array:23 [ "pii" => "S0210570501701665" "issn" => "02105705" "doi" => "10.1016/S0210-5705(01)70166-5" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "70166" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Gastroenterol Hepatol. 2001;24:250-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2580 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 1879 "PDF" => 691 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210570501701677" "issn" => "02105705" "doi" => "10.1016/S0210-5705(01)70167-7" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "70167" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Gastroenterol Hepatol. 2001;24:256-67" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 10893 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 6577 "PDF" => 4309 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "La barrera intestinal: trastornos funcionales en enfermedades digestivas y extradigestivas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "256" "paginaFinal" => "267" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Pascual, J. Martínez, M. Pérez-Mateo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Pascual" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Martínez" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Pérez-Mateo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501701677?idApp=UINPBA00004N" "url" => "/02105705/0000002400000005/v1_201307171026/S0210570501701677/v1_201307171026/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210570501701653" "issn" => "02105705" "doi" => "10.1016/S0210-5705(01)70165-3" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "70165" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Gastroenterol Hepatol. 2001;24:247-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4196 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 2800 "PDF" => 1380 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Quiste epidermoide: una causa infrecuente de patología quística hepática" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "247" "paginaFinal" => "249" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidermoid cyst: a rare cause of cystic liver disease" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Fernández-Castroagudín, M.Bustamante Montalvo, M.Delgado Blanco, A. González-Quintela, E. Varo Pérez, E.Pintos Martínez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Fernández-Castroagudín" ] 1 => array:2 [ "nombre" => "M.Bustamante" "apellidos" => "Montalvo" ] 2 => array:2 [ "nombre" => "M.Delgado" "apellidos" => "Blanco" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "González-Quintela" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Varo Pérez" ] 5 => array:2 [ "nombre" => "E.Pintos" "apellidos" => "Martínez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501701653?idApp=UINPBA00004N" "url" => "/02105705/0000002400000005/v1_201307171026/S0210570501701653/v1_201307171026/es/main.assets" ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Utilidad de los de registros de hepatotoxicidad por fármacos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "250" "paginaFinal" => "255" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R.J. Andrade, M.I. Lucena, M. García-Cortés" "autores" => array:3 [ 0 => array:4 [ "nombre" => "R.J." "apellidos" => "Andrade" "email" => array:1 [ 0 => "andrade@uma.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.I." "apellidos" => "Lucena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "García-Cortés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Hepatología, Servicio de Aparato Digestivo.ospital Universitario Virgen de la Victoria. Facultad de Medicina. Málaga" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Farmacología Clínica. Hospital Universitario Virgen de la Victoria. Facultad de Medicina. Málaga" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. R. J. Andrade. Unidad de Hepatología. Departamento de Medicina. Facultad de Medicina. Campus Universitario de Teatinos, s/n. 29071 Málaga." ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-01-31" "fechaAceptado" => "2001-01-31" "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hépatotoxicité des médicaments. 13emise á jour du fichier bibliographique des atteintes hépatiques et des médicaments reponsables" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Biour" 1 => "R. Poupon" 2 => "J-D Grangé" 3 => "O. Chazouilleres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterol Clin Biol" "fecha" => "2000" "volumen" => "24" "paginaInicial" => "1052" "paginaFinal" => "1091" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11139675" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.J. Zimmmerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1999" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benhamou J-P. Fulminant and subfulminant liver failure: definitions and causes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Bernuau" 1 => "B. Rueff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2008-1040593" "Revista" => array:6 [ "tituloSerie" => "Semin Liver Dis" "fecha" => "1986" "volumen" => "6" "paginaInicial" => "97" "paginaFinal" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3529410" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fulminant hepatic failure caused by ecarazine hydrochloride (a hydralazine derivative)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Tameda" 1 => "M. Hamada" 2 => "K. Takase" 3 => "T. Nakano" 4 => "Y. Kosaka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.1996.v23.pm0008617425" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "1996" "volumen" => "23" "paginaInicial" => "465" "paginaFinal" => "470" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8617425" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: a regulatory perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "O.M. Bakke" 1 => "M. Manocchia" 2 => "F. De Abajo" 3 => "K.I. Kaitin" 4 => "L. Lasagna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0009-9236(95)90078-0" "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther" "fecha" => "1995" "volumen" => "58" "paginaInicial" => "108" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7628177" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatotoxicity