Efectos adversos de atazanavir
Adverse effects of atazanavir
R. Palaciosa, M. Gonzálezb, J. Ruizb, Jesús Santosb,
Autor para correspondencia
med000854@saludalia.com
Correspondencia: Dr. J. Santos. Sección de Enfermedades Infecciosas. Hospital Virgen de la Victoria. Campus Teatinus, s/n. 29010 Málaga. España.
Correspondencia: Dr. J. Santos. Sección de Enfermedades Infecciosas. Hospital Virgen de la Victoria. Campus Teatinus, s/n. 29010 Málaga. España.
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España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Adverse effects of atazanavir" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec137566" "palabras" => array:5 [ 0 => "Atazanavir" 1 => "Perfil metabólico" 2 => "Efectos adversos" 3 => "Hiperbilirrubinemia" 4 => "Ictericia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec137567" "palabras" => array:5 [ 0 => "Atazanavir" 1 => "Metabolic profile" 2 => "Adverse effects" 3 => "Hyperbilirubinaemia" 4 => "Jaundice" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Atazanavir es un fármaco que inhibe la proteasa del virus de la inmunodeficiencia humana (VIH) con muchas de las características de otros inhibidores de la proteasa y algunas ventajas sobre éstos, como la posología sólo una vez al día, la baja carga de comprimidos, la menor alteración gastrointestinal y un perfil metabólico más favorable, incluida la alteración del metabolismo de los hidratos de carbono. 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Squires" 1 => "A. Lazzarin" 2 => "J. Gatell" 3 => "W.G. Powderly" 4 => "V. Potrovskiy" 5 => "J.F. Delfraissy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Acquir Immune Defic Syndr" "fecha" => "2004" "volumen" => "36" "paginaInicial" => "1011" "paginaFinal" => "1019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15247553" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Once daily atazanavir/ritonavir versus twice-daily lopinavir/ ritonavir, each in combination with tenofovir and emtricitabine, for managment of antiretroviral-naïve HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Molina" 1 => "J. Andrade-Villanueva" 2 => "J. Echevarría" 3 => "P. Chetchotisakd" 4 => "J. Corral" 5 => "N. David" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(08)61081-8" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2008" "volumen" => "372" "paginaInicial" => "646" "paginaFinal" => "655" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18722869" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of atazanavir, with or without ritonavir, as part of once-daily highly active antiretroviral therapy regimens in antiretroviral-naive patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.r. Malan" 1 => "E. Krantz" 2 => "N. David" 3 => "V. Wirtz" 4 => "J. Hammond" 5 => "D. McGrath" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAI.0b013e31815ace6a" "Revista" => array:6 [ "tituloSerie" => "J Acquir Immune Defic Syndr" "fecha" => "2008" "volumen" => "47" "paginaInicial" => "161" "paginaFinal" => "167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17971713" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/ emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.y. Smith" 1 => "W.G. Weinberg" 2 => "E. DeJesus" 3 => "M.A. Fischl" 4 => "Q. Liao" 5 => "L.L. Ross" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "AIDS Res Ther" "fecha" => "2008" "volumen" => "28" "paginaInicial" => "5" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ ritonavir in patients with multiple virologic failures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Johnson" 1 => "B. Grinsztjn" 2 => "C. Rodriguez" 3 => "J. Coco" 4 => "E. DeJesus" 5 => "A. Lazzarin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000216371.76689.63" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "711" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16514301" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of atazanavir-based highly active antiretroviral therapy in patients with virologic suppression switched from a stable, boosted or unboosted protease inhibitor treatment regimen: the SWAN Study (AI424-097) 48-week results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Gatell" 1 => "D. Salmon-Ceron" 2 => "A. Lazzarin" 3 => "E. Van