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Vol. 30. Núm. S2.
International Conference on Women and Societal Perspective on Quality of Life (WOSQUAL-2019)
Páginas 470-474 (marzo 2020)
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Vol. 30. Núm. S2.
International Conference on Women and Societal Perspective on Quality of Life (WOSQUAL-2019)
Páginas 470-474 (marzo 2020)
Interaction estrogen receptor polymorphism associates with psychosocial stress on menopausal women
Elizabet Catherine Jusufa,
Autor para correspondencia
elizabet.jusuf@gmail.com

Corresponding author.
, Nusratuddin Abdullaha, Andi Mardiah Tahira, Jayalangkara Tanrab, Muhammad Hattac
a Department of Obstetrics and Gynecology, Hasanuddin University, Indonesia
b Department of Psychiatry, Hasanuddin University, Indonesia
c Department of Microbiology, Hasanuddin University, Indonesia
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Tablas (3)
Table 1. Estimation of estrogen alpha Pvull receptor polymorphism with psychosocial stress in menopausal women.
Table 2. Relation of beta receptor polymorphisms with psychosocial stress in menopausal women.
Table 3. Relationship interaction of alpha Pvull receptors, alpha Xbal receptors, and beta receptors against psychosocial stress occurrences in menopausal women.
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Abstract
Objective

This research aimed to evaluate the interaction between polymorphisms of ERα & ERβ and associated with psychosocial stress on menopausal women.

Methods

It was a cross-sectional study, subject were 102 women aged 40–70 years who meet the inclusion criteria at the Obstetrics and Gynecology Education Hospital of Hasanuddin who agreed on filling questioner which have been determined. Then proceed with blood taking for the ERα and ERβ receptor polymorphisms. Genomic DNA was isolated from 1mL of EDTA anticoagulation edge blood sample using a salting-out procedure and examined interaction of polymorphisms receptors ERα and ERβ. The data were statistically analyzed using the chi-square test with p-value<0.05.

Results

This research showed that subjects who experienced psychosocial stress have the most ERα Pvull heterozygous Pp polymorphism, ERα Xbal homozygous recessive xx, and homozygous dominant ERβ AA. There is ERβ polymorphism relationship with the occurrence of psychosocial stress in menopausal women. But there is no relationship between polymorphisms ERα Pvull, ERα Xbal, as well as the interaction between polymorphisms of ERα and ERβ with the occurrence of psychosocial stress in menopausal women.

Conclusion

ERβ polymorphism relationship the occurrence of psychosocial stress in menopausal women.

Keywords:
Polymorphism
Estrogen receptor
Psychosocial stress
Menopause

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