metricas
covid
Buscar en
Gastroenterología y Hepatología
Toda la web
Inicio Gastroenterología y Hepatología Utilidad de los de registros de hepatotoxicidad por fármacos
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Utilidad de los de registros de hepatotoxicidad por fármacos
R.J. Andradea,
Autor para correspondencia
andrade@uma.es

Correspondencia: Dr. R. J. Andrade. Unidad de Hepatología. Departamento de Medicina. Facultad de Medicina. Campus Universitario de Teatinos, s/n. 29071 Málaga.
, M.I. Lucenab, M. García-Cortésa
a Unidad de Hepatología, Servicio de Aparato Digestivo.ospital Universitario Virgen de la Victoria. Facultad de Medicina. Málaga
b Servicio de Farmacología Clínica. Hospital Universitario Virgen de la Victoria. Facultad de Medicina. Málaga
Leído
4102
Veces
se ha leído el artículo
1464
Total PDF
2638
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S0210570501701665"
  "issn" => "02105705"
  "doi" => "10.1016/S0210-5705(01)70166-5"
  "estado" => "S300"
  "fechaPublicacion" => "2001-01-01"
  "aid" => "70166"
  "copyright" => "Elsevier España, S.L.. Todos los derechos reservados"
  "copyrightAnyo" => "2001"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Gastroenterol Hepatol. 2001;24:250-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2580
    "formatos" => array:3 [
      "EPUB" => 10
      "HTML" => 1879
      "PDF" => 691
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0210570501701677"
    "issn" => "02105705"
    "doi" => "10.1016/S0210-5705(01)70167-7"
    "estado" => "S300"
    "fechaPublicacion" => "2001-01-01"
    "aid" => "70167"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Gastroenterol Hepatol. 2001;24:256-67"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 10893
      "formatos" => array:3 [
        "EPUB" => 7
        "HTML" => 6577
        "PDF" => 4309
      ]
    ]
    "es" => array:7 [
      "idiomaDefecto" => true
      "titulo" => "La barrera intestinal: trastornos funcionales en enfermedades digestivas y extradigestivas"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "256"
          "paginaFinal" => "267"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S. Pascual, J. Martínez, M. Pérez-Mateo"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "S."
              "apellidos" => "Pascual"
            ]
            1 => array:2 [
              "nombre" => "J."
              "apellidos" => "Martínez"
            ]
            2 => array:2 [
              "nombre" => "M."
              "apellidos" => "Pérez-Mateo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501701677?idApp=UINPBA00004N"
    "url" => "/02105705/0000002400000005/v1_201307171026/S0210570501701677/v1_201307171026/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0210570501701653"
    "issn" => "02105705"
    "doi" => "10.1016/S0210-5705(01)70165-3"
    "estado" => "S300"
    "fechaPublicacion" => "2001-01-01"
    "aid" => "70165"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Gastroenterol Hepatol. 2001;24:247-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4196
      "formatos" => array:3 [
        "EPUB" => 16
        "HTML" => 2800
        "PDF" => 1380
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Quiste epidermoide: una causa infrecuente de patología quística hepática"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "247"
          "paginaFinal" => "249"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Epidermoid cyst: a rare cause of cystic liver disease"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Fernández-Castroagudín, M.Bustamante Montalvo, M.Delgado Blanco, A. González-Quintela, E. Varo Pérez, E.Pintos Martínez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "J."
              "apellidos" => "Fernández-Castroagudín"
            ]
            1 => array:2 [
              "nombre" => "M.Bustamante"
              "apellidos" => "Montalvo"
            ]
            2 => array:2 [
              "nombre" => "M.Delgado"
              "apellidos" => "Blanco"
            ]
            3 => array:2 [
              "nombre" => "A."
              "apellidos" => "González-Quintela"
            ]
            4 => array:2 [
              "nombre" => "E."
              "apellidos" => "Varo Pérez"
            ]
            5 => array:2 [
              "nombre" => "E.Pintos"
              "apellidos" => "Martínez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501701653?idApp=UINPBA00004N"
    "url" => "/02105705/0000002400000005/v1_201307171026/S0210570501701653/v1_201307171026/es/main.assets"
  ]
  "es" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Utilidad de los de registros de hepatotoxicidad por fármacos"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "250"
        "paginaFinal" => "255"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R.J. Andrade, M.I. Lucena, M. García-Cortés"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "R.J."
