero con posterior aparici&#243;n de pirosis en un porcentaje significativo de enfermos&#46; Para verificar la erradicaci&#243;n es recomendable un m&#233;todo no endosc&#243;pico&#44; por la mala aceptaci&#243;n de la t&#233;cnica&#46; Las tasas de resistencia a metronidazol son elevadas pero se conserva la sensibilidad a claritomicina&#44; y no se observa resistencia a amoxicilina"
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        "resumen" => "<span class="elsevierStyleBold">Background&#58;</span> a protocol was conducted to evaluate the compliance and results of Helicobacter pylori infection treatment in patients with ulcer disease&#46; To know the metronidazole&#44; clarithromycin and amoxicillin activities of Helicobacter pylori strains from such patients&#46; <br/>Patients and methods&#58; 35 patients with ulcer disease &#40;27 duodenal ulcer and 8 gastric ulcer&#41; were studied&#46; Diagnosis of Helicobacter pylori infection was performed by urease test and culture of mucosal gastric samples from patients undergoin endoscopy&#46; The patients received the following treatment during 7 days&#58; omeprazole &#40;20 mg bid&#41;&#44; clarithromycin &#40;500 mg bid&#41; and amoxicillin &#40;1 g bid&#41;&#44; OCA &#42; 7&#46; Susceptibility was determined by E-test system on Wilkins-Chalgren blood agar and read after 5 days&#46; <br/>Results&#58; 22&#47;24 patients who had completed the protocol design erradicated Helicobacter pylori &#40;91&#46;7&#37;&#41;&#44; 11 patients &#40;31&#46;4&#37;&#41; refused second endoscopy to verify control of eradication&#46; After treatment 10 patients presented with pyrosis &#171;de novo&#187; &#40;28&#37;&#41;&#46; The overall metronidazol&#44; claritromycin and amoxicillin resistance rate was 50&#37;&#44; 1&#46;5&#37; and 0&#37; respectively&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#58; OCA &#42; 7 treatment obtains a eradication rate higher than 90&#37; in our patients with ulcer disease&#44; despite smoking habit&#44; but with a significative number of patients presenting pyrosis after treatment&#46; We recommend a non-endoscopy method to verify eradication rate&#44; because of its poor acceptance&#46; 3&#46; Metronidazol resistance rate is high in our serie but clarithromycin susceptibility is mantained&#46;"
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