Wijnngaerden" 4 => "F. Antunes" 5 => "C. Leen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2007" "volumen" => "44" "paginaInicial" => "1484" "paginaFinal" => "1492" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of switching from boosted Lopinavir (LPV/r) to boosted Atazanavir (ATV/r) in patients with virologic suppression receiving a LPV/r containing HAART: The ATAZIP study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Mallolas" 1 => "D. Podzamczer" 2 => "P. Domingo" 3 => "B. Clotet" 4 => "E. Ribera" 5 => "F. Gutierrez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "4th Conference on HIV Pathogenesis, Treatment and Prevention" "conferencia" => "Sydney Australia, Julio" "serieFecha" => "2007" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of replacing lopinavir with atazanavir in HIV-infected patients with undetectable plasma viraemia: final results of the SLOAT trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Soriano" 1 => "P. Garcia-Gasco" 2 => "E. Vispo" 3 => "A. Ruiz-Sancho" 4 => "F. Blanco" 5 => "L. Martin-Carbonero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dkm413" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2008" "volumen" => "61" "paginaInicial" => "200" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17999977" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435 C->T polymorphism at the multidrug resistance gene 1" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Rodriguez-Novoa" 1 => "P. Barreiro" 2 => "A. Rendon" 3 => "A. Barrios" 4 => "A. Corral" 5 => "I. Jimenez-Nacher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/499056" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2006" "volumen" => "42" "paginaInicial" => "291" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16355344" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Specificity of human UDPglucuronosyltransferases and xenobiotic glucoronization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Burchell" 1 => "C. Brierley" 2 => "D. Rance" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Life Sci" "fecha" => "1995" "volumen" => "57" "paginaInicial" => "1819" "paginaFinal" => "1831" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7475929" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The genetic basis of the reduced expression of bilirubin UDP-glucuronosyl-transferase 1 in Gilbert's syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Bosma" 1 => "J. Chowdhury" 2 => "C. Bakker" 3 => "S. Gantla" 4 => "A. De Boer" 5 => "B. Oostra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199511023331802" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1995" "volumen" => "333" "paginaInicial" => "1171" "paginaFinal" => "1175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7565971" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic variation in bilirubin UPD-glucuronosyl-transferase gene promoter and Gilbert's syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Monaghan" 1 => "M. Ryan" 2 => "R. Seddon" 3 => "R. Hume" 4 => "B. Burchell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "347" "paginaInicial" => "578" "paginaFinal" => "581" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8596320" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Rodríguez-Novoa" 1 => "L. Martín-Carbonero" 2 => "P. Barreiro" 3 => "G. González-Pardo" 4 => "I. Jiménez-Nacher" 5 => "J. González-Lahoz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAD.0b013e328011d7c1" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "41" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17148966" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Sulkowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/380467" "Revista" => array:7 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2004" "volumen" => "38" "numero" => "Suppl 2" "paginaInicial" => "90" "paginaFinal" => "97" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14679453" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Noor" 1 => "R.A. Parker" 2 => "E. O’Mara" 3 => "D.M. Grasela" 4 => "A. Currie" 5 => "S.L. Hodder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2004" "volumen" => "18" "paginaInicial" => "2137" "paginaFinal" => "2144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15577646" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity: demonstrable differences in vitro and clinically" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Noor" 1 => "O.P. Flint" 2 => "J.F. Maa" 3 => "R.A. Parker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.aids.0000244200.11006.55" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "1813" "paginaFinal" => "1821" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16954722" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The mechanism of insulin resistance caused by HIV protease inhibitor therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Murata" 1 => "P.W. Hruz" 2 => "M. Mueckler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.C000228200" "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "2000" "volumen" => "275" "paginaInicial" => "20251" "paginaFinal" => "20254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10806189" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistencia insulínica en pacientes con infección por el VIH en tratamiento prolongado con efavirenz, lopinavir/ritonavir y atazanavir" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Bernal" 1 => "M. Masía" 2 => "S. Padilla" 3 => "M. Ramos" 4 => "A. Martín-Hidalgo" 5 => "F. Gutiérrez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2007" "volumen" => "129" "paginaInicial" => "252" "paginaFinal" => "254" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Switching to unboosted atazanavir improves glucose tolerance in highly pretreated HIV-1 infected subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Guffanti" 1 => "A. Caumo" 2 => "L. Galli" 3 => "A. Bigoloni" 4 => "A. Galli" 5 => "E. Dagba" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1530/EJE-06-0648" "Revista" => array:6 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "503" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17389467" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary stones in HIV- 1-positive patients treated with indinavir" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Daudon" 1 => "L. Estepa" 2 => "J.P. Viard" 3 => "D. Joly" 4 => "P. Jungers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1997" "volumen" => "349" "paginaInicial" => "1294" "paginaFinal" => "1295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9142068" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal calculi developing de novo in a patient taking saquinavir" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.T. Green" 1 => "M.W. McKendrick" 2 => "M.L. Schmid" 3 => "A.H. Mohsen" 4 => "S.F. Prakasam" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Std AIDS" "fecha" => "1998" "volumen" => "9" "paginaInicial" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9764944" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nelfinavir urinary stones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.S. Engeler" 1 => "H. John" 2 => "K.M. Rentsch" 3 => "C. Ruef" 4 => "D. Oertle" 5 => "S. Suter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "167" "paginaInicial" => "1384" "paginaFinal" => "1385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11832739" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lopinavir-ritonavir (Kaletra) and lithiasis: seven cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Doco-Lecompte" 1 => "A. Garrec" 2 => "L. Thomas" 3 => "P. Trechot" 4 => "T. May" 5 => "C. Rabaud" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2004" "volumen" => "18" "paginaInicial" => "705" "paginaFinal" => "706" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15090783" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atazanavir urinary stones in an HIV-infected patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Pacanowski" 1 => "J.M. Poirier" 2 => "I. Petit" 3 => "J.L. Meynard" 4 => "P.M. Girard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2006" "volumen" => "20" "paginaInicial" => "21" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16327315" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atazanavir urolithiasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.R. Chang" 1 => "P.M. Pella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMc061892" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "2158" "paginaFinal" => "2159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17108352" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atazanavir-associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.M. Chan-Tack" 1 => "M.M. Truffa" 2 => "K.A. Struble" 3 => "D.B. Birnkrant" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "AIDS" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "1215" "paginaFinal" => "1218" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urolithiasis in HIV-positive patients treated with atazanavir" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Couzigou" 1 => "M. Daudon" 2 => "J.C. Meynard" 3 => "F. Borsa-Lebas" 4 => "D. Higueret" 5 => "L. Escaut" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Infec Dis" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "105" "paginaFinal" => "108" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Bristol-Myers Squibb Company. Reyataz (atazanavir sulfate) package insert, revised February 2006. Princeton [accedido 13 Jun 2006]. Disponible en: <a class="elsevierStyleInterRef" href="http://www.bms.com/cgiin/anybin.pl?sql=elect+PPI+from+TB_PRODUCT_PPI+where+PPI_SEQ=103">http://www.bms.com/cgiin/anybin.pl?sql=elect+PPI+from+TB_PRODUCT_PPI+where+PPI_SEQ=103</a>." ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Bristol-Myers Squibb Company. BMS-232632: Atazanavir briefing document May 2003. Disponible en: <a class="elsevierStyleInterRef" href="http://www.fda.gov/ohrms/dockets/ac/03/briefing/3950B1_01_BristolMyersSquibbatazanavir.pdf">http://www.fda.gov/ohrms/dockets/ac/03/briefing/3950B1_01_BristolMyersSquibbatazanavir.pdf</a>." ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A common polymorphism associated with antibiotic-induced cardiac arrhythmia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F. Sesti" 1 => "G.W. Abbott" 2 => "J. Wei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.180223197" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "2000" "volumen" => "97" "paginaInicial" => "10613" "paginaFinal" => "10618" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10984545" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blockade of HERG channels by HIV protease inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.D. Anson" 1 => "J.G. Weaver" 2 => "M.J. Ackerman" 3 => "O. Akinsete" 4 => "K. Henry" 5 => "C.T. January" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)17950-1" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2005" "volumen" => "365" "paginaInicial" => "682" "paginaFinal" => "686" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15721475" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Gianottia" 1 => "M. Guffantia" 2 => "L. Gallia" 3 => "A. Margonato" 4 => "G. Chiaravallia" 5 => "A. Bigolonia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAD.0b013e32826fbc6a" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "1648" "paginaFinal" => "1651" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17630564" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolonged QT interval and torsades de pointes associated with atazanavir therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Ly" 1 => "M.E. Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/511875" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2007" "volumen" => "44" "paginaInicial" => "e67" "paginaFinal" => "e68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17304444" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Lundgren" 1 => "M. Battegay" 2 => "G. Behrens" 3 => "S. De Wit" 4 => "G. Guaraldi" 5 => "C. Katlama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1293.2007.00534.x" "Revista" => array:6 [ "tituloSerie" => "HIV Med" "fecha" => "2008" "volumen" => "9" "paginaInicial" => "72" "paginaFinal" => "81" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18257770" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/0213005X/0000002600000S17/v1_201305090109/S0213005X08766199/v1_201305090109/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/0213005X/0000002600000S17/v1_201305090109/S0213005X08766199/v1_201305090109/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X08766199?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 1 | 0 | 1 |
| 2024 Octubre | 53 | 6 | 59 |
