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Inicio Gastroenterología y Hepatología Implicación de la proteína HBx del virus de la hepatitis B en la respuesta inm...
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Vol. 26. Núm. 9.
Páginas 552-561 (enero 2003)
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Vol. 26. Núm. 9.
Páginas 552-561 (enero 2003)
Acceso a texto completo
Implicación de la proteína HBx del virus de la hepatitis B en la respuesta inmune y la progresión tumoral
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9908
E. Lara-Pezzia,*, R. Moreno-Oterob, M. López-Cabreraa
a Unidad de Biología Molecular. Hospital Universitario de La Princesa. Madrid. España
b Unidad de Hepatología. Hospital Universitario de La Princesa. Madrid. España
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Bibliografía
[1.]
F.V. Chisari.
Viruses, immunity, and cancer: lessons from hepatitis B.
Am J Pathol, 156 (2000), pp. 1118-1132
[2.]
D.F. Schafer, M.F. Sorrell.
Hepatocellular carcinoma.
Lancet, 353 (1999), pp. 1253-1257
[3.]
A.H. Malik, W.M. Lee.
Chronic hepatitis B virus infection: treatment strategies for the next millennium.
Ann Intern Med, 132 (2000), pp. 723-731
[4.]
P. Tiollais, C. Pourcel, A. Dejean.
The hepatitis B virus.
Nature, 317 (1985), pp. 489-495
[5.]
A. Kekule, U. Lauer, M. Meyer, W. Caselmann, P. Hofsschneider, R. Koshy.
The pre S2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator.
Nature, 343 (1990), pp. 457-460
[6.]
D. Ganem, H.E. Varmus.
The molecular biology of the hepatitis B virus.
Annu Rev Biochem, 56 (1987), pp. 651-693
[7.]
M.A. Feitelson, L.X. Duan.
Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.
Am J Pathol, 150 (1997), pp. 1141-1157
[8.]
J. Summers, W.S. Mason.
Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate.
Cell, 29 (1982), pp. 403-415
[9.]
S. Takada, H. Kido, A. Fukutomi, T. Mori, K. Koike.
Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.
Oncogene, 9 (1994), pp. 341-348
[10.]
S. Urban, E. Hildt, C. Eckerskorn, H. Sirma, A. Kekule, P.H. Hofschneider.
Isolation and molecular characterization of hepatitis B virus-X protein from a baculovirus expression system.
Hepatology, 26 (1997), pp. 1045-1053
[11.]
N. Scheck, R. Bartenschlager, C. Kuhn, H. Schaller.
Phosphorylation and rapid turnover of hepatitis B virus Xprotein expressed in HepG2 cells from a recombinant vaccinia virus.
Oncogene, 6 (1991), pp. 1735-1744
[12.]
S. Takada, K. Koike.
Three sites of the hepatitis B virus X protein cooperativaly interact with cellular proteins.
Virology, 205 (1994), pp. 503-510
[13.]
V. Kumar, N. Jayasuryan, R. Kumar.
A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.
Proc Natl Acad Sci USA, 93 (1996), pp. 5647-5652
[14.]
S. Murakami, J. Cheong, S. Kaneko.
Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.
J Biol Chem, 269 (1994), pp. 15118-15123
[15.]
Q. Su, C.H. Schroder, W.J. Hofmann, G. Otto, R. Pichlmayr, P. Bannasch.
Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas.
Hepatology, 27 (1998), pp. 1109-1120
[16.]
H. Sirma, R. Weil, O. Rosmorduc, S. Urban, A. Israel, D. Kremsdorf, et al.
Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome.
Oncogene, 16 (1998), pp. 2051-2063
[17.]
M. Dandri, J. Petersen, R.J. Stockert, T.M. Harris, C.E. Rogler.
Metabolic labeling of woodchuck hepatitis B virus X protein in naturally infected hepatocytes reveals a bimodal half-life and association with the nuclear framework.
J Virol, 72 (1998), pp. 9359-9364
[18.]
Z. Rahmani, K.W. Huh, R. Lasher, A. Siddiqui.
The hepatitis b virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential.
J Virol, 74 (2000), pp. 2840-2846
[19.]
G. Waris, K.W. Huh, A. Siddiqui.
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-αB via oxidative stress.
