Etravirina en primeras líneas de tratamiento
Etravirine in first-line therapy
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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2009;27 Supl 2:6-11" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1974 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 1463 "PDF" => 502 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Etravirina en pacientes ampliamente pretratados" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "11" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Etravirine in highly treatment-experienced patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Daniel Podzamczer Palter, Elena Ferrer Corbera, Juan Manuel Tiraboschi" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Daniel Podzamczer" "apellidos" => "Palter" ] 1 => array:2 [ "nombre" => "Elena Ferrer" "apellidos" => "Corbera" ] 2 => array:2 [ "nombre" => "Juan Manuel" "apellidos" => "Tiraboschi" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X09732136?idApp=UINPBA00004N" "url" => "/0213005X/00000027000000S2/v1_201305090145/S0213005X09732136/v1_201305090145/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Etravirina en primeras líneas de tratamiento" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "12" "paginaFinal" => "20" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Piedad Arazo Garcés, Esther Valero Tena" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Piedad Arazo" "apellidos" => "Garcés" "email" => array:1 [ 0 => "parazo@salud.aragon.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Esther Valero" "apellidos" => "Tena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Miguel Servet, Zaragoza, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario Miguel Servet, Zaragoza, España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Etravirine in first-line therapy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec137939" "palabras" => array:5 [ 0 => "VIH" 1 => "Etravirina" 2 => "Resistencias VIH" 3 => "Tolerabilidad" 4 => "Metadona" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec137940" "palabras" => array:5 [ 0 => "HIV" 1 => "Etravirine" 2 => "Resistances HIV" 3 => "Tolerability" 4 => "Methadone" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Etravirina (ETR) es un inhibidor de la transcriptasa inversa no análogo de nucleósidos (ITINAN), con potente y amplia actividad in vitro frente al virus de la inmunodeficiencia humana 1 y a virus con resistencias a ITINAN, lo que permite el uso secuencial de esta familia. La potencia, eficacia y seguridad están demostradas en pacientes multitratados, pero se dispone de pocos datos en primeras líneas de tratamiento antirretroviral (TAR), sin estar definido su papel en fases iniciales. La presencia de resistencias a ITINAN primarias y adquiridas durante la primera línea de tratamiento es cada vez más frecuente. Gracias a su barrera genética y eficacia, ETR puede formar parte de un segundo régimen de TAR en pacientes que han fallado en un primer régimen. En fases iniciales, los efectos adversos siguen siendo el motivo principal por el que se modifica el TAR. ETR se ha mostrado segura y con buena tolerabilidad. No presenta efectos adversos en el sistema nervioso central y tiene un buen perfil