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Laboratory tests showed neutropenia and peripheral blood smear (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) showing agranulocytosis (one white blood cell in smear) without any other blood dyscrasias. Methimazole treatment was suspended, empiric coverage was initiated with broad-spectrum antibiotic treatment (amikacin and piperacillin<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>tazobactam) and colony stimulating factors were administered. Agranulocytosis by methimazole is a type B side effect (independent of the effect of the medication), that is potentially serious (close to 10% mortality) and with an estimated incident rate on the population of between 7.3 and 9.3 cases per million per year.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Pedrazas López D, de Pablo Márquez B, García Font D, Sánchez García E. Agranulocitosis secundaria a tratamiento con metamizol. Med Clin (Barc). 2016;146:e41.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 671 "Ancho" => 1500 "Tamanyo" => 250753 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014600000007/v1_201607151011/S2387020616302558/v1_201607151011/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014600000007/v1_201607151011/S2387020616302558/v1_201607151011/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616302558?idApp=UINPBA00004N" ]
Journal Information
Vol. 146. Issue 7.
Pages e41 (April 2016)
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Vol. 146. Issue 7.
Pages e41 (April 2016)
Image in medicine
Methamizole-induced agranulocytosis
Agranulocitosis secundaria a tratamiento con metamizol
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