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array:23 [ "pii" => "S0025775300711754" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71175-4" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71175" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:19-21" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2565 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 2421 "PDF" => 136 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300711766" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71176-6" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71176" "copyright" => "Elsevier España, S.L." 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"apellidos" => "Fernández-López" ] 2 => array:2 [ "nombre" => "Radhamés" "apellidos" => "Hernández-Mejía" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711766?idApp=UINPBA00004N" "url" => "/00257753/0000011400000001/v1_201307291354/S0025775300711766/v1_201307291354/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300711742" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71174-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71174" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2000;114:16-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2604 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 2227 "PDF" => 366 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "La genética de la artritis reumatoide" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "16" "paginaFinal" => "18" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Jesús Gómez-Reino Carnota, Francisco Maceiras Pan" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Juan Jesús" "apellidos" => "Gómez-Reino Carnota" ] 1 => array:2 [ "nombre" => "Francisco" "apellidos" => "Maceiras Pan" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711742?idApp=UINPBA00004N" "url" => "/00257753/0000011400000001/v1_201307291354/S0025775300711742/v1_201307291354/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Enfermedad de Hodgkin en pacientes con infección por el virus de la inmunodeficiencia humana. Estudio de 15 casos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "19" "paginaFinal" => "21" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "José Tomás Navarro, Josep Maria Ribera, Javier Grau, Fuensanta Millá, Montserrat Batlle, Evarist Feliu" "autores" => array:6 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Tomás Navarro" ] 1 => array:4 [ "nombre" => "Josep" "apellidos" => "Maria Ribera" "email" => array:1 [ 0 => "jmribera@ns.hugtip.scs.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "Javier" "apellidos" => "Grau" ] 3 => array:2 [ "nombre" => "Fuensanta" "apellidos" => "Millá" ] 4 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Batlle" ] 5 => array:2 [ "nombre" => "Evarist" "apellidos" => "Feliu" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Hematología-Hemoterapia, Hospital Germans Trias i Pujol. Badalona. Universidad Autónoma de Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Dr. J.M. Ribera. Servicio de Hematología-Hemoterapia. Hospital Universitari Germans Trias i Pujol. Canyet, s/n. 08916 Badalona. Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "Carolina Frías, Manuel Vaquero, Guillermo Sirera" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Carolina" "apellidos" => "Frías" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "Manuel" "apellidos" => "Vaquero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 2 => array:3 [ "nombre" => "Guillermo" "apellidos" => "Sirera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Microbiología, Hospital Germans Trias i Pujol. Badalona. Universidad Autónoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Anatomía Patológica, Hospital Germans Trias i Pujol. Badalona. Universidad Autónoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "Unidad VIH. Hospital Germans Trias i Pujol. Badalona. Universidad Autónoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hodgkin's disease in patients infected by the human immunodeficiency virus. Study of fifteen cases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-10-05" "fechaAceptado" => "1999-11-09" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220504" "palabras" => array:2 [ 0 => "Enfermedad de Hodgkin" 1 => "Infecciones por VIH" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Aunque la enfermedad de Hodgkin (EH) no se considera como una entidad definitoriade sida, en los pacientes infectados por el VIH presenta unas características clínicas ybiológicas diferenciadas.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de las características clinicopatológicas y analíticas, de la presenciadel virus de Epstein-Barr (VEB) (reacción en cadena de la polimerasa) y del pronóstico en15 pacientes con EH e infección por el VIH diagnosticados en un solo centro durante un períodode 10 años.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Trece enfermos presentaban signos B; en 10 había afección extraganglionar y12 presentaban una EH avanzada. Los tipos histológicos más frecuentes fueron la celularidadmixta (6) y la depleción linfocítica (6). La media (DE) de linfocitos CD4 fue 0,10 (0,08) ×109/l. Se evidenció la presencia del VEB en la biopsia ganglionar en 3 de 4 pacientes analizados.Hubo respuesta completa al tratamiento en 7 de 14 pacientes (50%), la mediana desupervivencia global fue de 26 meses y la probabilidad de supervivencia libre de evento a los2 años fue del 60%.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La EH en los pacientes con infección por el VIH se presenta en estadios avanzados,subtipos histológicos desfavorables, frecuente afección extraganglionar y presencia de signosB. El pronóstico es malo, lo cual se debe, sobre todo, a una baja tasa de respuesta al tratamiento.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In spite of not being considered as an AIDS defining illnes, Hodgkin's disease(HD) has specific clinical and biological features in HIV-infected patients.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Study of clinicopathologic and analytic characteristics, Epstein-Barr virus(EBV) detection (polymerase chain reaction), and prognosis in 15 patients with HD and HIV infection.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Thirteen patients had B symptoms, 10 extranodal involvement and 12 advanced HD.The most frequent histologic subtypes were mixed cellularity (6) and lymphocyte depletion (6).The mean (SD) of CD4 lymphocytes was 0.10 (0.08) × 109/l. The presence of EBV in lymphnode biopsy was demonstrated in 3 out of 4 patients investigated. Complete remission (CR)was achieved in 7 out of 14 treated cases (50%), the median overall survival was 26 monthsand the 2 year event-free survival probability was 60%.</p> <span class="elsevierStyleSectionTitle">Conclussions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In HIV-infected patients, HD presents in advanced stages, unfavourable histologicsubtypes, frequent extranodal involvement and B symptoms. The prognosis is poor, mainlybecause of a low CR rate.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." 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