hepático, lipídico y gastrointestinal. El efecto adverso más frecuente es el exantema, efecto adverso común al resto de ITINAN. Su buen perfil de tolerabilidad lo convierte en un fármaco que se debe considerar en la configuración de un nuevo tratamiento en cambios por tolerabilidad. Las características de ETR, posibilidad de administración 1 vez al día, posibilidad de administrar disuelta en agua y no interacción con metadona, hacen que sea un fármaco especialmente atractivo en primeras líneas de tratamiento y en pacientes a los que se les ha atribuido mala adherencia, como son los usuarios de drogas por vía parenteral en tratamiento con metadona.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Etravirine (ETR) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with a potent and broad in vitro spectrum of activity against HIV-1 and viruses with NNRTI resistances, allowing sequential use of drugs of this family. The potency, efficacy and safety of etravirine have been demonstrated in multi-treated patients, but few data are available on first-line antiretroviral therapy (ART) and the role of this drug in initial treatment phases has not been defined. The presence of primary NNRTI resistances and those acquired during first-line therapy is increasingly frequent. Due to its genetic barrier and efficacy, ETR can form part of a second-line ART regimen in patients with failure to a first-line regimen. In the initial phases, adverse effects continue to be the main reason for modifying ART. ETR has demonstrated safety and tolerability, with no central nervous system adverse effects and a good liver, lipid and gastrointestinal safety profile. As with the other NNRTIs, the most common adverse effect is rash. Because of ETR good tolerability profile, this drug can be considered when a new treatment is required due to adverse effects. Because of the characteristics of ETR the possibility of once-daily administration and dissolution in water, as well as the absence of drug-drug interactions with methadone this drug is especially attractive as a firstline therapy and in patients with poor adherence, such as intravenous drug users receiving methadone treatment.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:59 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.J. Palella" 1 => "K.M. Delaney" 2 => "A.C. Moorman" 3 => "M.O. Loveless" 4 => "J. Fuhrer" 5 => "G.A. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 9 | 3 | 12 |
| 2024 Septiembre | 42 | 22 | 64 |
| 2024 Agosto | 21 | 11 | 32 |
| 2024 Julio | 13 | 6 | 19 |
| 2024 Junio | 14 | 5 | 19 |
| 2024 Mayo | 14 | 1 | 15 |
| 2024 Abril | 14 | 4 | 18 |
| 2024 Marzo | 10 | 8 | 18 |
| 2024 Febrero | 8 | 3 | 11 |
| 2024 Enero | 8 | 1 | 9 |
| 2023 Diciembre | 4 | 2 | 6 |
| 2023 Noviembre | 6 | 1 | 7 |
| 2023 Octubre | 7 | 2 | 9 |
| 2023 Septiembre | 7 | 1 | 8 |
| 2023 Agosto | 9 | 1 | 10 |
| 2023 Julio | 3 | 3 | 6 |
| 2023 Junio | 3 | 0 | 3 |
| 2023 Mayo | 5 | 0 | 5 |
| 2023 Abril | 2 | 5 | 7 |
| 2023 Marzo | 3 | 2 | 5 |
| 2023 Febrero | 2 | 1 | 3 |
| 2023 Enero | 9 | 2 | 11 |
| 2022 Diciembre | 3 | 4 | 7 |
| 2022 Noviembre | 4 | 10 | 14 |
| 2022 Octubre | 9 | 6 | 15 |
| 2022 Septiembre | 5 | 8 | 13 |
| 2022 Agosto | 7 | 9 | 16 |
| 2022 Julio | 12 | 6 | 18 |
| 2022 Junio | 8 | 8 | 16 |
