Infecciones por norovirus
Norovirus infections
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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2010;28 Supl 1:46-50" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3140 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2296 "PDF" => 837 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Infecciones cutáneas y de partes blandas por micobacterias no tuberculosas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "50" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cutaneous and soft skin infections due to non-tuberculous mycobacteria" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando Alcaide, Jaime Esteban" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "Alcaide" ] 1 => array:2 [ "nombre" => "Jaime" "apellidos" => "Esteban" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X10700082?idApp=UINPBA00004N" "url" => "/0213005X/00000028000000S1/v1_201305090227/S0213005X10700082/v1_201305090227/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Infecciones por norovirus" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "51" "paginaFinal" => "55" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan Manuel Ribes Fernández, Javier Buesa Gómez" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Juan Manuel Ribes" "apellidos" => "Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "Javier Buesa" "apellidos" => "Gómez" "email" => array:1 [ 0 => "javier.buesa@uv.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Microbiología y Ecología, Facultad de Medicina y Odontología, Universidad de Valencia, Valencia, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital Clínico Universitario, Valencia, España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Norovirus infections" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec138279" "palabras" => array:5 [ 0 => "Norovirus" 1 => "Calicivirus humanos" 2 => "Gastroenteritis" 3 => "Diarrea" 4 => "Diagnóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec138278" "palabras" => array:5 [ 0 => "Norovirus" 1 => "Human calicivirus" 2 => "Gastroenteritis" 3 => "Diarrhea" 4 => "Diagnosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Los norovirus infectan a personas de todas las edades, causando con frecuencia brotes epidémicos de gastroenteritis aguda, además de casos esporádicos. La aplicación de métodos moleculares en el diagnóstico de estas infecciones está permitiendo conocer su impacto real. La epidemiología molecular ha facilitado, además, la identificación de los genotipos que más frecuentemente infectan a la población. A pesar de que la gastroenteritis causada por norovirus es generalmente leve y de corta duración, la enfermedad puede llegar a ser grave, especialmente en los ancianos, y puede cronificarse en los pacientes inmunodeprimidos. Se han identificado factores de susceptibilidad a la infección por norovirus constituidos por grupos de antígenos histosanguíneos (ABO, Lewis y secretor) que están implicados en la unión de dichos virus a los enterocitos. Existe un gran polimorfismo genético en la expresión de estos antígenos en los seres humanos, lo cual, junto a la diversidad genética de los norovirus, hace que la interrelación entre estos virus y sus hospedadores humanos sea compleja. El diagnóstico no se suele realizar todavía de forma habitual en muchos laboratorios, aunque aquellos que participan en estudios de vigilancia epidemiológica han detectado la circulación de cepas de norovirus que evolucionan de forma secuencial a lo largo del tiempo, de forma similar a lo que sucede con los virus gripales.