in drug development: detection, significance and solutions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Ballet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Hepatol" "fecha" => "1997" "volumen" => "26" "numero" => "Supl 2" "paginaInicial" => "26" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9204407" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Larrey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Hepatol" "fecha" => "2000" "volumen" => "32" "numero" => "Supl 1" "paginaInicial" => "77" "paginaFinal" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10728796" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "R. Martín-Vivaldi" 3 => "M.C. Fernández" 4 => "F. Nogueras" 5 => "G. Peláez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "1999" "volumen" => "31" "paginaInicial" => "641" "paginaFinal" => "646" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10551387" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Nuevas perspectivas de la farmacovigilancia en España y en la Unión Europea" "serieFecha" => "1998" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Notificación voluntaria de reacciones adversas a medicamentos. Tarjeta amarilla. Divisió de Farmacología Clínica. Institut Catalá de Farmacología" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Informe anual" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Universitat Autónoma de Barcelona, abril" "fecha" => "1984" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El sistema español de farmacovigilancia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J-R Laporte" 1 => "D. Capellá" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1994" "volumen" => "103" "paginaInicial" => "335" "paginaFinal" => "336" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El sistema español de farmacovigilancia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Madurga" 1 => "F.J. De Abajo" 2 => "G. Martín-Serrano" 3 => "D. Montero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Nuevas perspectivas de la farmacovigilancia en España y en la Unión Europea" "paginaInicial" => "37" "paginaFinal" => "61" "serieFecha" => "1998" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La farmacovigilancia en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.J. De Abajo" 1 => "M. Madurga" 2 => "J.F. Olalla" 3 => "R. Palop" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Madrid: Instituto de Salud Carlos III" "fecha" => "1992" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Farmacoepidemiología. Secretariado de Publicaciones. Universidad de Valladolid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Carvajal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Valladolid" "fecha" => "1994" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Álvarez-Requejo" 1 => "A. Carvajal" 2 => "B. Bégaud" 3 => "Y. Moride" 4 => "T. Vega" 5 => "L.H. Arias" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Pharmacol" "fecha" => "1998" "volumen" => "54" "paginaInicial" => "483" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9776440" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bentazepamassociated chronic liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "R. Alcántara" 3 => "J.M. Fraile" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1994" "volumen" => "343" "paginaInicial" => "860" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7908110" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatic injury caused by acarbose" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "M. Rodríguez-Mendizabal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1996" "volumen" => "124" "paginaInicial" => "931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8610938" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tolcapone and fulminant hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Assal" 1 => "L. Spahr" 2 => "A. Hadengue" 3 => "L. Rubbia-Brandt" 4 => "P.R. Burkhard" 5 => "L. Rubbici-Bandt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)61512-7" "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "352" "paginaInicial" => "958" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9752822" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La carta al director" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Erill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1997" "volumen" => "109" "paginaInicial" => "513" "paginaFinal" => "514" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of UK General Practice Research Database for pharmacoepidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.A. García-Rodríguez" 1 => "S. Pérez-Gutthann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "1998" "volumen" => "45" "paginaInicial" => "419" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9643612" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of information recorded on general practitioner based computerised data resource in the United Kingdom" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Jick" 1 => "S.S. Jick" 2 => "L. Derby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1991" "volumen" => "302" "paginaInicial" => "766" "paginaFinal" => "768" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The risk of acute liver injury associated with cimetidine and other acidsuppressing anti-ulcer drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.A. García-Rodríguez" 1 => "M-A Wallander" 2 => "B.H. Stricker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "1997" "volumen" => "43" "paginaInicial" => "183" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9131951" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of nonsteroidal anti-inflammatory drugs in acute liver injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.A. García-Rodríguez" 1 => "S. Pérez-Gutthan" 2 => "A.M. Walker" 3 => "L. Lueck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1992" "volumen" => "305" "paginaInicial" => "1865" "paginaFinal" => "1868" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The increased risk of hospitalization fo acute liver injury in a population with exposure to multiples drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Perez-Guttham" 1 => "L.A. García-Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Epidemiology" "fecha" => "1993" "volumen" => "4" "paginaInicial" => "496" "paginaFinal" => "501" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8268277" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced acute liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Carson" 1 => "A. Duff" 2 => "B.L. Strom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pharmacoepidemiol Drug Safety" "fecha" => "1993" "volumen" => "2" "paginaInicial" => "S19" "paginaFinal" => "S23" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Jick" 1 => "A.M. Walker" 2 => "J. Porter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pharmacol" "fecha" => "1981" "volumen" => "21" "paginaInicial" => "359" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7276230" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proyecto de reacciones adversas hepatotóxicas en Andalucía: resultados preliminares" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "J.M. Pérez-Moreno" 3 => "M.C. Fernández" 4 => "R. Martín-Vivaldi" 5 => "M. Ramos-Lora" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev And Patol Digest" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "70" "paginaFinal" => "76" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Accuracy of hepatic adverse drug reactions in one English health region" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.P. Aithal" 1 => "M.D. Rawlins" 2 => "C.P. Day" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Br Med J" "fecha" => "1999" "volumen" => "319" "paginaInicial" => "1541" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe idiosyncratic acute hepatic injury caused by paracetamol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "M.D. García-Escaño" 3 => "R. Camargo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Hepatol" "fecha" => "1998" "volumen" => "28" "paginaInicial" => "1078" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9672188" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trovafloxacin-induced acute hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.I. Lucena" 1 => "R.J. Andrade" 2 => "L. Rodrigo" 3 => "J. Salmerón" 4 => "A. Álvarez" 5 => "M.A. López-Garrido" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/313680" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2000" "volumen" => "30" "paginaInicial" => "400" "paginaFinal" => "401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10671353" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "García-Cortés M, Andrade RJ, Lucena MI, Sánchez-Martínez H, Fernández MC, Ferrer T et al. Hepatotoxicidad por flutamida: análisis de una serie y revisión de la literatura. Rev Esp Enferm Digest 2001. En prensa." ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatotoxicidad por paracetamol a dosis terapéuticas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "M.C. Fernández-Sánchez" 3 => "G. Peláez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1997" "volumen" => "109" "paginaInicial" => "317" "paginaFinal" => "318" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "¿Hepatotoxicidad por isoniacida o por paracetamol?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "F. Melgarejo" 3 => "MD. García-Escaño" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterol Hepatol" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "314" "paginaFinal" => "315" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9711017" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Criteria for drug-induced liver disorders. Report of an International Consensus Meeting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Bénichou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "1990" "volumen" => "11" "paginaInicial" => "272" "paginaFinal" => "276" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2254635" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Causality assessment of adverse drug reactions to drugs I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Danan" 1 => "C. Bénichou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Epidemiol" "fecha" => "1993" "volumen" => "46" "paginaInicial" => "1323" "paginaFinal" => "1330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8229110" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Victorino RMM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.A.J. Maria" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.510260319" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "1997" "volumen" => "26" "paginaInicial" => "664" "paginaFinal" => "669" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9303497" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of two clinical scales for causality assessment in hepatotoxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.I. Lucena" 1 => "R. Camargo" 2 => "R.J. Andrade" 3 => "C. Perez-Sánchez" 4 => "F. Sánchez de la Cuesta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.2001.20645" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2001" "volumen" => "33" "paginaInicial" => "123" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11124828" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatología clínica y farmacoepidemiología: un enfoque multidisciplinar pendiente" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.J. Andrade" 1 => "M.I. Lucena" 2 => "G. Tognoni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterol Hepatol" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "449" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9882937" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02105705/0000002400000005/v1_201307171026/S0210570501701665/v1_201307171026/es/main.assets" "Apartado" => array:4 [ "identificador" => "15964" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Progresos en hepatología" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105705/0000002400000005/v1_201307171026/S0210570501701665/v1_201307171026/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570501701665?idApp=UINPBA00004N" ]
Información de la revista
Vol. 24. Núm. 5.
Páginas 250-255 (enero 2001)
Vol. 24. Núm. 5.
