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array:23 [ "pii" => "S0025775300712322" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71232-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71232" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:169-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2475 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 2338 "PDF" => 132 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712334" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71233-4" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71233" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:171-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1676 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1573 "PDF" => 97 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales Breves</span>" "titulo" => "Estudio de costes de un tratamiento de mantenimiento con metadona de bajo nivel de prestaciones" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "171" "paginaFinal" => "173" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cost study of a methadone maintenance treatment" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María de la Cruz Pellín, Carmen Gimeno, José Barril, José María Climent, Eugenio Vilanov" "autores" => array:5 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "de la Cruz Pellín" ] 1 => array:2 [ "nombre" => "Carmen" "apellidos" => "Gimeno" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Barril" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "María Climent" ] 4 => array:2 [ "nombre" => "Eugenio" "apellidos" => "Vilanov" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712334?idApp=UINPBA00004N" "url" => "/00257753/0000011400000005/v1_201307291446/S0025775300712334/v1_201307291446/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300712310" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71231-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71231" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:165-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1423 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1324 "PDF" => 92 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Factores asociados al desarrollo de atopia en adultos jóvenes" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "165" "paginaFinal" => "168" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Factors associated to the development of atopy in young Spanish adults" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xavier Cortès, Joan B. Soriano, Jordi Sunyer, Jesús Martínez-Moratalla, Nerea Muniozgoren, José Antonio Maldonado, Ramón Quirós, Josep M.<span class="elsevierStyleSup">a</span> Antó" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Xavier" "apellidos" => "Cortès" ] 1 => array:2 [ "nombre" => "Joan B." "apellidos" => "Soriano" ] 2 => array:2 [ "nombre" => "Jordi" "apellidos" => "Sunyer" ] 3 => array:2 [ "nombre" => "Jesús" "apellidos" => "Martínez-Moratalla" ] 4 => array:2 [ "nombre" => "Nerea" "apellidos" => "Muniozgoren" ] 5 => array:2 [ "nombre" => "José" "apellidos" => "Antonio Maldonado" ] 6 => array:2 [ "nombre" => "Ramón" "apellidos" => "Quirós" ] 7 => array:2 [ "nombre" => "Josep M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Antó" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712310?idApp=UINPBA00004N" "url" => "/00257753/0000011400000005/v1_201307291446/S0025775300712310/v1_201307291446/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales Breves</span>" "titulo" => "Anticuerpos neutralizantes en pacientes con esclerosis múltiple tratados con interferón beta-1b" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "169" "paginaFinal" => "170" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jordi Río, Narcis Barberà, Mar Tintoré, Luis Brieva, Xavier Montalbán" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Jordi" "apellidos" => "Río" "email" => array:1 [ 0 => "jri@hg.vhebron.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Narcis" "apellidos" => "Barberà" ] 2 => array:2 [ "nombre" => "Mar" "apellidos" => "Tintoré" ] 3 => array:2 [ "nombre" => "Luis" "apellidos" => "Brieva" ] 4 => array:2 [ "nombre" => "Xavier" "apellidos" => "Montalbán" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Neuroinmunología Clínica. Servicio de Neurología. Hospital General Universitario Vall d'Hebron. Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unidad de Neuroinmunología Clínica. Escuela de Enfermería, 5.<span class="elsevierStyleSup">a</span>planta. Hospital General Universitario Vall d'Hebron. P.o Vall d'Hebron, 119-129. 08035 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Neutralising antibodies in patients with multiple sclerosis treated with interferon beta-1b" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-28" "fechaAceptado" => "1999-11-30" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221273" "palabras" => array:3 [ 0 => "Anticuerpos neutralizantes" 1 => "Interferón beta-1b" 2 => "Esclerosis múltiple" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha descrito la aparición deanticuerpos neutralizantes (AN) en un terciode los pacientes con esclerosis múltiple tratadoscon interferón beta. Este estudio examinala frecuencia de aparición de dichosanticuerpos y sus implicaciones clínicas.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado 68 pacientes.La determinación de AN se realizómediante la técnica de la proteína A del mixovirus.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se detectaron AN en el 13% delos pacientes a los 2 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No parece existir una relaciónentre la presencia de AN y una peor evoluciónde la esclerosis múltiple.