Estadísticas

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      "titulo" => "Un corazón sano durante la quimioterapia"
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        "resumen" => "Aproximadamente 60&#37; de los ni&#241;os con enfermedades neopl&#225;sicas reciben antraciclinas y se estima que el da&#241;o cardiaco por estos f&#225;rmacos es superior a 57&#37;&#46; Se debe tomar en cuenta que los ni&#241;os tienen mayor riesgo de cardiotoxicidad que los adultos&#59; sin embargo la expectativa de curaci&#243;n en la poblaci&#243;n infantil hace imperativo disminuir las secuelas del tratamiento&#46; Para ello se ha usado limitar la dosis de antrac&#237;clico&#44; modificar el esquema de administraci&#243;n&#44; uso de an&#225;logos antrac&#237;clicos menos t&#243;xicos y el empleo de f&#225;rmacos cardioprotectores&#46; Cabe mencionar que limitar la dosis puede comprometer la curaci&#243;n y adem&#225;s&#44; no existe efecto ben&#233;fico significativo al usar esquemas de infusi&#243;n continua en comparaci&#243;n con administraci&#243;n en bolo&#46; No existen estudios prospectivos comparativos en ni&#241;os que aseguren que las formas pegiladas son menos cardiot&#243;xicas&#59; sin embargo&#44; los estudios en adultos concluyen que conservan la eficacia con menor toxicidad&#46; En estudios prospectivos en ni&#241;os&#44; el &#250;nico f&#225;rmaco que ha demostrado tener efecto cardioprotector&#44; sin disminuir la efectividad es el dexrazoxane&#46;"
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        "resumen" => "Approximately 60&#37; of children with neoplasic diseases receive anthracyclines and the cardiac damage produced by these drugs is more than 57&#37;&#46; We should take into account that children have more risk of cardiotoxicity than adults&#59; however&#44; the expectation of cure in children makes it essential to reduce the treatment’s side effects&#46; A limit to the dose of anthracyclines&#44; modification of administration schedule&#44; use of less toxic anthracyclines analogues and use of cardioprotective drug have been used&#46; Limiting the dose can affect the cure and there is no benefit when continuous infusion schedules are com pared with bolus administration&#46; The abscence of comparative and prospective studies in children to state that pegilated forms are less cardiotoxic&#59; although&#44; studies in adults have concluded they keep efficacy with less toxicity&#46; In prospective studies in children&#44; the only drug that has shown a cardio protective effect without decrease in efficacy is dexrazoxane&#46;"
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