Pepino extract (Solanum muricatum Ait.) on HDL and LDL in type 2 diabetic rats

Abstract

Objective

Pepino contains of flavonoid and phenol as antioxidant which can reduce total cholesterol. This research was aimed to study the effect of pepino extract on high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) in type 2 diabetic rats.

Method

The study was a randomized pre–posttest control group design. The subjects of this study were 20 male Wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg BW, pepino extract dosage 500 mg/kg BW, and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated on day 3 after alloxan injection, then HDL and LDL were monitored.

Results

The effect of pepino extract was not found significant to increase HDL or reduce LDL-C of diabetic rats at two different doses (p < 0.05). However, high dose of pepino extract (500 mg/kg BW) successfully inhibited the LDL increase in mice significantly.

Conclusion

Pepino extract can maintain HDL-C and LDL-C on alloxan induced diabetic rats. This food can potentially be a functional food that maintains the cholesterol profile.