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array:23 [ "pii" => "S0025775300711730" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71173-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71173" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:13-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1209 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 1062 "PDF" => 137 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300711742" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71174-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71174" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Med Clin. 2000;114:16-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2604 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 2227 "PDF" => 366 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "La genética de la artritis reumatoide" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "16" "paginaFinal" => "18" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Jesús Gómez-Reino Carnota, Francisco Maceiras Pan" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Juan Jesús" "apellidos" => "Gómez-Reino Carnota" ] 1 => array:2 [ "nombre" => "Francisco" "apellidos" => "Maceiras Pan" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711742?idApp=UINPBA00004N" "url" => "/00257753/0000011400000001/v1_201307291354/S0025775300711742/v1_201307291354/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300711729" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71172-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71172" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:7-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1958 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1785 "PDF" => 166 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Reducción de concentraciones elevadas de homocisteína con ácido fólico y vitaminas B en pacientes con tromboembolia venosa: relación entre respuesta y genotipo C677T de la metilén tetrahidrofólico reductasa (MTHFR)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "12" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Lowering high levels of fasting total homocysteine with folic acid and vitamins B in patients with venous thromboembolism: relationship between response and the C677T methylenetetrahydrofolate reductase (MTHFR) genotype" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ángel José González Ordóñez, Jesús María Medina Rodríguez, Carmen Rosa Fernández Álvarez, Javier Sánchez García, José Manuel Fernández Carreira, María Victoria Álvarez Martínez, Eliecer Coto García" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Ángel José" "apellidos" => "González Ordóñez" ] 1 => array:2 [ "nombre" => "Jesús María" "apellidos" => "Medina Rodríguez" ] 2 => array:2 [ "nombre" => "Carmen Rosa" "apellidos" => "Fernández Álvarez" ] 3 => array:2 [ "nombre" => "Javier" "apellidos" => "Sánchez García" ] 4 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Fernández Carreira" ] 5 => array:2 [ "nombre" => "María Victoria" "apellidos" => "Álvarez Martínez" ] 6 => array:2 [ "nombre" => "Eliecer" "apellidos" => "Coto García" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711729?idApp=UINPBA00004N" "url" => "/00257753/0000011400000001/v1_201307291354/S0025775300711729/v1_201307291354/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Expresión fenotípica de la Lp(a) en niños y adolescentes españoles" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "13" "paginaFinal" => "15" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan Antonio Gómez Gerique, Dolores López Martínez, Pilar Cancelas, María Teresa Montoya, María Dolores Gutiérrez, Amelia Porres" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Juan Antonio" "apellidos" => "Gómez Gerique" "email" => array:1 [ 0 => "jagomezg@meditex.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Dolores" "apellidos" => "López Martínez" ] 2 => array:2 [ "nombre" => "Pilar" "apellidos" => "Cancelas" ] 3 => array:2 [ "nombre" => "María" "apellidos" => "Teresa Montoya" ] 4 => array:2 [ "nombre" => "María" "apellidos" => "Dolores Gutiérrez" ] 5 => array:2 [ "nombre" => "Amelia" "apellidos" => "Porres" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Bioquímica Clínica. Fundación Jiménez Díaz. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Dr. J.A. Gómez Gerique. Departamento de Bioquímica Clínica. Fundación Jiménez Díaz. Avda. Reyes Católicos, 2. 28040 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Phenotypic expressión of Lp(a) in Spanish children and adolescents" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-06-26" "fechaAceptado" => "1999-11-09" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220498" "palabras" => array:2 [ 0 => "Lipoproteína" 1 => "Fenotipo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer la distribución de los fenotipos de Lp(a) en una población infantojuvenil.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se determinó el perfil lipoproteico, lipoproteína(a), apolipoproteínas y fenotipos de Lp(a) en 105 niños, seleccionados según sus concentraciones de colesterol.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las concentraciones medias de Lp(a) eran significativamente mayores en el grupo con isoformas de bajo peso molecular respecto a los de alto peso molecular. La isoforma más frecuente fue S3.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las concentraciones de Lp(a) se correlaccionaron inversamente con el peso molecular de las isoformas de Apo(a).