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array:22 [ "pii" => "S0025775300711997" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71199-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71199" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:81-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1729 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1571 "PDF" => 152 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712000" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71200-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71200" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:85-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2307 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 2142 "PDF" => 157 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Presión arterial nocturna y factores de riesgo cardiovascular en pacientes con hipertensión arterial" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "85" "paginaFinal" => "88" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Nocturnal blood pressure and cardiovascular risk factors in hypertensive patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando Cobo Martínez, Blas Gil Extremera, Antonia Maldonado Martín, Juan de Dios Luna Castillo, Fabiola Muñoz Parra, Francisca Huertas Hernández, M.<span class="elsevierStyleSup">a</span> Teresa León-Espinosa de los Monteros, M.<span class="elsevierStyleSup">a</span> Fuensanta Ruiz López" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "Cobo Martínez" ] 1 => array:2 [ "nombre" => "Blas" "apellidos" => "Gil Extremera" ] 2 => array:2 [ "nombre" => "Antonia" "apellidos" => "Maldonado Martín" ] 3 => array:2 [ "nombre" => "Juan" "apellidos" => "de Dios Luna Castillo" ] 4 => array:2 [ "nombre" => "Fabiola" "apellidos" => "Muñoz Parra" ] 5 => array:2 [ "nombre" => "Francisca" "apellidos" => "Huertas Hernández" ] 6 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Teresa León-Espinosa de los Monteros" ] 7 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Fuensanta Ruiz López" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712000?idApp=UINPBA00004N" "url" => "/00257753/0000011400000003/v1_201307291400/S0025775300712000/v1_201307291400/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Biopsia extemporánea en la valoración de órganos para trasplante" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "84" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Francisco Vera-Sempere, José Luis Vicente, Mireya Prieto, Puri Gironés, María Jordá" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Francisco" "apellidos" => "Vera-Sempere" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José Luis" "apellidos" => "Vicente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mireya" "apellidos" => "Prieto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Puri" "apellidos" => "Gironés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "María" "apellidos" => "Jordá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital Universitario La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Equipo de Coordinación de Trasplantes. Hospital Universitario La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Dr. F.J. Vera-Sempere. Servicio de Anatomía Patológica. Hospital Universitario La Fe. Avda. Campanar, 21. 46009 Valencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Frozen section biopsy in donor graft evaluation" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-09-14" "fechaAceptado" => "1999-11-30" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220569" "palabras" => array:3 [ 0 => "Trasplante" 1 => "Donantes de órganos" 2 => "Biopsia extemporánea pretrasplante" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El éxito de los trasplantes y el aumento de indicaciones hacen que las donacionesde órganos no permitan cubrir la totalidad de las demandas. Ampliar los criterios de selecciónde donantes, aceptando a los llamados donantes subóptimos, obliga a una cuidadosa valoraciónindividualizada de la validez de cada donante, indicándose a menudo un estudio biópsicopretrasplante.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se evalúa la realización de biopsias extemporáneas como forma de validaciónde órganos y donantes en la actividad trasplantadora del Hospital Universitario La Fe, deValencia, a lo largo de 1998, año en el que se realizaron 301 trasplantes de órganos sólidos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se realizaron 60 biopsias extemporáneas pretrasplante (29 biopsias hepáticas, 21renales, 3 de adenopatías, 3 cerebrales, 2 prostáticas, 1 miometrial y 1 pericárdica). Como resultadode la biopsia se invalidó la realización de 18 trasplantes (30% de los biopsiados). Lascausas más frecuentes de no validación fueron la macrosteatosis hepática (7 casos), tumoresmalignos (5 casos) y lesión parenquimatosa renal (5 casos). Dentro del diagnóstico tumoral seemitió un falso positivo y un falso negativo de malignidad.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La realización de biopsias extemporáneas en los donantes subóptimos o con sospechade enfermedad permite integrar el análisis morfológico en la toma de decisiones por partedel equipo trasplantador, introduciendo un factor de calidad en la selección de donantes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The success of transplantation and the increase in its indications has caused organdonations to be unable to meet the global demand. By broadening the donor selection criteriaand accepting so-called suboptimal donors in an attempt to solve this problem, a carefulindividualized assessment is required of the validity of each donor. This often implies the needfor a pretransplantation biopsy study.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Evaluation of frozen section biopsy studies in the assessment of graft anddonor validness in the the transplantation program of the La Fe University Hospital (Valencia,Spain) during 1998, when a total of 301 solid organ transplantations were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Sixty pretransplantation frozen section biopsies were performed (29 of the liver, 21 renal,3 lymph nodes, 3 brain, 2 prostatic, 1 myometrial and 1 pericardial). As a result of thebiopsic study, 18 transplantations were invalidated (30% of all biopsies). The most frequentcauses of invalidation were liver macroesteatosis (7 cases), malignancies (5 cases) and renalparenchymal lesions (5 cases). Among the tumor diagnosis there were one false-positive andone false-negative results of malignancy.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Frozen section biopsies evaluation in suboptimal organ donors or donors suspectedof suffering disease integrates morphological analysis in the transplantation team decision process,and affords a quality factor in the selection of donors.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unidad de Coordinación de Trasplantes. 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