Atazanavir en terapias de rescate
Efficacy of atazanavir in rescue therapy
Joaquín Portilla
, Vicente Boix, Esperanza Merino, Sergio Reus
Autor para correspondencia
portilla-joa@gva.es
Correspondencia: Dr. J. Portilla. Unidad Enfermedades Infecciosas. Hospital Generla Universitario. Pintor Baeza, s/n. Alicante, 03010.
Correspondencia: Dr. J. Portilla. Unidad Enfermedades Infecciosas. Hospital Generla Universitario. Pintor Baeza, s/n. Alicante, 03010.
Unidad de Enfermedades Infecciosas. Hospital General Universitario de Alicante. España
Leído
2072
Vecesse ha leído el artículo
699
Total PDF
1373
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S0213005X08766163" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(08)76616-3" "estado" => "S300" "fechaPublicacion" => "2008-12-01" "aid" => "76616" "copyright" => "Elsevier España S.L.. Todos los derechos reservados" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2008;26 Supl 17:22-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1512 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1081 "PDF" => 423 ] ] "itemSiguiente" => array:18 [ "pii" => "S0213005X08766175" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(08)76617-5" "estado" => "S300" "fechaPublicacion" => "2008-12-01" "aid" => "76617" "copyright" => "Elsevier España S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2008;26 Supl 17:28-33" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3492 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 2473 "PDF" => 1011 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Resistencia viral y barrera genética de atazanavir" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "28" "paginaFinal" => "33" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Viral resistance and genetic barrier of atazanavir" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen De Mendoza, Carolina Garrido, Ana Treviño, Lourdes Anta, Eva Poveda, Vicente Soriano" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Carmen De" "apellidos" => "Mendoza" ] 1 => array:2 [ "nombre" => "Carolina" "apellidos" => "Garrido" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Treviño" ] 3 => array:2 [ "nombre" => "Lourdes" "apellidos" => "Anta" ] 4 => array:2 [ "nombre" => "Eva" "apellidos" => "Poveda" ] 5 => array:2 [ "nombre" => "Vicente" "apellidos" => "Soriano" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X08766175?idApp=UINPBA00004N" "url" => "/0213005X/0000002600000S17/v1_201305090109/S0213005X08766175/v1_201305090109/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0213005X08766151" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(08)76615-1" "estado" => "S300" "fechaPublicacion" => "2008-12-01" "aid" => "76615" "copyright" => "Elsevier España S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2008;26 Supl 17:14-21" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1759 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1037 "PDF" => 715 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Atazanavir en el tratamiento de simplificación" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "14" "paginaFinal" => "21" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of atazanavir in simplification regimens" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Zamora, José María Gatell" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Zamora" ] 1 => array:2 [ "nombre" => "José María" "apellidos" => "Gatell" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X08766151?idApp=UINPBA00004N" "url" => "/0213005X/0000002600000S17/v1_201305090109/S0213005X08766151/v1_201305090109/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Atazanavir en terapias de rescate" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "22" "paginaFinal" => "27" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Joaquín Portilla, Vicente Boix, Esperanza Merino, Sergio Reus" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Joaquín" "apellidos" => "Portilla" "email" => array:1 [ 0 => "portilla-joa@gva.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Vicente" "apellidos" => "Boix" ] 2 => array:2 [ "nombre" => "Esperanza" "apellidos" => "Merino" ] 3 => array:2 [ "nombre" => "Sergio" "apellidos" => "Reus" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Enfermedades Infecciosas. Hospital General Universitario de Alicante. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. J. Portilla. Unidad Enfermedades Infecciosas. Hospital Generla Universitario. Pintor Baeza, s/n. Alicante, 03010." