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Inicio Enfermería Clínica Asialoglycoprotein receptor expression in placenta of women with Hepatitis B Vir...
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Vol. 30. Núm. S2.
International Conference on Women and Societal Perspective on Quality of Life (WOSQUAL-2019)
Páginas 255-258 (marzo 2020)
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Vol. 30. Núm. S2.
International Conference on Women and Societal Perspective on Quality of Life (WOSQUAL-2019)
Páginas 255-258 (marzo 2020)
Asialoglycoprotein receptor expression in placenta of women with Hepatitis B Virus e Antigen (HBeAg) positive and negative
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1
Agus Priyo Wibowoa,
Autor para correspondencia
pmc@agri.unhas.ac.id

Corresponding author.
, Rina Masadaha, Berti J. Nelwanaa, Djumadi Achmada, Gunawan Arsyadia, Maisuri T. Chalidb, Andi Alfian Zainuddinc
a Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
b Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
c Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
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Tablas (3)
Table 1. Frequency of maternal HBeAg serum (n=52).
Table 2. Immunohistochemistry of Asialoglycoprotein placenta receptors (n=52).
Table 3. The relationship between maternal serum HBeAg with immunohistochemistry of placental Asialoglycoprotein receptor.
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Abstract
Objective

This study aimed to determine the relationship between Asialoglycoprotein receptor (ASGP-R) on the placenta and positivity of HBeAg in the mother's serum.

Method

We collected 52 placentas from delivered mothers who have HbsAg-positive serum. The HbsAg-positive serum was then examined for HBeAg-positive and HBeAg-negative. Immunohistochemistry staining was performed on block paraffin sections using monoclonal antibody of ASGP-R.

Results

The expression of ASGP-R of 52 placenta samples demonstrated that 37 samples were scored I, five samples were score II, two samples were score III, and eight samples were score IV. We found that 14 of 52 serum samples were HBeAg-positive and 38 were HBeAg-negative.

Conclusion

There is a significant correlation between ASGP-R on the placenta and positivity of HBeAg in the mother's serum. The expression of the ASGP-R could increase the risk of HBV transmission. The result of this study could be used as a guideline for preventing and therapeutic approach of HBV from mother to child.

Keywords:
Asialoglycoprotein receptor
ASGP-R
HBeAg
Placenta

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