Efectos indirectos de la infección por citomegalovirus
Indirect effects of cytomegalovirus infection
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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2011;29 Supl 6:4-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3469 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 2490 "PDF" => 969 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Definiciones y conceptos de interés en la infección por citomegalovirus: infección frente a enfermedad. Replicación, carga viral, profilaxis universal. Terapia anticipada" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "5" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Key definitions and concepts in cytomegalovirus: infection versus disease. Replication, viral load, universal prophylaxis. 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En estos pacientes, además de efectos directos, como el síndrome viral o la enfermedad invasiva de órgano, el CMV puede ocasionar efectos indirectos que resultan de la interacción del virus con el sistema inmune del huésped. Esta interacción puede desembocar en un mayor grado de inmunosupresión, con el consiguiente aumento de infecciones oportunistas, en un mayor riesgo de malignidad (enfermedad linfoproliferativa postrasplante asociada al virus de Epstein-Barr) y en un mayor riesgo de disfunción del injerto. Aunque en la actualidad no puede establecerse una relación directa de causalidad entre el CMV y la mayoría de los efectos indirectos descritos, numerosos estudios experimentales y clínicos han evidenciado una asociación entre la aparición de estos efectos y el CMV. Además, se ha evidenciado la disminución del riesgo de alguno de estos efectos, como la aparición de infecciones oportunistas, con la instauración de pautas de profilaxis frente al virus.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Despite improvements in prevention strategies, cytomegalovirus (CMV) continues to be the main cause of infection in solid organ transplant recipients. In these patients, in addition to direct effects, such as viral syndrome or invasive organ disease, CMV can cause indirect effects resulting from the interaction of the virus with the host's immune system. This interaction may increase immunosuppression, with a consequent rise in opportunistic infections and the risk of malignancies (Epstein<span class="elsevierStyleItalic">-</span>Barr virus-associated posttransplantation lymphoproliferative disease) and graft dysfunction. Currently, a direct causal relation between CMV and most of the indirect effects described cannot be established. However, numerous experimental and clinical studies have found an association between the development of these effects and CMV. Moreover, some of these effects, such as the development of opportunistic infections, have been reduced by CMV prophylaxis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:54 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.T. Reyburn" 1 => "O. Mandelboim" 2 => "M. Vales-Gómez" 3 => "D.M. Davis" 4 => "L. Pazmany" 5 => "J.L. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 3 | 1 | 4 |
| 2024 Octubre | 14 | 4 | 18 |
| 2024 Septiembre | 25 | 11 | 36 |
| 2024 Agosto | 15 | 4 | 19 |
| 2024 Julio | 15 | 6 | 21 |
| 2024 Junio | 13 | 5 | 18 |
| 2024 Mayo | 14 | 7 | 21 |
| 2024 Abril | 21 | 4 | 25 |
| 2024 Marzo | 23 | 4 | 27 |
| 2024 Febrero | 11 | 1 | 12 |
| 2024 Enero | 15 | 0 | 15 |
| 2023 Diciembre | 31 | 3 | 34 |
| 2023 Noviembre | 34 | 6 | 40 |
| 2023 Octubre | 31 | 1 | 32 |
| 2023 Septiembre | 16 | 1 | 17 |
| 2023 Agosto | 17 | 3 | 20 |
| 2023 Julio | 12 | 5 | 17 |
| 2023 Junio | 12 | 1 | 13 |
| 2023 Mayo | 18 | 16 | 34 |