Mol Cell Biol, 21 (2001), pp. 7721-7730
[20.]
S. Takada, Y. Shirakata, N. Kaneniwa, K. Koike.
Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death.
Oncogene, 18 (1999), pp. 6965-6973
[21.]
M. Lopez-Cabrera, J. Letovsky, K.Q. Hu, A. Siddiqui.
Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: transactivation and repression by CCAAT/enhancer binding protein.
Proc Natl Acad Sci USA, 87 (1990), pp. 5069-5073
[22.]
R. Dikstein, O. Faktor, R. Ben-Levy, Y. Shaul.
Functional organization of the hepatitis B virus enhancer.
Mol Cell Biol, 10 (1990), pp. 3682-3689
[23.]
O. Faktor, Y. Shaul.
The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax.
Oncogene, 5 (1990), pp. 867-872
[24.]
H. Nakatake, O. Chisaka, S. Yamamoto, K. Matsubara, R. Koshy.
Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication.
Virology, 195 (1993), pp. 305-314
[25.]
A. Kekule, U. Lauer, L. Weiss, B. Luber, P. Hofsschneider.
Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway.
Nature, 361 (1993), pp. 742-745
[26.]
M. Doria, N. Klein, R. Lucito, R.J. Schneider.
The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.
EMBO J, 14 (1995), pp. 4747-4757
[27.]
M.J. Bouchard, L.H. Wang, R.J. Schneider.
Calcium signaling by HBx protein in hepatitis B virus DNA replication.
Science, 294 (2001), pp. 2376-2378
[28.]
N.P. Klein, R.J. Schneider.
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
Mol Cell Biol, 17 (1997), pp. 6427-6436
[29.]
N.P. Klein, M.J. Bouchard, L.H. Wang, C. Kobarg, R.J. Schneider.
Src kinases involved in hepatitis B virus replication.
EMBO J, 18 (1999), pp. 5019-5027
[30.]
J. Benn, R.J. Schneider.
Hepatitis virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signalling cascade.
Proc Natl Acad Sci USA, 91 (1994), pp. 10350-10354
[31.]
J. Benn, F. Su, M. Doria, R.J. Schneider.
Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-jun N-terminal mitogen-activated protein kinases.
J Virol, 70 (1996), pp. 4978-4985
[32.]
G. Natoli, M. Avantaggiati, P. Chirillo, P. Puri, A. Ianni, C. Balsano, et al.
Ras-and Raf-dependent activation of c-jun transcriptional activity by hepatitis B virustransactivator pX.
Oncogene, 9 (1994), pp. 2836-2843
[33.]
P. Chirillo, M. Falco, P.L. Puri, M. Artini, C. Balsano, M. Levrero, et al.
Hepatitis B virus pX activates NF-αB dependent transcription through a Raf-independent pathway.
J Virol, 70 (1996), pp. 641-646
[34.]
R. Lucito, R.J. Schneider.
Hepatitis B virus X protein activates transcription factor NF-αB without a requirement for protein kinase C.
J Virol, 1992 (1992), pp. 983-991
[35.]
Y-H Lee, Y. Yun.
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
J Biol Chem, 273 (1998), pp. 25510-25515
[36.]
W.L. Shih, M.L. Kuo, S.E. Chuang, A.L. Cheng, S.L. Doong.
Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway.
J Biol Chem, 275 (2000), pp. 25858-25864
[37.]
J. Huang, J. Kwong, E. Sun, T. Liang.
Proteosome complex as a potential cellular target of hepatis B virus X protein.
J Virol, 70 (1996), pp. 5582-5591
[38.]
D.K. Lee, S.H. Park, Y. Yi, S.G. Choi, C. Lee, W.T. Parks, et al.
The hepatitis B virus encoded oncoprotein pX amplifies TGFbeta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis.
Genes Dev, 15 (2001), pp. 455-466
[39.]
Y.I. Lee, S. Lee, Y. Lee, Y.S. Bong, S.W. Hyun, Y.D. Yoo, et al.
The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4.
Oncogene, 16 (1998), pp. 2367-2380
[40.]
Y.D. Yoo, H. Ueda, K. Park, K.C. Flanders, Y.I. Lee, G. Jay, et al.
