Carbapenemasas en especies del género Pseudomonas | Enfermedades Infecciosas y Microbiología Clínica

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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2010;28 Supl 1:12-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6962 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 3688 "PDF" => 3263 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Betalactamasas de espectro extendido en enterobacterias distintas de Escherichia coli y Klebsiella" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "12" "paginaFinal" => "18" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Extended-spectrum beta-lactamases in enterobacteria other than Escherichia coli and Klebsiella" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cristina Seral García, María Pardos de la Gándara, Francisco Javier Castillo García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Cristina Seral" "apellidos" => "García" ] 1 => array:2 [ "nombre" => "María Pardos" "apellidos" => "de la Gándara" ] 2 => array:2 [ "nombre" => "Francisco Javier Castillo" "apellidos" => "García" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X10700033?idApp=UINPBA00004N" "url" => "/0213005X/00000028000000S1/v1_201305090227/S0213005X10700033/v1_201305090227/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Carbapenemasas en especies del género Pseudomonas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "19" "paginaFinal" => "28" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carlos Juan Nicolau, Antonio Oliver" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Carlos Juan" "apellidos" => "Nicolau" "email" => array:1 [ 0 => "carlos.juan@ssib.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Antonio" "apellidos" => "Oliver" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Microbiología, Hospital Son Dureta, Palma de Mallorca; Área de Microbiología, Universitat de les Illes Balears (UIB), Institut Universitari d’ Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Carbapenemases in Pseudomonas spp" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec138269" "palabras" => array:3 [ 0 => "Género Pseudomonas" 1 => "Carbapenemasas" 2 => "Metalo-β-lactamasas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec138268" "palabras" => array:3 [ 0 => "Pseudomonas spp" 1 => "Carbapenemases" 2 => "Metallo-β-lactamases" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Pseudomonas aeruginosa es uno de los patógenos nosocomiales más relevantes, así como una de las principales causas de infección respiratoria crónica en pacientes con enfermedades de base, como la fibrosis quística o la enfermedad pulmonar obstructiva crónica. Su elevado nivel de resistencia intrínseca a los antibióticos, unido a su extraordinaria capacidad para desarrollar resistencias adicionales por mutaciones cromosómicas, hacen de este patógeno uno de los más difíciles de tratar. Aún es más preocupante, si cabe, la creciente detección en este microorganismo de múltiples determinantes de resistencia, frecuentemente localizados en integrones, adquiridos por transferencia horizontal a través de plásmidos o transposones. Entre estos mecanismos destacan las carbapenemasas, por el abanico de antibióticos afectados (pues en conjunto hidrolizan a prácticamente todos los betalactámicos), variedad y capacidad de dispersión. En el presente trabajo se revisa la epidemiología, el impacto y la detección de las carbapenemasas descritas hasta la fecha en el género Pseudomonas, que pertenecen principalmente a la clase B (metalo-β-lactamasas [MBL]: IMP, VIM, SPM, GIM, AIM o DIM]), pero también, en menor medida, a las clases A (GES y KPC) y D (OXA). La presencia de estas carbapenemasas transferibles no sólo es importante en P. aeruginosa, sino también en otras especies clínicamente menos relevantes dentro del género, pero que pueden actuar como reservorio y vector de dispersión de estos determinantes de resistencia. La frecuencia creciente de cepas clínicas portadoras de carbapenemasas apremia a la puesta a punto de estrategias que faciliten su detección y reduzcan la expansión de estas cepas multirresistentes y de los mecanismos transferibles implicados." ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Pseudomonas aeruginosa is one of the most relevant nosocomial pathogens, as well as one of the main causes of chronic respiratory infections in patients with underlying diseases such as cystic fibrosis or chronic obstructive pulmonary disease. The high intrinsic antibiotic resistance of this pathogen, together with its extraordinary capacity for acquiring additional resistances through chromosomal mutations, determines a major threat for antimicrobial therapy in hospitals worldwide. Even more concerning is the increasing detection of multiple antimicrobial resistance determinants in this microorganism, frequently located on integrons, acquired by horizontal transfer through plasmids and/or transposons. Among these mechanisms, the carbapenemases are particularly relevant, due to the wide spectrum of antibiotics affected. This work reviews the epidemiology, impact, and detection of the carbapenemases described so far in the Pseudomonas spp., that mainly include class B enzymes (metallo-β-lactamases [MBL]: IMP, VIM, SPM, GIM, AIM, or DIM), but also, to a lower extent, class A (GES y KPC) and D (OXA) beta-lactamases. The presence of transferable carbapenemases is not only important in P. aeruginosa, but also in other less clinically-relevant species of the genus, since they can act as reservoires and dispersion vectors of these resistance determinants. The growing prevalence of carbapenemase-producing clinical isolates calls for the implementation of multidisciplinary strategies to optimize the detection and minimize the dissemination of these multidrug resistant strains and the involved transferable genetic elements." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:89 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudomonas aeruginosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. 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Carbapenemasas en especies del género Pseudomonas