            "apellidos" => "Andrade"
            "email" => array:1 [
              0 => "andrade@uma.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;I&#46;"
            "apellidos" => "Lucena"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Garc&#237;a-Cort&#233;s"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Hepatolog&#237;a&#44; Servicio de Aparato Digestivo&#46;ospital Universitario Virgen de la Victoria&#46; Facultad de Medicina&#46; M&#225;laga"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Farmacolog&#237;a Cl&#237;nica&#46; Hospital Universitario Virgen de la Victoria&#46; Facultad de Medicina&#46; M&#225;laga"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Dr&#46; R&#46; J&#46; Andrade&#46; Unidad de Hepatolog&#237;a&#46; Departamento de Medicina&#46; Facultad de Medicina&#46; Campus Universitario de Teatinos&#44; s&#47;n&#46; 29071 M&#225;laga&#46;"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2001-01-31"
    "fechaAceptado" => "2001-01-31"
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:38 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "H&#233;patotoxicit&#233; des m&#233;dicaments&#46; 13emise &#225; jour du fichier bibliographique des atteintes h&#233;patiques et des m&#233;dicaments reponsables"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Biour"
                            1 => "R&#46; Poupon"
                            2 => "J-D Grang&#233;"
                            3 => "O&#46; Chazouilleres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterol Clin Biol"
                        "fecha" => "2000"
                        "volumen" => "24"
                        "paginaInicial" => "1052"
                        "paginaFinal" => "1091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11139675"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatotoxicity&#58; the adverse effects of drugs and other chemicals on the liver"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;J&#46; Zimmmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1999"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benhamou J-P&#46; Fulminant and subfulminant liver failure&#58; definitions and causes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Bernuau"
                            1 => "B&#46; Rueff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-2008-1040593"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Liver Dis"
                        "fecha" => "1986"
                        "volumen" => "6"
                        "paginaInicial" => "97"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3529410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fulminant hepatic failure caused by ecarazine hydrochloride &#40;a hydralazine derivative&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Tameda"
                            1 => "M&#46; Hamada"
                            2 => "K&#46; Takase"
                            3 => "T&#46; Nakano"
                            4 => "Y&#46; Kosaka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jhep.1996.v23.pm0008617425"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "1996"
                        "volumen" => "23"
                        "paginaInicial" => "465"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8617425"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug safety discontinuations in the United Kingdom&#44; the United States&#44; and Spain from 1974 through 1993&#58; a regulatory perspective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46;M&#46; Bakke"
                            1 => "M&#46; Manocchia"
                            2 => "F&#46; De Abajo"
                            3 => "K&#46;I&#46; Kaitin"
                            4 => "L&#46; Lasagna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0009-9236(95)90078-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther"
                        "fecha" => "1995"
                        "volumen" => "58"
                        "paginaInicial" => "108"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7628177"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatotoxicity in drug development&#58; detection&#44; significance and solutions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Ballet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "1997"
                        "volumen" => "26"
                        "numero" => "Supl 2"
                        "paginaInicial" => "26"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9204407"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug-induced liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Larrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2000"
                        "volumen" => "32"
                        "numero" => "Supl 1"
                        "paginaInicial" => "77"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10728796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute liver injury associated with the use of ebrotidine&#44; a new H2-receptor antagonist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "R&#46; Mart&#237;n-Vivaldi"
                            3 => "M&#46;C&#46; Fern&#225;ndez"
                            4 => "F&#46; Nogueras"
                            5 => "G&#46; Pel&#225;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "1999"
                        "volumen" => "31"
                        "paginaInicial" => "641"
                        "paginaFinal" => "646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10551387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Nuevas perspectivas de la farmacovigilancia en Espa&#241;a y en la Uni&#243;n Europea"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Notificaci&#243;n voluntaria de reacciones adversas a medicamentos&#46; Tarjeta amarilla&#46; Divisi&#243; de Farmacolog&#237;a Cl&#237;nica&#46; Institut Catal&#225; de Farmacolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Informe anual"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Universitat Aut&#243;noma de Barcelona&#44; abril"