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of atazanavir in rescue therapy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec137558" "palabras" => array:3 [ 0 => "Atazanavir" 1 => "Tratamiento antirretroviral" 2 => "Inhibidores de la proteasa" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec137559" "palabras" => array:3 [ 0 => "Atazanavir" 1 => "Antiretroviral treatment" 2 => "Protease inhibitors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El fracaso virológico del tratamiento antirretroviral aumenta la morbilidad y la mortalidad asociada con sida. Con los fármacos disponibles en el momento actual es posible conseguir una carga viral plasmática del VIH < 50 copias de ARN/ml en un porcentaje importante de pacientes en situación de fracaso virológico, incluso en los que acumulan un número importante de mutaciones de resistencia en el genoma viral. La adhesión sigue siendo la causa más importante de fracaso al tratamiento antirretroviral. Atazanavir potenciado con ritonavir presenta claras ventajas sobre otros inhibidores de la proteasa (IP), como son su administración una vez al día, el escaso número de comprimidos y la buena tolerancia, que facilitan la adhesión, así como una menor toxicidad metabólica y un perfil de resistencias diferente al de otros IP. Atazanavir potenciado en tratamientos de rescate estaría fuertemente recomendado en pacientes naïve a IP o cuando en el genotipo basal hay < 3 mutaciones en las posiciones: 10F/I/V, 16E, 33I/F/V, 46I/L, 60E, 84V, 85 V y 90M del gen de la proteasa, especialmente cuando el paciente presenta problemas de adhesión al tratamiento antirretroviral o alteraciones metabólicas como dislipidemia, resistencia insulínica, glucemia basal alterada, riesgo cardiovascular a los 10 años > 10% o enfermedad cardiovascular.</p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Virological failure of antiretroviral treatment increases the morbidity and mortality associated with AIDS. With currently available drugs it is possible to achieve an HIV - PVL < 50 copies of aRNA/mL in a significant percentage of patients with virological failure, even in those who accumulate a considerable number of resistant mutations in the viral genome. Compliance continues to be the most significant cause of antiretroviral treatment failure. Atazanavir boosted with ritonavir has clear advantages over other protease inhibitors (PI), such as its administration once per day, low number of tablets and a good tolerance which helps in compliance, as well as a lower metabolic toxicity and a resistances profile different to other PIs. Boosted Atazanavir in rescue treatments would be strongly recommended in patients naive to a PI or when there are < 3 mutations in the basic genotype in positions: 10F/I/V, 16E, 33I/F/V, 46I/L, 60E, 84V, 85 V and 90M of the protease gene, particularly when the patient has problems of compliance to antiretroviral treatment or metabolic disorders, such as dyslipaemia, insulin resistance, fasting blood glucose changes, a cardiovascular risk at 10 years of > 10% or cardiovascular disease.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Gulick" 1 => "H.J. Ribaudo" 2 => "C.M. Shikuma" 3 => "S. Lustgarten" 4 => "K.E. Squires" 5 => "W.A. Meyer III." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa031772" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "1850" "paginaFinal" => "1861" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15115831" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Van Leeuwen" 1 => "C. Katlama" 2 => "R.L. Murphy" 3 => "K. Squires" 4 => "J. Gatell" 5 => "A. Horban" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000060356.78202.6c" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "987" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12700448" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral breakthrough after suppression with highly active antiretroviral therapy: experience from 233 individuals with viral loads of less than 50 copies/ ml followed for up to 4 years" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.C. Lampe" 1 => "M.A. Johnson" 2 => "M. Lipman" 3 => "C. Loveday" 4 => "M. Youle" 5 => "D. Ransom" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000050876.71999.11" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "768" "paginaFinal" => "770" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12646806" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Durability of HIV-1 viral suppression over 3.3 years with multi-drug antiretroviral therapy in previously drug-naive individuals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.N. Phillips" 1 => "V. Miller" 2 => "C. Sabin" 3 => "A. Cozzi Lepri" 4 => "S. Klauke" 5 => "M. Bickel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2001" "volumen" => "15" "paginaInicial" => "2379" "paginaFinal" => "2384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11740188" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of initial highly active antiretroviral therapy on future treatment sequences in HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.B. Klein" 1 => "P. Willemot" 2 => "T. Murphy" 3 => "R.G. Lalonde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2004" "volumen" => "18" "paginaInicial" => "1895" "paginaFinal" => "1904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15353975" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiretroviral therapy of HIV infection: duration and reasons for changing the first therapeutic regimen in 518 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Gratacos" 1 => "M. Tuset" 2 => "C. Codina" 3 => "J.M. Miro" 4 => "J. Mallolas" 5 => "N. Miserachs" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2006" "volumen" => "126" "paginaInicial" => "241" "paginaFinal" => "245" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.G. Deeks" 1 => "F.M. Hecht" 2 => "M. Swanson" 3 => "T. Elbeik" 4 => "R. Loftus" 5 => "P.T. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "AIDS" "fecha" => "1999" "volumen" => "13" "paginaInicial" => "35" "paginaFinal" => "43" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.M. Lucas" 1 => "R.E. Chaisson" 2 => "R.D. Moore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1999" "volumen" => "131" "paginaInicial" => "81" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10419445" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Ledergerber" 1 => "M. Egger" 2 => "M. Opravil" 3 => "A. Telenti" 4 => "B. Hirschel" 5 => "M. Battegay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1999" "volumen" => "353" "paginaInicial" => "863" "paginaFinal" => "868" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: results from the EuroSIDA study group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Mocroft" 1 => "B. Ledergerber" 2 => "J.P. Viard" 3 => "S. Staszewski" 4 => "M. Murphy" 5 => "A. Chiesi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/425424" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2004" "volumen" => "190" "paginaInicial" => "1947" "paginaFinal" => "1956" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15529259" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of trend in CD4-positive T-cell count and mortality among HIV-1- infected individuals with virological failure to all three antiretroviral-drug classes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Ledergerber" 1 => "J.D. Lundgren" 2 => "A.S. Walker" 3 => "C. Sabin" 4 => "A. Justice" 5 => "P. Reiss" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)16589-6" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "364" "paginaInicial" => "51" "paginaFinal" => "62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15234856" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.N. Phillips" 1 => "C. Leen" 2 => "A. Wilson" 3 => "J. Anderson" 4 => "D. Dunn" 5 => "A. Schwenk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2007" "volumen" => "370" "paginaInicial" => "1923" "paginaFinal" => "1928" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistance issues with new nucleoside/nucleotide backbone options" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. Wainberg" 1 => "D. Turner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Acquir Immune Defic Syndr" "fecha" => "2004" "volumen" => "37" "numero" => "Suppl 1" "paginaInicial" => "S36" "paginaFinal" => "S43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15319668" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Recomendaciones de Gesida/Plan Nacional sobre el Sida respecto al tratamiento antirretroviral en adultos infectados por el virus de la inmunodeficiencia humana [accedido 12 Jun 2008] Disponible en: <a class="elsevierStyleInterRef" href="http://www.gesida.seimc.org/index.asp">http://www.gesida.seimc.org/index.asp</a>." ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Department of Health and Human Services, US. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents: January 29, 2008 [accedido 12 Jun 2008]. Disponible en: <a class="elsevierStyleInterRef" href="http://www.aidsinfo.nih.gov/Guidelines/">http://www.aidsinfo.nih.gov/Guidelines/</a>" ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atazanavir. A review of its use in the management of HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.J. Harrison TSand Scott" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drugs" "fecha" => "2006" "volumen" => "65" "paginaInicial" => "2309" "paginaFinal" => "2336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16266202" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of atazanavir-based highly active antiretroviral therapy in patients with virologic suppression switched from a stable, boosted or unboosted protease inhibitor treatment regimen: the SWAN Study (AI424-097) 48-week results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Gatell" 1 => "D. Salmon-Ceron" 2 => "A. Lazzarin" 3 => "E. Van Wijngaerden" 4 => "F. Antunes" 5 => "C. Leen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2007" "volumen" => "44" "paginaInicial" => "1484" "paginaFinal" => "1492" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of NNRTI and NRTI resistance on the response to the regimen of TMC125 plus two NRTIs in study TMC125-C227" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Woodfall" 1 => "J. Vingerhoets" 2 => "M. Peeters" 3 => "I. Peeters" 4 => "G. De Smedt" 5 => "G.D. Miralles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "8th International Congress on Drug Therapy in HIV Infection" "conferencia" => "Glasgow" "serieFecha" => "2006" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic staging of extensively pretreated patients with advanced HIV-1 disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Montaner" 1 => "D. Guimaraes" 2 => "J. Chung" 3 => "Z. Gafoor" 4 => "M. Salgo" 5 => "R. DeMasi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1310/0XH7-F2V2-1K0R-NU2W" "Revista" => array:6 [ "tituloSerie" => "HIV Clin Trials" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "281" "paginaFinal" => "290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16566082" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and a decreased cholesterol" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Latham" 1 => "J. Stebbing" 2 => "S. Mandalia" 3 => "C. Michailidis" 4 => "E. Davies" 5 => "M. Bower" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dki170" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2005" "volumen" => "56" "paginaInicial" => "186" "paginaFinal" => "189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15911551" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Once-daily directly observed therapy lopinavir/ ritonavir plus indinavir as a protease inhibitor-only salvage therapy in heavily pretreated HIV-1-infected patients: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Elzi" 1 => "H.H. Hirsch" 2 => "M. Battegay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "129" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16327333" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Johnson" 1 => "B. Grinsztejn" 2 => "C. Rodriguez" 3 => "J. Coco" 4 => "E. De Jesus" 5 => "A. Lazzarin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2005" "volumen" => "19" "paginaInicial" => "153" "paginaFinal" => "162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15668540" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "96-week comparison of once-daily atazanavir/ritonavir and lopinavir/ritonavir in patients with multiple virologic failures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Jhonson" 1 => "B. Ginsztejn" 2 => "C. Rodríguez" 3 => "J. Coco" 4 => "E. De Jesus" 5 => "A. Lazzarin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000216371.76689.63" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "711" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16514301" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salvage therapy with atazanavir/ritonavir combined to tenofovir in HIV-infected patients with multiple treatment failures: randomized ANRS 107 trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Piketty" 1 => "L. Gerard" 2 => "C. Chazallon" 3 => "A.G. Marcelin" 4 => "F. Clavel" 5 => "A.M. Taburet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antivir Ther" "fecha" => "2006" "volumen" => "11" "paginaInicial" => "213" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16640102" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapy with atazanavir plus saquinavir in patients failing highly active antiretroviral therapy: a randomized comparative pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.W. Haas" 1 => "C. Zala" 2 => "S. Schrader" 3 => "P. Piliero" 4 => "H. Jaeger" 5 => "D. Nunes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000060389.18106.0a" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "1339" "paginaFinal" => "1349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12799555" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rescue therapy with once-daily atazanavir-based regimens for antiretroviral-experienced HIV-infected patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Dronda" 1 => "A. Antela" 2 => "M.J. Perez-Elias" 3 => "J.L. Casado" 4 => "A. Moreno" 5 => "S. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.qai.0000219780.50668.80" "Revista" => array:6 [ "tituloSerie" => "J Acquir Immune Defic Syndr" "fecha" => "2006" "volumen" => "42" "paginaInicial" => "258" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16645550" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance of six different ritonavir-boosted protease inhibitorbased regimens in heavily antiretroviral-experienced HIV-infected patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. De Mendoza" 1 => "L. Valer" 2 => "E. Ribera" 3 => "P. Barreiro" 4 => "L. Martín Carbonero" 5 => "C. Ramirez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "HIV Clin Trials" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "163" "paginaFinal" => "171" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Defining clinically relevant HIV drug resistance -from drug development to clinical reality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000218559.90026.d1" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "929" "paginaFinal" => "931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16549979" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of baseline protease genotype and phenotype on HIV response to atazanavir/ritonavir in treatment-experienced patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.K. Naeger" 1 => "K.A. Struble" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000218548.77457.76" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "847" "paginaFinal" => "853" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16549968" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical validation of atazanavirritonavir genotypic score in protease inhibitor- experienced patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Vora" 1 => "A.G. Marcelin" 2 => "H.F. Günthard" 3 => "P. Flandre" 4 => "H.H. Hirsch" 5 => "B. Masquelier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "35" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16327317" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update of the drug resistance mutations in HIV-1: 2007" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V.A. Johnson" 1 => "F. Brun Vézinet" 2 => "B. Clotet" 3 => "H.F. Günthard" 4 => "D.R. Kuritzkes" 5 => "D. Pillay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Top HIV Med" "fecha" => "2007" "volumen" => "15" "paginaInicial" => "119" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17720996" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Virological to atazanavir-ritonavir-based regimens: resistance-substitutions score and pharmacokinetic parameters (Reyaphar study)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Pellegrin" 1 => "D. Breilh" 2 => "J.M. Ragnaud" 3 => "S. Boucher" 4 => "D. Neau" 5 => "H. Fleury" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antiviral Therapy" "fecha" => "2006" "volumen" => "11" "paginaInicial" => "421" "paginaFinal" => "429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16856615" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Genotypic Inhibitory Quotient. A predictive factor of Atazanavir response HIV-1-Infected Treatment-Experienced Patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Solas" 1 => "P. Colson" 2 => "I. Ravaux" 3 => "I. Poizot-Martin" 4 => "J. Moreau" 5 => "B. Lacarelle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAI.0b013e318164226a" "Revista" => array:6 [ "tituloSerie" => "J Acquir Immune Defic Syndr" "fecha" => "2008" "volumen" => "48" "paginaInicial" => "177" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18197119" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Switching to atazanavir improves metabolic disorders in antirretroviral- experienced patients with severe hyperlipidemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "U. Möbius" 1 => "M. Lubach-Ruitman" 2 => "B. Castro-Frenzel" 3 => "M. Stoll" 4 => "S. Esser" 5 => "E. Voigt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Acquir Immune Defic Syndr" "fecha" => "2005" "volumen" => "39" "paginaInicial" => "174" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15905733" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overview of boosted protease inhibitors in treatment-experienced HIV-infectede patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Youle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2007" "volumen" => "60" "paginaInicial" => "1195" "paginaFinal" => "1205" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/0213005X/0000002600000S17/v1_201305090109/S0213005X08766163/v1_201305090109/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/0213005X/0000002600000S17/v1_201305090109/S0213005X08766163/v1_201305090109/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X08766163?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 1 | 0 | 1 |
