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Inicio Enfermedades Infecciosas y Microbiología Clínica Circulation of other respiratory viruses and viral co-infection during the 2009 ...
Información de la revista
Vol. 30. Núm. S4.
The first influenza pandemic of the 21st century. The REIPI/SEIMC experience
Páginas 25-31 (octubre 2012)
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Vol. 30. Núm. S4.
The first influenza pandemic of the 21st century. The REIPI/SEIMC experience
Páginas 25-31 (octubre 2012)
Acceso a texto completo
Circulation of other respiratory viruses and viral co-infection during the 2009 pandemic influenza
Circulación de otros virus respiratorios y coinfección viral durante la pandemia de gripe en 2009
Visitas
2887
José María Navarro-María, Mercedes Pérez-Ruiza,
Autor para correspondencia
, Juan Carlos Galán Montemayorb, María Ángeles Marcos Maesoc, Jordi Reinad, María de Oña Navarroe, Carlos Gustavo Cilla Eguiluzf
a Microbiology Service, Hospital Universitario Virgen de las Nieves, Granada, Spain
b Microbiology Service, Hospital Ramón y Cajal, Madrid, Spain
c Centro de Diagnóstico Biomédico-Microbiología, Hospital Clínic, Barcelona, Spain
d Virology Unit, Clinical Microbiology Service, Hospital Universitario Son Espases, Palma de Mallorca, Spain
e Microbiology Service, Hospital Universitario Central de Asturias, Oviedo, Spain
f Microbiology Service, Hospital Donostia, Biomedical Research Center Network for Respiratory Diseases (CIBERES), San Sebastián, Spain
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Abstract

Coinciding with the pandemic wave of the influenza A(H1N1)pdm09 virus, other respiratory viruses have co-circulated in our area and were responsible for many acute respiratory infections and influenza-like illness (ILI). Apart from the pandemic virus that was responsible for most ILI cases, incidence rates of other viruses have varied among geographical areas. In general, human rhinovirus was the most frequent among individuals from the community, and respiratory syncytial virus among hospitalized patients. Detection rates of other respiratory viruses such as human metapneumovirus, adenovirus or parainfluenza viruses have been much lower. On the basis of an interference mechanism, human rhinovirus may contribute to modulate the pandemic wave, although available data are not conclusive to support this hypothesis. In contrast, the epidemic wave of respiratory syncytial virus during 2009–2010 was similar to previous seasons. Overall, incidence rates of respiratory viruses other than influenza did not change significantly during the pandemic season compared to other seasons. No association has been found between coinfection of pandemic influenza and other respiratory viruses with the prognosis of patients with influenza. The involvement of clinical virology laboratories in the etiological diagnosis of ILI cases has improved and has optimized diagnostic procedures.

Keywords:
Co-infection
Influenza-like illness
Pandemic influenza
Resumen

Coincidiendo con la onda pandémica 2009 por el virus de la gripe A(H1N1)pdm09, otros virus respiratorios han circulado en nuestro medio, provocando numerosos casos de infección respiratoria aguda y de síndrome gripal (ILI, influenza-like illness). Aparte del virus pandémico, que fue responsable de la mayoría de los casos de ILI, la incidencia de otros virus ha sido diferente según la zona. En general, rinovirus fue el virus más frecuente en la comunidad y virus respiratorio sincitial en pacientes hospitalizados. Las tasas de detección de otros virus como metaneumovirus humano, adenovirus o virus parainfluenza han sido mucho menores. Sobre la base de un mecanismo de interferencia, la presencia de rinovirus pudo contribuir a modular la onda pandémica de gripe, aunque los datos existentes no apoyan esta hipótesis de modo concluyente, mientras que la onda de virus respiratorio sincitial en 2009–2010 se ha presentado de forma similar a otros años. En conjunto, la incidencia de los distintos virus respiratorios de gripe no varió significativamente durante la temporada de la pandemia con respecto a otros años. Por otro lado, no se ha asociado la coinfección por virus de la gripe con otros virus respiratorios con el pronóstico de los pacientes con gripe. La implicación de los laboratorios de virología clínica en el diagnóstico de ILI ha supuesto una mejora y una mayor optimización en los procedimientos diagnósticos.