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Noroviruses infect persons of all ages, often causing epidemic outbreaks of acute gastroenteritis as well as sporadic cases. The application of novel molecular methods to the diagnosis of norovirus infections is now revealing their real impact. Molecular epidemiology studies have identified the most common viral genotypes responsible for human infections. Norovirus gastroenteritis is usually mild and of short duration, although the disease can also be severe, especially in the elderly, or may become chronic, as occurred in the immunocompromised patients. Several factors have been identified regarding the differential susceptibility to norovirus infection among individuals, consisting of several histo-blood antigens (ABO, Lewis and secretor) that are involved in the binding process of noroviruses to the enterocytes. The expression of these antigens in humans is genetically encoded, and shows a high polymorphism, which combined with the genetic diversity of noroviruses, makes the virus-host relationship rather complex. The diagnosis of norovirus infections is not performed routinely in many laboratories, but those involved in epidemiological surveillance have identified norovirus strains that evolve sequentially over time, similarly to Influenza viruses.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:45 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 16 | 4 | 20 |
| 2024 Octubre | 113 | 31 | 144 |
| 2024 Septiembre | 98 | 49 | 147 |
| 2024 Agosto | 67 | 25 | 92 |
| 2024 Julio | 60 | 23 | 83 |
| 2024 Junio | 64 | 34 | 98 |
| 2024 Mayo | 132 | 44 | 176 |
| 2024 Abril | 76 | 65 | 141 |
| 2024 Marzo | 88 | 41 | 129 |
| 2024 Febrero | 56 | 20 | 76 |
| 2024 Enero | 52 | 21 | 73 |
| 2023 Diciembre | 73 | 26 | 99 |
| 2023 Noviembre | 95 | 22 | 117 |
| 2023 Octubre | 66 | 36 | 102 |
| 2023 Septiembre | 50 | 22 | 72 |
| 2023 Agosto | 41 | 31 | 72 |
| 2023 Julio | 68 | 26 | 94 |
| 2023 Junio | 56 | 61 | 117 |
| 2023 Mayo | 78 | 42 | 120 |
| 2023 Abril | 57 | 58 | 115 |
| 2023 Marzo | 62 | 75 | 137 |
| 2023 Febrero | 22 | 58 | 80 |
| 2023 Enero | 18 | 27 | 45 |
| 2022 Diciembre | 29 | 52 | 81 |
| 2022 Noviembre | 39 | 59 | 98 |
| 2022 Octubre | 42 | 32 | 74 |
| 2022 Septiembre | 34 | 53 | 87 |
| 2022 Agosto | 68 | 41 | 109 |
| 2022 Julio | 61 | 12 | 73 |
| 2022 Junio | 53 | 25 | 78 |
| 2022 Mayo | 37 | 25 | 62 |
| 2022 Abril | 40 | 28 | 68 |
| 2022 Marzo | 29 | 20 | 49 |
| 2022 Febrero | 32 | 19 | 51 |
| 2022 Enero | 59 | 40 | 99 |
| 2021 Diciembre | 39 | 37 | 76 |
| 2021 Noviembre | 40 | 50 | 90 |
| 2021 Octubre | 58 | 33 | 91 |
| 2021 Septiembre | 75 | 49 | 124 |
| 2021 Agosto | 89 | 49 | 138 |
