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Úlceras de Cameron e inhibidores de la recaptación de serotonina: una asociación infrecuente
Cameron lesions and selective serotonin reuptake inhibitors: An uncommon combination
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(A) The distribution by age, sex and degree of pigmentation of 750 patients suffering from MC. As shown in (A1), women aged 50–59 years old accounted for most of the cases, while the most cases in men were found in the group aged 60–69 years. As shown in (A2), as the degree of pigmentation increased, the percentage of cases decreased. (B) Relationship between the melanosis score and the number of affected segments. The colon was divided into six parts, including the cecum, ascending colon, transverse colon, descending colon, sigmoid colon and rectum. The intensity of melanosis was determined by calculating the sum of the melanosis grades of individual segments. The grade of melanosis in each segment ranged from 0 to 3 according to the degree of pigmentation. As the melanosis score increased, the number of affected segments increased, and the number of patients decreased. Therefore, compared with a few affected segments with severe pathological character, more affected segments with lower grade of melanosis are easier to be seen in the same score of MC. (C) A total of 417 segments were affected by MC in 119 patients. As shown in (C1), the patients included both men and women. Only men are shown in (C2), and only women are shown in (C3). The incidence of affected segments was relatively higher for the ascending colon and transverse colon and lower for the sigmoid colon and rectum in both men and women.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ningning Yang, Mengting Ruan, Shizhu Jin" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ningning" "apellidos" => "Yang" ] 1 => array:2 [ "nombre" => "Mengting" "apellidos" => "Ruan" ] 2 => array:2 [ "nombre" => "Shizhu" "apellidos" => "Jin" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444382420300547" "doi" => "10.1016/j.gastre.2020.01.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300547?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570520300224?idApp=UINPBA00004N" "url" => "/02105705/0000004300000005/v1_202005010648/S0210570520300224/v1_202005010648/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0210570519302559" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2019.10.003" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "1462" "copyright" => "Elsevier España, S.L.U." 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Zhuraida Salman Monte" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Marta" "apellidos" => "Izquierdo Romero" "email" => array:1 [ 0 => "martaizquierdoromero@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Jorge" "apellidos" => "Rodríguez Prida" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Benito" "apellidos" => "Hermida Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Zhuraida" "apellidos" => "Salman Monte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Aparato Digestivo, Hospital Universitario de Cabueñes, Gijón, Asturias, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario de Cabueñes, Gijón, Asturias, España" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cameron lesions and selective serotonin reuptake inhibitors: An uncommon combination" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 589 "Ancho" => 750 "Tamanyo" => 98279 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen endoscópica en retroflexión de erosiones lineales múltiples en saco herniario compatibles con úlceras de Cameron.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Mujer de 66 años con cuadro de vómitos en posos de café y melenas, sin otra clínica relevante. Entre sus antecedentes destacaba síndrome ansioso con trastorno de la personalidad, a tratamiento con fluoxetina y olanzapina. Analíticamente se evidenció una hemoglobina de 9,4<span class="elsevierStyleHsp" style=""></span>g/dl, lo que suponía una anemización de hasta 4 puntos respecto a sus valores habituales, así como urea 110<span class="elsevierStyleHsp" style=""></span>mg/dl, con creatinina normal. Se realizó gastroscopia evidenciando una hernia de hiato de gran tamaño con erosiones lineales múltiples compatibles con úlceras de Cameron, con escaso sangrado activo (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>). Se instauró tratamiento con inhibidores de la bomba de protones (IBP) a altas dosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Las úlceras de Cameron son lesiones únicas o múltiples de la mucosa gástrica que aparecen en el saco de una hernia hiatal, sobre todo si esta es de gran tamaño<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a>. Este tipo de lesiones son habitualmente un hallazgo incidental y constituyen una causa poco frecuente de hemorragia digestiva alta con repercusión hematimétrica o hemodinámica, lo que la convierte en una entidad infradiagnosticada<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a>. Los inhibidores selectivos de la recaptación de serotonina (ISRS) se han asociado clásicamente a un aumento del riesgo de sangrado gastrointestinal; un metaanálisis reciente parece confirmar dicha sospecha, demostrando un aumento del riesgo de sangrado de al menos un 36% con este grupo de fármacos<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a>. Además cabe recordar que los ISRS asociados a AAS/AINE son una indicación de profilaxis con IBP.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 589 "Ancho" => 750 "Tamanyo" => 98279 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen endoscópica en retroflexión de erosiones lineales múltiples en saco herniario compatibles con úlceras de Cameron.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cameron lesions in patients with hiatal hernias: Prevalence, presentation, and treatment, outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.M. Gray" 1 => "V. Kushnir" 2 => "G. Kalra" 3 => "A. Rosenstock" 4 => "M.A. Alsakka" 5 => "A. Patel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dote.12223" "Revista" => array:6 [ "tituloSerie" => "Dis Esophagus" "fecha" => "2015" "volumen" => "28" "paginaInicial" => "448" "paginaFinal" => "452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24758713" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cameron lesions: A still overlooked diagnosis Case report and systematic review of literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Zullo" 1 => "R. Manta" 2 => "V. de Francesco" 3 => "G. Fiorini" 4 => "E. Lahner" 5 => "D. Vaira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinre.2018.05.002" "Revista" => array:6 [ "tituloSerie" => "Clin Res Hepatol Gastroenterol" "fecha" => "2018" "volumen" => "42" "paginaInicial" => "604" "paginaFinal" => "609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29910147" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bleeding risk under selective serotonin reuptake inhibitor (SSRI) antidepressants: A meta-analysis of observational studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Laporte" 1 => "C. Chapelle" 2 => "P. Caillet" 3 => "M.N. Beyens" 4 => "F. Bellet" 5 => "X. Delavenne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.phrs.2016.08.017" "Revista" => array:6 [ "tituloSerie" => "Pharmacol Res" "fecha" => "2017" "volumen" => "118" "paginaInicial" => "19" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27521835" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02105705/0000004300000005/v1_202005010648/S0210570520300170/v1_202005010648/es/main.assets" "Apartado" => array:4 [ "identificador" => "75365" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imágenes del mes" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105705/0000004300000005/v1_202005010648/S0210570520300170/v1_202005010648/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570520300170?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
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