Palabras clave:
Coinfección
Síndrome gripal
Gripe pandémica
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References
[1.]
G. Zuccotti, D. Dilillo, A. Zappa, E. Galli, A. Amendola, M. Martinelli, et al.
Epidemiological and clinical features of respiratory viral infections in hospitalized children during the circulation of influenza virus A(H1N1) 2009.
Influenza Other Respi Viruses, 5 (2011), pp. e528-e534
[2.]
J. Reina, E. Riera, C. Déniz.
Análisis de la etiología de las infecciones respiratorias víricas en el año de la pandemia de gripe A(H1N1) 2009.
Rev Esp Pediatr, 68 (2012), pp. 183-185
[3.]
P.A. Chan.
Distinguishing characteristics between pandemic 2009–2010 influenza A (H1N1) and other viruses in patients hospitalized with respiratory illness.
PloS One, 6 (2011), pp. e24734
[4.]
S.M. Raboni, V. Stella, C.R. Cruz, J.B. França, S. Moreira, L. Gonçalves, et al.
Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in Southern Brazil.
J Clin Microbiol, 49 (2011), pp. 1287-1293
[5.]
F. Lovato-Salas, L. Matienzo-Serment, C. Monjarás-Avila, E.E. Godoy-Lozano, A. Comas-Garcia, M. Aguilera-Barragán, et al.
Pandemic influenza A (H1N1) 2009 and respiratory syncytial virus associated hospitalizations.
J Infect, 61 (2010), pp. 382-390
[6.]
F. Renois, D. Talmud, A. Huguenin, L. Moutte, C. Strady, J. Cousson, et al.
Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcription-PCR DNA microarray system.
J Clin Microbiol, 48 (2010), pp. 3836-3842
[7.]
S.D. Thiberville, L. Ninove, V.V. Hai, E. Botelho-Nevers, C. Gazin, L. Thirion, et al.
The viral etiology of an influenza-like illness during the 2009 pandemic.
J Med Virol, 84 (2012), pp. 1071-1079
[8.]
V.J. Lee, J. Yap, A.R. Cook, C.H. Tan, J.P. Loh, W.H. Koh, et al.
A clinical diagnostic model for predicting influenza among young adult military personnel with febrile respiratory illness in Singapore.
[9.]
M.A. Marcos, S. Ramón, A. Antón, E. Martinez, A. Vilella, V. Olivé, et al.
Clinical relevance of mixed respiratory viral infections in adult with influenza A H1N1.
Eur Respir J, 38 (2011), pp. 739-742
[10.]
J.M. Mansbach, P.A. Piedra, S.J. Teach, A.F. Sullivan, T. Forgey, S. Clark, et al.
Prospective Multicenter Study of Viral Etiology and Hospital Length of Stay in Children With Severe Bronchiolitis.
Arch Pediatr Adolesc Med, (2012),
[11.]
W.J. Shieh, D.M. Blau, A.M. Denison, M. Deleon-Carnes, P. Adem, J. Bhatnagar, et al.
2009 pandemic influenza A(H1N1): pathology and pathogenesis of 100 fatal cases in the United States.
Am J Pathol, 177 (2010), pp. 166-175
[12.]
M.P. Romero-Gómez, L. Guereta, J. Pareja-Grande, J. Martínez-Alarcón, I. Casas, G. Ruiz- Carrascoso, et al.
Myocarditis caused by human parainfluenza virus in an immunocompetent child initially associated with 2009 influenza A (H1N1) virus.
J Clin Microbiol, 49 (2011), pp. 2072-2073
[13.]
Centers for Disease Control and Prevention. Overview of Influenza Surveillance in the United States. 2010. Available at: http://www.cdc.gov/flu/weekly/overview.htm.
[14.]
A. Hombrouck, M. Sabbe, V. Van Casteren, F. Wuillaume, D. Hue, M. Reynders, et al.
Viral aetiology of influenza-like illness in Belgium during the influenza A(H1N1)2009 pandemic.
Eur J Clin Microbiol Infect Dis, 31 (2012), pp. 999-1007
[15.]
