Estadísticas

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      "titulo" => "Distribución de serotipos de Salmonella spp. aislados en España durante un período de 4 años (1993-1996)"
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          "titulo" => "The distribution of serotypes of Salmonella spp. isolated in Spain during a 4-year period (1993-1996)"
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      "titulo" => "Gestión en microbiología clínica"
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          "autoresLista" => "J J Picazo"
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    "titulo" => "Valoración de la técnica de reacción en cadena de la polimerasa para el diagnóstico de las meningitis causadas por N. meningitidis y H. influenzae"
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        "titulo" => "Evaluation of the polymerase chain reaction technique for the diagnosis of meningitis caused by Neisseria meningitidis and Haemophilus influenzae"
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        "resumen" => "<span class="elsevierStyleBold">Background&#58;</span> Bacterial meningitis is a severe infection of the central nervous system &#40;CNS&#41;&#44; most frequently caused by Neisseria meningitidis in our setting&#46; Microbiologic diagnosis of bacterial meningitis is not enough sensitive because its efficiency can be affected by the therapeutic regim given to the patient&#46; Polymerase chain reaction &#40;PCR&#41; can provide a more sensitive diagnosis and allow us to get an earlier result&#46; <br/> <span class="elsevierStyleBold">Objectives&#58;</span> To asses the sensitivity and specificity of a PCR technique for the diagnosis of meningitis caused by N&#46; meningitidis and Haemophilus influenzae&#46; <br/> <span class="elsevierStyleBold">Material and Methods&#58;</span> Ninety-six patients who were attended because of suspected bacterial meningitis on the Hospital de Sant Joan de D&#233;u&#44; Corporaci&#243; Sanit&#224;ria Parc Taul&#237; and Hospital de la Santa Creu i Sant Pau&#44; and had negative results by conventional laboratory methods&#44; were selected for the study&#46; A total of 99 cerebrospinal fluid samples &#40;CSF&#41; were obtained and evaluated for PCR&#46; <br/>DNA extracts of the CSF samples were amplified by universal primers&#46; Amplification products were hybridized with specific probes for Haemophilus genus and N&#46; meningitidis&#46; Positive and negative controls were included to asses the reliability of PCR&#46; <br/> <span class="elsevierStyleBold">Results&#58;</span> Eight of the 99 CSF samples &#40;8&#37;&#41; were positive by PCR and subsequent hybridization with the specific probe of N&#46; meningitidis&#46; None of the amplicons hybridized with the probe of Haemophilus genus&#46; Thirteen percent of the patients &#40;8&#47;59&#41; with clinical suspicious of non-neonatal sepsis or meningitis were diagnosed by PCR&#44; amongst them&#44; 36&#37; of the cases &#40;4&#47;11&#41; with initial diagnosis of meningococcal sepsis or meningitis&#46; <br/> <span class="elsevierStyleBold">Conclusions&#58;</span> The sensitivity and the specificity of the PCR technique afford a complementary method to conventional ones&#44; in special for the diagnosis of meningococcal meningitis in the group of pediatric patients"
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