Infecciones en pacientes neutropénicos
Epidemiología de las infecciones en el paciente neutropénico
Epidemiology of infections in neutropenic patients
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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2005;23 Supl 5:2-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6313 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 5329 "PDF" => 976 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Infecciones en pacientes neutropénicos</span>" "titulo" => "Neutropenia febril: pasado, presente y futuro" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "2" "paginaFinal" => "6" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Febrile neutropenia: past, present and future" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Enric Carreras, Josep Mensa" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Enric" "apellidos" => "Carreras" ] 1 => array:2 [ "nombre" => "Josep" "apellidos" => "Mensa" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X05752265?idApp=UINPBA00004N" "url" => "/0213005X/00000023000000S5/v1_201305090005/S0213005X05752265/v1_201305090005/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Infecciones en pacientes neutropénicos</span>" "titulo" => "Epidemiología de las infecciones en el paciente neutropénico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "13" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Joaquín Díaz-Mediavilla, Manuel Lizasoain" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Joaquín" "apellidos" => "Díaz-Mediavilla" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Manuel" "apellidos" => "Lizasoain" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Hematología. Hospital Clínico de San Carlos. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Enfermedades Infecciosas. Hospital 12 de Octubre. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. J. Díaz Mediavilla. Hospital Clínico de San Carlos. Servicio de Hematología. Profesor Martín Lagos, s/n. 28040 Madrid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidemiology of infections in neutropenic patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec136851" "palabras" => array:6 [ 0 => "Neutropenia" 1 => "Infección" 2 => "Profilaxis" 3 => "Leucemia" 4 => "Linfoma" 5 => "Mieloma" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec136850" "palabras" => array:6 [ 0 => "Neutropenia" 1 => "Infection" 2 => "Prophylaxis" 3 => "Leukemie" 4 => "Lymphoma" 5 => "Myeloma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Los datos epidemiológicos son útiles para conocer los cambios de formas de expresión clínica y de agentes microbianos causales de las infecciones. Ello permite diseñar tratamientos empíricos o anticipados y orientar pruebas diagnósticas, así como clasificarlos por grupos de riesgo para decidir la necesidad o no de hospitalización.</p><p class="elsevierStyleSimplePara elsevierViewall">La incidencia de neutropenia está aumentando como consecuencia de la mayor agresividad de los tratamientos antineoplásicos empleados y por la ampliación del rango de edad de los pacientes que los reciben. Se ha calculado que en Estados Unidos se producen unas 60.000 hospitalizaciones anuales a causa de la neutropenia, y que la tercera parte de ellas corresponde a pacientes hematológicos.</p><p class="elsevierStyleSimplePara elsevierViewall">Los focos de infección más frecuentes son: neumonía (38%), bacteriemia (35%) y afecciones urinarias (11%). De las bacterias causantes de infección, dos tercios son grampositivas y el resto, bacilos gramnegativos. En los últimos años parece que vuelve a observarse un incremento de gramnegativos.</p><p class="elsevierStyleSimplePara elsevierViewall">Los aislamientos fúngicos representan el 2-10% de los casos, según el tipo de pacientes neutropénicos que se considere, y se producen preferentemente en los que presentan una neutropenia prolongada u otros déficit inmunológicos asociados, como en los pacientes con trasplantes alogénicos de médula ósea o en quienes han recibido análogos de las purinas.</p><p class="elsevierStyleSimplePara elsevierViewall">Los virus herpéticos son muy frecuentes. Los virus respiratorios parece que se perfilan como patógenos emergentes para este grupo de pacientes.