| 2024 Octubre | 5 | 3 | 8 |
| 2024 Septiembre | 7 | 5 | 12 |
| 2024 Agosto | 10 | 2 | 12 |
| 2024 Julio | 8 | 1 | 9 |
| 2024 Junio | 5 | 2 | 7 |
| 2024 Mayo | 9 | 2 | 11 |
| 2024 Abril | 5 | 4 | 9 |
| 2024 Marzo | 6 | 3 | 9 |
| 2024 Febrero | 2 | 2 | 4 |
| 2024 Enero | 7 | 0 | 7 |
| 2023 Diciembre | 7 | 3 | 10 |
| 2023 Noviembre | 2 | 3 | 5 |
| 2023 Octubre | 4 | 3 | 7 |
| 2023 Septiembre | 6 | 1 | 7 |
| 2023 Agosto | 4 | 1 | 5 |
| 2023 Julio | 2 | 4 | 6 |
| 2023 Junio | 5 | 0 | 5 |
| 2023 Mayo | 3 | 3 | 6 |
| 2023 Abril | 1 | 0 | 1 |
| 2023 Marzo | 4 | 1 | 5 |
| 2023 Febrero | 2 | 1 | 3 |
| 2023 Enero | 3 | 2 | 5 |
| 2022 Diciembre | 5 | 3 | 8 |
| 2022 Noviembre | 7 | 5 | 12 |
| 2022 Octubre | 9 | 11 | 20 |
| 2022 Septiembre | 10 | 5 | 15 |
| 2022 Agosto | 12 | 6 | 18 |
| 2022 Julio | 8 | 6 | 14 |
| 2022 Junio | 4 | 6 | 10 |
| 2022 Mayo | 7 | 5 | 12 |
| 2022 Abril | 6 | 9 | 15 |
| 2022 Marzo | 7 | 7 | 14 |
| 2022 Febrero | 4 | 6 | 10 |
| 2022 Enero | 5 | 7 | 12 |
| 2021 Diciembre | 5 | 11 | 16 |
| 2021 Noviembre | 4 | 11 | 15 |
| 2021 Octubre | 4 | 6 | 10 |
| 2021 Septiembre | 4 | 6 | 10 |
| 2021 Agosto | 4 | 9 | 13 |
| 2021 Julio | 7 | 5 | 12 |
| 2021 Junio | 4 | 9 | 13 |
| 2021 Mayo | 3 | 4 | 7 |
| 2021 Abril | 6 | 8 | 14 |
| 2021 Marzo | 5 | 11 | 16 |
| 2021 Febrero | 9 | 6 | 15 |
| 2021 Enero | 3 | 8 | 11 |
| 2020 Diciembre | 5 | 5 | 10 |
| 2020 Noviembre | 4 | 11 | 15 |
| 2020 Octubre | 1 | 3 | 4 |
| 2020 Septiembre | 5 | 8 | 13 |
| 2020 Agosto | 5 | 7 | 12 |
| 2020 Julio | 6 | 10 | 16 |
| 2020 Junio | 3 | 3 | 6 |
| 2020 Mayo | 5 | 7 | 12 |
| 2020 Abril | 2 | 2 | 4 |
| 2020 Marzo | 6 | 4 | 10 |
| 2020 Febrero | 2 | 3 | 5 |
| 2020 Enero | 2 | 7 | 9 |
| 2019 Diciembre | 2 | 7 | 9 |
| 2019 Noviembre | 4 | 2 | 6 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 4 | 1 | 5 |
| 2019 Agosto | 0 | 2 | 2 |
| 2019 Julio | 8 | 23 | 31 |
| 2019 Junio | 16 | 16 | 32 |
| 2019 Mayo | 59 | 26 | 85 |
| 2019 Abril | 22 | 2 | 24 |
| 2019 Marzo | 6 | 4 | 10 |
| 2019 Febrero | 2 | 23 | 25 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Diciembre | 1 | 2 | 3 |
| 2018 Noviembre | 1 | 5 | 6 |
| 2018 Octubre | 3 | 1 | 4 |
| 2018 Septiembre | 5 | 2 | 7 |
| 2018 Agosto | 2 | 9 | 11 |
| 2018 Julio | 13 | 5 | 18 |
| 2018 Junio | 6 | 8 | 14 |
| 2018 Mayo | 7 | 8 | 15 |
| 2018 Abril | 5 | 4 | 9 |
| 2018 Marzo | 0 | 3 | 3 |
| 2018 Febrero | 0 | 2 | 2 |
| 2018 Enero | 0 | 3 | 3 |
| 2017 Diciembre | 2 | 2 | 4 |
| 2017 Noviembre | 1 | 1 | 2 |
| 2017 Octubre | 2 | 5 | 7 |
| 2017 Septiembre | 0 | 1 | 1 |
| 2017 Agosto | 3 | 4 | 7 |
| 2017 Julio | 0 | 6 | 6 |
| 2017 Junio | 2 | 20 | 22 |
| 2017 Mayo | 4 | 8 | 12 |
| 2017 Abril | 4 | 3 | 7 |
| 2017 Marzo | 10 | 12 | 22 |
| 2017 Febrero | 4 | 5 | 9 |
| 2017 Enero | 9 | 3 | 12 |
| 2016 Diciembre | 4 | 4 | 8 |
| 2016 Noviembre | 3 | 2 | 5 |
| 2016 Octubre | 9 | 1 | 10 |
| 2016 Septiembre | 7 | 2 | 9 |
| 2016 Agosto | 6 | 1 | 7 |
| 2016 Julio | 7 | 1 | 8 |
| 2016 Junio | 10 | 7 | 17 |
| 2016 Mayo | 11 | 14 | 25 |
| 2016 Abril | 10 | 14 | 24 |
| 2016 Marzo | 10 | 7 | 17 |
| 2016 Febrero | 4 | 5 | 9 |
| 2016 Enero | 7 | 7 | 14 |
| 2015 Diciembre | 7 | 13 | 20 |
| 2015 Noviembre | 9 | 4 | 13 |
| 2015 Octubre | 13 | 7 | 20 |
| 2015 Septiembre | 13 | 6 | 19 |
| 2015 Agosto | 10 | 6 | 16 |
| 2015 Julio | 6 | 6 | 12 |
| 2015 Junio | 2 | 0 | 2 |
| 2015 Mayo | 4 | 1 | 5 |
| 2015 Abril | 9 | 5 | 14 |
| 2015 Marzo | 9 | 5 | 14 |
| 2015 Febrero | 8 | 12 | 20 |
| 2015 Enero | 17 | 3 | 20 |
| 2014 Diciembre | 18 | 5 | 23 |
| 2014 Noviembre | 12 | 1 | 13 |
| 2014 Octubre | 27 | 2 | 29 |
| 2014 Septiembre | 20 | 1 | 21 |
| 2014 Agosto | 20 | 1 | 21 |
| 2014 Julio | 23 | 4 | 27 |
| 2014 Junio | 35 | 1 | 36 |
| 2014 Mayo | 21 | 1 | 22 |
| 2014 Abril | 20 | 3 | 23 |
| 2014 Marzo | 17 | 3 | 20 |
| 2014 Febrero | 13 | 2 | 15 |
| 2014 Enero | 18 | 1 | 19 |
| 2013 Diciembre | 19 | 7 | 26 |
| 2013 Noviembre | 17 | 5 | 22 |
| 2013 Octubre | 21 | 4 | 25 |
| 2013 Septiembre | 9 | 4 | 13 |
| 2013 Agosto | 20 | 1 | 21 |
| 2013 Julio | 15 | 1 | 16 |
| 2008 Diciembre | 330 | 0 | 330 |
Mostrar todo
