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array:22 [ "pii" => "S0025775300712449" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71244-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71244" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:201-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3085 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2868 "PDF" => 210 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712450" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71245-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71245" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:205-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 606 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 401 "PDF" => 199 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Efectividad y seguridad de la palidotomía posteroventral en el tratamiento de la enfermedad de Parkinson avanzada" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "205" "paginaFinal" => "208" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy and safety of posteroventral pallidotomy for the treatment of advanced parkinson's disease" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "José Luis Molinuevo, Francesc Valldeoriola, Fritz A. Nobbe, Eduardo Tolosa" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Luis Molinuevo" ] 1 => array:2 [ "nombre" => "Francesc" "apellidos" => "Valldeoriola" ] 2 => array:2 [ "nombre" => "Fritz A." "apellidos" => "Nobbe" ] 3 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Tolosa" ] ] ] 1 => array:2 [ "autoresLista" => "Jordi Rumià, Enric Ferrer" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Jordi" "apellidos" => "Rumià" ] 1 => array:2 [ "nombre" => "Enric" "apellidos" => "Ferrer" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712450?idApp=UINPBA00004N" "url" => "/00257753/0000011400000006/v1_201307291356/S0025775300712450/v1_201307291356/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Infección por citomegalovirus en pacientes con colitis ulcerosa tratados con colectomía" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "204" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "María José Alcalá, Francesc Casellas, Juan-Ramón Malagelada" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "José Alcalá" ] 1 => array:3 [ "nombre" => "Francesc" "apellidos" => "Casellas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "Juan-Ramón" "apellidos" => "Malagelada" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "<span class="elsevierStyleItalic">Servicio de Aparato Digestivo. Hospital General Vall d'Hebron. Barcelona</span>" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servei de Digestiu. Hospital General Vall d'Hebron. P<span class="elsevierStyleSup">o</span>. Vall d'Hebron, 119. 08035 Barcelona." ] ] ] 1 => array:3 [ "autoresLista" => "Judith Pallarés, Inés de Torres" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Judith" "apellidos" => "Pallarés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "Inés" "apellidos" => "de Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Departamento de Anatomía Patológica. Hospital General Vall d'Hebron. Barcelona</span>" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Infection by cytomegalovirus in patients with ulcerative colitis requiring colonic resection" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-12-31" "fechaAceptado" => "2000-01-18" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220525" "palabras" => array:5 [ 0 => "Citomegalovirus" 1 => "Infecciones por citomegalovirus" 2 => "Colitis ulcerosa" 3 => "Colectomía" 4 => "Inmunodepresión" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Investigar la presencia de infección colónica por citomegalovirus (CMV) en piezasde colectomía de pacientes con colitis ulcerosa (CU) que han precisado tratamiento quirúrgicopor refractariedad al tratamiento médico o complicaciones de la enfermedad.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se incluyen 39 pacientes (26 varones y 13 mujeres) colectomizados porCU refractaria o complicada. Se han analizado las características clínicas y farmacológicas quepudieran predisponer a la infección por CMV. En todos los casos se practicó inmunohistoquímicaespecífica para CMV en cortes obtenidos de bloques parafinados.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La inmunohistoquímica fue positiva para CMV en 7 de los 39 pacientes. Desde1985 hasta 1994 sólo hubo un caso de CMV, mientras que de 1995 a 1998 se detectaron 6(p < 0,05). Todos los pacientes con infección por CMV habían recibido tratamiento parenteralpreoperatorio con glucocorticoides y, además, 5 de ellos habían recibido ciclosporina. Veintidósde los 32 pacientes sin evidencia de infección por CMV también habían recibido tratamientoparenteral con glucocorticoides, y 12 de ellos, además, ciclosporina, metotrexato o azatioprina,(la tasa de inmunodepresión farmacológica previa a la intervención en los pacientes no fue diferenteentre los infectados y no infectados por CMV). La duración del tratamiento antes de laintervención (mediana [IC del 95%]) fue similar en los pacientes sin CMV (17 meses [18-89])y en los infectados (30 meses [13-49], p = NS). Cuatro pacientes con infección por CMV fallecieronpor complicaciones en el postoperatorio.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La infección por CMV en pacientes con CU de curso complicado destaca tantopor su frecuencia como por su gravedad. En los últimos años se aprecia un aumento de la prevalenciade infección por CMV, que no parece atribuible a diferencias en el tratamiento inmunodepresorrecibido.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The objective was to determine the rate of colonic infection by cytomegalovirus(CMV) in patients with ulcerative colitis (UC) who have required colonic resection because oflack of response to medical treatment or complications.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Thirty nine patients (26 males, 13 females) colectomized because of refractoryor complicated UC were included. Clinical and pharmacological characteristics wereanalyzed. Specific immunohistochemistry for CMV was performed in biopsic samples of all specimens.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry was positive for CMV in 7 out of the 39 patients. Since 1985to 1994 there was only one case of CMV that contrasts with the 6 cases diagnosed from 1995to 1998 (p < 0.05). All patients with CMV infection have received systemic corticosteroids beforesurgery, and additionally cyclosporine in 5 of them. Twenty two out of the 32 patients withoutCMV infection have also received corticosteroids, cyclosporine, azatioprine or methotrexatebefore surgery. The rate of immunosuppression was not different between the patients with orwithout CMV infection. Length of treatment before surgery was also similar for both groups ofpatients: (17 months (18-89) in non-infected group and 30 months (13-49) in CMV infectedgroup; p = NS). Four patients infected by CMV died in the postoperatory.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">CMV infection in patients with refractory or complicated UC is a serious complicationdue to its frequency and prognosis. A significant increase in the prevalence of CMV infection,not related with differences in therapeutic immunosupression, has been observed inrecent years.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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