C.S. Kraft, J.T. Jacob, M.H. Sears, E.M. Burd, A.M. Caliendo, G.M. Lyon.
Severity of human rhinovirus infection in immunocompromised adults is similar to that of 2009 H1N1 influenza.
J Clin Microbiol, 50 (2012), pp. 1061-1063
[16.]
A. Isaacs, J. Lindenmann.
Virus interference. I. The interferon.
J Interferon Res, 7 (1987), pp. 429-438
[17.]
J.S. Casalegno, M. Ottmann, M. Bouscambert-Duchamp, M. Valette, F. Morfin, B. Lina.
Impact of the 2009 influenza A(H1N1) pandemic wave on the pattern of hibernal respiratory virus epidemics. France, 2009.
Euro Surveill, 15 (2010), pp. 19485
[18.]
J.S. Casalegno, M. Ottmann, M.B. Duchamp, V. Escuret, G. Billaud, E. Frobert, et al.
Rhinoviruses delayed the circulation of the pandemic influenza A (H1N1) 2009 virus in France.
Clin Microbiol Infect, 16 (2010), pp. 326-329
[19.]
A. Linde, M. Rotzén-Östlund, B. Zweygberg-Wirgart, S. Rubinova, M. Brytting.
Does viral interference affect spread of influenza?.
Euro Surveill, 14 (2009), pp. 19354
[20.]
G. Ånestad, S.A. Nordbø.
Virus interference. Did rhinoviruses activity hamper the progress of the 2009 influenza A (H1N1) pandemic in Norway?.
Med Hypotheses, 77 (2011), pp. 1132-1134
[21.]
N. Schnepf, M. Resche-Rigon, A. Chaillon, A. Scemla, G. Gras, O. Semoun, et al.
High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France.
[22.]
G.C. Mak, A.H. Wong, W.Y. Ho, W. Lim.
The impact of pandemic influenza A (H1N1) 2009 on the circulation of respiratory viruses. 2009–2011.
Influenza Other Respi Viruses, 6 (2012), pp. e6-e10
[23.]
R.M. Greer, P. McErlean, K.E. Arden, C.E. Faux, A. Nitsche, S.B. Lambert, et al.
Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?..
J Clin Virol, 45 (2009), pp. 10-15
[24.]
European Centre for Disease Prevention and Control. Surveillance report. Weekly influenza surveillance overview. 28 May 2010. Available at: http://ecdc.europa.eu/en/publications/Publications/100528_SUR_Weekly_Influenza_Surveillance_Overview.pdf.
[25.]
European Centre for Disease Prevention and Control. Scientific advice. Hypothesis: Possible epidemiological interactions between pandemic viruses and rhinoviruses in France during the 2009 pandemic. 16 April 2010. Available at: http://www.ecdc.europa.eu/en/activities/sciadvice/Lists/ECDC%20Reviews/ECDC_DispForm.aspx?List=512ff74f%2D77d4%2D4ad8%2Db6d6%2Dbf0f23083f30&ID=783.
[26.]
M. Bergmann, A. Garcia-Sastre, E. Carnero, H. Pehamberger, K. Wolff, P. Palese, et al.
Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.
J Virol, 74 (2000), pp. 6203-6206
[27.]
E.C. Smith, A. Popa, A. Chang, C. Masante, R.E. Dutch.
Viral entry mechanisms: the increasing diversity of paramyxovirus entry.
[28.]
J.M. Nicholls, R.W. Chan, R.J. Russell, G.M. Air, J.S. Peiris.
Evolving complexities of influenza virus and its receptors.
Trends Microbiol, 16 (2008), pp. 149-157
[29.]
Red Nacional de Vigilancia Epidemiológica. Instituto de Salud Carlos III. Vigilancia de la gripe en España. Resumen de la temporada 2008–2009. (Desde la semana 20/2008 hasta la 19/2009). Available at: http://www.isciii.es/ISCIII/es/contenidos/fd-servicios-cientifico-tecnicos/fd-vigilancias-alertas/fd-enfermedades/Vigilancia_de_la_Gripe_en_Espana_Informe_Temporada_2008-2009.pdf.
[30.]