</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To know the distribution of phenotypes Lp(a) in an young population.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Lipoprotein levels, lipoprotein(a), apolipoproteins and the Lp(a) phenotypes were determinated in 105 children, selected according to their cholesterol concentrations.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The Lp(a) concentrations were significantly higher in group with low molecular weight respect to group with high molecular weight. The most frequent isoform was S3.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The Lp(a) concentrations correlate inversely with the molecular weight of Apo(a) isoforms.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipoprotein(a) in PROCAM participants and young myocardial infarction survivors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Sandkamp" 1 => "G. Assmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Lipoprotein(a): 25 years progress" "paginaInicial" => "183" "paginaFinal" => "204" "serieFecha" => "1990" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib00010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structure and metabolism of lipoprotein(a)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Marcovina" 1 => "J.D. Morrissett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Lipidol" "fecha" => "1995" "volumen" => "6" "paginaInicial" => "136" "paginaFinal" => "145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7648002" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib00015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics of the quantitative Lp(a) lipoprotein trait. II: Inheritance of Lp(a) glycoprotein phenotypes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Utermann" 1 => "C. Duba" 2 => "H.J. Menzel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Genet" "fecha" => "1988" "volumen" => "78" "paginaInicial" => "47" "paginaFinal" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2828221" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib00020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipoprotein(a) as a correlate of stroke and transient ischemic attack prevalence in a biracial cohort: the ARIC Study. Atherosclerosis Risk in Communities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.J. Schreiner" 1 => "L.E. Chambles" 2 => "S.A. Brown" 3 => "R.L. Watson" 4 => "J. Toole" 5 => "G. Heiss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Epidemiol" "fecha" => "1994" "volumen" => "4" "paginaInicial" => "351" "paginaFinal" => "359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7981841" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib00025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Apo(a) isoforms predict risk for coronary heart disease. A study in six populations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Sandholzer" 1 => "N. Saha" 2 => "J.D. Kark" 3 => "A. Rees" 4 => "W. Jaross" 5 => "H. 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Vivanco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1996" "volumen" => "107" "paginaInicial" => "366" "paginaFinal" => "370" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib00035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial (black-white) differences in serum Lipoprotein(a) distribution and its relation to parental myocardial infarction in children. Bogalusa Heart Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Srinivasan" 1 => "G. Dahlen" 2 => "R. Jarpa" 3 => "L. Webber" 4 => "G. Berenson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1991" "volumen" => "84" "paginaInicial" => "160" "paginaFinal" => "167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1829398" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib00040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common «null» allele at the apo(a) locus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Gaw" 1 => "E. Boerwinkle" 2 => "J.C. Cohen" 3 => "H.H. Hobbs" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI117263" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1994" "volumen" => "93" "paginaInicial" => "2526" "paginaFinal" => "2534" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8200989" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib00045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad cardíaca coronaria y lipoproteína(a): su relación con otros factores lipídicos de riesgo cardiovascular" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "X. Nogués" 1 => "M. Sentí" 2 => "J. Pedro-Botet" 3 => "L. Molina" 4 => "R. Serrat" 5 => "S. Pons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1992" "volumen" => "98" "paginaInicial" => "171" "paginaFinal" => "174" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib00050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Levels of lipoprotein(a) and plasma lipids in Spanish children aged from 4 to 18 years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Gómez-Gerique" 1 => "A. Porres" 2 => "D. López-Martínez" 3 => "L.A. Álvarez-Sala" 4 => "M.T. Montoya" 5 => "M. De Oya" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Paediatr" "fecha" => "1996" "volumen" => "85" "paginaInicial" => "38" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8834977" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011400000001/v1_201307291354/S0025775300711730/v1_201307291354/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011400000001/v1_201307291354/S0025775300711730/v1_201307291354/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711730?idApp=UINPBA00004N" ]