| 2021 Julio | 44 | 30 | 74 |
| 2021 Junio | 183 | 71 | 254 |
| 2021 Mayo | 52 | 56 | 108 |
| 2021 Abril | 100 | 71 | 171 |
| 2021 Marzo | 64 | 49 | 113 |
| 2021 Febrero | 70 | 54 | 124 |
| 2021 Enero | 69 | 70 | 139 |
| 2020 Diciembre | 110 | 101 | 211 |
| 2020 Noviembre | 90 | 138 | 228 |
| 2020 Octubre | 33 | 69 | 102 |
| 2020 Septiembre | 52 | 75 | 127 |
| 2020 Agosto | 37 | 104 | 141 |
| 2020 Julio | 42 | 82 | 124 |
| 2020 Junio | 51 | 99 | 150 |
| 2020 Mayo | 85 | 98 | 183 |
| 2020 Abril | 65 | 156 | 221 |
| 2020 Marzo | 50 | 148 | 198 |
| 2020 Febrero | 55 | 157 | 212 |
| 2020 Enero | 46 | 101 | 147 |
| 2019 Diciembre | 44 | 83 | 127 |
| 2019 Noviembre | 69 | 189 | 258 |
| 2019 Octubre | 46 | 147 | 193 |
| 2019 Septiembre | 62 | 175 | 237 |
| 2019 Agosto | 46 | 102 | 148 |
| 2019 Julio | 69 | 134 | 203 |
| 2019 Junio | 128 | 176 | 304 |
| 2019 Mayo | 305 | 323 | 628 |
| 2019 Abril | 150 | 242 | 392 |
| 2019 Marzo | 46 | 289 | 335 |
| 2019 Febrero | 53 | 349 | 402 |
| 2019 Enero | 36 | 238 | 274 |
| 2018 Diciembre | 36 | 186 | 222 |
| 2018 Noviembre | 48 | 213 | 261 |
| 2018 Octubre | 46 | 13 | 59 |
| 2018 Septiembre | 21 | 93 | 114 |
| 2018 Agosto | 8 | 198 | 206 |
| 2018 Julio | 12 | 111 | 123 |
| 2018 Junio | 20 | 178 | 198 |
| 2018 Mayo | 21 | 188 | 209 |
| 2018 Abril | 12 | 236 | 248 |
| 2018 Marzo | 18 | 106 | 124 |
| 2018 Febrero | 8 | 92 | 100 |
| 2018 Enero | 14 | 46 | 60 |
| 2017 Diciembre | 11 | 49 | 60 |
| 2017 Noviembre | 18 | 63 | 81 |
| 2017 Octubre | 33 | 82 | 115 |
| 2017 Septiembre | 13 | 66 | 79 |
| 2017 Agosto | 17 | 58 | 75 |
| 2017 Julio | 15 | 26 | 41 |
| 2017 Junio | 24 | 67 | 91 |
| 2017 Mayo | 34 | 69 | 103 |
| 2017 Abril | 30 | 37 | 67 |
| 2017 Marzo | 36 | 51 | 87 |
| 2017 Febrero | 30 | 42 | 72 |
| 2017 Enero | 22 | 19 | 41 |
| 2016 Diciembre | 29 | 15 | 44 |
| 2016 Noviembre | 49 | 28 | 77 |
| 2016 Octubre | 63 | 25 | 88 |
| 2016 Septiembre | 50 | 22 | 72 |
| 2016 Agosto | 27 | 31 | 58 |
| 2016 Julio | 17 | 7 | 24 |
| 2016 Junio | 14 | 35 | 49 |
| 2016 Mayo | 11 | 24 | 35 |
| 2016 Abril | 17 | 36 | 53 |
| 2016 Marzo | 10 | 28 | 38 |
| 2016 Febrero | 9 | 17 | 26 |
| 2016 Enero | 18 | 12 | 30 |
| 2015 Diciembre | 10 | 12 | 22 |
| 2015 Noviembre | 4 | 24 | 28 |
| 2015 Octubre | 20 | 16 | 36 |
| 2015 Septiembre | 13 | 6 | 19 |
| 2015 Agosto | 4 | 10 | 14 |
| 2015 Julio | 10 | 1 | 11 |
| 2015 Junio | 20 | 2 | 22 |
| 2015 Mayo | 10 | 9 | 19 |
| 2015 Abril | 7 | 12 | 19 |
| 2015 Marzo | 19 | 3 | 22 |
| 2015 Febrero | 7 | 4 | 11 |
| 2015 Enero | 37 | 3 | 40 |
| 2014 Diciembre | 39 | 8 | 47 |
| 2014 Noviembre | 37 | 7 | 44 |
| 2014 Octubre | 59 | 5 | 64 |
| 2014 Septiembre | 46 | 3 | 49 |
| 2014 Agosto | 39 | 2 | 41 |
| 2014 Julio | 50 | 7 | 57 |
| 2014 Junio | 43 | 5 | 48 |
| 2014 Mayo | 37 | 4 | 41 |
| 2014 Abril | 37 | 1 | 38 |
| 2014 Marzo | 38 | 6 | 44 |
| 2014 Febrero | 22 | 1 | 23 |
| 2014 Enero | 33 | 2 | 35 |
| 2013 Diciembre | 35 | 4 | 39 |
| 2013 Noviembre | 24 | 7 | 31 |
| 2013 Octubre | 28 | 4 | 32 |
| 2013 Septiembre | 33 | 4 | 37 |
| 2013 Agosto | 20 | 3 | 23 |
| 2013 Julio | 22 | 3 | 25 |
| 2010 Enero | 802 | 0 | 802 |
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