Regulation of transforming growth factor-β1 expression by the hepatitis B virus (HBV) X transactivator.
J Clin Invest, 97 (1996), pp. 388-395
[41.]
B.H. Choi, G.T. Park, H.M. Rho.
Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein a synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.
J Cell Biol, 274 (1999), pp. 2858-2865
[42.]
H.F. Maguire, J.P. Hoeffler, A. Siddiqui.
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by proteinprotein interactions.
Science, 252 (1991), pp. 842-844
[43.]
I. Haviv, Y. Matza, Y. Shaul.
pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants.
Genes Dev, 12 (1998), pp. 1217-1226
[44.]
Y. Lin, H. Tang, T. Nomura, D. Dorjsuren, N. Hayashi, W. Wei, et al.
The hepatitis B virus X protein is a co-activator of activated transcription that modulates the transcription machinery and distal binding activators.
J Biol Chem, 273 (1998), pp. 27097-27103
[45.]
I. Haviv, M. Shamay, G. Doitsh, Y. Shaul.
Hepatitis B virus pX targets TFIIB in transcription coactivation.
Mol Cell Biol, 18 (1998), pp. 1562-1569
[46.]
I. Qadri, J.W. Conaway, R.C. Conaway, J. Schaack, A. Siddiqui.
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.
Proc Natl Acad Sci USA, 93 (1996), pp. 10578-10583
[47.]
I. Qadri, H. Maguire, A. Siddiqui.
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.
Proc Natl Acad Sci USA, 92 (1995), pp. 1003-1007
[48.]
J. Cheong, M. Yi, Y. Lin, S. Murakami.
Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.
EMBO J, 14 (1995), pp. 143-150
[49.]
D. Dorjsuren, Y. Lin, W. Wei, T. Yamashita, T. Nomura, N. Hayashi, et al.
RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.
Mol Cell Biol, 18 (1998), pp. 7546-7555
[50.]
K. Reifenberg, H. Wilts, J. Lohler, P. Nusser, R. Hanano, L.G. Guidotti, et al.
The hepatitis B virus X protein transactivates viral core gene expression in vivo.
J Virol, 73 (1999), pp. 10399-10405
[51.]
D.F. Spandau, C.H. Lee.
Trans-activation of viral enhancers by the hepatitis B virus X protein.
J Virol, 62 (1988), pp. 427-434
[52.]
J.S. Twu, W.S. Robinson.
Hepatitis B virus X gene can transactivate heterologous viral sequences.
Proc Natl Acad Sci USA, 86 (1989), pp. 2046-2050
[53.]
M. Levrero, C. Balsano, G. Natoli, M.L. Avantaggiati, E. Elfassi.
Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2.
J Virol, 64 (1990), pp. 3082-3086
[54.]
C. Ferrari, M. Pilli, A. Penna, A. Bertoletti, A. Valli, A. Cavalli, et al.
Autopresentation of hepatitis B virus envelope antigens by T cells.
J Virol, 66 (1992), pp. 2536-2540
[55.]
A. Franco, M. Paroli, U. Testa, R. Benvenuto, C. Peschle, F. Balsano, et al.
Transferrin receptor mediates up-take and presentation of hepatitis B envelope antigens by T cells.
J Exp Med, 175 (1992), pp. 1195-1205
[56.]
M. Gomez-Gonzalo, M. Carretero, J. Rullas, E. Lara-Pezzi, J. Aramburu, B. Berkhout, et al.
The hepatitis B virus X protein induces HIV-1 replication and transcription in synergy with Tcell activation signals: functional roles of NF-kappaB/NF-AT and SP1-binding sites in the HIV-1 long terminal repeat promoter.
J Biol Chem, 276 (2001), pp. 35435-35443
[57.]
A. Eskild, P. Magnus, G. Petersen, C. Sohlberg, F. Jensen, P. Kittelsen, et al.
Hepatitis B antibodies in HIV-infected homosexual men are associated with more rapid progression to AIDS.
AIDS, 6 (1992), pp. 571-574
[58.]
M.L. Avantaggiati, G. Natoli, C. Balsano, P. Chirillo, M. Artini, E.D. Marzio, et al.
The hepatitis B virus (HBV) pX transactivates the c-fos promoter through multiple cis-acting elements.