Páginas 250-255 (enero 2001)
Acceso a texto completo
Utilidad de los de registros de hepatotoxicidad por fármacos
Visitas
4101
R.J. Andradea,
, M.I. Lucenab, M. García-Cortésa
Autor para correspondencia
andrade@uma.es
Correspondencia: Dr. R. J. Andrade. Unidad de Hepatología. Departamento de Medicina. Facultad de Medicina. Campus Universitario de Teatinos, s/n. 29071 Málaga.
Correspondencia: Dr. R. J. Andrade. Unidad de Hepatología. Departamento de Medicina. Facultad de Medicina. Campus Universitario de Teatinos, s/n. 29071 Málaga.
Este artículo ha recibido
Información del artículo
El Texto completo está disponible en PDF
Bibliografía
[1.]
M. Biour, R. Poupon, J-D Grangé, O. Chazouilleres.
Hépatotoxicité des médicaments. 13emise á jour du fichier bibliographique des atteintes hépatiques et des médicaments reponsables.
Gastroenterol Clin Biol, 24 (2000), pp. 1052-1091
[2.]
H.J. Zimmmerman.
Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver.
[3.]
J. Bernuau, B. Rueff.
Benhamou J-P. Fulminant and subfulminant liver failure: definitions and causes.
Semin Liver Dis, 6 (1986), pp. 97-106
[4.]
Y. Tameda, M. Hamada, K. Takase, T. Nakano, Y. Kosaka.
Fulminant hepatic failure caused by ecarazine hydrochloride (a hydralazine derivative).
Hepatology, 23 (1996), pp. 465-470
[5.]
O.M. Bakke, M. Manocchia, F. De Abajo, K.I. Kaitin, L. Lasagna.
Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: a regulatory perspective.
Clin Pharmacol Ther, 58 (1995), pp. 108-117
[6.]
F. Ballet.
Hepatotoxicity in drug development: detection, significance and solutions.
J Hepatol, 26 (1997), pp. 26-36
[8.]
R.J. Andrade, M.I. Lucena, R. Martín-Vivaldi, M.C. Fernández, F. Nogueras, G. Peláez, et al.
Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist.
J Hepatol, 31 (1999), pp. 641-646
[9.]
Nuevas perspectivas de la farmacovigilancia en España y en la Unión Europea,
[10.]
Informe anual.
Notificación voluntaria de reacciones adversas a medicamentos. Tarjeta amarilla. Divisió de Farmacología Clínica. Institut Catalá de Farmacología.
Universitat Autónoma de Barcelona, abril, (1984),
[11.]
J-R Laporte, D. Capellá.
El sistema español de farmacovigilancia.
Med Clin (Barc), 103 (1994), pp. 335-336
[12.]
M. Madurga, F.J. De Abajo, G. Martín-Serrano, D. Montero.
El sistema español de farmacovigilancia.
Nuevas perspectivas de la farmacovigilancia en España y en la Unión Europea, pp. 37-61
[13.]
F.J. De Abajo, M. Madurga, J.F. Olalla, R. Palop.
La farmacovigilancia en España.
Madrid: Instituto de Salud Carlos III, (1992),
[14.]
A. Carvajal.
Farmacoepidemiología. Secretariado de Publicaciones. Universidad de Valladolid.
Valladolid, (1994),
[15.]
A. Álvarez-Requejo, A. Carvajal, B. Bégaud, Y. Moride, T. Vega, L.H. Arias, et al.
Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system.
Eur J Clin Pharmacol, 54 (1998), pp. 483-488
[16.]
R.J. Andrade, M.I. Lucena, R. Alcántara, J.M. Fraile.
Bentazepamassociated chronic liver disease.
Lancet, 343 (1994), pp. 860
[17.]
R.J. Andrade, M.I. Lucena, M. Rodríguez-Mendizabal.
Hepatic injury caused by acarbose.
Ann Intern Med, 124 (1996), pp. 931
[18.]
F. Assal, L. Spahr, A. Hadengue, L. Rubbia-Brandt, P.R. Burkhard, L. Rubbici-Bandt.
Tolcapone and fulminant hepatitis.
Lancet, 352 (1998), pp. 958
[19.]
S. Erill.
La carta al director.
