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array:22 [ "pii" => "S0025775300715363" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71536-3" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71536" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:281-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2292 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2149 "PDF" => 136 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300715375" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71537-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71537" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:287-93" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3875 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3783 "PDF" => 86 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Evolución de la producción científica española en revistas internacionales de sistema respiratorio de 1987 a 1998" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "287" "paginaFinal" => "293" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Evolution of Spanish scientific production in international respiratory system journals from 1987 to 1998" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Francisca García Río, Rodolfo Álvarez-Sala, Antonio Ruiz Peña, Soledad Serrano Peña, José María Pino García, José Villamor León" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Francisca" "apellidos" => "García Río" ] 1 => array:2 [ "nombre" => "Rodolfo" "apellidos" => "Álvarez-Sala" ] 2 => array:2 [ "nombre" => "Antonio" "apellidos" => "Ruiz Peña" ] 3 => array:2 [ "nombre" => "Soledad" "apellidos" => "Serrano Peña" ] 4 => array:2 [ "nombre" => "José" "apellidos" => "María Pino García" ] 5 => array:2 [ "nombre" => "José" "apellidos" => "Villamor León" ] ] ] 1 => array:2 [ "autoresLista" => "M. Antonia Gómez Mendieta, José Luis Álvarez-Sala" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M. Antonia" "apellidos" => "Gómez Mendieta" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Luis Álvarez-Sala" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300715375?idApp=UINPBA00004N" "url" => "/00257753/0000011500000008/v1_201307291646/S0025775300715375/v1_201307291646/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Características epidemiológicas relacionadas con el cáncer de mama en mujeres pre y posmenopáusicas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "286" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María Concepción Díez Collar, Paloma Ortega Molina, Rosa Villanueva Orbaiz, Romana Albaladejo Vicente, Paloma Astasio Arbiza, Elisa Calle Purón" "autores" => array:7 [ 0 => array:3 [ "nombre" => "María Concepción" "apellidos" => "Díez Collar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Paloma" "apellidos" => "Ortega Molina" "email" => array:1 [ 0 => "pomolina@eucmax.sim.ucm.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Rosa" "apellidos" => "Villanueva Orbaiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Romana" "apellidos" => "Albaladejo Vicente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Paloma" "apellidos" => "Astasio Arbiza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:2 [ "apellidos" => "M" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Elisa" "apellidos" => "Calle Purón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Inspección Acreditación Sanitaria. Consejería de Sanidad. Comunidad de Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Preventiva, Salud Pública e Historia de la Ciencia. Universidad Complutense de Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Departamento de Medicina Preventiva Salud Pública e Historia de la Ciencia. Facultad de Medicina. Universidad Complutense de Madrid. Ciudad Universitaria. 28040 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidemiological characteristics of breast cancer development in pre and postmenopausal women" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-12-28" "fechaAceptado" => "2000-06-20" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec222503" "palabras" => array:5 [ 0 => "Cáncer de mama" 1 => "Epidemiología" 2 => "Antecedentes familiares" 3 => "Premenopausia" 4 => "Posmenopausia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Caracterizar la relación entre el cáncer de mama distintas variables, personales, familiares sociodemográficas. Para ello se analizó a todas las mujeres en conjunto, clasificadas en dos grupos: pre posmenopáusicas.</p> <span class="elsevierStyleSectionTitle">Población métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realizó un estudio de casos controles, equiparando caso control en función de la edad, el área sanitaria la actividad hormonal. En total se estudiaron 274 casos 274 controles. Las variables de estudio se obtuvieron mediante un cuestionario que recogía el nivel de estudios, la historia reproductiva, los antecedentes personales familiares los estilos de vida. Se realizó un análisis de regresión logística múltiple en los grupos de estudio.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En las mujeres consideradas en conjunto, la menarquia tardía se comportó como variable de riesgo, al igual que la primiparidad añosa los antecedentes familiares maternos, como factor de protección el menor nivel de estudios el consumo de anticonceptivos orales. Este último patrón se repitió en la población posmenopáusica, con excepción del consumo de anticonceptivos, que no se mantuvo en el modelo final de regresión. En la población premeno-páusica, se comportaron como factor de riesgo los antecedentes familiares maternos los ante-cedentes personales de enfermedad mamaria. Así mismo, el nivel de estudios inferior apareció como factor de protección.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La presencia de antecedentes familiares maternos actuó como variable de riesgo en todas las poblaciones, constituyendo el primer factor en importancia en las mujeres preme-nopáusicas. En las dos categorías de estudio, el menor nivel de estudios apareció como factor protector.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the relation between breast cancer and different risk factors, personal, familial and demmographic factors. An statistic and epidemiologic study was also carried on a whole population of women and then classified on pre and postmenopausal women.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A matched case-control study was performed based on age, urban area and hormonal activity. Total population was composed by 274 cases and same number of controls. Studied variables were obtained by a questionnarire asking for study level, reproductive and personal history, familial considerations and lifestyles. A multiples logistic regression model was made.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Over total population, late menarcheal age, late first pregnancy, and familial history of breast cancer were shown as independent risk factors, but a low study level, and oral contraception were shown as protective factors. This risk model was confirmed on postmenopausal women but no over premenopausal women, so in this group, main risk factors were familial breast cancer history and a medical history of bening breast disease. Moreover, the low study level was also a protective factor.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Familial history of breast cancer in mothers or sisters was the main risk factor for breast cancer, mainly in premenopausal women, and low study level showed as protective factor.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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