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array:23 [ "pii" => "S0025775300716289" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71628-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71628" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:573-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1768 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1599 "PDF" => 162 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716290" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71629-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71629" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2000;115:576-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 989 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 903 "PDF" => 81 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Infección por el virus de la inmunodeficiencia humana en la era de la terapia antirretroviral potente: necesidad de un enfoque multidisciplinario" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "576" "paginaFinal" => "578" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lucía Gallego Deike" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Lucía" "apellidos" => "Gallego Deike" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716290?idApp=UINPBA00004N" "url" => "/00257753/0000011500000015/v1_201307291747/S0025775300716290/v1_201307291747/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300716277" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71627-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71627" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:568-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1948 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1805 "PDF" => 135 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Frecuencia cardíaca y taquicardia clínica aislada en pacientes con hipertensión arterial" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "568" "paginaFinal" => "572" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Heart rate and isolated clinical tachycardia in hypertensive patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ernest Vinyoles, Mariano de la Figuera, Maria Bosom, Cristina González, Núria Moreno, Valeria Pacheco" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Ernest" "apellidos" => "Vinyoles" ] 1 => array:2 [ "nombre" => "Mariano" "apellidos" => "de la Figuera" ] 2 => array:2 [ "nombre" => "Maria" "apellidos" => "Bosom" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "González" ] 4 => array:2 [ "nombre" => "Núria" "apellidos" => "Moreno" ] 5 => array:2 [ "nombre" => "Valeria" "apellidos" => "Pacheco" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716277?idApp=UINPBA00004N" "url" => "/00257753/0000011500000015/v1_201307291747/S0025775300716277/v1_201307291747/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Análisis mutacional de p53 en la leucemia linfoblástica T" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "573" "paginaFinal" => "575" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "Josep F. Nomdedéu, Camino Estivili, Jorge Sierra" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Josep F." "apellidos" => "Nomdedéu" "email" => array:1 [ 0 => "jnomdedeu@santpau.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Camino" "apellidos" => "Estivili" ] 2 => array:2 [ "nombre" => "Jorge" "apellidos" => "Sierra" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamentos de Hematologia, Hospital de la Santa Creu i Sant Pau. Barcelona." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr.Josep F. Nomdedéu. Departament d'Hematologia. Hospital de la Santa Creu i Sant Pau. Avda. Sant Antoni M. Claret, 167. 08025 Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "Isabel Badell, Elisabeth del Río, Montserrat Baiget" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Isabel" "apellidos" => "Badell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Elisabeth" "apellidos" => "del Río" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Montserrat" "apellidos" => "Baiget" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Pediatría Hospital de la Santa Creu i Sant Pau. Barcelona." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Genética. Hospital de la Santa Creu i Sant Pau. Barcelona." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mutational analysis of p53 in T-acute lymphoblastic leukemia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-22" "fechaAceptado" => "2000-09-26" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec223109" "palabras" => array:2 [ 0 => "Leucemia linfoblástica aguda T" 1 => "Linfoma p53" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Para valorar la frecuencia de mutaciones de p53 en la leucemia linfo-blástica aguda T se analizan las muestras obtenidas en nuestro hospital durante un período de 9 años.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 32 mues-tras correspondientes a 27 pacientes me-diante SSCP radiactivo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se identificó una mutación en heterozigosis en el codón 273 en un niño en tercera recaída. La mutación se hizo do-minante con desaparición del alelo normal en una muestra obtenida tras haber recibi-do un protocolo de rescate.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las mutaciones de p53 son poco frecuentes la leucemia linfoblástica aguda T.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">p53 mutations were analysed in a consecutive series of patients with T-ALL from one hospital over a period of 9 years.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Thirty two samples from 27 patients with T-ALL were included in the study. Exons 5-9 were analysed using SSCP.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A mutation at codon 273 was identified in a child in third relapse. The mutated clone became dominant in a sam-ple obtained one month following a course of salvage chemotherapy.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">p53 mutations are not frequent in T-ALL even in patients at relapse</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 in hematologic malignancies." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. 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