                        "fecha" => "1984"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El sistema espa&#241;ol de farmacovigilancia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J-R Laporte"
                            1 => "D&#46; Capell&#225;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1994"
                        "volumen" => "103"
                        "paginaInicial" => "335"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El sistema espa&#241;ol de farmacovigilancia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Madurga"
                            1 => "F&#46;J&#46; De Abajo"
                            2 => "G&#46; Mart&#237;n-Serrano"
                            3 => "D&#46; Montero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Nuevas perspectivas de la farmacovigilancia en Espa&#241;a y en la Uni&#243;n Europea"
                        "paginaInicial" => "37"
                        "paginaFinal" => "61"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La farmacovigilancia en Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;J&#46; De Abajo"
                            1 => "M&#46; Madurga"
                            2 => "J&#46;F&#46; Olalla"
                            3 => "R&#46; Palop"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Madrid&#58; Instituto de Salud Carlos III"
                        "fecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Farmacoepidemiolog&#237;a&#46; Secretariado de Publicaciones&#46; Universidad de Valladolid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Carvajal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Valladolid"
                        "fecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Under-reporting of adverse drug reactions&#46; Estimate based on a spontaneous reporting scheme and a sentinel system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; &#193;lvarez-Requejo"
                            1 => "A&#46; Carvajal"
                            2 => "B&#46; B&#233;gaud"
                            3 => "Y&#46; Moride"
                            4 => "T&#46; Vega"
                            5 => "L&#46;H&#46; Arias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Pharmacol"
                        "fecha" => "1998"
                        "volumen" => "54"
                        "paginaInicial" => "483"
                        "paginaFinal" => "488"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9776440"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bentazepamassociated chronic liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "R&#46; Alc&#225;ntara"
                            3 => "J&#46;M&#46; Fraile"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1994"
                        "volumen" => "343"
                        "paginaInicial" => "860"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7908110"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatic injury caused by acarbose"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "M&#46; Rodr&#237;guez-Mendizabal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1996"
                        "volumen" => "124"
                        "paginaInicial" => "931"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8610938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tolcapone and fulminant hepatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Assal"
                            1 => "L&#46; Spahr"
                            2 => "A&#46; Hadengue"
                            3 => "L&#46; Rubbia-Brandt"
                            4 => "P&#46;R&#46; Burkhard"
                            5 => "L&#46; Rubbici-Bandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)61512-7"
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1998"
                        "volumen" => "352"
                        "paginaInicial" => "958"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9752822"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La carta al director"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Erill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1997"
                        "volumen" => "109"
                        "paginaInicial" => "513"
                        "paginaFinal" => "514"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of UK General Practice Research Database for pharmacoepidemiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;A&#46; Garc&#237;a-Rodr&#237;guez"
                            1 => "S&#46; P&#233;rez-Gutthann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Clin Pharmacol"
                        "fecha" => "1998"
                        "volumen" => "45"
                        "paginaInicial" => "419"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9643612"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of information recorded on general practitioner based computerised data resource in the United Kingdom"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Jick"
                            1 => "S&#46;S&#46; Jick"
                            2 => "L&#46; Derby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1991"
                        "volumen" => "302"
                        "paginaInicial" => "766"
                        "paginaFinal" => "768"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The risk of acute liver injury associated with cimetidine and other acidsuppressing anti-ulcer drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;A&#46; Garc&#237;a-Rodr&#237;guez"
                            1 => "M-A Wallander"
                            2 => "B&#46;H&#46; Stricker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Clin Pharmacol"
                        "fecha" => "1997"
                        "volumen" => "43"