Oncogene, 8 (1993), pp. 1567-1574
[59.]
C. Balsano, M.L. Avantaggiati, G. Natoli, E.D. Marzio, H. Will, M. Perricaudet, et al.
Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cmyc protooncogene at the transcriptional level.
Biochem Biophys Res Commun, 176 (1991), pp. 985-992
[60.]
S. Menzo, M. Clementi, E. Alfani, P. Bagnarelli, S. Iacovacci, A.M. Dandri, et al.
Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus-X gene product.
Virology, 196 (1993), pp. 878-882
[61.]
D.K. Hsu, C.A. Dowling, K.C. Jeng, J.T. Chen, R.Y. Yang, F.T. Liu.
Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma.
Int J Cancer, 81 (1999), pp. 519-526
[62.]
S.O. Kim, J.G. Park, Y.I. Lee.
Increased expression of the Insulin-like groth factor I (IGF-I) receptor gene in hepatocelular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product.
Cancer Res, 56 (1996), pp. 3831-3836
[63.]
S.L. Feng, Y. Guo, V.M. Factor, S.S. Thorgeirsson, D.W. Bell, J.R. Testa, et al.
The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinoma.
Am J Pathol, 156 (2000), pp. 1253-1261
[64.]
E.C. Shin, J.S. Shin, J.H. Park, H. Kim, S.J. Kim.
Expression of Fas ligand in human hepatoma cell lines: role of hepatitis-B virus X (HBx) in induction of Fas ligand.
Int J Cancer, 82 (1999), pp. 587-591
[65.]
Y. Lee, U.S. Park, I. Choi, S.K. Yoon, Y.M. Park, Y.I. Lee.
Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells.
Clin Cancer Res, 4 (1998), pp. 1711-1717
[66.]
K.Q. Hu, C.H. Yu, J.M. Vierling.
Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.
Proc Natl Acad Sci USA, 89 (1992), pp. 11441-11445
[67.]
K. Hu, J. Vierling, A. Siddiqui.
Trans-activation of HLA-DR gene by hepatitis B virus X gene product.
Proc Natl Acad Sci USA, 87 (1990), pp. 7140-7144
[68.]
M. Lee, Y. Choi, E. Shin, H. Kang, Y. Kim, S. Jeong, et al.
Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection.
J Hepatol, 37 (2002), pp. 380
[69.]
B. Aufiero, R. Schneider.
The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.
EMBO J, 9 (1990), pp. 497-504
[70.]
H.D. Wang, A. Trivedi, D.L. Johnson.
Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated ras and TATA-binding protein.
Mol Cell Biol, 18 (1998), pp. 7086-7094
[71.]
H.S. Chen, S. Kaneko, R. Girones, R.W. Anderson, W.E. Hornbuckle, B.C. Tennant, et al.
The woodchuck hepatitis virus X gene is important for establishment of virus infection of woodchucks.
J Virol, 67 (1993), pp. 1218-1226
[72.]
F. Zoulim, J. Saputelli, C. Seeger.
Woodchuck hepatitis virus X protein is required for viral infection in vivo.
J Virol, 68 (1994), pp. 2026-2030
[73.]
F. Chisari, C. Ferrari.
Hepatitis B virus immunopathogenesis.
Annu Rev Immunol, 13 (1995), pp. 29-60
[74.]
L.G. Guidotti, K. Ando, M.V. Hobbs, T. Ishikawa, R.D. Runkel, R.D. Schreiber, et al.
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.
Proc Natl Acad Sci USA, 91 (1994), pp. 3764-3768
[75.]
L.G. Guidotti, T. Ishikawa, M.V. Hobbs, B. Matzke, R. Schreiber, F.V. Chisari.
Intracellular inactivation of the hepatitis B Virus by cytotoxic T lymphocytes.
Immunity, 4 (1996), pp. 25-36
[76.]
L.G. Guidotti, F.V. Chisari.
Noncytolytic control of viral infections by the innate and adoptive immune response.
Annu Rev Immunol, 19 (2001), pp. 65-91
[77.]
P. Vassalli.
The pathophysiology of tumor necrosis factor.
Annu Rev Immunol, 10 (1992), pp. 411-452
[78.]
K.J. Simpson, N.W. Lukacs, L. Colletti, R.M. Strieter, S.L. Kunkel.
Cytokines and the liver.
J Hepatol, 27 (1997), pp. 1120-1132
[79.]
P.L. Majano, C. Garcia-Monzon, M. Lopez-Cabrera, E. Lara-Pezzi, E. Fernandez-Ruiz, C. Garcia-Iglesias, et al.
Inducible nitric oxide synthase expression in chronic viral hepatitis.
J Clin Invest, 101 (1998), pp. 1343-1352
[80.]
L.G. Guidotti, H. McClary, J.M. Loudis, F.V. Chisari.
Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice.
J Exp Med, 191 (2001), pp. 1247-1252
[81.]
R.M. Rai, F.Y. Lee, A. Rosen, S.Q. Yang, H.Z. Lin, A. Koteish, et al.
Impaired liver regeneration in inducible nitric oxide synthase-deficient mice.
Proc Natl Acad Sci USA, 95 (1998), pp. 13829-13834
[82.]
F. Su, C.N. Theodosis, R.J. Schneider.
Role of NF-αB and Myc proteins in apoptosis induced by hepatitis B virus HBx protein.
[83.]
A.A. Beg, W.C. Sha, R.T. Bronson, S. Ghosh, D. Baltimore.
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-αB.
Nature, 376 (1995), pp. 167-170
[84.]
J. Diao, R. Garces, C.D. Richardson.
X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathyways during the course of viral infections and hepatocarcinogenesis.
Cytokine Growth Factor Rev, 12 (2001), pp. 189-205
[85.]
G.G. Chen, P.B. Lai, P.K. Chan, E.C. Chak, J.H. Yip, R.L. Ho, et al.
Decreased expression of Bid in human hepatocellular carcinoma is related to hepatitis B virus X protein.
Arv, 37 (2001), pp. 1695-1702
[86.]
K. Gottlob, M. Fulco, M. Levrero, A. Graessmann.
The hepatitis B virus HBx protein inhibits caspase 3 activity.
J Biol Chem, 273 (1998), pp. 33347-33353
[87.]
J. Diao, A.A. Khine, F. Sarangi, E. Hsu, C. Iorio, L.A. Tibbles, et al.
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
J Biol Chem, 276 (2001), pp. 8328-8340
[88.]
X.W. Wang, M.K. Gibson, W. Vermeulen, K. Forrester, H. Yeh, H.W. Sturzbecher, et al.
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene.
Cancer Res, 55 (1995), pp. 6012-6016
[89.]
E. Lara-Pezzi, P.L. Majano, M. Gomez-Gonzalo, C. Garcia-Monzon, R. Moreno-Otero, M. Levrero, et al.
Hepatitis B virus X protein up-regulates tumor necrosis factor-α gene expression in hepatocytes.
Hepatology, 28 (1998), pp. 1013-1021
[90.]
A.M. Diehl.
Cytokine regulation of liver injury and repair.
Immunol Rev, 174 (2000), pp. 160-171
[91.]
A. Alcami, U.H. Koszinowski.
Viral mechanisms of immune evasion.
Immunol Today, 21 (2000), pp. 447-455
[92.]
B.H. Davis, T.F. Kresina.
Hepatic fibrogenesis.
Clin Lab Med, 16 (1996), pp. 361-387
[93.]
Y. Nakamoto, L.G. Guidotti, C.V. Kuhlen, P. Fowler, F.V. Chisari.
Immune pathogenesis of hepatocellular carcinoma.
J Exp Med, 188 (1998), pp. 341-350
[94.]
F.V. Chisari, K. Klopchin, T. Moriyama, C. Pasquinelli, H.A. Dunsford, S. Sell, et al.
Molecular pathogenesis of hepatocelular carcinoma in hepatitis B virus transgenic mice.
Cell, 59 (1989), pp. 1145-1156
[95.]
H.A. Dunsford, S. Sell, F.V. Chisari.
Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice.
Cancer Res, 50 (1990), pp. 3400-3407
[96.]
T.Y. Hsu, T. Moroy, J. Etiemble, A. Louise, C. Trepo, P. Tiollais, et al.
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma.
Cell, 55 (1988), pp. 627-635
[97.]