Sistema de Vigilancia de la Gripe en España. Red Nacional de Vigilancia Epidemiológica. Instituto de Salud Carlos III. Vigilancia de la gripe en España. Evolución de la gripe pandémica por AnH1N1. (Desde la semana 20/2009 hasta la semana 20/2010). Available at: http://vgripe.isciii.es/gripe/documentos/20092010/InformesAnuales/Informe_anual_temporada_2009-2010.pdf.
[32.]
M.A. Miller, C. Viboud, M. Balinska, L. Simonsen.
The signature features of influenza pandemics—implications for policy.
N Engl J Med, 360 (2009), pp. 2595-2598
[33.]
V. Shinde, C.B. Bridges, T.M. Uyeki, B. Shu, A. Balish, X. Xu, et al.
Triple-reassortant swine influenza A (H1) in humans in the United States, 2005–2009.
N Engl J Med, 360 (2009), pp. 2616-2625
[34.]
A.M. Siston, S.A. Rasmussen, M.A. Honein, A.M. Fry, K. Seib, W.M. Callaghan, Pandemic H1N1 Influenza in Pregnancy Working Group, et al.
Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States.
JAMA, 303 (2010), pp. 1517-1525
[35.]
García-Suárez J, Martín Y, Callejas M, Rodriguez-Dominguez M, Galán JC, Burgaleta C. Favourable outcome of pneumonia due to novel influenza A/H1N1 2009 virus in a splenectomised adult patient undergoing therapy for non-Hodgkin lymphoma. Br J Haematol. 2010148:808–10.
[36.]
G. Vernet.
Use of molecular assays for the diagnosis of influenza.
Expert Rev Anti Infect Ther, 1 (2007), pp. 89-104
[37.]
C.B. Hall, G.A. Weinberg, M.K. Iwane, A.K. Blumkin, K.M. Edwards, M.A. Staat, et al.
The burden of respiratory syncytial virus infection in young children.
N Engl J Med, 360 (2009), pp. 588-598
[38.]
P.C. Woo, S.S. Chiu, W.H. Seto, M. Peiris.
Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients.
J Clin Microbiol, 35 (1997), pp. 1579-1581
[39.]
J. Barenfanger, C. Drake, N. Leon, T. Mueller, T. Troutt.
Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study.
J Clin Microbiol, 38 (2000), pp. 2824-2828
[40.]
B.A. Cunha, U. Syed, N. Mickail, S. Strollo.
Rapid clinical diagnosis in fatal swine influenza (H1N1) pneumonia in an adult with negative rapid influenza diagnostic tests (RIDTs): diagnostic swine influenza triad.
Heart Lung, 39 (2010), pp. 78-86
[41.]
J.M. Navarro-Marí, M. Pérez-Ruiz.
Virus respiratorios: viejos y nuevos virus. Revisión de métodos diagnósticos.
Enferm Infecc Microbiol Clin, 25 (2007), pp. 60-65
[42.]
K.J. Henrickson.
Cost-effective use of rapid diagnostic techniques in the treatment and prevention of viral respiratory infections.
Pediatr Ann, 34 (2005), pp. 24-31
[43.]
M. Giannella, B. Rodríguez-Sánchez, P.L. Roa, P. Catalán, P. Muñoz, D.G. De Viedma, the Gregorio Marañón Task Force for Pneumonia (GANG), et al.
Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the Influenza season?.
Crit Care, 16 (2012), pp. R104
[44.]
J.B. Mahony, G. Blackhouse, J. Babwah, M. Smieja, S. Buracond, S. Chong, et al.
Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections.
J Clin Microbiol, 9 (2009), pp. 2812-2817
[45.]
N.E. Dundas, M.S. Ziadie, P.A. Revell, E. Brock, M. Mitui, N.K. Leos, et al.
A lean laboratory: operational simplicity and cost effectiveness of the Luminex xTAG™ respiratory viral panel.
J Mol Diagn, 13 (2011), pp. 175-179
[46.]
S.C. Kehl, S. Kumar.
Utilization of nucleic acid amplification assays for the detection of respiratory viruses.
Clin Lab Med, 29 (2009), pp. 661-671
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