Carbapenemases in Pseudomonas spp

Carlos Juan Nicolau

Autor para correspondencia

carlos.juan@ssib.es

Autor para correspondencia.

, Antonio Oliver

Servicio de Microbiología, Hospital Son Dureta, Palma de Mallorca; Área de Microbiología, Universitat de les Illes Balears (UIB), Institut Universitari d’ Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca, España

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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> es uno de los pat&#243;genos nosocomiales m&#225;s relevantes&#44; as&#237; como una de las principales causas de infecci&#243;n respiratoria cr&#243;nica en pacientes con enfermedades de base&#44; como la fibrosis qu&#237;stica o la enfermedad pulmonar obstructiva cr&#243;nica&#46; Su elevado nivel de resistencia intr&#237;nseca a los antibi&#243;ticos&#44; unido a su extraordinaria capacidad para desarrollar resistencias adicionales por mutaciones cromos&#243;micas&#44; hacen de este pat&#243;geno uno de los m&#225;s dif&#237;ciles de tratar&#46; A&#250;n es m&#225;s preocupante&#44; si cabe&#44; la creciente detecci&#243;n en este microorganismo de m&#250;ltiples determinantes de resistencia&#44; frecuentemente localizados en integrones&#44; adquiridos por transferencia horizontal a trav&#233;s de pl&#225;smidos o transposones&#46; Entre estos mecanismos destacan las carbapenemasas&#44; por el abanico de antibi&#243;ticos afectados &#40;pues en conjunto hidrolizan a pr&#225;cticamente todos los betalact&#225;micos&#41;&#44; variedad y capacidad de dispersi&#243;n&#46; En el presente trabajo se revisa la epidemiolog&#237;a&#44; el impacto y la detecci&#243;n de las carbapenemasas descritas hasta la fecha en el g&#233;nero <span class="elsevierStyleItalic">Pseudomonas</span>&#44; que pertenecen principalmente a la clase B &#40;metalo-&#946;-lactamasas &#91;MBL&#93;&#58; IMP&#44; VIM&#44; SPM&#44; GIM&#44; AIM o DIM&#93;&#41;&#44; pero tambi&#233;n&#44; en menor medida&#44; a las clases A &#40;GES y KPC&#41; y D &#40;OXA&#41;&#46; La presencia de estas carbapenemasas transferibles no s&#243;lo es importante en <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; sino tambi&#233;n en otras especies cl&#237;nicamente menos relevantes dentro del g&#233;nero&#44; pero que pueden actuar como reservorio y vector de dispersi&#243;n de estos determinantes de resistencia&#46; La frecuencia creciente de cepas cl&#237;nicas portadoras de carbapenemasas apremia a la puesta a punto de estrategias que faciliten su detecci&#243;n y reduzcan la expansi&#243;n de estas cepas multirresistentes y de los mecanismos transferibles implicados&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> is one of the most relevant nosocomial pathogens&#44; as well as one of the main causes of chronic respiratory infections in patients with underlying diseases such as cystic fibrosis or chronic obstructive pulmonary disease&#46; The high intrinsic antibiotic resistance of this pathogen&#44; together with its extraordinary capacity for acquiring additional resistances through chromosomal mutations&#44; determines a major threat for antimicrobial therapy in hospitals worldwide&#46; Even more concerning is the increasing detection of multiple antimicrobial resistance determinants in this microorganism&#44; frequently located on integrons&#44; acquired by horizontal transfer through plasmids and&#47;or transposons&#46; Among these mechanisms&#44; the carbapenemases are particularly relevant&#44; due to the wide spectrum of antibiotics affected&#46; This work reviews the epidemiology&#44; impact&#44; and detection of the carbapenemases described so far in the <span class="elsevierStyleItalic">Pseudomonas</span> spp&#46;<span class="elsevierStyleItalic">&#44;</span> that mainly include class B enzymes &#40;metallo-&#946;-lactamases &#91;MBL&#93;&#58; IMP&#44; VIM&#44; SPM&#44; GIM&#44; AIM&#44; or DIM&#41;&#44; but also&#44; to a lower extent&#44; class A &#40;GES y KPC&#41; and D &#40;OXA&#41; beta-lactamases&#46; The presence of transferable carbapenemases is not only important in <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; but also in other less clinically-relevant species of the genus&#44; since they can act as reservoires and dispersion vectors of these resistance determinants&#46; The growing prevalence of carbapenemase-producing clinical isolates calls for the implementation of multidisciplinary strategies to optimize the detection and minimize the dissemination of these multidrug resistant strains and the involved transferable genetic elements&#46;</p>"
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Información del artículo

