Estadísticas

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      "titulo" => "Utilidad de la PCR en el diagnóstico de las lesiones cerebrales focales en pacientes infectados por el VIH"
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          "titulo" => "The usefulness of PCR in the diagnosis of focal brain lesions in patients with HIV infection"
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      "titulo" => "Infección por el VIH en el área sanitaria de León. Estudio de la incidencia en el período 1983-1997"
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    "titulo" => "Sensibilidad a eritromicina y claritromicina de aislados de Streptococcus betahemolítico del grupo A productores de faringoamigdalitis en la edad pediátrica: estudio multicéntrico en atención primaria"
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        "titulo" => "Sensitivity to erythromycin and clarithromycin from isolates of group A beta-haemolytic Streptococcus (GABHS) producers of pharyngotonsillitis during childhood: a primary care multicenter study"
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        "resumen" => "<span class="elsevierStyleBold">Fundamento&#58;</span> El reciente incremento de la prevalencia de aislados de Streptococcus betahemol&#237;tico del grupo A &#40;SBHGA&#41; resistentes a macr&#243;lidos observado en algunas zonas de Espa&#241;a y en varios pa&#237;ses de nuestro entorno subraya la conveniencia de evaluar peri&#243;dicamente&#44; con la metodolog&#237;a adecuada&#44; el nivel de su sensibilidad a estos antimicrobianos&#44; de uso frecuente en nuestro pa&#237;s en el tratamiento emp&#237;rico de las faringoamigdalitis agudas bacterianas y de las infecciones respiratorias&#46; <br/> <span class="elsevierStyleBold">Pacientes y m&#233;todos&#58;</span> Se eval&#250;a la sensibilidad a los macr&#243;lidos eritromicina y claritromicina de 293 aislados de SBHGA mediante el m&#233;todo de microdiluci&#243;n en caldo recomendado por la NCCLS &#40;1997&#41;&#46; Los aislados fueron obtenidos de otros tantos ni&#241;os con faringoamigdalitis aguda de presumible etiolog&#237;a bacteriana &#40;n &#61; 757&#41; atendidos ambulatoriamente en 10 ciudades espa&#241;olas&#46; <br/> <span class="elsevierStyleBold">Resultados&#58;</span> Se encontr&#243; una prevalencia media de aislados de SBHGA resistentes a eritromicina y claritromicina del 8&#44;9 y el 7&#44;8&#37;&#44; respectivamente&#46; El porcentaje de aislados resistentes en las distintas ciudades evaluadas vari&#243; considerablemente &#40;0-33&#37;&#41;&#46; En general&#44; la actividad intr&#237;nseca de claritromicina &#40;CMI50 y CMI90 de 0&#44;007 y 0&#44;25 mg&#47;ml&#44; respectivamente&#41; fue discretamente superior a la de eritromicina &#40;CMI50 y CMI90 de 0&#44;015 y 0&#44;5 mg&#47;ml&#44; respectivamente&#41;&#46; Todos los aislados estudiados fueron uniformemente sensibles a penicilina&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#58;</span> Los macr&#243;lidos eritromicina y claritromicina contin&#250;an siendo muy activos frente a SBHGA&#46; El nivel medio de resistencias a estos macr&#243;lidos en Espa&#241;a en aislados procedentes de infecciones comunitarias y recogidos prospectivamente es comparable al de otros pa&#237;ses de nuestro entorno"
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        "resumen" => "<span class="elsevierStyleBold">Background&#58;</span> The recent increase in the prevalence of macrolide-resistant group A beta-haemolytic Streptococcus &#40;BHSGA&#41; strains reported in some areas in Spain and several neighboring countries underscores the need to perform a periodic surveillance&#44; with the adequate methodology&#44; of the level of its susceptibility to these antimicrobials which are frequently used in our country for the treatment of acute streptococal pharingotonsillitis and respiratory tract infections&#46; <br/> <span class="elsevierStyleBold">Patients and Methods&#58;</span> The susceptibility of 293 isolates of BHSGA to the macrolides erythromycin and clarithromycin was evaluated by the broth microdilution procedure recommended by the NCCLS &#40;1997&#41;&#46; The isolates were prospectively obtained from children with acute pharyngotonsillitis &#40;n &#61; 757&#41; who were seen at primary care centers in ten Spanish cities&#46; <br/> <span class="elsevierStyleBold">Results&#58;</span> An overall prevalence of 8&#46;9 and 7&#46;8&#37; erythromycin- and clarithromycin-resistant BHSGA isolates was respectively found&#46; The percentage of resistant isolates varied considerably among the different cities subjected to study &#40;0-33&#37;&#41;&#46; Overall&#44; the intrinsic activity of clarithromycin &#40;MIC50 and MIC90 of 0&#46;007 and 0&#46;25 mg&#47;ml&#44; respectively&#41; was slightly higher than that of erythromycin &#40;MIC50 and MIC90 of 0&#46;015 and 0&#46;5 mg&#47;ml&#44; respectively&#41;&#46; All strains studied were uniformly susceptible to penicillin&#46; <br/> <span class="elsevierStyleBold">Conclusions&#58;</span> Macrolide antibiotics&#44; erythromycin and clarithromycin&#44; continue to be highly active against BHSGA&#46; The mean level of resistant strains found in Spain from community acquired infections and recovered prospectively is comparable to that of our neighboring countries&#46;"
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