</p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Epidemiological data are useful to determine changes in forms of clinical expression and in the microbial agents causing infections. This allows empirical or preemptive treatments to be designed and can guide diagnostic tests. Empirical data also allow patients to be classified by risk group in order to decide on the need for hospitalization. The incidence of neutropenia is increasing as a result of the more aggressive antineoplastic treatments used and the broader age range of patients who receive them. It has been calculated that in the USA neutropenia causes approximately 60,000 hospitalizations per year and that a third of these occur in hematological patients.</p><p class="elsevierStyleSimplePara elsevierViewall">The most frequent foci of infection are: pneumonia (38%), bacteremia (35%) and urinary (11%).</p><p class="elsevierStyleSimplePara elsevierViewall">Of the bacteria causing infection, two thirds are Grampositive and the remaining bacilli are Gram-negative. In the last few years, an increase of Gram-negative bacteria seems to have reemerged.</p><p class="elsevierStyleSimplePara elsevierViewall">The incidence of fungal isolates represents 2-10%, depending on the type of neutropenic patient analyzed. Fungal isolates are found preferentially in patients with prolonged neutropenia and/or other associated immunodeficiencies, as occurs in allogenic bone marrow transplantation or in patients who have received purine analogs.</p><p class="elsevierStyleSimplePara elsevierViewall">Viruses are very frequent. Respiratory viruses seem to be emerging pathogens in this group of patients.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Información del artículo
ISSN: 0213005XIdioma original: Español
DOI:10.1157/13091240
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| 2019 Agosto | 1 | 6 | 7 |
| 2019 Julio | 13 | 21 | 34 |
| 2019 Junio | 9 | 55 | 64 |
| 2019 Mayo | 54 | 100 | 154 |
| 2019 Abril | 32 | 95 | 127 |
| 2019 Marzo | 2 | 38 | 40 |
| 2019 Febrero | 2 | 39 | 41 |
| 2019 Enero | 2 | 42 | 44 |
| 2018 Diciembre | 2 | 23 | 25 |
| 2018 Noviembre | 9 | 48 | 57 |
| 2018 Octubre | 11 | 9 | 20 |
| 2018 Septiembre | 0 | 28 | 28 |
| 2018 Agosto | 2 | 84 | 86 |
| 2018 Julio | 0 | 64 | 64 |
| 2018 Junio | 2 | 55 | 57 |
| 2018 Mayo | 4 | 28 | 32 |
| 2018 Abril | 1 | 30 | 31 |
| 2018 Marzo | 1 | 18 | 19 |
| 2018 Febrero | 1 | 11 | 12 |
| 2018 Enero | 2 | 7 | 9 |
| 2017 Diciembre | 1 | 7 | 8 |
| 2017 Noviembre | 4 | 17 | 21 |
| 2017 Octubre | 1 | 7 | 8 |
| 2017 Septiembre | 2 | 5 | 7 |
| 2017 Agosto | 6 | 8 | 14 |
| 2017 Julio | 3 | 2 | 5 |
| 2017 Junio | 3 | 14 | 17 |
| 2017 Mayo | 7 | 17 | 24 |
| 2017 Abril | 5 | 3 | 8 |
| 2017 Marzo | 16 | 22 | 38 |
| 2017 Febrero | 11 | 3 | 14 |
| 2017 Enero | 2 | 4 | 6 |
| 2016 Diciembre | 3 | 0 | 3 |
| 2016 Noviembre | 2 | 4 | 6 |
| 2016 Octubre | 10 | 2 | 12 |
| 2016 Septiembre | 5 | 4 | 9 |
| 2016 Agosto | 6 | 0 | 6 |
| 2016 Julio | 22 | 1 | 23 |
| 2016 Junio | 67 | 20 | 87 |
| 2016 Mayo | 94 | 14 | 108 |
| 2016 Abril | 79 | 18 | 97 |
| 2016 Marzo | 83 | 12 | 95 |
| 2016 Febrero | 58 | 22 | 80 |
| 2016 Enero | 64 | 13 | 77 |
| 2015 Diciembre | 34 | 10 | 44 |
| 2015 Noviembre | 55 | 11 | 66 |
| 2015 Octubre | 84 | 13 | 97 |
| 2015 Septiembre | 59 | 10 | 69 |
| 2015 Agosto | 73 | 3 | 76 |
| 2015 Julio | 80 | 12 | 92 |
| 2015 Junio | 34 | 7 | 41 |
| 2015 Mayo | 57 | 7 | 64 |
| 2015 Abril | 33 | 8 | 41 |
| 2015 Marzo | 120 | 6 | 126 |
| 2015 Febrero | 39 | 2 | 41 |
| 2015 Enero | 37 | 5 | 42 |
| 2014 Diciembre | 37 | 10 | 47 |
| 2014 Noviembre | 24 | 4 | 28 |
| 2014 Octubre | 38 | 3 | 41 |
| 2014 Septiembre | 37 | 3 | 40 |
| 2014 Agosto | 29 | 2 | 31 |
| 2014 Julio | 50 | 9 | 59 |
| 2014 Junio | 30 | 2 | 32 |
| 2014 Mayo | 20 | 3 | 23 |
| 2014 Abril | 17 | 2 | 19 |
| 2014 Marzo | 19 | 2 | 21 |
| 2014 Febrero | 18 | 2 | 20 |
| 2014 Enero | 12 | 2 | 14 |
| 2013 Diciembre | 20 | 1 | 21 |
| 2013 Noviembre | 28 | 3 | 31 |
| 2013 Octubre | 21 | 6 | 27 |
| 2013 Septiembre | 15 | 8 | 23 |
| 2013 Agosto | 31 | 6 | 37 |
| 2013 Julio | 28 | 2 | 30 |
| 2005 Diciembre | 2901 | 0 | 2901 |
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