                        "paginaInicial" => "183"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9131951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of nonsteroidal anti-inflammatory drugs in acute liver injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;A&#46; Garc&#237;a-Rodr&#237;guez"
                            1 => "S&#46; P&#233;rez-Gutthan"
                            2 => "A&#46;M&#46; Walker"
                            3 => "L&#46; Lueck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1992"
                        "volumen" => "305"
                        "paginaInicial" => "1865"
                        "paginaFinal" => "1868"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The increased risk of hospitalization fo acute liver injury in a population with exposure to multiples drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Perez-Guttham"
                            1 => "L&#46;A&#46; Garc&#237;a-Rodr&#237;guez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Epidemiology"
                        "fecha" => "1993"
                        "volumen" => "4"
                        "paginaInicial" => "496"
                        "paginaFinal" => "501"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8268277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug-induced acute liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;L&#46; Carson"
                            1 => "A&#46; Duff"
                            2 => "B&#46;L&#46; Strom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharmacoepidemiol Drug Safety"
                        "fecha" => "1993"
                        "volumen" => "2"
                        "paginaInicial" => "S19"
                        "paginaFinal" => "S23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drug-induced liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Jick"
                            1 => "A&#46;M&#46; Walker"
                            2 => "J&#46; Porter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "1981"
                        "volumen" => "21"
                        "paginaInicial" => "359"
                        "paginaFinal" => "364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7276230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proyecto de reacciones adversas hepatot&#243;xicas en Andaluc&#237;a&#58; resultados preliminares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "J&#46;M&#46; P&#233;rez-Moreno"
                            3 => "M&#46;C&#46; Fern&#225;ndez"
                            4 => "R&#46; Mart&#237;n-Vivaldi"
                            5 => "M&#46; Ramos-Lora"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev And Patol Digest"
                        "fecha" => "1998"
                        "volumen" => "21"
                        "paginaInicial" => "70"
                        "paginaFinal" => "76"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of hepatic adverse drug reactions in one English health region"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;P&#46; Aithal"
                            1 => "M&#46;D&#46; Rawlins"
                            2 => "C&#46;P&#46; Day"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1999"
                        "volumen" => "319"
                        "paginaInicial" => "1541"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe idiosyncratic acute hepatic injury caused by paracetamol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "M&#46;D&#46; Garc&#237;a-Esca&#241;o"
                            3 => "R&#46; Camargo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "1998"
                        "volumen" => "28"
                        "paginaInicial" => "1078"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9672188"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trovafloxacin-induced acute hepatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;I&#46; Lucena"
                            1 => "R&#46;J&#46; Andrade"
                            2 => "L&#46; Rodrigo"
                            3 => "J&#46; Salmer&#243;n"
                            4 => "A&#46; &#193;lvarez"
                            5 => "M&#46;A&#46; L&#243;pez-Garrido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/313680"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2000"
                        "volumen" => "30"
                        "paginaInicial" => "400"
                        "paginaFinal" => "401"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10671353"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Garc&#237;a-Cort&#233;s M&#44; Andrade RJ&#44; Lucena MI&#44; S&#225;nchez-Mart&#237;nez H&#44; Fern&#225;ndez MC&#44; Ferrer T et al&#46; Hepatotoxicidad por flutamida&#58; an&#225;lisis de una serie y revisi&#243;n de la literatura&#46; Rev Esp Enferm Digest 2001&#46; En prensa&#46;"
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatotoxicidad por paracetamol a dosis terap&#233;uticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "M&#46;C&#46; Fern&#225;ndez-S&#225;nchez"
                            3 => "G&#46; Pel&#225;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1997"
                        "volumen" => "109"
                        "paginaInicial" => "317"
                        "paginaFinal" => "318"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Hepatotoxicidad por isoniacida o por paracetamol&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "F&#46; Melgarejo"
                            3 => "MD&#46; Garc&#237;a-Esca&#241;o"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterol Hepatol"
                        "fecha" => "1998"
                        "volumen" => "21"
                        "paginaInicial" => "314"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9711017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Criteria for drug-induced liver disorders&#46; Report of an International Consensus Meeting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; B&#233;nichou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "1990"
