Etravirina en poblaciones especiales
Etravirine in special populations
Ignacio De Los Santos Gil
Servicio de Medicina Interna-Infecciosas, Hospital Universitario de la Princesa, Madrid, España
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La mayoría de los fármacos presentan riesgo en algunos procesos asociados o no a la infección por virus de la inmunodeficiencia humana y es de gran interés disponer de otros que solucionen estos problemas. La aparición de etravirina, nuevo inhibidor de la transcriptasa inversa no análogo de nucleósido, va a permitir su uso en esos procesos con un menor riesgo de efectos secundarios y, por lo tanto, de empeorar la evolución y de posible abandono del tratamiento. Nos referimos a los pacientes coinfectados por los virus de las hepatitis B y/o C en situación activa, y a los pacientes con antecedentes de trastornos psiquiátricos o en tratamiento con fármacos psicotropos. También es importante el posible uso en mujeres en edad fértil, por el menor riesgo de teratogenicidad en caso de que se quedaran embarazadas durante el tratamiento. Y no podemos olvidar otros aspectos, como los pacientes con insuficiencia renal o la población de niños y adolescentes, que aunque menos estudiada ya se está comenzando a disponer de datos.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The choice of antiretroviral treatment in comorbidities requires thorough knowledge of the interactions, pharmacokinetics and adverse effects of the drug to be used. Most drugs carry some risk in certain processes associated or not with HIV infection and drugs that can be used in these situations are of great interest. The development of etravirine, a new non-nucleoside reverse transcriptase inhibitor, will allow its use in these processes, with a lower risk of secondary effects and therefore of worsening the course of the disease and of treatment withdrawal. This is the case of patients coinfected with active hepatitis B and/or C virus and patients with a history of psychiatric disorders or receiving psychotropic drugs. The possible use of etravirine in women of fertile age is also of interest, due to the lower risk of teratogenicity if pregnancy occurs during treatment. Other collectives, such as patients with renal insufficiency or children and adolescents should not be forgotten; although these populations are less well studied, data are beginning to become available.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manual sobre el SIDA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rivero Román" 1 => "J. Pachón Díaz" 2 => "E. 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| 2019 Octubre | 3 | 3 | 6 |
| 2019 Septiembre | 1 | 9 | 10 |
| 2019 Agosto | 5 | 1 | 6 |
| 2019 Julio | 10 | 10 | 20 |
| 2019 Junio | 27 | 21 | 48 |
| 2019 Mayo | 54 | 33 | 87 |
| 2019 Abril | 5 | 27 | 32 |
| 2019 Marzo | 3 | 4 | 7 |
| 2019 Febrero | 2 | 5 | 7 |
| 2019 Enero | 2 | 5 | 7 |
| 2018 Diciembre | 5 | 4 | 9 |
| 2018 Noviembre | 8 | 4 | 12 |
| 2018 Octubre | 2 | 4 | 6 |
| 2018 Septiembre | 1 | 4 | 5 |
| 2018 Agosto | 2 | 1 | 3 |
| 2018 Julio | 1 | 5 | 6 |
| 2018 Junio | 0 | 2 | 2 |
| 2018 Mayo | 1 | 2 | 3 |
| 2018 Abril | 2 | 5 | 7 |
| 2018 Marzo | 3 | 1 | 4 |
| 2018 Febrero | 2 | 1 | 3 |
| 2018 Enero | 2 | 2 | 4 |
| 2017 Diciembre | 3 | 1 | 4 |
| 2017 Noviembre | 2 | 4 | 6 |
| 2017 Octubre | 4 | 3 | 7 |
| 2017 Septiembre | 6 | 11 | 17 |
| 2017 Agosto | 1 | 4 | 5 |
| 2017 Julio | 5 | 3 | 8 |
| 2017 Junio | 5 | 12 | 17 |
| 2017 Mayo | 3 | 10 | 13 |
| 2017 Abril | 8 | 10 | 18 |
| 2017 Marzo | 14 | 38 | 52 |
| 2017 Febrero | 19 | 0 | 19 |
| 2017 Enero | 7 | 2 | 9 |
| 2016 Diciembre | 15 | 5 | 20 |
| 2016 Noviembre | 13 | 2 | 15 |
| 2016 Octubre | 27 | 7 | 34 |
| 2016 Septiembre | 38 | 5 | 43 |
| 2016 Agosto | 22 | 1 | 23 |
| 2016 Julio | 14 | 1 | 15 |
| 2016 Junio | 11 | 7 | 18 |
| 2016 Mayo | 19 | 11 | 30 |
| 2016 Abril | 23 | 4 | 27 |
| 2016 Marzo | 16 | 4 | 20 |
| 2016 Febrero | 5 | 4 | 9 |
| 2016 Enero | 6 | 10 | 16 |
| 2015 Diciembre | 12 | 6 | 18 |
| 2015 Noviembre | 9 | 4 | 13 |
| 2015 Octubre | 13 | 10 | 23 |
| 2015 Septiembre | 8 | 1 | 9 |
| 2015 Agosto | 8 | 5 | 13 |
| 2015 Julio | 7 | 5 | 12 |
| 2015 Junio | 9 | 2 | 11 |
| 2015 Mayo | 6 | 0 | 6 |
| 2015 Abril | 5 | 7 | 12 |
| 2015 Marzo | 9 | 7 | 16 |
| 2015 Febrero | 15 | 3 | 18 |
| 2015 Enero | 20 | 5 | 25 |
| 2014 Diciembre | 12 | 7 | 19 |
| 2014 Noviembre | 14 | 1 | 15 |
| 2014 Octubre | 23 | 2 | 25 |
| 2014 Septiembre | 17 | 0 | 17 |
| 2014 Agosto | 13 | 3 | 16 |
| 2014 Julio | 24 | 3 | 27 |
| 2014 Junio | 33 | 3 | 36 |
| 2014 Mayo | 14 | 3 | 17 |
| 2014 Abril | 16 | 2 | 18 |
| 2014 Marzo | 17 | 1 | 18 |
| 2014 Febrero | 11 | 0 | 11 |
| 2014 Enero | 10 | 1 | 11 |
| 2013 Diciembre | 27 | 3 | 30 |
| 2013 Noviembre | 16 | 2 | 18 |
| 2013 Octubre | 20 | 3 | 23 |
| 2013 Septiembre | 12 | 3 | 15 |
| 2013 Agosto | 19 | 3 | 22 |
| 2013 Julio | 14 | 1 | 15 |
| 2009 Diciembre | 320 | 0 | 320 |
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