| 2024 Septiembre | 97 | 9 | 106 |
| 2024 Agosto | 68 | 13 | 81 |
| 2024 Julio | 52 | 8 | 60 |
| 2024 Junio | 81 | 16 | 97 |
| 2024 Mayo | 70 | 3 | 73 |
| 2024 Abril | 83 | 5 | 88 |
| 2024 Marzo | 77 | 11 | 88 |
| 2024 Febrero | 93 | 14 | 107 |
| 2024 Enero | 86 | 6 | 92 |
| 2023 Diciembre | 65 | 8 | 73 |
| 2023 Noviembre | 80 | 20 | 100 |
| 2023 Octubre | 107 | 9 | 116 |
| 2023 Septiembre | 76 | 9 | 85 |
| 2023 Agosto | 71 | 1 | 72 |
| 2023 Julio | 110 | 7 | 117 |
| 2023 Junio | 62 | 4 | 66 |
| 2023 Mayo | 76 | 2 | 78 |
| 2023 Abril | 61 | 5 | 66 |
| 2023 Marzo | 88 | 26 | 114 |
| 2023 Febrero | 54 | 7 | 61 |
| 2023 Enero | 43 | 14 | 57 |
| 2022 Diciembre | 44 | 13 | 57 |
| 2022 Noviembre | 59 | 13 | 72 |
| 2022 Octubre | 37 | 8 | 45 |
| 2022 Septiembre | 67 | 15 | 82 |
| 2022 Agosto | 36 | 17 | 53 |
| 2022 Julio | 65 | 11 | 76 |
| 2022 Junio | 28 | 10 | 38 |
| 2022 Mayo | 49 | 15 | 64 |
| 2022 Abril | 32 | 17 | 49 |
| 2022 Marzo | 61 | 31 | 92 |
| 2022 Febrero | 50 | 20 | 70 |
| 2022 Enero | 93 | 26 | 119 |
| 2021 Diciembre | 70 | 21 | 91 |
| 2021 Noviembre | 66 | 24 | 90 |
| 2021 Octubre | 82 | 31 | 113 |
| 2021 Septiembre | 99 | 42 | 141 |
| 2021 Agosto | 74 | 40 | 114 |
| 2021 Julio | 44 | 25 | 69 |
| 2021 Junio | 50 | 13 | 63 |
| 2021 Mayo | 68 | 15 | 83 |
| 2021 Abril | 159 | 25 | 184 |
| 2021 Marzo | 99 | 45 | 144 |
| 2021 Febrero | 59 | 34 | 93 |
| 2021 Enero | 66 | 32 | 98 |
| 2020 Diciembre | 55 | 21 | 76 |
| 2020 Noviembre | 83 | 28 | 111 |
| 2020 Octubre | 60 | 19 | 79 |
| 2020 Septiembre | 34 | 15 | 49 |
| 2020 Agosto | 90 | 27 | 117 |
| 2020 Julio | 64 | 24 | 88 |
| 2020 Junio | 68 | 15 | 83 |
| 2020 Mayo | 67 | 19 | 86 |
| 2020 Abril | 138 | 26 | 164 |
| 2020 Marzo | 62 | 28 | 90 |
| 2020 Febrero | 38 | 21 | 59 |
| 2020 Enero | 36 | 20 | 56 |
| 2019 Diciembre | 34 | 32 | 66 |
| 2019 Noviembre | 26 | 14 | 40 |
| 2019 Octubre | 21 | 38 | 59 |
| 2019 Septiembre | 27 | 29 | 56 |
| 2019 Agosto | 12 | 24 | 36 |
| 2019 Julio | 14 | 24 | 38 |
| 2019 Junio | 40 | 64 | 104 |
| 2019 Mayo | 83 | 152 | 235 |
| 2019 Abril | 35 | 96 | 131 |
| 2019 Marzo | 5 | 108 | 113 |
| 2019 Febrero | 7 | 116 | 123 |
| 2019 Enero | 10 | 124 | 134 |
| 2018 Diciembre | 7 | 138 | 145 |
| 2018 Noviembre | 5 | 145 | 150 |
| 2018 Octubre | 11 | 35 | 46 |
| 2018 Septiembre | 17 | 22 | 39 |
| 2018 Agosto | 2 | 97 | 99 |
| 2018 Julio | 4 | 74 | 78 |
| 2018 Junio | 3 | 64 | 67 |
| 2018 Mayo | 5 | 106 | 111 |
| 2018 Abril | 6 | 64 | 70 |
| 2018 Marzo | 5 | 43 | 48 |
| 2018 Febrero | 3 | 32 | 35 |
| 2018 Enero | 7 | 23 | 30 |
| 2017 Diciembre | 5 | 28 | 33 |
| 2017 Noviembre | 10 | 19 | 29 |
| 2017 Octubre | 9 | 17 | 26 |
| 2017 Septiembre | 9 | 24 | 33 |
| 2017 Agosto | 7 | 33 | 40 |
| 2017 Julio | 11 | 16 | 27 |
| 2017 Junio | 27 | 18 | 45 |
| 2017 Mayo | 26 | 18 | 44 |
| 2017 Abril | 19 | 13 | 32 |
| 2017 Marzo | 23 | 5 | 28 |
| 2017 Febrero | 9 | 17 | 26 |
| 2017 Enero | 12 | 3 | 15 |
| 2016 Diciembre | 8 | 4 | 12 |
| 2016 Noviembre | 11 | 6 | 17 |
| 2016 Octubre | 14 | 3 | 17 |
| 2016 Septiembre | 9 | 9 | 18 |
| 2016 Agosto | 5 | 3 | 8 |
| 2016 Julio | 7 | 1 | 8 |
| 2016 Junio | 22 | 50 | 72 |
| 2016 Mayo | 13 | 57 | 70 |
| 2016 Abril | 19 | 53 | 72 |
| 2016 Marzo | 20 | 29 | 49 |
| 2016 Febrero | 13 | 35 | 48 |
| 2016 Enero | 17 | 29 | 46 |
| 2015 Diciembre | 4 | 32 | 36 |
| 2015 Noviembre | 12 | 31 | 43 |
| 2015 Octubre | 16 | 30 | 46 |
| 2015 Septiembre | 15 | 26 | 41 |
| 2015 Agosto | 11 | 15 | 26 |
| 2015 Julio | 12 | 14 | 26 |
| 2015 Junio | 5 | 6 | 11 |
| 2015 Mayo | 0 | 7 | 7 |
| 2015 Abril | 7 | 13 | 20 |
| 2015 Marzo | 4 | 14 | 18 |
| 2015 Febrero | 7 | 6 | 13 |
| 2015 Enero | 27 | 3 | 30 |
| 2014 Diciembre | 27 | 5 | 32 |
| 2014 Noviembre | 28 | 3 | 31 |
| 2014 Octubre | 26 | 6 | 32 |
| 2014 Septiembre | 21 | 2 | 23 |
| 2014 Agosto | 18 | 5 | 23 |
| 2014 Julio | 25 | 5 | 30 |
| 2014 Junio | 22 | 2 | 24 |
| 2014 Mayo | 22 | 1 | 23 |
| 2014 Abril | 15 | 1 | 16 |
| 2014 Marzo | 20 | 1 | 21 |
| 2014 Febrero | 23 | 2 | 25 |
| 2014 Enero | 21 | 4 | 25 |
| 2013 Diciembre | 34 | 2 | 36 |
| 2013 Noviembre | 28 | 5 | 33 |
| 2013 Octubre | 21 | 4 | 25 |
| 2013 Septiembre | 22 | 18 | 40 |
| 2013 Agosto | 28 | 9 | 37 |
| 2013 Julio | 16 | 1 | 17 |
| 2008 Diciembre | 532 | 0 | 532 |
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