Med Clin (Barc), 109 (1997), pp. 513-514
[20.]
L.A. García-Rodríguez, S. Pérez-Gutthann.
Use of UK General Practice Research Database for pharmacoepidemiology.
Br J Clin Pharmacol, 45 (1998), pp. 419-425
[21.]
H. Jick, S.S. Jick, L. Derby.
Validation of information recorded on general practitioner based computerised data resource in the United Kingdom.
Br Med J, 302 (1991), pp. 766-768
[22.]
L.A. García-Rodríguez, M-A Wallander, B.H. Stricker.
The risk of acute liver injury associated with cimetidine and other acidsuppressing anti-ulcer drugs.
Br J Clin Pharmacol, 43 (1997), pp. 183-188
[23.]
L.A. García-Rodríguez, S. Pérez-Gutthan, A.M. Walker, L. Lueck.
The role of nonsteroidal anti-inflammatory drugs in acute liver injury.
Br Med J, 305 (1992), pp. 1865-1868
[24.]
S. Perez-Guttham, L.A. García-Rodríguez.
The increased risk of hospitalization fo acute liver injury in a population with exposure to multiples drugs.
Epidemiology, 4 (1993), pp. 496-501
[25.]
J.L. Carson, A. Duff, B.L. Strom.
Drug-induced acute liver disease.
Pharmacoepidemiol Drug Safety, 2 (1993), pp. S19-S23
[26.]
H. Jick, A.M. Walker, J. Porter.
Drug-induced liver disease.
J Clin Pharmacol, 21 (1981), pp. 359-364
[27.]
R.J. Andrade, M.I. Lucena, J.M. Pérez-Moreno, M.C. Fernández, R. Martín-Vivaldi, M. Ramos-Lora, et al.
Proyecto de reacciones adversas hepatotóxicas en Andalucía: resultados preliminares.
Rev And Patol Digest, 21 (1998), pp. 70-76
[28.]
G.P. Aithal, M.D. Rawlins, C.P. Day.
Accuracy of hepatic adverse drug reactions in one English health region.
Br Med J, 319 (1999), pp. 1541
[29.]
R.J. Andrade, M.I. Lucena, M.D. García-Escaño, R. Camargo.
Severe idiosyncratic acute hepatic injury caused by paracetamol.
J Hepatol, 28 (1998), pp. 1078
[30.]
M.I. Lucena, R.J. Andrade, L. Rodrigo, J. Salmerón, A. Álvarez, M.A. López-Garrido, et al.
Trovafloxacin-induced acute hepatitis.
Clin Infect Dis, 30 (2000), pp. 400-401
[31.]
García-Cortés M, Andrade RJ, Lucena MI, Sánchez-Martínez H, Fernández MC, Ferrer T et al. Hepatotoxicidad por flutamida: análisis de una serie y revisión de la literatura. Rev Esp Enferm Digest 2001. En prensa.
[32.]
R.J. Andrade, M.I. Lucena, M.C. Fernández-Sánchez, G. Peláez.
Hepatotoxicidad por paracetamol a dosis terapéuticas.
Med Clin (Barc), 109 (1997), pp. 317-318
[33.]
R.J. Andrade, M.I. Lucena, F. Melgarejo, MD. García-Escaño.
¿Hepatotoxicidad por isoniacida o por paracetamol?.
Gastroenterol Hepatol, 21 (1998), pp. 314-315
[34.]
C. Bénichou.
Criteria for drug-induced liver disorders. Report of an International Consensus Meeting.
J Hepatol, 11 (1990), pp. 272-276
[35.]
G. Danan, C. Bénichou.
Causality assessment of adverse drug reactions to drugs I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
J Clin Epidemiol, 46 (1993), pp. 1323-1330
[36.]
V.A.J. Maria.
Victorino RMM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis.
Hepatology, 26 (1997), pp. 664-669
[37.]
M.I. Lucena, R. Camargo, R.J. Andrade, C. Perez-Sánchez, F. Sánchez de la Cuesta.
Comparison of two clinical scales for causality assessment in hepatotoxicity.
Hepatology, 33 (2001), pp. 123-130
Copyright © 2001. Elsevier España, S.L.. Todos los derechos reservados