                        "volumen" => "11"
                        "paginaInicial" => "272"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2254635"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Causality assessment of adverse drug reactions to drugs I&#46; A novel method based on the conclusions of international consensus meetings&#58; application to drug-induced liver injuries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Danan"
                            1 => "C&#46; B&#233;nichou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "1993"
                        "volumen" => "46"
                        "paginaInicial" => "1323"
                        "paginaFinal" => "1330"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8229110"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Victorino RMM&#46; Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46;A&#46;J&#46; Maria"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.510260319"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "1997"
                        "volumen" => "26"
                        "paginaInicial" => "664"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9303497"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of two clinical scales for causality assessment in hepatotoxicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;I&#46; Lucena"
                            1 => "R&#46; Camargo"
                            2 => "R&#46;J&#46; Andrade"
                            3 => "C&#46; Perez-S&#225;nchez"
                            4 => "F&#46; S&#225;nchez de la Cuesta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jhep.2001.20645"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2001"
                        "volumen" => "33"
                        "paginaInicial" => "123"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11124828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatolog&#237;a cl&#237;nica y farmacoepidemiolog&#237;a&#58; un enfoque multidisciplinar pendiente"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Andrade"
                            1 => "M&#46;I&#46; Lucena"
                            2 => "G&#46; Tognoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterol Hepatol"
                        "fecha" => "1998"
                        "volumen" => "21"
                        "paginaInicial" => "449"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9882937"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02105705/0000002400000005/v1_201307171026/S0210570501701665/v1_201307171026/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "15964"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Progresos en hepatolog&#237;a"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02105705/0000002400000005/v1_201307171026/S0210570501701665/v1_201307171026/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501701665?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 02105705
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 6 0 6
2024 Octubre 6 5 11
2024 Septiembre 9 7 16
2024 Agosto 7 6 13
2024 Julio 9 14 23
2024 Junio 12 13 25
2024 Mayo 6 4 10
2024 Abril 9 13 22
2024 Marzo 13 26 39
2024 Febrero 11 12 23
2024 Enero 11 12 23
2023 Diciembre 14 22 36
2023 Noviembre 16 37 53
2023 Octubre 12 27 39
2023 Septiembre 6 10 16
2023 Agosto 8 8 16
2023 Julio 5 15 20
2023 Junio 7 19 26
2023 Mayo 34 4 38
2023 Abril 26 4 30
2023 Marzo 21 8 29
2023 Febrero 5 9 14
2023 Enero 7 14 21
2022 Diciembre 6 11 17
2022 Noviembre 6 10 16
2022 Octubre 18 18 36
2022 Septiembre 8 33 41
2022 Agosto 12 17 29
2022 Julio 10 16 26
2022 Junio 11 10 21
2022 Mayo 12 10 22
2022 Abril 29 15 44
2022 Marzo 32 7 39
2022 Febrero 16 6 22
2022 Enero 23 10 33
2021 Diciembre 11 12 23
2021 Noviembre 6 19 25
2021 Octubre 27 21 48
2021 Septiembre 22 9 31
2021 Agosto 32 9 41
2021 Julio 23 11 34
2021 Junio 9 11 20
2021 Mayo 7 10 17
2021 Abril 26 55 81
2021 Marzo 49 28 77
2021 Febrero 13 11 24
2021 Enero 6 8 14
2020 Diciembre 7 14 21
2020 Noviembre 7 9 16
2020 Octubre 3 5 8
2020 Septiembre 15 13 28
2020 Agosto 10 15 25
2020 Julio 9 11 20
2020 Junio 4 7 11
2020 Mayo 8 11 19
2020 Abril 7 19 26
2020 Marzo 12 6 18
2020 Febrero 10 22 32
2020 Enero 8 11 19
2019 Diciembre 20 25 45
2019 Noviembre 7 8 15
2019 Octubre 16 5 21
2019 Septiembre 15 19 34
2019 Agosto 3 13 16
2019 Julio 14 36 50
2019 Junio 19 37 56
2019 Mayo 54 104 158
2019 Abril 8 48 56
2019 Marzo 7 7 14
2019 Febrero 9 21 30
2019 Enero 9 10 19
2018 Diciembre 15 18 33
2018 Noviembre 16 16 32
2018 Octubre 15 19 34
2018 Septiembre 5 2 7
2018 Agosto 3 9 12
2018 Julio 1 7 8
2018 Junio 0 8 8
2018 Mayo 1 11 12
2018 Abril 3 1 4
2018 Marzo 2 1 3
2018 Febrero 5 1 6
2018 Enero 1 5 6
2017 Diciembre 2 0 2
2017 Noviembre 6 10 16
2017 Octubre 9 1 10
2017 Septiembre 5 6 11
2017 Agosto 5 2 7
2017 Julio 8 3 11
2017 Junio 9 8 17
2017 Mayo 8 7 15
2017 Abril 12 10 22
2017 Marzo 16 13 29
2017 Febrero 11 5 16
2017 Enero 10 0 10
2016 Diciembre 30 9 39
2016 Noviembre 36 5 41
2016 Octubre 45 2 47
2016 Septiembre 25 10 35
2016 Agosto 15 3 18
2016 Julio 14 2 16
2016 Junio 19 6 25
2016 Mayo 11 4 15
2016 Abril 15 5 20
2016 Marzo 13 6 19
2016 Febrero 14 9 23
2016 Enero 13 8 21
2015 Diciembre 15 2 17
2015 Noviembre 14 8 22
2015 Octubre 25 3 28
2015 Septiembre 9 3 12
2015 Agosto 35 1 36
2015 Julio 33 5 38
2015 Junio 15 5 20
2015 Mayo 29 3 32
2015 Abril 25 10 35
2015 Marzo 13 3 16
2015 Febrero 11 5 16
2015 Enero 16 4 20
2014 Diciembre 29 2 31
2014 Noviembre 15 1 16
2014 Octubre 30 0 30
2014 Septiembre 21 3 24
2014 Agosto 29 2 31
2014 Julio 28 1 29
2014 Junio 35 1 36
2014 Mayo 18 2 20
2014 Abril 13 3 16
2014 Marzo 21 3 24
2014 Febrero 18 2 20
2014 Enero 18 3 21
2013 Diciembre 18 0 18
2013 Noviembre 20 3 23
2013 Octubre 19 7 26
2013 Septiembre 17 8 25
2013 Agosto 19 5 24
2013 Julio 18 2 20
2001 Abril 639 0 639
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos