Compartir
array:22 [ "pii" => "S0210570524002929" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2024.502283" "estado" => "S5" "fechaPublicacion" => "2024-10-29" "aid" => "502283" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2024" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S021057052400284X" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2024.502277" "estado" => "S100" "fechaPublicacion" => "2024-10-31" "aid" => "502277" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Comparative evaluation of point of care assay with ELISA techniques for quantifying serum concentrations of ustekinumab in inflammatory bowel disease patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación comparativa de un ensayo Point of Care y técnicas ELISA para la determinación de concentraciones séricas de ustekinumab en pacientes con enfermedad inflamatoria intestinal" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1738 "Ancho" => 2050 "Tamanyo" => 228306 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Correlation and Bland–Altman analysis of ustekinumab concentrations measured by different assays. Panels A–C: Scatter plots comparing ustekinumab concentrations measured by POC-AFIAS, ELISA-PRO, and ELISA-RDSC assays. The line of best fit is shown with the corresponding equation and <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> value, indicating the degree of correlation between the methods. Panels D–F: Bland–Altman plots showing the agreement between the assays. The solid line represents the mean difference (bias) between the two assays, while the dashed lines represent the upper and lower limits of agreement (LOA), calculated as the mean difference<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.96 times the standard deviation of the differences.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carles Iniesta-Navalón, Manuel Ríos-Saorín, Lorena Rentero-Redondo, Rebeca Añez-Castaño, Elena Urbieta-Sanz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Carles" "apellidos" => "Iniesta-Navalón" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Ríos-Saorín" ] 2 => array:2 [ "nombre" => "Lorena" "apellidos" => "Rentero-Redondo" ] 3 => array:2 [ "nombre" => "Rebeca" "apellidos" => "Añez-Castaño" ] 4 => array:2 [ "nombre" => "Elena" "apellidos" => "Urbieta-Sanz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021057052400284X?idApp=UINPBA00004N" "url" => "/02105705/unassign/S021057052400284X/v1_202410310622/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S0210570520302533" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2020.05.020" "estado" => "S200" "fechaPublicacion" => "2020-09-04" "aid" => "1593" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "ret" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "WITHDRAWN: Higher appendicular skeletal muscle mass percentage is an independent protective factor for non-alcoholic steatohepatitis and significant fibrosis in male with NAFLD" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yilun Xu, Yaqi Guan, Wenyi Jin, Li Ding, Jinming Wu" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Yilun" "apellidos" => "Xu" ] 1 => array:2 [ "nombre" => "Yaqi" "apellidos" => "Guan" ] 2 => array:2 [ "nombre" => "Wenyi" "apellidos" => "Jin" ] 3 => array:2 [ "nombre" => "Li" "apellidos" => "Ding" ] 4 => array:2 [ "nombre" => "Jinming" "apellidos" => "Wu" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570520302533?idApp=UINPBA00004N" "url" => "/02105705/unassign/S0210570520302533/v2_202101310608/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "The impact of anxiety and depression on quality of life in a cohort of inflammatory bowel disease patients from northeastern of brazil" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Raiza Lima Silva, Francisca Isabelle da Silva e Sousa, Gabriel Lucas Ferreira da Silva, Victória Danielly Rabelo Almeida, Simão Barbosa Silva, Mateus Mendes Santos Freire, Marcellus Henrique Loiola Ponte de Souza, Lucia Libanez Bessa Campelo Braga" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Raiza Lima" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Francisca Isabelle" "apellidos" => "da Silva e Sousa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Gabriel Lucas Ferreira da" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Victória Danielly Rabelo" "apellidos" => "Almeida" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Simão Barbosa" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Mateus Mendes Santos" "apellidos" => "Freire" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Marcellus Henrique Loiola" "apellidos" => "Ponte de Souza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 7 => array:4 [ "nombre" => "Lucia Libanez Bessa Campelo" "apellidos" => "Braga" "email" => array:1 [ 0 => "lucialib@terra.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil" "etiqueta" => "1" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Internal Medicine, Federal University of Ceará, Walter Cantídio University Hospital, Fortaleza, CE, Brazil" "etiqueta" => "2" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author: Doctorate in Gastroenterology, Department of Internal Medicine - Federal University of Ceará, Prof. Costa Mendes, 1608, 4th floor - Rodolfo Teófilo, Brazil" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El impacto de la ansiedad y la depresión en la calidad de vida en una cohorte de pacientes con enfermedad inflamatoria intestinal en el nordeste de brasil." ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-08-03" "fechaAceptado" => "2024-10-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1900054" "palabras" => array:3 [ 0 => "Anxiety" 1 => "depression" 2 => "inflammatory bowel disease" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1900055" "palabras" => array:3 [ 0 => "Ansiedad" 1 => "depresión" 2 => "enfermedad inflamatoria intestinal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Objective: This study aims to assess the association between chronic pathologies and depressive and/or anxious disorders is high resulting in a reduction in the patient's quality of life.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients and methods: This is a prospective cross-sectional study with a descriptive and analytical design. Sociodemographic data and lifestyle habits were collected. Subsequently, the Inflammatory Bowel Disease Questionnaire (IBDQ) and the Hospital Anxiety and Depression Scale (HADS) were applied.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Results A total of 141 patients participated in the study, with a mean age of 45.78 (SD 16.01) years, of which 60.3% were female (n=85) and 39.7% were male (n=56). 58.9% had ulcerative colitis (UC) (n=83), and 41.1% had Crohn's disease (CD) (n=58). 16.5% of patients had a previous diagnosis of generalized anxiety disorder (GAD) and/or major depression (MD) (n=23). Regarding IBDQ scores, participants with anxiety had significantly lower mean scores in all IBDQ items (p<0.001), while the depression diagnosis obtained significantly lower mean values for systemic (p=0.015), emotional (p=0.001), and intestinal symptoms (p=0.005).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Conclusion The results indicate that anxiety and depression negatively impact the quality of life of patients with IBD independently of the disease activity.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Objetivo: El presente estudio tiene como objetivo evaluar la asociación entre patologías crónicas y trastornos depresivos y/o ansiosos es alta resultando en una reducción de la calidad de vida del paciente.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Pacientes y métodos: Se trata de un estudio prospectivo transversal con un diseño descriptivo y analítico. Se recogieron datos sociodemográficos y hábitos de vida. Posteriormente, se aplicaron el Cuestionario de Enfermedad Inflamatoria Intestinal (IBDQ) y la Escala Hospitalaria de Ansiedad y Depresión (HADS).</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Resultados: Participaron en el estudio 141 pacientes, con una edad media de 45,78 (DE 16,01) años, de los cuales el 60,3% eran mujeres (n=85) y el 39,7% varones (n=56). La mayoría padecía colitis ulcerosa (CU) (n=83; 58,9%), y el 41,1% enfermedad de Crohn (EC) (n=58). El 16,5% de los pacientes tenía un diagnóstico previo de trastorno de ansiedad generalizada (TAG) y/o depresión mayor (DM) (n=23). En cuanto a las puntuaciones del IBDQ, los participantes con ansiedad presentaron puntuaciones medias significativamente inferiores en todos los ítems del IBDQ (p<0,001), mientras que el diagnóstico de depresión obtuvo valores medios significativamente inferiores para los síntomas sistémicos (p=0,015), emocionales (p=0,001) e intestinales (p=0,005).</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Conclusión: Los resultados indican que la ansiedad y la depresión afectan negativamente a la calidad de vida de los pacientes con EII independientemente de la actividad de la enfermedad.</p></span>" ] ] ] "idiomaDefecto" => "en" "url" => "/02105705/unassign/S0210570524002929/v1_202410291637/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/02105705/unassign/S0210570524002929/v1_202410291637/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570524002929?idApp=UINPBA00004N" ]
