The study aimed to determine the prognosticators of career growth and development among nurses in tertiary hospitals in Region III, Philippines. The study included 223 nurse-leaders from nineteen (19) participating hospitals as participants via census sampling. The tool utilized for the study was an adopted survey questionnaire that underwent validation before its distribution. Using SEM-PLS through WARPLS, data were analyzed and presented. SPSS v. 21 was used for computation of demographics. Results showed that there is significant result when it comes to knowledge in relation to career growth and development (path=0.217, p<.05, f2=.167). Second, professional values affect the career growth and development of nurses (path=0.564, p<.05, f2=.450). Lastly, competency reveals that it does not affect the career growth and development among nurses (path=0.037, p<.05, f2=.028). It was found that all the three prognosticators of career growth and development (knowledge, professional values, and competency) among nurses have strong significant relationships to each other.
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