Estadísticas

 array:20 [
  "pii" => "X1665920109500626"
  "issn" => "16659201"
  "estado" => "S300"
  "fechaPublicacion" => "2009-07-01"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "GAMO. 2009;8 Supl 3:20-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3677
    "formatos" => array:3 [
      "EPUB" => 37
      "HTML" => 1266
      "PDF" => 2374
    ]
  ]
  "itemSiguiente" => array:16 [
    "pii" => "X1665920109500634"
    "issn" => "16659201"
    "estado" => "S300"
    "fechaPublicacion" => "2009-07-01"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "GAMO. 2009;8 Supl 3:28-34"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1625
      "formatos" => array:3 [
        "EPUB" => 38
        "HTML" => 960
        "PDF" => 627
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Un corazón sano durante la quimioterapia"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "28"
          "paginaFinal" => "34"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Keeping a healthy heart during chemotherapy"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Alejandra Meaney, Eduardo Meaney, Guillermo Ceballos"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Alejandra"
              "apellidos" => "Meaney"
            ]
            1 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Meaney"
            ]
            2 => array:2 [
              "nombre" => "Guillermo"
              "apellidos" => "Ceballos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1665920109500634?idApp=UINPBA00004N"
    "url" => "/16659201/00000008000000S3/v0_201306121413/X1665920109500634/v0_201306121413/es/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X1665920109500618"
    "issn" => "16659201"
    "estado" => "S300"
    "fechaPublicacion" => "2009-07-01"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "GAMO. 2009;8 Supl 3:13-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2006
      "formatos" => array:3 [
        "EPUB" => 30
        "HTML" => 1271
        "PDF" => 705
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Estrategias de cardioprotección&#59; ¿mantienen la efectividad de la quimioterapia?"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "13"
          "paginaFinal" => "19"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Strategies of cardioprotection&#59; is effectiveness of chemotherapy affected?"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Alberto Serrano Olvera"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Serrano Olvera"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1665920109500618?idApp=UINPBA00004N"
    "url" => "/16659201/00000008000000S3/v0_201306121413/X1665920109500618/v0_201306121413/es/main.assets"
  ]
  "es" => array:11 [
    "idiomaDefecto" => true
    "titulo" => "Cardioprotección con Dexrazoxane"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "20"
        "paginaFinal" => "27"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Augusto Pereira González"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "Augusto"
            "apellidos" => "Pereira González"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servicio de oncología. Hospital de Niños J. M. de los Ríos. Caracas, Venezuela. Centro Clínico Profesional Caracas. Caracas, Venezuela."
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Cardioprotection with Dexrazoxane"
      ]
    ]
    "pdfFichero" => "305v08nSupl.3a13150062pdf001.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec176505"
          "palabras" => array:1 [
            0 => "cardioprotecci&#243;n&#44; dexrazoxane&#44; antraciclinas"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec176506"
          "palabras" => array:1 [
            0 => "cardiotoxicity&#44; dexrazoxane&#44; anthracyclines"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "El dexrazoxane &#40;ICRF-187&#41; es permeable a las c&#233;lulas y se distribuye r&#225;pidamente por los tejidos&#46; Su metabolito activo &#40;ADR-925&#41;&#44; es capaz de quelar iones f&#233;rricos &#40;Fe&#179;&#43;&#41;&#44; que evitan la formaci&#243;n de complejos antraciclina- Fe&#179;&#43;&#44; lo que reduce la incidencia de cardiotoxicidad&#46; Su seguridad cl&#237;nica y eficacia han sido evaluadas adecuadamente&#44; en cerca de dos mil pacientes mediante diversos ensayos cl&#237;nicos controlados aleatorizados &#40;ECCA&#41;&#46; Aproximadamente&#44; la mitad de estos pacientes que hab&#237;an alcanzado dosis de doxorrubicina iguales o superiores a 300 mg&#47;m2&#44; y recibieron por primera vez antraciclinas&#44; se trataron con dexrazoxane&#46; La mayor&#237;a de los pacientes fueron adultos con c&#225;ncer de mama&#44; pero tambi&#233;n ni&#241;os con sarcomas&#44; leucemias y otras neoplasias&#46; La tolerancia fue buena y los datos registrados indican que el f&#225;rmaco no aumenta la incidencia ni la gravedad de la toxicidad de los reg&#237;menes quimioter&#225;picos con antraciclinas&#46; La evidencia cl&#237;nica confirma su utilidad cardioprotectora&#44; porque reduce la incidencia de insuficiencia cardiaca y de toxicidad subcl&#237;nica&#44; sin afectar la supervivencia&#46; Se necesitan m&#225;s ECCA&#44; de preferencia multic&#233;ntricos&#44; que eval&#250;en el efecto del dexrazoxane en m&#225;s padecimientos y desde el inicio de la terapia&#44; incluyendo el uso de biomarcadores como las troponinas&#44; entre otros&#46;"
      ]
      "en" => array:1 [
        "resumen" => "Dexrazoxane &#40;ICRF-187&#41; is permeable to cells and has a rapid tissue distribution&#44; its active metabolite &#40;ADR-925&#41;&#44; is able to chelate ferrous ions &#40;Fe&#179;&#43;&#41;&#44; avoiding the formation of anthracycline-&#40;Fe&#179;&#43;&#41; complexes&#44; which reduces the incidence of cardiotoxicity in these patients&#46; The clinical safety and effi- cacy of dexrazoxane has been properly evaluated&#44; by various randomized and controlled clinical trials in about two thousand patients&#46; Approximately&#44; half of these patients had reached doxorubicin dose equal to or above 300 mg&#47;m2&#44; and who received first anthracyclines&#44; were treated with dexrazoxane&#46; Most patients were adults with breast cancer&#44; but also children with sarcomas&#44; leukemias and other malignancies&#46; Tolerance was good and dexrazoxane data suggest that the drug does not increase the incidence or severity of the toxicity of chemotherapy regimens with anthracyclines&#46; The evidence confirms the clinical cardioprotective effect of dexrazoxane&#46; It reduces the incidence of heart failure and sub-clinical toxicity&#44; without affecting survival&#46; We need more randomized clinical studies&#44; preferably multicenter&#44; to evaluate the effect of dexrazoxane in a greater number of diseases and since the beginning of therapy&#44; including the use of biomarkers such as troponin&#44; among others&#46;"
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/16659201/00000008000000S3/v0_201306121413/X1665920109500626/v0_201306121413/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "11782"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Gu&#237;as para la prevenci&#243;n de la cardiotoxicidad en oncolog&#237;a y hematolog&#237;a"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/16659201/00000008000000S3/v0_201306121413/X1665920109500626/v0_201306121413/es/305v08nSupl.3a13150062pdf001.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1665920109500626?idApp=UINPBA00004N"
]