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(Fibromialgia, ¿comorbilidad marcadora de vulnerabilidad?)”, by Fernando Rico-Villademoros and Elena P. Calandre,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> in which they referred to the original article “Impact of fibromyalgia in the chronic fatigue syndrome (Impacto de la fibromialgia en el síndrome de fatiga crónica)” by Faro et al.,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> we would like to make the following comments:</p><p id="par0010" class="elsevierStylePara elsevierViewall">When we decided to conduct the aforementioned study, we aimed to assess whether patients with chronic fatigue syndrome (CFS), who fitted the criteria of the comorbid phenomenon of fibromyalgia (FM), developed a different profile in relation to the impact on their quality of life and occupational disability.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Following the line of thought that considers CFS as a genetic-based immune-inflammatory entity, like rheumatoid arthritis and systemic lupus erythematosus, we consider appropriate the comment made by Yunus<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3–8</span></a> with regard to the assessment of the FM epiphenomenon in immune-based developments, where pain and fatigue can be observed by competent professionals within an immune primary disease outbreak, all of which wrongfully lead to an intensification of the treatment of a base disease, when, actually, the right course of action would be to diagnose and treat the FM.</p><p id="par0020" class="elsevierStylePara elsevierViewall">On the other hand, we think that the title of the publication is very confusing, since FM in CFS causes further physical and intellectual disability and leads to a major disruption of the patient's quality of life.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> However, we do not believe that patients with CFS are more susceptible to any further developments because they present FM, even though they are more likely to develop cancer,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> intracellular infections or ischaemic phenomena since FM is a process that increases metabolic and vascular risks.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Lastly, we consider the central sensitisation theory to be a pathogenic mechanism in CFS and FM. Nevertheless, it is difficult to attribute all the symptoms of these entities to the so-called central sensitisation syndrome.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> Furthermore, we consider that in CFS, the foremost research is currently focused on genetic susceptibility, the study of triggers, the lymphoid cell processes involved and energetic metabolism.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> In FM, research is focused on different mechanisms involved in pain genesis, with neurobiochemical, electrophysiological and neuroimaging studies, among others.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Faro M, Alegre J. La fibromialgia como fenómeno comórbido en las enfermedades inmunoinflamatorias. Med Clin (Barc). 2015;144:525.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibromialgia: ¿comorbilidad marcadora de vulnerabilidad?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Rico-Villademoros" 1 => "E.P. 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Journal Information
Vol. 144. Issue 11.
Pages 525 (June 2015)
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Vol. 144. Issue 11.
Pages 525 (June 2015)
Letter to the Editor
Fibromyalgia as a comorbid phenomenon in autoinflammatory diseases
La fibromialgia como fenómeno comórbido en las enfermedades inmunoinflamatorias
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Med Clin. 2015;144:525-610.1016/j.medcle.2014.10.002
Fernando Rico-Villademoros, Elena P. Calandre
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