ISSN: 0213005X
Idioma original: Español

DOI:10.1016/S0213-005X(10)70004-5

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2022 Enero	55	22	77
2021 Diciembre	40	17	57
2021 Noviembre	42	28	70
2021 Octubre	58	25	83
2021 Septiembre	58	27	85
2021 Agosto	56	26	82
2021 Julio	54	17	71
2021 Junio	48	22	70
2021 Mayo	59	19	78
2021 Abril	169	26	195
2021 Marzo	226	29	255
2021 Febrero	113	7	120
2021 Enero	78	24	102
2020 Diciembre	66	34	100
2020 Noviembre	57	30	87
2020 Octubre	55	14	69
2020 Septiembre	68	34	102
2020 Agosto	65	49	114
2020 Julio	73	41	114
2020 Junio	49	9	58
2020 Mayo	65	51	116
2020 Abril	67	9	76
2020 Marzo	89	18	107
2020 Febrero	92	13	105
2020 Enero	81	20	101
2019 Diciembre	64	15	79
2019 Noviembre	54	27	81
2019 Octubre	72	47	119
2019 Septiembre	50	35	85
2019 Agosto	30	21	51
2019 Julio	25	27	52
2019 Junio	75	48	123
2019 Mayo	119	61	180
2019 Abril	88	66	154
2019 Marzo	33	39	72
2019 Febrero	29	24	53
2019 Enero	28	27	55
2018 Diciembre	18	17	35
2018 Noviembre	22	28	50
2018 Octubre	54	13	67
2018 Septiembre	19	42	61
2018 Agosto	28	61	89
2018 Julio	85	66	151
2018 Junio	21	81	102
2018 Mayo	19	84	103
2018 Abril	19	56	75
2018 Marzo	5	32	37
2018 Febrero	6	11	17
2018 Enero	20	13	33
2017 Diciembre	7	14	21
2017 Noviembre	18	13	31
2017 Octubre	19	22	41
2017 Septiembre	17	12	29
2017 Agosto	15	13	28
2017 Julio	17	9	26
2017 Junio	29	21	50
2017 Mayo	24	11	35
2017 Abril	24	11	35
2017 Marzo	38	33	71
2017 Febrero	22	14	36
2017 Enero	23	14	37
2016 Diciembre	39	16	55
2016 Noviembre	43	17	60
2016 Octubre	58	17	75
2016 Septiembre	80	23	103
2016 Agosto	51	34	85
2016 Julio	22	14	36
2016 Junio	23	33	56
2016 Mayo	40	30	70
2016 Abril	23	30	53
2016 Marzo	20	25	45
2016 Febrero	16	24	40
2016 Enero	13	26	39
2015 Diciembre	22	27	49
2015 Noviembre	22	27	49
2015 Octubre	28	31	59
2015 Septiembre	16	24	40
2015 Agosto	13	14	27
2015 Julio	16	12	28
2015 Junio	12	17	29
2015 Mayo	23	13	36
2015 Abril	18	13	31
2015 Marzo	17	17	34
2015 Febrero	20	17	37
2015 Enero	30	5	35
2014 Diciembre	61	10	71
2014 Noviembre	45	10	55
2014 Octubre	46	8	54
2014 Septiembre	35	7	42
2014 Agosto	42	5	47
2014 Julio	36	7	43
2014 Junio	39	9	48
2014 Mayo	29	4	33
2014 Abril	29	8	37
2014 Marzo	35	4	39
2014 Febrero	30	1	31
2014 Enero	26	6	32
2013 Diciembre	37	1	38
2013 Noviembre	39	7	46
2013 Octubre	40	17	57
2013 Septiembre	31	22	53
2013 Agosto	47	15	62
2013 Julio	26	4	30
2010 Enero	809	0	809

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