| 2023 Abril | 16 | 4 | 20 |
| 2023 Marzo | 15 | 7 | 22 |
| 2023 Febrero | 9 | 0 | 9 |
| 2023 Enero | 17 | 6 | 23 |
| 2022 Diciembre | 19 | 7 | 26 |
| 2022 Noviembre | 28 | 9 | 37 |
| 2022 Octubre | 16 | 9 | 25 |
| 2022 Septiembre | 14 | 7 | 21 |
| 2022 Agosto | 10 | 10 | 20 |
| 2022 Julio | 18 | 7 | 25 |
| 2022 Junio | 16 | 9 | 25 |
| 2022 Mayo | 12 | 11 | 23 |
| 2022 Abril | 19 | 15 | 34 |
| 2022 Marzo | 34 | 10 | 44 |
| 2022 Febrero | 33 | 3 | 36 |
| 2022 Enero | 49 | 7 | 56 |
| 2021 Diciembre | 37 | 15 | 52 |
| 2021 Noviembre | 31 | 8 | 39 |
| 2021 Octubre | 39 | 15 | 54 |
| 2021 Septiembre | 37 | 19 | 56 |
| 2021 Agosto | 31 | 8 | 39 |
| 2021 Julio | 19 | 7 | 26 |
| 2021 Junio | 15 | 6 | 21 |
| 2021 Mayo | 26 | 12 | 38 |
| 2021 Abril | 61 | 8 | 69 |
| 2021 Marzo | 58 | 10 | 68 |
| 2021 Febrero | 36 | 10 | 46 |
| 2021 Enero | 41 | 13 | 54 |
| 2020 Diciembre | 38 | 10 | 48 |
| 2020 Noviembre | 41 | 6 | 47 |
| 2020 Octubre | 34 | 13 | 47 |
| 2020 Septiembre | 38 | 8 | 46 |
| 2020 Agosto | 71 | 14 | 85 |
| 2020 Julio | 30 | 15 | 45 |
| 2020 Junio | 34 | 7 | 41 |
| 2020 Mayo | 59 | 12 | 71 |
| 2020 Abril | 46 | 8 | 54 |
| 2020 Marzo | 67 | 22 | 89 |
| 2020 Febrero | 48 | 14 | 62 |
| 2020 Enero | 49 | 13 | 62 |
| 2019 Diciembre | 32 | 11 | 43 |
| 2019 Noviembre | 21 | 17 | 38 |
| 2019 Octubre | 22 | 11 | 33 |
| 2019 Septiembre | 43 | 12 | 55 |
| 2019 Agosto | 17 | 17 | 34 |
| 2019 Julio | 17 | 31 | 48 |
| 2019 Junio | 40 | 57 | 97 |
| 2019 Mayo | 90 | 118 | 208 |
| 2019 Abril | 43 | 61 | 104 |
| 2019 Marzo | 12 | 16 | 28 |
| 2019 Febrero | 9 | 24 | 33 |
| 2019 Enero | 8 | 20 | 28 |
| 2018 Diciembre | 10 | 17 | 27 |
| 2018 Noviembre | 16 | 19 | 35 |
| 2018 Octubre | 15 | 18 | 33 |
| 2018 Septiembre | 24 | 14 | 38 |
| 2018 Agosto | 6 | 34 | 40 |
| 2018 Julio | 5 | 16 | 21 |
| 2018 Junio | 5 | 12 | 17 |
| 2018 Mayo | 4 | 38 | 42 |
| 2018 Abril | 8 | 12 | 20 |
| 2018 Marzo | 3 | 7 | 10 |
| 2018 Febrero | 4 | 6 | 10 |
| 2018 Enero | 4 | 2 | 6 |
| 2017 Diciembre | 6 | 3 | 9 |
| 2017 Noviembre | 4 | 9 | 13 |
| 2017 Octubre | 8 | 7 | 15 |
| 2017 Septiembre | 7 | 10 | 17 |
| 2017 Agosto | 9 | 7 | 16 |
| 2017 Julio | 5 | 6 | 11 |
| 2017 Junio | 15 | 6 | 21 |
| 2017 Mayo | 13 | 6 | 19 |
| 2017 Abril | 4 | 10 | 14 |
| 2017 Marzo | 18 | 45 | 63 |
| 2017 Febrero | 15 | 19 | 34 |
| 2017 Enero | 10 | 3 | 13 |
| 2016 Diciembre | 23 | 9 | 32 |
| 2016 Noviembre | 26 | 11 | 37 |
| 2016 Octubre | 42 | 14 | 56 |
| 2016 Septiembre | 35 | 13 | 48 |
| 2016 Agosto | 30 | 24 | 54 |
| 2016 Julio | 22 | 3 | 25 |
| 2016 Junio | 17 | 13 | 30 |
| 2016 Mayo | 20 | 16 | 36 |
| 2016 Abril | 14 | 16 | 30 |
| 2016 Marzo | 22 | 22 | 44 |
| 2016 Febrero | 11 | 12 | 23 |
| 2016 Enero | 15 | 10 | 25 |
| 2015 Diciembre | 15 | 9 | 24 |
| 2015 Noviembre | 28 | 10 | 38 |
| 2015 Octubre | 35 | 12 | 47 |
| 2015 Septiembre | 27 | 8 | 35 |
| 2015 Agosto | 22 | 4 | 26 |
| 2015 Julio | 31 | 4 | 35 |
| 2015 Junio | 18 | 4 | 22 |
| 2015 Mayo | 32 | 9 | 41 |
| 2015 Abril | 19 | 13 | 32 |
| 2015 Marzo | 32 | 6 | 38 |
| 2015 Febrero | 23 | 3 | 26 |
| 2015 Enero | 24 | 3 | 27 |
| 2014 Diciembre | 28 | 10 | 38 |
| 2014 Noviembre | 20 | 6 | 26 |
| 2014 Octubre | 29 | 4 | 33 |
| 2014 Septiembre | 25 | 2 | 27 |
| 2014 Agosto | 26 | 3 | 29 |
| 2014 Julio | 26 | 3 | 29 |
| 2014 Junio | 23 | 3 | 26 |
| 2014 Mayo | 28 | 7 | 35 |
| 2014 Abril | 13 | 4 | 17 |
| 2014 Marzo | 16 | 3 | 19 |
| 2014 Febrero | 26 | 1 | 27 |
| 2014 Enero | 26 | 0 | 26 |
| 2013 Diciembre | 20 | 2 | 22 |
| 2013 Noviembre | 37 | 3 | 40 |
| 2013 Octubre | 29 | 7 | 36 |
| 2013 Septiembre | 17 | 2 | 19 |
| 2013 Agosto | 28 | 5 | 33 |
| 2013 Julio | 14 | 6 | 20 |
| 2011 Diciembre | 136 | 0 | 136 |
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