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Neutralising antibodies (NABs)against interferon beta have been describedin one third of patients with multiple sclerosistreated with interferon beta. We haveanalysed the frequency of NABs and theirclinical consequences.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have studied 68patients. NABs were determined by proteinA Myxovirus assay.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Positive NABs were detected in 13%of the patients after 2 years of treatment.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">It does not seem to exist a relationshipbetween presence of NABs and apoor evolution of the disease in our patientswith multiple sclerosis treated with beta interferon.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon beta-1b in the treatment of multiple sclerosis. Final outcome of the randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis group." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1995" "volumen" => "45" "paginaInicial" => "1277" "paginaFinal" => "1285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7617182" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib00010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis group." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1996" "volumen" => "47" "paginaInicial" => "889" "paginaFinal" => "894" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8857714" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib00015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon β-1b" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.P.A. Rice" 1 => "B. Paszner" 2 => "J. Oger" 3 => "J. Lesaux" 4 => "D. Paty" 5 => "G. Ebers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1999" "volumen" => "52" "paginaInicial" => "1277" "paginaFinal" => "1279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10214759" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib00020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New diagnostic criteria for multiple sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Poser" 1 => "D.W. Paty" 2 => "L. Scheinberg" 3 => "W.I. McDonald" 4 => "F.A. Davis" 5 => "G.C. Ebers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410130302" "Revista" => array:6 [ "tituloSerie" => "Ann Neurol" "fecha" => "1983" "volumen" => "13" "paginaInicial" => "227" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6847134" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib00025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioavailability of interferon beta 1b in MS patients with and without neuralizing antibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Deisenhammer" 1 => "M. Reindl" 2 => "J. Harvey" 3 => "T. Gasse" 4 => "T. Dilitz" 5 => "T. Berger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1999" "volumen" => "52" "paginaInicial" => "1239" "paginaFinal" => "1243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10214750" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib00030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutralizing antibodies: are they an issue?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Arnason" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int MSJ" "fecha" => "1997" "volumen" => "4" "paginaInicial" => "40" "paginaFinal" => "42" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib00035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of interferon beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.A. Stone" 1 => "J.A. Frank" 2 => "P.S. Albert" 3 => "C. Bash" 4 => "M.E. Smith" 5 => "H. Maloni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410370511" "Revista" => array:6 [ "tituloSerie" => "Ann Neurol" "fecha" => "1995" "volumen" => "37" "paginaInicial" => "611" "paginaFinal" => "619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7755356" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib00040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomised double-blind placebo-controlled study of interferon β-1 a in relapsing-remitting multiple sclerosis" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "PRIMS Study Group." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "352" "paginaInicial" => "1498" "paginaFinal" => "1504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9820297" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib00045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-oral steroids reduce flu-like symptoms at the initiation of IFNβ-1b in relapsing-remitting M.S" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Rio" 1 => "C. Nos" 2 => "M.E. Marzo" 3 => "M. Tintore" 4 => "X. Montalban" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1998" "volumen" => "50" "paginaInicial" => "1910" "paginaFinal" => "1912" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9633761" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib00050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for physicians with patients on IFN-1b: the use of an assay for neutralizing antibody" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.W. Paty" 1 => "D. Goodkin" 2 => "A. Thompson" 3 => "G. Rice" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1996" "volumen" => "47" "paginaInicial" => "865" "paginaFinal" => "866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8857709" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011400000005/v1_201307291446/S0025775300712322/v1_201307291446/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011400000005/v1_201307291446/S0025775300712322/v1_201307291446/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712322?idApp=UINPBA00004N" ]