A. Dejean, P. Sonigo, S. Wain-Hobson, P. Tiollais.
Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.
Proc Natl Acad Sci USA, 81 (1984), pp. 5350-5354
[98.]
T. Matsubara, T. Tokina.
Integration of hepatitis B virus DNA and its implications for carcinogenesis.
Mol Biol Med, 7 (1990), pp. 243-260
[99.]
P. Paterlini, K. Poussin, M. Kew, D. Franco, C. Brechot.
Selective accumulation of the transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma.
Hepatology, 21 (1995), pp. 313-321
[100.]
S.F. Chang, H.J. Netter, E. Hildt, R. Schuster, S. Schaefer, Y.C. Hsu, et al.
Duck hepatitis B virus expresses a regulatory HBxlike protein from a hidden open reading frame.
[101.]
C.M. Kim, K. Koike, I. Saito, T. Miyamura, G. Jay.
HBx gene of hepatitis B virus induces liver cancer in transgenic mice.
Nature, 351 (1991), pp. 317-320
[102.]
D.Y. Yu, H.B. Moon, J.K. Son, S. Jeong, S.L. Yu, H. Yoon, et al.
Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein.
J Hepatol, 31 (1999), pp. 123-132
[103.]
O. Terradillos, O. Billet, C.A. Renard, R. Levy, T. Molina, P. Briand, et al.
The hepatitis B virus X gene potentiates cmyc-induced liver oncogenesis in transgenic mice.
Oncogene, 14 (1997), pp. 395-404
[104.]
B.L. Slagle, T.H. Lee, D. Medina, M.J. Finegold, J.S. Butel.
Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene.
[105.]
M. Hohne, S. Schaefer, M. Seifer, M.A. Feitelson, D. Paul, W.H. Gerlich.
Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.
EMBO J, 9 (1990), pp. 1137-1145
[106.]
R. Truant, J. Antunovic, J. Greenblatt, C. Prives, J.A. Cromlish.
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation.
J Virol, 69 (1995), pp. 1851-1859
[107.]
X.W. Wang, K. Forrester, H. Yeh, M.A. Feitelson, J.R. Gu, C.C. Harris.
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.
Proc Natl Acad Sci USA, 91 (1994), pp. 2230-2234
[108.]
S.A. Becker, T.H. Lee, J.S. Butel, B.L. Slagle.
Hepatitis B virus X Protein interferes with cellular DNA repair.
J Virol, 72 (1998), pp. 266-272
[109.]
S.W. Lee, Y.M. Lee, S.K. Bae, S. Murakami, Y. Yun, K.W. Kim.
Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesis.
Biochem Biophys Res Commun, 268 (2000), pp. 456-461
[110.]
K. Koike, K. Moriya, H. Yotsuyanagi, S. Lino, K. Kurokawa.
Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblasts.
J Clin Invest, 94 (1994), pp. 44-49
[111.]
J. Benn, R.J. Schneider.
Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.
Proc Natl Acad Sci USA, 92 (1995), pp. 11215-11219
[112.]
J.Y. Ahn, E.Y. Jung, H.J. Kwun, C.W. Lee, Y.C. Sung, K.L. Jang.
Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53.
J Gen Virol, 83 (2002), pp. 2765-2772
[113.]
E. Lara-Pezzi, J.M. Serrador, M.C. Montoya, D. Zamora, M. Yáñez-Mó, M. Carretero, et al.
The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis.
Hepatology, 33 (2001), pp. 1270-1281
[114.]
E. Lara-Pezzi, S. Roche, O.M. Andrisani, F. Sánchez-Madrid, M. López-Cabrera.
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner.
Oncogene, 20 (2001), pp. 3323-3331
[115.]
E. Lara-Pezzi, P.L. Majano, M. Yáñez-Mo, M. Gómez-Gonzalo, M. Carretero, R. Moreno-Otero, et al.
Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrix.
J Hepatol, 34 (2001), pp. 409-415
[116.]
E. Lara-Pezzi, M.V. Gómez-Gaviro, B.G. Gálvez, E. Mira, M.A. Iñiguez, M. Fresno, et al.
The hepatitis B virus X protein promotes tumor cell invasion by inducing MT1-MMP and COX-2 expression.
J Clin Invest, 110 (2002), pp. 1831-1838
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