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array:23 [ "pii" => "S0025775301717745" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71774-5" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71774" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:214-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2600 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2081 "PDF" => 512 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717757" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71775-7" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71775" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2001;116:217-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1033 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 859 "PDF" => 169 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Cáncer cutáneo en el paciente trasplantado. Un problema creciente" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "217" "paginaFinal" => "219" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Ferrándiz, María José Fuente" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Ferrándiz" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "José Fuente" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717757?idApp=UINPBA00004N" "url" => "/00257753/0000011600000006/v1_201307291450/S0025775301717757/v1_201307291450/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775301717733" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71773-3" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71773" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:209-13" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1390 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1204 "PDF" => 179 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Análisis poblacional de la necesidad de cambios y tasas de continuidad de los diferentes fármacos antihipertensivos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "209" "paginaFinal" => "213" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A population-based study of need for changes and continuing rates of antihypertensive drugs" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Francisco Javier Sierra Alonso, Carlos Lagarejos Tricas, Francisco Cirujano Pita, Natalia Villalba Guijorro, M.<span class="elsevierStyleSup">a</span> Jesús Muñoz Sanz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Javier Sierra Alonso" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Lagarejos Tricas" ] 2 => array:2 [ "nombre" => "Francisco" "apellidos" => "Cirujano Pita" ] 3 => array:2 [ "nombre" => "Natalia" "apellidos" => "Villalba Guijorro" ] 4 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Jesús Muñoz Sanz" ] ] ] 1 => array:2 [ "autoresLista" => "Francisco Rodríguez Salvanés" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Rodríguez Salvanés" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717733?idApp=UINPBA00004N" "url" => "/00257753/0000011600000006/v1_201307291450/S0025775301717733/v1_201307291450/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Conversión a esclerosis múltiple clínicamente definida tras un síndrome medular aislado: valor de la resonancia magnética craneal y medular" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "214" "paginaFinal" => "216" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "Imma Pericot, Mar Tintoré, Luis Brieva, Xavier Montalbán" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Imma" "apellidos" => "Pericot" "email" => array:1 [ 0 => "esclerosismultiple@hgvhebron.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Mar" "apellidos" => "Tintoré" ] 2 => array:2 [ "nombre" => "Luis" "apellidos" => "Brieva" ] 3 => array:2 [ "nombre" => "Xavier" "apellidos" => "Montalbán" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unitat de Neuroimmunologia Clínica. Servei de Neurologia. Hospital Vall d’Hebron. Barcelona." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dra. I. Pericot. Unitat de Neuroimmunologia Clínica. Escuela de Enfermería (5.<span class="elsevierStyleSup">a</span> planta). Passeig Vall d'Hebron, 110-129. 08035 Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "Elisenda Grivé, Alex Rovira" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Elisenda" "apellidos" => "Grivé" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Alex" "apellidos" => "Rovira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Unitat de Resonància Magnètica (IDI). Servei de Radiologia. Hospital Vall d’Hebron. Barcelona." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Conversion to clinically definite multiple sclerosis after isolated spinal cord syndrome: value of brain and spinal MRI" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-05-22" "fechaAceptado" => "2001-01-09" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221350" "palabras" => array:4 [ 0 => "Síndrome medular aislado" 1 => "Esclerosis múltiple clínicamente definida" 2 => "RM craneal" 3 => "RM medular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec221351" "palabras" => array:4 [ 0 => "Isolated spinal cord syndrome" 1 => "Clinically definite multiple sclerosis" 2 => "Brain MRI" 3 => "Spinal cord MRI" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los síndromes medulares aislados (SMA) pueden ser el primer brote de esclerosis múltiple. El objetivo del presente estudio fue evaluar las características clínicas, paraclínicas y la utilidad de la resonancia magnética (RM) medular y craneal para predecir la conversión a esclerosis múltiple clínicamente definida (EMCD) en pacientes con un SMA.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluamos a 38 pacientes con un SMA. Se practicó un protocolo clínico, así como pruebas paraclínicas y RM craneal y medular.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El 42,8% de los pacientes que cumplían los criterios diagnósticos de la RM craneal de Paty (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,01), el 54,5% de los que tenían criterios de Fazekas (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,007) y el 80% de los que cumplían criterios de Barkhof (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,009) presentaron conversión a EMCD. La RM medular fue patológica en todos los pacientes que convirtieron a EMCD, presentando un predominio de localización cervical, con afección marginal y diámetro menor de 2<span class="elsevierStyleHsp" style=""></span>cm.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La RM craneal permite detectar a pacientes con un alto riesgo de desarrollar una EMCD y la RM medular aumenta la sensibilidad de conversión a EMCD.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Isolated spinal cord syndrome might be due to a first episode of multiple sclerosis. The aim of the study was to determine the clinical usefulness and paraclinical characteristics and of spinal and brain MR imaging predicting conversion to clinically definite multiple sclerosis (CDMS) in patients with an isolated spinal cord syndrome.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have evaluate thirtyeight patients with isolated spinal cord syndrome. A clinical protocol, lumbar puncture, evoked potential and brain-spinal cord MRI were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Twenty two percent of the patients fulfilling brain MRI Paty criteria (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01), 54.5% Fazekas (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.007) and 80% of patients fulfilling Barkhof criteria (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.009) presented CDMS. The spinal MR imaging from CDMS patients was always abnormal, showing cervical and marginal location with a diameter<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Brain MRI is strongly predictive of the risk of developing CDMS and spinal cord MRI may increase the sensitivity to detect conversion to CDMS.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Compston" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain" "fecha" => "1996" "volumen" => "119" "paginaInicial" => "709" "paginaFinal" => "714" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8673484" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute transverse myelopathy: spinal and cranial MR study with clinical followup" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Campi" 1 => "M. Filippi" 2 => "G. Comi" 3 => "V. Martinelli" 4 => "C. Baratti" 5 => "M. Rovaris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Neuroradiol" "fecha" => "1995" "volumen" => "16" "paginaInicial" => "115" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7900579" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011600000006/v1_201307291450/S0025775301717745/v1_201307291450/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011600000006/v1_201307291450/S0025775301717745/v1_201307291450/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717745?idApp=UINPBA00004N" ]
