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array:23 [ "pii" => "S0025775300716277" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71627-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71627" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:568-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1948 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1805 "PDF" => 135 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300716289" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71628-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71628" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:573-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1768 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1599 "PDF" => 162 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Análisis mutacional de p53 en la leucemia linfoblástica T" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "573" "paginaFinal" => "575" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mutational analysis of p53 in T-acute lymphoblastic leukemia" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Josep F. Nomdedéu, Camino Estivili, Jorge Sierra" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Josep F." "apellidos" => "Nomdedéu" ] 1 => array:2 [ "nombre" => "Camino" "apellidos" => "Estivili" ] 2 => array:2 [ "nombre" => "Jorge" "apellidos" => "Sierra" ] ] ] 1 => array:2 [ "autoresLista" => "Isabel Badell, Elisabeth del Río, Montserrat Baiget" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Isabel" "apellidos" => "Badell" ] 1 => array:2 [ "nombre" => "Elisabeth" "apellidos" => "del Río" ] 2 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Baiget" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716289?idApp=UINPBA00004N" "url" => "/00257753/0000011500000015/v1_201307291747/S0025775300716289/v1_201307291747/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300716265" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71626-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71626" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;115:564-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1617 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1461 "PDF" => 150 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Marcadores predictivos de progresión a sida en niños infectados por transmisión vertical por el virus de la inmunodeficiencia humana tipo 1" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "564" "paginaFinal" => "567" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prognostic markers of progression to aids in infants vertically infected by human immunodeficiency virus type-1" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Salvador Resino, José M.<span class="elsevierStyleSup">a</span> Bellóon, Dolores Gurbindo, José Tomás Ramos, Jesús Ruiz Contreras, M.<span class="elsevierStyleSup">a</span> Ángeles Muñoz-Fernández" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Salvador" "apellidos" => "Resino" ] 1 => array:2 [ "nombre" => "José M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Bellóon" ] 2 => array:2 [ "nombre" => "Dolores" "apellidos" => "Gurbindo" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "Tomás Ramos" ] 4 => array:2 [ "nombre" => "Jesús" "apellidos" => "Ruiz Contreras" ] 5 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Ángeles Muñoz-Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300716265?idApp=UINPBA00004N" "url" => "/00257753/0000011500000015/v1_201307291747/S0025775300716265/v1_201307291747/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Frecuencia cardíaca y taquicardia clínica aislada en pacientes con hipertensión arterial" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "568" "paginaFinal" => "572" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ernest Vinyoles, Mariano de la Figuera, Maria Bosom, Cristina González, Núria Moreno, Valeria Pacheco" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Ernest" "apellidos" => "Vinyoles" "email" => array:1 [ 0 => "23561evb@comb.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Mariano" "apellidos" => "de la Figuera" ] 2 => array:2 [ "nombre" => "Maria" "apellidos" => "Bosom" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "González" ] 4 => array:2 [ "nombre" => "Núria" "apellidos" => "Moreno" ] 5 => array:2 [ "nombre" => "Valeria" "apellidos" => "Pacheco" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "<span class="elsevierStyleItalic">CAP La Mina. Sant Adri àde Besòs. Unitat Docent de Medicina Familiar i Comuniària de Barcelona</span>." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. E. Vinyoles.CAP La Mina. Mar, s/n. 08930 Sant Adrià de Besòs. Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Heart rate and isolated clinical tachycardia in hypertensive patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-04-27" "fechaAceptado" => "2000-09-21" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec223110" "palabras" => array:4 [ 0 => "Frecuencia cardíaca" 1 => "Hipertensión arterial" 2 => "Monitorización ambulatoria de la presión arterial" 3 => "Taquicardia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existe muy poca información sobre la taquicardia clínica aislada (TCA), es decir, taquicardia en la consulta pero frecuencia cardíaca (FC) ambulatoria normal. Nuestro objetivo fue describirla y conocer las diferencias entre pacientes afectados de hipertensión arterial (HTA) con y sin TCA.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio comparativo tras intervención diagnóstica (monitorización ambulatoria de presión arterial, MAPA, SpaceLabs 90202-90207), con muestreo a conveniencia de hipertensos no tratados atendidos en atención primaria. Se excluyeron los pacientes con afecciones cardíacas, tiroideas o pulmonares. Definimos TCA a partir del percentil 90 de la FC de consulta y de vigilia de toda la muestra.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 256 hipertensos, 128 (50%) mujeres, de 49,1 (16,1) años de edad, y presión arterial (PA) en la consulta 151 (17,1)/92 (11,9) mmHg. La prevalencia de TCA fue del 7,03% (IC del 95%, 4,03-11,07) (n = 18). No hallamos asociación entre hipertensión clínica aislada y TCA (p = 0,87). Los pacientes con TCA presentan menores PA en la consulta y sistólica nocturna, menor variabilidad nocturna, mayor caída tensional nocturna aunque mayores FC de 24 h y diurnas en comparación con el resto de hipertensos. En el modelo multiva-riante, únicamente la PA diastólica (OR, 0,93 [IC del 95%, 0,87-0,98], por cada mmHg de incremento) y la FC (OR, 1,2 [IC del 95%, 1,11-1,28], por cada latido por minuto de incremento), ambas de consulta, fueron predictoras de TCA.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En este estudio, un 7,03% de pacientes con HTA presenta TCA, entidad con características que sugieren un perfil de riesgo cardiovascular más favorable que en el resto de hipertensos. Unicamente la PA diastólica y la FC-ambas en la consulta- fueron variables predictoras de TCA.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">There is poor information for isolated clinical tachycardia (ICT), that is to say, office tachycardia but normal ambulatory heart rate (HR). Our objective was to describe it and to know differences between hypertensive subjects with and without ICT.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Comparative study after a diagnostic intervention (ambulatory blood pres-sure monitoring, ABPM, SpaceLabs 90202-90207), with convenience sampling of non-treated hypertensive patients attended in primary care. We excluded subjects with heart, thyroid or lung disease. ICT were defined on the basis of office and daytime HR percentil 90 of the whole sample.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 256 subjects were included, 128 (50%) women, age 49.1 (16.1) years, with mean office blood pressure (BP) 151 (17.1)/92 (11.9) mmHg. The prevalence of ICT was 7.03% (CI 95%, 4.03-11.07) (n = 18). We didn't find any association between isolated clinical hypertension and ICT (p = 0.87). Patients with ICT have lower office and systolic nightime BP, lower nightime variability, higher nightime BP fall, although higher 24 hours-HR and dayti-me-HR in comparison with non ICT hipertensive patients. In the multivariate analysis only office diastolic BP (OR, 0.93 [CI 95%, 0.87-0.98], for each mmHg increment) and office HR (OR, 1.2 [CI 95%, 1.11-1.28], for each beat for minute increment) were predictive of ICT.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In this study 7.03% of non treated hipertensive patients present ICT, which suggest a profile of more favorable cardiovascular risk than that without ICT. Only office diastolic BP and office HR were predictive variables of ICT.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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