| 2022 Mayo | 7 | 5 | 12 |
| 2022 Abril | 10 | 14 | 24 |
| 2022 Marzo | 10 | 7 | 17 |
| 2022 Febrero | 5 | 4 | 9 |
| 2022 Enero | 5 | 9 | 14 |
| 2021 Diciembre | 5 | 8 | 13 |
| 2021 Noviembre | 5 | 11 | 16 |
| 2021 Octubre | 4 | 14 | 18 |
| 2021 Septiembre | 6 | 8 | 14 |
| 2021 Agosto | 7 | 7 | 14 |
| 2021 Julio | 3 | 7 | 10 |
| 2021 Junio | 4 | 6 | 10 |
| 2021 Mayo | 6 | 7 | 13 |
| 2021 Abril | 5 | 19 | 24 |
| 2021 Marzo | 11 | 4 | 15 |
| 2021 Febrero | 5 | 10 | 15 |
| 2021 Enero | 3 | 8 | 11 |
| 2020 Diciembre | 2 | 3 | 5 |
| 2020 Noviembre | 6 | 5 | 11 |
| 2020 Octubre | 0 | 6 | 6 |
| 2020 Septiembre | 5 | 5 | 10 |
| 2020 Agosto | 1 | 1 | 2 |
| 2020 Julio | 4 | 5 | 9 |
| 2020 Junio | 6 | 3 | 9 |
| 2020 Mayo | 8 | 6 | 14 |
| 2020 Abril | 4 | 1 | 5 |
| 2020 Marzo | 9 | 9 | 18 |
| 2020 Febrero | 5 | 8 | 13 |
| 2020 Enero | 6 | 7 | 13 |
| 2019 Diciembre | 4 | 6 | 10 |
| 2019 Noviembre | 4 | 3 | 7 |
| 2019 Octubre | 1 | 0 | 1 |
| 2019 Septiembre | 6 | 6 | 12 |
| 2019 Agosto | 3 | 1 | 4 |
| 2019 Julio | 5 | 18 | 23 |
| 2019 Junio | 11 | 12 | 23 |
| 2019 Mayo | 53 | 8 | 61 |
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| 2019 Marzo | 5 | 7 | 12 |
| 2019 Febrero | 5 | 5 | 10 |
| 2019 Enero | 4 | 10 | 14 |
| 2018 Diciembre | 1 | 4 | 5 |
| 2018 Noviembre | 6 | 6 | 12 |
| 2018 Octubre | 6 | 6 | 12 |
| 2018 Septiembre | 4 | 3 | 7 |
| 2018 Agosto | 2 | 10 | 12 |
| 2018 Julio | 3 | 8 | 11 |
| 2018 Junio | 1 | 4 | 5 |
| 2018 Mayo | 1 | 14 | 15 |
| 2018 Abril | 9 | 3 | 12 |
| 2018 Marzo | 0 | 4 | 4 |
| 2018 Febrero | 4 | 1 | 5 |
| 2018 Enero | 1 | 0 | 1 |
| 2017 Diciembre | 5 | 1 | 6 |
| 2017 Noviembre | 4 | 4 | 8 |
| 2017 Octubre | 7 | 3 | 10 |
| 2017 Septiembre | 4 | 25 | 29 |
| 2017 Agosto | 7 | 2 | 9 |
| 2017 Julio | 6 | 3 | 9 |
| 2017 Junio | 4 | 20 | 24 |
| 2017 Mayo | 18 | 7 | 25 |
| 2017 Abril | 18 | 12 | 30 |
| 2017 Marzo | 10 | 57 | 67 |
| 2017 Febrero | 1 | 1 | 2 |
| 2016 Diciembre | 12 | 4 | 16 |
| 2016 Noviembre | 37 | 3 | 40 |
| 2016 Octubre | 35 | 11 | 46 |
| 2016 Septiembre | 24 | 3 | 27 |
| 2016 Agosto | 18 | 3 | 21 |
| 2016 Julio | 19 | 3 | 22 |
| 2016 Junio | 18 | 8 | 26 |
| 2016 Mayo | 23 | 16 | 39 |
| 2016 Abril | 3 | 5 | 8 |
| 2016 Marzo | 12 | 5 | 17 |
| 2016 Febrero | 8 | 7 | 15 |
| 2016 Enero | 11 | 8 | 19 |
| 2015 Diciembre | 18 | 10 | 28 |
| 2015 Noviembre | 16 | 6 | 22 |
| 2015 Octubre | 17 | 4 | 21 |
| 2015 Septiembre | 21 | 4 | 25 |
| 2015 Agosto | 14 | 6 | 20 |
| 2015 Julio | 14 | 3 | 17 |
| 2015 Junio | 16 | 6 | 22 |
| 2015 Mayo | 19 | 2 | 21 |
| 2015 Abril | 8 | 3 | 11 |
| 2015 Marzo | 18 | 4 | 22 |
| 2015 Febrero | 18 | 3 | 21 |
| 2015 Enero | 29 | 4 | 33 |
| 2014 Diciembre | 20 | 7 | 27 |
| 2014 Noviembre | 25 | 3 | 28 |
| 2014 Octubre | 39 | 4 | 43 |
| 2014 Septiembre | 27 | 2 | 29 |
| 2014 Agosto | 22 | 2 | 24 |
| 2014 Julio | 38 | 2 | 40 |
| 2014 Junio | 28 | 2 | 30 |
| 2014 Mayo | 16 | 4 | 20 |
| 2014 Abril | 14 | 3 | 17 |
| 2014 Marzo | 19 | 2 | 21 |
| 2014 Febrero | 12 | 0 | 12 |
| 2014 Enero | 11 | 1 | 12 |
| 2013 Diciembre | 21 | 5 | 26 |
| 2013 Noviembre | 25 | 5 | 30 |
| 2013 Octubre | 19 | 6 | 25 |
| 2013 Septiembre | 13 | 3 | 16 |
| 2013 Agosto | 34 | 5 | 39 |
| 2013 Julio | 19 | 1 | 20 |
| 2009 Diciembre | 412 | 0 | 412 |
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